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Protein

Proteasome subunit alpha type-4

Gene

pas-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-8948751. Regulation of PTEN stability and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.973.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-4 (EC:3.4.25.1)
Alternative name(s):
Proteasome subunit alpha 3
Gene namesi
Name:pas-3
ORF Names:Y110A7A.14
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY110A7A.14; CE30307; WBGene00003924; pas-3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241071 – 250Proteasome subunit alpha type-4Add BLAST250

Proteomic databases

EPDiQ9N599.
PaxDbiQ9N599.
PeptideAtlasiQ9N599.
PRIDEiQ9N599.

Expressioni

Gene expression databases

BgeeiWBGene00003924.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi37600. 1 interactor.
IntActiQ9N599. 1 interactor.
MINTiMINT-212838.
STRINGi6239.Y110A7A.14.2.

Structurei

3D structure databases

ProteinModelPortaliQ9N599.
SMRiQ9N599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0178. Eukaryota.
COG0638. LUCA.
GeneTreeiENSGT00550000074827.
HOGENOMiHOG000091085.
InParanoidiQ9N599.
KOiK02728.
OMAiMSKTMDS.
OrthoDBiEOG091G0F2L.
PhylomeDBiQ9N599.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
IPR034647. Proteasome_subunit_alpha4.
PANTHERiPTHR11599:SF13. PTHR11599:SF13. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9N599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRYDSRTT IFSPEGRLYQ VEYAMEAISH AGTCLGILSS EGIVVAAERK
60 70 80 90 100
NVHKLLDDSV MTEKVYRLSD NISCTVAGIT ADANILINHL RWWAASYRNS
110 120 130 140 150
YGEEMPVEQL VQNLCNEKQR YTQIGGKRPF GVSLLYIGWD KHYGYQLYQS
160 170 180 190 200
DPSGNYTGWK ATCIGSNHQA AVTLLKQEYK SPNLEEAKQL AIKVLWKTLD
210 220 230 240 250
VKLASEKVEM AVLTRRDGKT VLEELTTKEV DALIAEHEKK EKEAETAEKK
Length:250
Mass (Da):28,282
Last modified:December 8, 2000 - v2
Checksum:i692E037F345317A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080728 Genomic DNA. Translation: CCD66205.1.
RefSeqiNP_491520.2. NM_059119.5.
UniGeneiCel.23223.

Genome annotation databases

EnsemblMetazoaiY110A7A.14.1; Y110A7A.14.1; WBGene00003924.
Y110A7A.14.2; Y110A7A.14.2; WBGene00003924.
GeneIDi172139.
KEGGicel:CELE_Y110A7A.14.
UCSCiY110A7A.14.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiPSA4_CAEEL
AccessioniPrimary (citable) accession number: Q9N599
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: December 8, 2000
Last modified: November 22, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families