Q9N5L4 (PME4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly(ADP-ribose) glycohydrolase pme-4
EC=3.2.1.143

Alternative name(s):
Poly ADP-ribose metabolism enzyme 4

Gene names

Name:	pme-4
ORF Names:	H23L24.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells By similarity.
Catalytic activity	Hydrolyzes poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.
Sequence similarities	Belongs to the poly(ADP-ribose) glycohydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	poly(ADP-ribose) glycohydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Poly(ADP-ribose) glycohydrolase pme-4		PRO_0000066606

Sequences

	Sequence		Length	Mass (Da)
	Q9N5L4 [UniParc]. Last modified March 1, 2003. Version 2. Checksum: 86367DDBAB15081F	FASTA	485	55,574
	10 20 30 40 50 60 MDHENLMKYL EEFRSIRFQP DFQKVDAERN VRYCEITDFP ISNISFELLE TGVSQQWRNC 70 80 90 100 110 120 DQNLFNEYLK TYKNGGYSQF EDLLFKIWGY SEEKERFDLP ALKSFYRKMS EIVGEDEVLE 130 140 150 160 170 180 KLARLVRITK SACEVLPEKI YRLVGDIESA TFSHIQCASL IAWMFFSDTP RLSFIIILQK 190 200 210 220 230 240 TTCVAVEKLK FLFTYFDKMS IDPPIGAVSF RKMRITHKQY LENWKLRETN LLPDVQVFDK 250 260 270 280 290 300 MSIEETALCT QIDFANKRLG GGVLKGGAVQ EEIRFMMCPE MMVAILLNDV TQDLEAISIV 310 320 330 340 350 360 GAYVFSSYTG YSNTLKWAKI TPKHSAQNNN SFRDQFGRLQ TETVAIDAVR NAGTPLECLL 370 380 390 400 410 420 NQLTTEKLTR EVRKAAIGFL SAGDGFSKIP VVSGWWGCGA FRGNKPLKFL IQVIACGISD 430 440 450 460 470 480 RPLQFCTFGD TELAKKCEEM MTLFRNNNVR TGQLFLIINS IGPPLNYSEQ YVFDAIRAKI NSTKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of poly(ADP-ribose) glycohydrolases in the nematode Caenorhabditis elegans." Gagnon S.N., Hardy I., Desnoyers S. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF548468 mRNA. Translation: AAN40699.1. FO081083 Genomic DNA. Translation: CCD68980.1.
RefSeq	NP_501496.2. NM_069095.3.
UniGene	Cel.12729.
3D structure databases
ProteinModelPortal	Q9N5L4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	H23L24.5; H23L24.5; H23L24.5.
GeneID	186765.
KEGG	cel:H23L24.5.
NMPDR	fig|6239.3.peg.14340.
UCSC	H23L24.5. c. elegans.
Organism-specific databases
CTD	186765.
WormBase	H23L24.5; CE32685; WBGene00004052; pme-4.
Phylogenomic databases
eggNOG	meNOG05921.
GeneTree	EMGT00050000000627.
InParanoid	Q9N5L4.
OMA	CTQIDFA.
PhylomeDB	Q9N5L4.
Enzyme and pathway databases
BRENDA	3.2.1.143. 1045.
Gene expression databases
ArrayExpress	Q9N5L4.
Family and domain databases
InterPro	IPR007724. Poly_GlycHdrlase. [Graphical view]
KO	K07759.
PANTHER	PTHR12837. Poly_glchydro. 1 hit.
Pfam	PF05028. PARG_cat. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	932914.

Entry information

Entry name

PME4_CAEEL

Accession

Primary (citable) accession number: Q9N5L4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	March 1, 2003
Last modified:	December 14, 2011
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project