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Protein
Submitted name:

FI03258p

Gene

hrg

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions. Also active with manganese.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi121Magnesium 1; catalyticUniRule annotation1
Metal bindingi121Magnesium 2; catalyticUniRule annotation1
Metal bindingi123Magnesium 1; catalyticUniRule annotation1
Metal bindingi123Magnesium 2; catalyticUniRule annotation1
Metal bindingi175Magnesium 2; catalyticUniRule annotation1
Binding sitei175ATPUniRule annotation1
Binding sitei236ATPUniRule annotation1
Binding sitei245ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi108 – 110ATPUniRule annotation3
Nucleotide bindingi121 – 123ATPUniRule annotation3
Nucleotide bindingi254 – 255ATPUniRule annotation2

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • polynucleotide adenylyltransferase activity Source: FlyBase
  • RNA binding Source: InterPro

GO - Biological processi

  • mRNA polyadenylation Source: FlyBase

Keywordsi

Molecular functionNucleotidyltransferaseImported, Transferase
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-109688 Cleavage of Growing Transcript in the Termination Region
R-DME-72163 mRNA Splicing - Major Pathway
R-DME-72187 mRNA 3'-end processing
R-DME-77595 Processing of Intronless Pre-mRNAs

Names & Taxonomyi

Protein namesi
Submitted name:
FI03258pImported
Submitted name:
Hiiragi, isoform AImported
Submitted name:
Hiiragi, isoform BImported (EC:2.7.7.19Imported)
Submitted name:
Hiiragi, isoform CImported
Submitted name:
Poly A polymeraseImported
Submitted name:
RE09914pImported
Gene namesi
Name:hrgImported
Synonyms:hrg-RAImported, PAPImported
ORF Names:CG9854Imported, Dmel_CG9854Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0015949 hrg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ9N6D7

Expressioni

Gene expression databases

BgeeiFBgn0015949
ExpressionAtlasiQ9N6D7 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ9N6D7, 2 interactors

Structurei

3D structure databases

SMRiQ9N6D7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 371PAP_centralInterPro annotationAdd BLAST343
Domaini96 – 181NTP_transf_2InterPro annotationAdd BLAST86
Domaini374 – 535PAP_RNA-bindInterPro annotationAdd BLAST162

Phylogenomic databases

eggNOGiKOG2245 Eukaryota
COG5186 LUCA
GeneTreeiENSGT00390000017928
KOiK14376
OMAiPISLACP
OrthoDBiEOG091G0571

Family and domain databases

InterProiView protein in InterPro
IPR011068 NuclTrfase_I-like_C
IPR007012 PolA_pol_cen_dom
IPR007010 PolA_pol_RNA-bd_dom
IPR014492 PolyA_polymerase
IPR002934 Polymerase_NTP_transf_dom
PANTHERiPTHR10682 PTHR10682, 2 hits
PfamiView protein in Pfam
PF01909 NTP_transf_2, 1 hit
PF04928 PAP_central, 1 hit
PF04926 PAP_RNA-bind, 1 hit
PIRSFiPIRSF018425 PolyA_polymerase, 1 hit
SUPFAMiSSF55003 SSF55003, 1 hit

Sequencei

Sequence statusi: Complete.

Q9N6D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNSEPTHRQ HHQHNGNSTS GGPPAKQLGM TSAISLAEPR PEDLQRTDEL
60 70 80 90 100
RGSLEPYNVF ESQDELNHRM EILAKLNTLV KQWVKEISVS KNMPESAAEK
110 120 130 140 150
LGGKIYTFGS YRLGVHHKGA DIDALCVAPR NIERTDYFQS FFEVLKKQPE
160 170 180 190 200
VTECRSVEEA FVPVIKMNFD GIEIDLLFAR LSLKEIPDDF DLRDDNLLRN
210 220 230 240 250
LDHRSVRSLN GCRVTDEILA LVPNIENFRL ALRTIKLWAK KHGIYSNSLG
260 270 280 290 300
YFGGVTWAML VARTCQLYPN AAAATLVHKF FLVFSRWKWP NPVLLKHPDN
310 320 330 340 350
VNLRFQVWDP RVNASDRYHL MPIITPAYPQ QNSTFNVSES TKKVILTEFN
360 370 380 390 400
RGMNITDEIM LGRIPWERLF EAPSFFYRYR HFIVLLVNSQ TADDHLEWCG
410 420 430 440 450
LVESKVRLLI GNLERNPHIA LAHVNPKCFE FKKGQSANNS QNNSGNEDDL
460 470 480 490 500
KQSQGNQSAV TSAPFCSMWF IGLEFERSEN LNVDLTESIQ NFTEHVMMHG
510 520 530 540 550
VNIKMLKEGM TIDARHVKRK QLSLYLDSDF LKRERKSMES HNNFNNTLLA
560 570 580 590 600
NRKRLSTELA QSQDPLPPGQ QPSSGNRGRD SGAKIQRLSD SLTEENSNAS
610 620 630 640 650
SDMGAGTPTT PTTAQLSAPS FKSSGKNGSE IDVVEQEPTQ PHNNGNASSN

TTTTEVACS
Length:659
Mass (Da):74,530
Last modified:October 1, 2000 - v1
Checksum:i83A8EDE287DCA066
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231704 mRNA Translation: AAF36978.1
AE013599 Genomic DNA Translation: AAF57528.2
AE013599 Genomic DNA Translation: AAM68424.1
BT001541 mRNA Translation: AAN71296.1
AE013599 Genomic DNA Translation: ABI31107.1
BT050444 mRNA Translation: ACJ13151.1
AB018431 mRNA Translation: BAB03279.1
RefSeqiNP_001036562.1, NM_001043097.3
NP_536790.1, NM_080529.4
NP_725919.1, NM_166372.3
UniGeneiDm.1536

Genome annotation databases

EnsemblMetazoaiFBtr0086483; FBpp0085678; FBgn0015949
FBtr0086484; FBpp0085679; FBgn0015949
FBtr0111010; FBpp0110309; FBgn0015949
FBtr0330248; FBpp0303281; FBgn0015949
GeneIDi49636
KEGGidme:Dmel_CG9854
UCSCiCG9854-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9N6D7_DROME
AccessioniPrimary (citable) accession number: Q9N6D7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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