Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9N599

- PSA4_CAEEL

UniProt

Q9N599 - PSA4_CAEEL

Protein

Proteasome subunit alpha type-4

Gene

pas-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (08 Dec 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.By similarity

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    ReactomeiREACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_183279. ER-Phagosome pathway.
    REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_184635. Orc1 removal from chromatin.
    REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_215136. Asymmetric localization of PCP proteins.

    Protein family/group databases

    MEROPSiT01.973.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-4 (EC:3.4.25.1)
    Alternative name(s):
    Proteasome subunit alpha 3
    Gene namesi
    Name:pas-3
    ORF Names:Y110A7A.14
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiY110A7A.14; CE30307; WBGene00003924; pas-3.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Proteasome subunit alpha type-4PRO_0000124107Add
    BLAST

    Proteomic databases

    PaxDbiQ9N599.
    PRIDEiQ9N599.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Protein-protein interaction databases

    BioGridi37600. 1 interaction.
    IntActiQ9N599. 1 interaction.
    MINTiMINT-212838.
    STRINGi6239.Y110A7A.14.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9N599.
    SMRiQ9N599. Positions 2-234.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    GeneTreeiENSGT00550000074827.
    HOGENOMiHOG000091085.
    InParanoidiQ9N599.
    KOiK02728.
    OMAiKQEYKDD.
    PhylomeDBiQ9N599.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9N599-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARRYDSRTT IFSPEGRLYQ VEYAMEAISH AGTCLGILSS EGIVVAAERK    50
    NVHKLLDDSV MTEKVYRLSD NISCTVAGIT ADANILINHL RWWAASYRNS 100
    YGEEMPVEQL VQNLCNEKQR YTQIGGKRPF GVSLLYIGWD KHYGYQLYQS 150
    DPSGNYTGWK ATCIGSNHQA AVTLLKQEYK SPNLEEAKQL AIKVLWKTLD 200
    VKLASEKVEM AVLTRRDGKT VLEELTTKEV DALIAEHEKK EKEAETAEKK 250
    Length:250
    Mass (Da):28,282
    Last modified:December 8, 2000 - v2
    Checksum:i692E037F345317A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080728 Genomic DNA. Translation: CCD66205.1.
    RefSeqiNP_491520.2. NM_059119.5.
    UniGeneiCel.23223.

    Genome annotation databases

    EnsemblMetazoaiY110A7A.14.1; Y110A7A.14.1; WBGene00003924.
    Y110A7A.14.2; Y110A7A.14.2; WBGene00003924.
    GeneIDi172139.
    KEGGicel:CELE_Y110A7A.14.
    UCSCiY110A7A.14.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080728 Genomic DNA. Translation: CCD66205.1 .
    RefSeqi NP_491520.2. NM_059119.5.
    UniGenei Cel.23223.

    3D structure databases

    ProteinModelPortali Q9N599.
    SMRi Q9N599. Positions 2-234.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 37600. 1 interaction.
    IntActi Q9N599. 1 interaction.
    MINTi MINT-212838.
    STRINGi 6239.Y110A7A.14.2.

    Protein family/group databases

    MEROPSi T01.973.

    Proteomic databases

    PaxDbi Q9N599.
    PRIDEi Q9N599.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y110A7A.14.1 ; Y110A7A.14.1 ; WBGene00003924 .
    Y110A7A.14.2 ; Y110A7A.14.2 ; WBGene00003924 .
    GeneIDi 172139.
    KEGGi cel:CELE_Y110A7A.14.
    UCSCi Y110A7A.14.1. c. elegans.

    Organism-specific databases

    CTDi 172139.
    WormBasei Y110A7A.14 ; CE30307 ; WBGene00003924 ; pas-3.

    Phylogenomic databases

    eggNOGi COG0638.
    GeneTreei ENSGT00550000074827.
    HOGENOMi HOG000091085.
    InParanoidi Q9N599.
    KOi K02728.
    OMAi KQEYKDD.
    PhylomeDBi Q9N599.

    Enzyme and pathway databases

    Reactomei REACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_183279. ER-Phagosome pathway.
    REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_184635. Orc1 removal from chromatin.
    REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_215136. Asymmetric localization of PCP proteins.

    Miscellaneous databases

    NextBioi 874181.
    PROi Q9N599.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPSA4_CAEEL
    AccessioniPrimary (citable) accession number: Q9N599
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 8, 2000
    Last sequence update: December 8, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3