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Protein

Eukaryotic translation initiation factor 5A

Gene

eIF5A

Organism
Leishmania infantum
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorImported
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5AUniRule annotation
Short name:
eIF-5AUniRule annotation
Gene namesi
Name:eIF5AImported
Synonyms:EIF5A1Imported
ORF Names:LINJ_25_0740Imported, LINJ_25_0750Imported
OrganismiLeishmania infantumImported
Taxonomic identifieri5671 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000008153 Componenti: Chromosome 25

Organism-specific databases

EuPathDBiTriTrypDB:LinJ.25.0740
TriTrypDB:LinJ.25.0750

PTM / Processingi

Post-translational modificationi

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).UniRule annotation

Keywords - PTMi

HypusineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi435258.XP_003392596.1

Structurei

3D structure databases

SMRiQ9N9V6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 161eIF-5aInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the eIF-5A family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3271 Eukaryota
COG0231 LUCA
KOiK03263

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11673 PTHR11673, 1 hit
PfamiView protein in Pfam
PF01287 eIF-5a, 1 hit
PIRSFiPIRSF003025 eIF5A, 1 hit
SMARTiView protein in SMART
SM01376 eIF-5a, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00037 eIF_5A, 1 hit
PROSITEiView protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9N9V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEDHDFSH QGGGDNASKT YPLPAGALKK GGYVCINGRP CKVIDLSVSK
60 70 80 90 100
TGKHGHAKVS IVATDIFTGN RLEDQAPSTH NVEVPFVKTF TYSVLDIQPN
110 120 130 140 150
EDPSLPSHLS LMDDEGESRE DLDMPPDVAL ATQIKEQFDS GKEVLVVVVS
160
AMGTEQVLQT KNAAEK
Length:166
Mass (Da):17,880
Last modified:October 1, 2000 - v1
Checksum:i26687A0314544D35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278539 mRNA Translation: CAB95733.1
FR796457 Genomic DNA Translation: CAM68543.1
FR796457 Genomic DNA Translation: CBZ08765.1
RefSeqiXP_001466105.1, XM_001466068.1
XP_003392596.1, XM_003392548.1

Genome annotation databases

EnsemblProtistsiCAM68543; CAM68543; LINJ_25_0750
CBZ08765; CBZ08765; LINJ_25_0740
GeneDBiLinJ.25.0740:pep
LinJ.25.0750:pep
GeneIDi10966659
5069539
KEGGilif:LINJ_25_0740
lif:LINJ_25_0750

Similar proteinsi

Entry informationi

Entry nameiQ9N9V6_LEIIN
AccessioniPrimary (citable) accession number: Q9N9V6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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