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Protein
Submitted name:

FI03258p

Gene

hrg

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • polynucleotide adenylyltransferase activity Source: FlyBase
  • RNA binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-DME-109688. Cleavage of Growing Transcript in the Termination Region.
R-DME-72163. mRNA Splicing - Major Pathway.
R-DME-72187. mRNA 3'-end processing.
R-DME-77595. Processing of Intronless Pre-mRNAs.

Names & Taxonomyi

Protein namesi
Submitted name:
FI03258pImported
Submitted name:
Hiiragi, isoform AImported
Submitted name:
Hiiragi, isoform BImported
Submitted name:
Hiiragi, isoform CImported (EC:2.7.7.19Imported)
Submitted name:
Poly A polymeraseImported
Submitted name:
RE09914pImported
Gene namesi
Name:hrgImported
Synonyms:hrg-RAImported, PAPImported
ORF Names:CG9854Imported, Dmel_CG9854Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0015949. hrg.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

MINTiMINT-919584.
STRINGi7227.FBpp0303281.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 371343PAP_centralInterPro annotationAdd
BLAST
Domaini96 – 18186NTP_transf_2InterPro annotationAdd
BLAST
Domaini374 – 535162PAP_RNA-bindInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG2245. Eukaryota.
COG5186. LUCA.
GeneTreeiENSGT00390000017928.
KOiK14376.

Family and domain databases

Gene3Di3.30.70.590. 1 hit.
InterProiIPR011068. NuclTrfase_I_C.
IPR007012. PolA_pol_cen_dom.
IPR007010. PolA_pol_RNA-bd_dom.
IPR014492. PolyA_polymerase.
IPR002934. Polymerase_NTP_transf_dom.
[Graphical view]
PANTHERiPTHR10682. PTHR10682. 2 hits.
PfamiPF01909. NTP_transf_2. 1 hit.
PF04928. PAP_central. 1 hit.
PF04926. PAP_RNA-bind. 1 hit.
[Graphical view]
PIRSFiPIRSF018425. PolyA_polymerase. 1 hit.
SUPFAMiSSF55003. SSF55003. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9N6D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNSEPTHRQ HHQHNGNSTS GGPPAKQLGM TSAISLAEPR PEDLQRTDEL
60 70 80 90 100
RGSLEPYNVF ESQDELNHRM EILAKLNTLV KQWVKEISVS KNMPESAAEK
110 120 130 140 150
LGGKIYTFGS YRLGVHHKGA DIDALCVAPR NIERTDYFQS FFEVLKKQPE
160 170 180 190 200
VTECRSVEEA FVPVIKMNFD GIEIDLLFAR LSLKEIPDDF DLRDDNLLRN
210 220 230 240 250
LDHRSVRSLN GCRVTDEILA LVPNIENFRL ALRTIKLWAK KHGIYSNSLG
260 270 280 290 300
YFGGVTWAML VARTCQLYPN AAAATLVHKF FLVFSRWKWP NPVLLKHPDN
310 320 330 340 350
VNLRFQVWDP RVNASDRYHL MPIITPAYPQ QNSTFNVSES TKKVILTEFN
360 370 380 390 400
RGMNITDEIM LGRIPWERLF EAPSFFYRYR HFIVLLVNSQ TADDHLEWCG
410 420 430 440 450
LVESKVRLLI GNLERNPHIA LAHVNPKCFE FKKGQSANNS QNNSGNEDDL
460 470 480 490 500
KQSQGNQSAV TSAPFCSMWF IGLEFERSEN LNVDLTESIQ NFTEHVMMHG
510 520 530 540 550
VNIKMLKEGM TIDARHVKRK QLSLYLDSDF LKRERKSMES HNNFNNTLLA
560 570 580 590 600
NRKRLSTELA QSQDPLPPGQ QPSSGNRGRD SGAKIQRLSD SLTEENSNAS
610 620 630 640 650
SDMGAGTPTT PTTAQLSAPS FKSSGKNGSE IDVVEQEPTQ PHNNGNASSN

TTTTEVACS
Length:659
Mass (Da):74,530
Last modified:October 1, 2000 - v1
Checksum:i83A8EDE287DCA066
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231704 mRNA. Translation: AAF36978.1.
AE013599 Genomic DNA. Translation: AAF57528.2.
AE013599 Genomic DNA. Translation: AAM68424.1.
BT001541 mRNA. Translation: AAN71296.1.
AE013599 Genomic DNA. Translation: ABI31107.1.
BT050444 mRNA. Translation: ACJ13151.1.
AB018431 mRNA. Translation: BAB03279.1.
RefSeqiNP_001036562.1. NM_001043097.3.
NP_536790.1. NM_080529.4.
NP_725919.1. NM_166372.3.
UniGeneiDm.1536.

Genome annotation databases

EnsemblMetazoaiFBtr0086483; FBpp0085678; FBgn0015949.
FBtr0086484; FBpp0085679; FBgn0015949.
FBtr0111010; FBpp0110309; FBgn0015949.
GeneIDi49636.
KEGGidme:Dmel_CG9854.
UCSCiCG9854-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231704 mRNA. Translation: AAF36978.1.
AE013599 Genomic DNA. Translation: AAF57528.2.
AE013599 Genomic DNA. Translation: AAM68424.1.
BT001541 mRNA. Translation: AAN71296.1.
AE013599 Genomic DNA. Translation: ABI31107.1.
BT050444 mRNA. Translation: ACJ13151.1.
AB018431 mRNA. Translation: BAB03279.1.
RefSeqiNP_001036562.1. NM_001043097.3.
NP_536790.1. NM_080529.4.
NP_725919.1. NM_166372.3.
UniGeneiDm.1536.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-919584.
STRINGi7227.FBpp0303281.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0086483; FBpp0085678; FBgn0015949.
FBtr0086484; FBpp0085679; FBgn0015949.
FBtr0111010; FBpp0110309; FBgn0015949.
GeneIDi49636.
KEGGidme:Dmel_CG9854.
UCSCiCG9854-RA. d. melanogaster.

Organism-specific databases

CTDi3273.
FlyBaseiFBgn0015949. hrg.

Phylogenomic databases

eggNOGiKOG2245. Eukaryota.
COG5186. LUCA.
GeneTreeiENSGT00390000017928.
KOiK14376.

Enzyme and pathway databases

ReactomeiR-DME-109688. Cleavage of Growing Transcript in the Termination Region.
R-DME-72163. mRNA Splicing - Major Pathway.
R-DME-72187. mRNA 3'-end processing.
R-DME-77595. Processing of Intronless Pre-mRNAs.

Miscellaneous databases

ChiTaRSihrg. fly.
GenomeRNAii49636.

Family and domain databases

Gene3Di3.30.70.590. 1 hit.
InterProiIPR011068. NuclTrfase_I_C.
IPR007012. PolA_pol_cen_dom.
IPR007010. PolA_pol_RNA-bd_dom.
IPR014492. PolyA_polymerase.
IPR002934. Polymerase_NTP_transf_dom.
[Graphical view]
PANTHERiPTHR10682. PTHR10682. 2 hits.
PfamiPF01909. NTP_transf_2. 1 hit.
PF04928. PAP_central. 1 hit.
PF04926. PAP_RNA-bind. 1 hit.
[Graphical view]
PIRSFiPIRSF018425. PolyA_polymerase. 1 hit.
SUPFAMiSSF55003. SSF55003. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of poly(A) polymerase gene of Drosophila melanogaster."
    Murata T., Yokoyama K.K.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. "Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in Drosophila."
    Juge F., Zaessinger S., Temme C., Wahle E., Simonelig M.
    EMBO J. 21:6603-6613(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  6. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  9. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  14. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  15. FlyBase
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9N6D7_DROME
AccessioniPrimary (citable) accession number: Q9N6D7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.