Q9N4X8GSTPA_CAEELGlutathione S-transferase P 102.5.1.18GST 5.4GST class-piGSTP2-2gst-10Y45G12C.2Caenorhabditis elegansEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditisInvertebrate glutathione transferases conjugating 4-hydroxynonenal: CeGST 5.4 from Caenorhabditis elegans.NUCLEOTIDE SEQUENCE [MRNA]PROTEIN SEQUENCE OF 2-11FUNCTIONGenome sequence of the nematode C. elegans: a platform for investigating biology.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal.FUNCTIONBIOPHYSICOCHEMICAL PROPERTIESTISSUE SPECIFICITYLifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2.FUNCTIONDISRUPTION PHENOTYPECe-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans.FUNCTIONConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Responsible for approximately one-third of 4-hydroxy-2-nonenal conjugation (Ref.1, PubMed:16164425, PubMed:16300482). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection (PubMed:22216003).glutathione + RX = a halide anion + an S-substituted glutathione + H(+)50 uM for 4-HNE10.3 umol/min/mg enzymeHomodimer.Expressed in cells at the mouth and adjacent to the pharyngeal bulbs of the head and also in the tail.Increase in susceptibility to 4-hydroxy-2-nonenal, paraquat and heat shock and a reduced lifespan.Belongs to the GST superfamily. Pi family.Direct protein sequencingReference proteomeTransferaseglutathioneglutathioneglutathioneglutathioneglutathioneMAVPQLYYFTIRGFGEYIRLLFLDNGIKFEDIRFDYEGNEWQEFKKGMLLGQLPCLKVDGQEIVQTGAIMRHLGRVHGLNGSNEQEATFLDMFFEGVRDVRMKYVRYIYYDEGTREDCVNKTIPEALVKLEELFKAHSGDFIIGNKISYADYILFEELDVYHVLDANILDKFPTLKSFWERMWKRPNLNAYLEKRKADKVWINAIEKGMN
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