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Protein

Proteasome subunit alpha type-4

Gene

pas-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_283635. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_283838. ER-Phagosome pathway.
REACT_297004. degradation of DVL.
REACT_297277. Degradation of beta-catenin by the destruction complex.
REACT_297611. Hedgehog 'on' state.
REACT_297963. Ubiquitin-dependent degradation of Cyclin D1.
REACT_302900. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_312971. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_338516. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_338846. Orc1 removal from chromatin.
REACT_339957. SCF-beta-TrCP mediated degradation of Emi1.
REACT_341484. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.973.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-4 (EC:3.4.25.1)
Alternative name(s):
Proteasome subunit alpha 3
Gene namesi
Name:pas-3
ORF Names:Y110A7A.14
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY110A7A.14; CE30307; WBGene00003924; pas-3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Proteasome subunit alpha type-4PRO_0000124107Add
BLAST

Proteomic databases

PaxDbiQ9N599.
PRIDEiQ9N599.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi37600. 1 interaction.
IntActiQ9N599. 1 interaction.
MINTiMINT-212838.
STRINGi6239.Y110A7A.14.2.

Structurei

3D structure databases

ProteinModelPortaliQ9N599.
SMRiQ9N599. Positions 2-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00550000074827.
HOGENOMiHOG000091085.
InParanoidiQ9N599.
KOiK02728.
OMAiLVSHLCD.
PhylomeDBiQ9N599.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9N599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRYDSRTT IFSPEGRLYQ VEYAMEAISH AGTCLGILSS EGIVVAAERK
60 70 80 90 100
NVHKLLDDSV MTEKVYRLSD NISCTVAGIT ADANILINHL RWWAASYRNS
110 120 130 140 150
YGEEMPVEQL VQNLCNEKQR YTQIGGKRPF GVSLLYIGWD KHYGYQLYQS
160 170 180 190 200
DPSGNYTGWK ATCIGSNHQA AVTLLKQEYK SPNLEEAKQL AIKVLWKTLD
210 220 230 240 250
VKLASEKVEM AVLTRRDGKT VLEELTTKEV DALIAEHEKK EKEAETAEKK
Length:250
Mass (Da):28,282
Last modified:December 8, 2000 - v2
Checksum:i692E037F345317A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080728 Genomic DNA. Translation: CCD66205.1.
RefSeqiNP_491520.2. NM_059119.5.
UniGeneiCel.23223.

Genome annotation databases

EnsemblMetazoaiY110A7A.14.1; Y110A7A.14.1; WBGene00003924.
Y110A7A.14.2; Y110A7A.14.2; WBGene00003924.
GeneIDi172139.
KEGGicel:CELE_Y110A7A.14.
UCSCiY110A7A.14.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080728 Genomic DNA. Translation: CCD66205.1.
RefSeqiNP_491520.2. NM_059119.5.
UniGeneiCel.23223.

3D structure databases

ProteinModelPortaliQ9N599.
SMRiQ9N599. Positions 2-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37600. 1 interaction.
IntActiQ9N599. 1 interaction.
MINTiMINT-212838.
STRINGi6239.Y110A7A.14.2.

Protein family/group databases

MEROPSiT01.973.

Proteomic databases

PaxDbiQ9N599.
PRIDEiQ9N599.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY110A7A.14.1; Y110A7A.14.1; WBGene00003924.
Y110A7A.14.2; Y110A7A.14.2; WBGene00003924.
GeneIDi172139.
KEGGicel:CELE_Y110A7A.14.
UCSCiY110A7A.14.1. c. elegans.

Organism-specific databases

CTDi172139.
WormBaseiY110A7A.14; CE30307; WBGene00003924; pas-3.

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00550000074827.
HOGENOMiHOG000091085.
InParanoidiQ9N599.
KOiK02728.
OMAiLVSHLCD.
PhylomeDBiQ9N599.

Enzyme and pathway databases

ReactomeiREACT_283635. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_283838. ER-Phagosome pathway.
REACT_297004. degradation of DVL.
REACT_297277. Degradation of beta-catenin by the destruction complex.
REACT_297611. Hedgehog 'on' state.
REACT_297963. Ubiquitin-dependent degradation of Cyclin D1.
REACT_302900. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_312971. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_338516. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_338846. Orc1 removal from chromatin.
REACT_339957. SCF-beta-TrCP mediated degradation of Emi1.
REACT_341484. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

NextBioi874181.
PROiQ9N599.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPSA4_CAEEL
AccessioniPrimary (citable) accession number: Q9N599
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: December 8, 2000
Last modified: July 22, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.