Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione S-transferase P 10

Gene

gst-10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Responsible for approximately one-third of 4-hydroxy-2-nonenal conjugation (Ref. 1, PubMed:16164425, PubMed:16300482). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection (PubMed:22216003).4 Publications

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Kineticsi

  1. KM=50 µM for 4-HNE1 Publication
  1. Vmax=10.3 µmol/min/mg enzyme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei41GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

  • glutathione transferase activity Source: WormBase

GO - Biological processi

  • determination of adult lifespan Source: UniProtKB
  • glutathione metabolic process Source: WormBase
  • heat acclimation Source: UniProtKB
  • oxidation-reduction process Source: WormBase
  • response to hydrogen peroxide Source: UniProtKB
  • response to UV-C Source: UniProtKB

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-CEL-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P 10 (EC:2.5.1.18)
Alternative name(s):
GST 5.4
GST class-pi
GSTP2-2
Gene namesi
Name:gst-10Imported
ORF Names:Y45G12C.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiY45G12C.2 ; CE21937 ; WBGene00001758 ; gst-10

Pathology & Biotechi

Disruption phenotypei

Increase in susceptibility to 4-hydroxy-2-nonenal, paraquat and heat shock and a reduced lifespan.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001859122 – 210Glutathione S-transferase P 10Add BLAST209

Proteomic databases

EPDiQ9N4X8
PaxDbiQ9N4X8
PeptideAtlasiQ9N4X8
PRIDEiQ9N4X8

Expressioni

Tissue specificityi

Expressed in cells at the mouth and adjacent to the pharyngeal bulbs of the head and also in the tail.1 Publication

Gene expression databases

BgeeiWBGene00001758
ExpressionAtlasiQ9N4X8 baseline and differential

Interactioni

Subunit structurei

Homodimer.By similarityCurated

Protein-protein interaction databases

IntActiQ9N4X8, 1 interactor
STRINGi6239.Y45G12C.2

Structurei

3D structure databases

ProteinModelPortaliQ9N4X8
SMRiQ9N4X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 81GST N-terminalAdd BLAST80
Domaini83 – 200GST C-terminalAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 53Glutathione bindingBy similarity2
Regioni65 – 66Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.By similarity

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115733
InParanoidiQ9N4X8
KOiK00799
OMAiQHIPILR
OrthoDBiEOG091G0O3D
PhylomeDBiQ9N4X8

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N4X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPQLYYFT IRGFGEYIRL LFLDNGIKFE DIRFDYEGNE WQEFKKGMLL
60 70 80 90 100
GQLPCLKVDG QEIVQTGAIM RHLGRVHGLN GSNEQEATFL DMFFEGVRDV
110 120 130 140 150
RMKYVRYIYY DEGTREDCVN KTIPEALVKL EELFKAHSGD FIIGNKISYA
160 170 180 190 200
DYILFEELDV YHVLDANILD KFPTLKSFWE RMWKRPNLNA YLEKRKADKV
210
WINAIEKGMN
Length:210
Mass (Da):24,796
Last modified:January 23, 2007 - v3
Checksum:i31AF3BC1ED43594B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080245 Genomic DNA Translation: CCD62297.1
RefSeqiNP_503701.1, NM_071300.7
UniGeneiCel.34291

Genome annotation databases

EnsemblMetazoaiY45G12C.2a; Y45G12C.2a; WBGene00001758
GeneIDi178725
KEGGicel:CELE_Y45G12C.2
UCSCiY45G12C.2.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGSTPA_CAEEL
AccessioniPrimary (citable) accession number: Q9N4X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health