Reviewed, UniProtKB/Swiss-Prot Q9N4Z0 (L2HDH_CAEEL)

Names and origin

Protein names

Recommended name:
    L-2-hydroxyglutarate dehydrogenase, mitochondrial
    EC=1.1.99.2

Gene names

ORF Names:

Y45G12B.3

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
Cofactor	FAD By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the L2HGDH family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2-hydroxyglutarate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 433		L-2-hydroxyglutarate dehydrogenase, mitochondrial		PRO_0000331211

Sequences

	Sequence		Length	Mass (Da)
	Q9N4Z0-1 [UniParc]. Last modified October 1, 2001. Version 2. Checksum: 2565A7A72A5582BA	FASTA	433	47,901
	10 20 30 40 50 60 MLNRGTFQVF RGISGPPKKS VDLPKYDLVI VGGGIVGCAT ARQLLIEKPQ LKVALIEKEK 70 80 90 100 110 120 ELAVHQSGHN SGVIHAGIYY TPGSLKAKLC VEGLDLSYEF FDKEKVPYKK TGKLIVAVEP 130 140 150 160 170 180 EEVPRLDALF SRAQTNGCRD IEMIDSSKIT ELEPHCRGLK ALWSPHTGIV DWGYVTKRFG 190 200 210 220 230 240 EDFEKRGGKI YTSYPLEKIS DNHDPGYPIR VSSGPALAEF ETKNLITCAG LQSDRVAALS 250 260 270 280 290 300 GCSTDPKIVP FRGEYLLLKP EKRHLVKTNI YPVPDPRFPF LGVHFTPRMN GDIWLGPNAV 310 320 330 340 350 360 LAYKREGYSY FSISPSDLLE SLSYSGMQKL VKKHFTFGIK ELYRGVWIAA QVKQLQRFIP 370 380 390 400 410 420 ELKLSDVTRG PAGVRAQAMD SAGNLVDDFV FDSGTGKLSP LLMHVRNAPS PAATSSLAIA 430 KMITSEAINR FKL

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC006768 Genomic DNA. Translation: AAF60576.2.
RefSeq	NP_503730.1.
UniGene	Cel.1737
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	Y45G12B.3. Caenorhabditis elegans. [Contig view]
GeneID	178733.
KEGG	cel:Y45G12B.3.
Organism-specific databases
WormBase	WBGene00021564. Y45G12B.3.
WormPep	Y45G12B.3. CE28366. [WorfDB]
Phylogenomic databases
OMA	Q9N4Z0. KIVPFRG.
Gene expression databases
ArrayExpress	Q9N4Z0.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	902318.

Entry information

Entry name

L2HDH_CAEEL

Accession

Primary (citable) accession number: Q9N4Z0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	October 1, 2001
Last modified:	June 16, 2009
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project