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Protein

Claudin

Gene

cldn

Organism
Halocynthia roretzi (Sea squirt) (Cynthia roretzi)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:cldnImported
OrganismiHalocynthia roretzi (Sea squirt) (Cynthia roretzi)Imported
Taxonomic identifieri7729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaStolidobranchiaPyuridaeHalocynthia

Subcellular locationi

  • Cell junctiontight junction UniRule annotation
  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei85 – 10723HelicalUniRule annotationAdd
BLAST
Transmembranei119 – 14527HelicalUniRule annotationAdd
BLAST
Transmembranei165 – 18521HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotation, Membrane, Tight junctionUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG000643.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9N9W1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNEVLQVFG FLLTVLGWLL SIVTCSISSW KRSDVKGEVI ESITRTTGLW
60 70 80 90 100
IRCTQQATGH WTCDNYDSYF LGLPVPLQGA RATTLLSLLL GFFGILLAIF
110 120 130 140 150
GLSCTTIAAE NARLKARMVV ASGMLHVAGG VSLGTGVCWF AATVLQDYQN
160 170 180 190 200
PGNQVSAGRY VYGEALFVGW AAMVVGILGG IAMCISSWST KDDDDHHHHH
210 220
HMERHIPPYT YNPPRPKQNS TEYI
Length:224
Mass (Da):24,562
Last modified:October 1, 2000 - v1
Checksum:i3536FBCF1765ED83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278045 mRNA. Translation: CAB96130.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278045 mRNA. Translation: CAB96130.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000643.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9N9W1_HALRO
AccessioniPrimary (citable) accession number: Q9N9W1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.