Q9N4M4 (ANC1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear anchorage protein 1
Short name=Anchorage 1 protein

Alternative name(s):
Nesprin homolog

Gene names

Name:	anc-1
ORF Names:	T03A1.3/T03A1.4, ZK973.6

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	8545 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a central role in nuclear and mitochondrial anchoring. Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus. Ref.1
Subunit structure	Interacts with F-actin via its N-terminal domain. Interacts indirecty with unc-84. Ref.1
Subcellular location	Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side Potential. Cytoplasm › cytoskeleton. Note: The largest part of the protein is cytoplasmic, while its C-terminal part is associated either with the nuclear envelope, most probably the outer nuclear membrane, or with mitochondrial membrane.
Tissue specificity	Ubiquitously expressed in all postembryonic cells.
Developmental stage	First expressed in L1 larvae, and thereafter.
Domain	The large coiled coil domains are composed of 6 nearly exact repeats of 903 residues. The last repeat is partial. These repeats are conserved in Hawai (CB4856), Australia (AB4) and Germany (RC301) strains. The length of the repeat may be maintained because of a selective advantage to keep the protein large and allow a single molecule to extent more than 0,5 micrometers. The KASH domain, which contains a potential transmembrane domain, is essential for the nuclear envelope targeting.
Sequence similarities	Belongs to the nesprin family. Contains 1 actin-binding domain. Contains 2 CH (calponin-homology) domains. Contains 1 KASH domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Membrane Nucleus
Domain	Coiled coil Repeat Transmembrane Transmembrane helix
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytoskeleton organization Inferred from mutant phenotype Ref.1. Source: WormBase pronuclear migration Inferred from mutant phenotype PubMed 21798253. Source: WormBase
Cellular_component	cytoplasm Inferred from direct assay Ref.1. Source: WormBase cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	actin binding Inferred from sequence or structural similarity Ref.1. Source: WormBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 8545	8545	Nuclear anchorage protein 1		PRO_0000163593
Regions
	Topological domain	1 – 8494	8494	Cytoplasmic Potential
	Transmembrane	8495 – 8513	19	Helical; Anchor for type IV membrane protein; Potential
	Topological domain	8514 – 8545	32	Perinuclear space Potential
	Domain	1 – 325	325	Actin-binding
	Domain	23 – 130	108	CH 1
	Domain	222 – 325	104	CH 2
	Repeat	3241 – 4143	903	1
	Repeat	4144 – 5097	954	2
	Repeat	5098 – 6000	903	3
	Repeat	6001 – 6903	903	4
	Repeat	6904 – 7806	903	5
	Repeat	7807 – 8199	393	6
	Domain	8486 – 8545	60	KASH
	Region	3241 – 8199	4959	6 X tandem repeat
	Coiled coil	754 – 774	21	Potential
	Coiled coil	1072 – 1101	30	Potential
	Coiled coil	1215 – 1236	22	Potential
	Coiled coil	1324 – 1384	61	Potential
	Coiled coil	1574 – 1629	56	Potential
	Coiled coil	1725 – 1754	30	Potential
	Coiled coil	1950 – 1981	32	Potential
	Coiled coil	2103 – 2580	478	Potential
	Coiled coil	2682 – 2712	31	Potential
	Coiled coil	2852 – 2949	98	Potential
	Coiled coil	3002 – 3119	118	Potential
	Coiled coil	3178 – 3295	118	Potential
	Coiled coil	3346 – 3417	72	Potential
	Coiled coil	3482 – 3552	71	Potential
	Coiled coil	3587 – 3703	117	Potential
	Coiled coil	3781 – 3839	59	Potential
	Coiled coil	3902 – 4022	121	Potential
	Coiled coil	4114 – 4198	85	Potential
	Coiled coil	4249 – 4320	72	Potential
	Coiled coil	4436 – 4506	71	Potential
	Coiled coil	4541 – 4657	117	Potential
	Coiled coil	4735 – 4793	59	Potential
	Coiled coil	4856 – 4976	121	Potential
	Coiled coil	5035 – 5152	118	Potential
	Coiled coil	5203 – 5274	72	Potential
	Coiled coil	5339 – 5409	71	Potential
	Coiled coil	5444 – 5560	117	Potential
	Coiled coil	5638 – 5696	59	Potential
	Coiled coil	5759 – 5879	121	Potential
	Coiled coil	5938 – 6055	118	Potential
	Coiled coil	6106 – 6177	72	Potential
	Coiled coil	6242 – 6312	71	Potential
	Coiled coil	6347 – 6463	117	Potential
	Coiled coil	6541 – 6599	59	Potential
	Coiled coil	6662 – 6782	121	Potential
	Coiled coil	6841 – 6958	118	Potential
	Coiled coil	7009 – 7080	72	Potential
	Coiled coil	7145 – 7215	71	Potential
	Coiled coil	7250 – 7366	117	Potential
	Coiled coil	7444 – 7502	59	Potential
	Coiled coil	7565 – 7685	121	Potential
	Coiled coil	7744 – 7861	118	Potential
	Coiled coil	7912 – 7983	72	Potential
	Coiled coil	8048 – 8118	71	Potential
	Coiled coil	8153 – 8204	52	Potential
	Coiled coil	8273 – 8329	57	Potential
	Coiled coil	8370 – 8390	21	Potential
	Compositional bias	1655 – 1658	4	Poly-Arg
	Compositional bias	3021 – 3029	9	Poly-Lys
	Compositional bias	3924 – 3932	9	Poly-Lys
	Compositional bias	4878 – 4886	9	Poly-Lys
	Compositional bias	5781 – 5789	9	Poly-Lys
	Compositional bias	6684 – 6692	9	Poly-Lys
	Compositional bias	7587 – 7595	9	Poly-Lys

Sequences

	Sequence		Length	Mass (Da)
	Q9N4M4 [UniParc]. Last modified March 28, 2003. Version 3. Checksum: 02A94D994BEE19E3	FASTA	8,545	956,482
	10 20 30 40 50 60 MSSSPPARPC CVCFRFRPHE DEKAQKNTFT RWINFHLEEH SSSGRIEDLF EDIRDGVLLC 70 80 90 100 110 120 HLIEVLTGEA LAVHKGRVSK RVHHIANLTT ALTVLRRRGL ELINNNAADI ADGNPRIVLG 130 140 150 160 170 180 LIWQIILHFQ IETNMILLRE WGWAATGTEE PTSSAQPEVV VTAPSPTPSS KKSHSKVSSL 190 200 210 220 230 240 SGSKTSLASG EKAPSSPLRQ RIASFLTPTK KAPKLTAQPV KQSVEQVFLR WINAEIGDLV 250 260 270 280 290 300 GGRRVENMDK QWRDGILFCA LVSRWRPDVI SMREVTNANP RDNLELAFNL AHQHLGVRRL 310 320 330 340 350 360 LAVEDMMIEK PDKRSVITYV SQFVRMFGER SPMQGREQHE IFLAWLEATY LLCTRHELNS 370 380 390 400 410 420 QECSRIRREF IEHRPLFNTI IVTKVNYDVE ELVEIEKKWD CIRETLEKYA RRSERDLPEP 430 440 450 460 470 480 FASIATWIAG AEHILSRPLD LDATDAKKTV TMLQKLISEH QKYMEDLPKR QEDFEEAVKH 490 500 510 520 530 540 GGLGGRPVAP EFSEPLRARF AQIEEENEPR ISTLRILTTH YILLQYLQHI DEKIILWRTA 550 560 570 580 590 600 DSVTLLLRWI KEYTQLNAEN PQAKCASYIN KITLTMANDQ NSKLDKEAIL NTSNEKTAET 610 620 630 640 650 660 LKRFESLWIE LKLLKVEWVE WETHVSQLEE IIEERRRNGV PPTPEDEQAL AVITAGADQL 670 680 690 700 710 720 APKLGASARL SNNQRLDVLT HSFKKLTKTT IKIGGRLVVE LEPSTSEQAS KISYSWQASD 730 740 750 760 770 780 ELLKVEMQLR DRIQRDADSS DREQLEYRAE TFRNIRDKLI ELERLNEIYD NHSRDQVDTP 790 800 810 820 830 840 NRNLIRHDMG TIIYGLQAGQ YANFVDLSCY AFVYDEYNQV PVNLTENVLS EDYVREIVNR 850 860 870 880 890 900 KKAILTRREN NEDEIRESIR DMEECDRIIE GWQSTEIEEL RAEWNIKLSE FESWHEMMQQ 910 920 930 940 950 960 VEVLSQTIQT RLDVTVIQTI WILKERSYDI KHSELGGTLR ESLEQLATTS ETSVNRHLQN 970 980 990 1000 1010 1020 LELSNEQDCP DAIEFLEEVG RESVSKLSAA VDDRYIYTLH VLRTKMELFR RLQNFCDAVK 1030 1040 1050 1060 1070 1080 ILRSQNTKWN GIKISQIDQV QSEIDTLIVR LDEEWTQDAN QLRAELASIH GSFFQLEFDR 1090 1100 1110 1120 1130 1140 LNEKLNMLIH DKDKLRELMV HRRHYLTAAN ELITDSKTDL AQRATSSDHP DDILRATDEV 1150 1160 1170 1180 1190 1200 TKALDIKGEE LRRLGELAEM NITDLVVVAL ILSFRRRQLG SEGEPEVEEL RRALREIIAR 1210 1220 1230 1240 1250 1260 PITEPRDVSP DAIVADILRM KDEKKRDEKT IDEIQATTLT DEQRASFAPL IEDYRRRADR 1270 1280 1290 1300 1310 1320 HRIVFEHLVM IYLDWLSRQF DELEDEIGMT IQTSRADDLR RMNSTEWNKW KTDLANIERQ 1330 1340 1350 1360 1370 1380 VGPDTKKALS AELADLHRKR DSMEARINKY LTHSAKINAK LTQFEKWLNA IEEDIEQTER 1390 1400 1410 1420 1430 1440 QFEDPERSYR FGSLHEVALA KQRLVAKLER LNVANKEEVL RLCERYHTIM HKLTPFQTAV 1450 1460 1470 1480 1490 1500 GLPLHVSTNL DRNGPFQSQI SVSSIASSEL ERPESVMSLT SSIGVIPADV AELSPFEAKI 1510 1520 1530 1540 1550 1560 NKLLQKLHII EDSYLKGPKP IDTVREDVKQ LEKYRNRGAE ILQQLSTSNI EDAEKEGLKH 1570 1580 1590 1600 1610 1620 RFVLMLNNYD DILRSIENEI RDDNELTAKN QEILAELSNA EQTLQNSPLE DLDISAELDR 1630 1640 1650 1660 1670 1680 LQMQLDLVKV MCNKPRKYVE CELIDSSREG SPQERRRRKK KVMVMVSNTI TTIIHVVEER 1690 1700 1710 1720 1730 1740 LEASDISRNP DVQQKLVAVK ENLRELDTTT VTPHPPSIMS PLGTENRNDL EEVKRLAAEI 1750 1760 1770 1780 1790 1800 DRAIDTASSM YEDAPTDEDA LKSAIHLLDD QKVTLNHLHV VLEGIPEKNE QDRTDAIDIA 1810 1820 1830 1840 1850 1860 SSVGEKLGNL KSAVEEVYEE VLASTNPVKE DQPLQHIQEV QTTPAEQSNW DTDEFSRQPP 1870 1880 1890 1900 1910 1920 VLSDERIELK TDPSAIDKFE VRSDEDPVPK IIDLFGQLQT AVNEASPLAC EGTDDVDALQ 1930 1940 1950 1960 1970 1980 VASDKLTKQD RTIRKIHAIL DTIDDPVQKP AIIESLDKIK DQINNARDNI NRQIDNLNYN 1990 2000 2010 2020 2030 2040 QTPVVVPKES TKTPLNEIED AVRQASTVVS DELCNTEKLL SARQTLANVK PQVDSVEANV 2050 2060 2070 2080 2090 2100 WSNPETIETV TPILEEYTTL VDNIEKKLAN EIEVPTNDPS RQDLVQQLQD VILECEEVVV 2110 2120 2130 2140 2150 2160 NCDNIEKLEE SKLKLEKARP LLDQIGDNVE KLSREQSPDT SDAIDALSNV HQQYNATIMS 2170 2180 2190 2200 2210 2220 IDDKIDELKN PEEDTSAADQ LISELHVISE MPAVTIDLSM LNAIEEGLST LPAHQAENVQ 2230 2240 2250 2260 2270 2280 AKIDELRQKK EVADQTEQIL SDLNAFGDMP AITLDLDLLK SVEDGIAVLP VEDSERIKAK 2290 2300 2310 2320 2330 2340 IVDLRKKKED ADQAEALLQE LSVISDMPIS TLDLNMLQGI EDNLNSLPAE ESDEIREKLN 2350 2360 2370 2380 2390 2400 ELRRRKQESD QAEALLQELS VISDMPISTL DLNMLQGVED NLNSLPTEEA DKIREKINDL 2410 2420 2430 2440 2450 2460 RRRKQESDLA EALLQELSVI YDMPTSTIDL NMLQGIEDNL NSLPAEESDK IREKINDLRR 2470 2480 2490 2500 2510 2520 RKQESDLAEA LLQELSVIYD MPTSTIDLNM LQGIEDNLNS LPAEESDKIR EKINDLRRRK 2530 2540 2550 2560 2570 2580 QESDQAEALL QELSVVSDMP ASTIDINMLQ SIEDGLSTLL SEDRSKIQQA IDSLRKKKSD 2590 2600 2610 2620 2630 2640 SDLAQHALEA LSVQSKLPSV SINLEELKKL EETLSTVPVE DSKVIRDKIA ELKTEKALAD 2650 2660 2670 2680 2690 2700 HAENYLVELK KIEDMPISAV GSDVLATIED QILQMPVQYQ PSVKETLDKL KQAKEEDDKL 2710 2720 2730 2740 2750 2760 AGVYDELEKI AKLPARDYDN KLLAKIDEKL NSLPKDQIAE THRKVEDIKV TKADIVAQID 2770 2780 2790 2800 2810 2820 VLDKLPAKDI DEHLLNSIEE KLPTIPSDSS DQLQIAIGKL RDRKQANIDE GKKILNELAE 2830 2840 2850 2860 2870 2880 IQKMPADSLN EHALNLLATE SDKFGSEISD KIMQEIDVLR EKQNNHEVAR LNAESVLQQL 2890 2900 2910 2920 2930 2940 DKISEEPHLS LTEERLAPFL QNIDTVPACF VDKIRNKINE VQKLHDEAVQ DEKDELKEKL 2950 2960 2970 2980 2990 3000 VAKVQNIGKT SIDDVNVSDF EEIEREINGS LEAFEAEPLL AKIQELREAK RVGDEARSAA 3010 3020 3030 3040 3050 3060 HDQIVALEKE AEDVTAKESA KKKKKDKKKS PQEMIDELSA KVVEAKALIP KIEEAAKNEN 3070 3080 3090 3100 3110 3120 LPADDKPKAE QLVSNLEAFV KDVETQVSEK QDELDKLNNA NDAIKRLGDA LDDAEKTVVP 3130 3140 3150 3160 3170 3180 SSVPALSEFK DRIAPHLATL VEAVNDVPAS VEPSAVALRD RAAKFVSDLE KNIQKTGDDE 3190 3200 3210 3220 3230 3240 KRADELKNDV GNAVKNVEDV VSKYQNQPQP LDVAKDDANK LKATVEQLTK LAESSDKIDP 3250 3260 3270 3280 3290 3300 QVAKDIKDSK TKAKELLQAL EKAIPQEDAI RREQAEINDR LNNLEKELTK VDEFKPEDAL 3310 3320 3330 3340 3350 3360 PIVDQLAANT NTLKTATDSN NEKAVAPSSL ISHDDLVVGL PEKVFQLQHA IDDKKQALNK 3370 3380 3390 3400 3410 3420 AAAVNEIAPK LQLVSQQLQS VPQEVPASLD EQKQLLEDVE NQKHNLENLL ANLPENDPTA 3430 3440 3450 3460 3470 3480 DELRQKSQWD LSRLKDLLKQ LGSAVGDKLA ALAAFNAARK NAEDALLDIT REDGGDDNKS 3490 3500 3510 3520 3530 3540 PDELIDDLAK KEETVAKLLD TVSGVKPDEL DDKERAEYND LLARLATAAD VLKNKRAELE 3550 3560 3570 3580 3590 3600 QAVKAKADEK SLHDSVDRIV SRLVPLVRES DELRHNAEAV PTQYAPKAEE LKKEVEAAKA 3610 3620 3630 3640 3650 3660 VIANAPSSDA HVQQLEQAVA TAETLIPDLE ERARLWNEFL AARNDIDALI EQLQQPLDAV 3670 3680 3690 3700 3710 3720 LAQPKRSAEE AAQDVENLRN NSQQLSDLDN KIANLQRISE LLDPLESAYA DVRFFDVDAE 3730 3740 3750 3760 3770 3780 QTRHQYDDVL NDVAAELEDE TLLKQSASQV ANEIDDISKM IDSTDPERSI LDTIAKSDIP 3790 3800 3810 3820 3830 3840 ALKAQINRIK DRIVNADASR KHVTTDPKIA EDLDNKLAKL QTELDDAIKT SDEHDKEQLI 3850 3860 3870 3880 3890 3900 LSLKLNISQF EQIPLDQLKS DDLKTAEKEI TNSLKPEEAE PLLAKIQELR EAKRVGDEAR 3910 3920 3930 3940 3950 3960 SAAHDQIVAL EKEAEDVTAK ESAKKKKKDK KKSPQEMIDE LSAKVVEAKA LIPKIEEAAK 3970 3980 3990 4000 4010 4020 NENLPADDKP KAEQLVSNLE AFVKDVETQV SEKQDELDKL NNANDAIKRL GDALDDAEKT 4030 4040 4050 4060 4070 4080 VVPSSVPALS EFKDRIAPHL ATLVEAVNDV PASVEPSAVA LRDRAAKFVS DLEKNIQKTG 4090 4100 4110 4120 4130 4140 DDEKRADELK NDDGNAVKNV EDVVSKYQNQ PQPLDVAKDD ANKLKATVEQ LTKLAESSDK 4150 4160 4170 4180 4190 4200 IDPQVAKDIK DSKTKAKELL QALEKAIPQE DAIRREQAEI NDRLNNLEKE LTKVDEFKPE 4210 4220 4230 4240 4250 4260 DALPIVDQLA ANTNTLKTAT DSNNEKAVAP SSLISHDDLV VGLPEKVFQL QHAIDDKKQA 4270 4280 4290 4300 4310 4320 LNKAAAVNEI APKLQLVSQQ LQSVPQEVPA SLDEQKQLLE DVENQKHNLE NLLANLPEND 4330 4340 4350 4360 4370 4380 PTADELRQKS QWDLSRLKDL LKQLGSAVGD KLAALAAFNA ARKNAEDALL DITREDGGDD 4390 4400 4410 4420 4430 4440 NKSPDELIDD RGRSTGSAVG DKLAALAAFN AARKNAEDAL LDITREDGGD DNKSPDELID 4450 4460 4470 4480 4490 4500 DLAKKEETVA KLLDTVSGVK PDELDDKERA EYNDLLARLA TAADVLKNKR AELEQAVKAK 4510 4520 4530 4540 4550 4560 ADEKSLHDSV DRIVSRLVPL VRESDELRHN AEAVPTQYAP KAEELKKEVE AAKAVIANAP 4570 4580 4590 4600 4610 4620 SSDAHVQQLE QAVATAETLI PDLEERARLW NEFLAARNDI DALIEQLQQP LDAVLAQPKR 4630 4640 4650 4660 4670 4680 SAEEAAQDVE NLRNNSQQLS DLDNKIANLQ RISELLDPLE SAYADVRFFD VDAEQTRHQY 4690 4700 4710 4720 4730 4740 DDVLNDVAAE LEDETLLKQS ASQVANEIDD ISKMIDSTDP ERSILDTIAK SDIPALKAQI 4750 4760 4770 4780 4790 4800 NRIKDRIVNA DASRKHVTTD PKIAEDLDNK LAKLQTELDD AIKTSDEHDK EQLILSLKLN 4810 4820 4830 4840 4850 4860 ISQFEQIPLD QLKSDDLKTA EKEITNSLKP EEAEPLLAKI QELREAKRVG DEARSAAHDQ 4870 4880 4890 4900 4910 4920 IVALEKEAED VTAKESAKKK KKDKKKSPQE MIDELSAKVV EAKALIPKIE EAAKNENLPA 4930 4940 4950 4960 4970 4980 DDKPKAEQLV SNLEAFVKDV ETQVSEKQDE LDKLNNANDA IKRLGDALDD AEKTVVPSSV 4990 5000 5010 5020 5030 5040 PALSEFKDRI APHLATLVEA VNDVPASVEP SAVALRDRAA KFVSDLEKNI QKTGDDEKRA 5050 5060 5070 5080 5090 5100 DELKNDVGNA VKNVEDVVSK YQNQPQPLDV AKDDANKLKA TVEQLTKLAE SSDKIDPQVA 5110 5120 5130 5140 5150 5160 KDIKDSKTKA KELLQALEKA IPQEDAIRRE QAEINDRLNN LEKELTKVDE FKPEDALPIV 5170 5180 5190 5200 5210 5220 DQLAANTNTL KTATDSNNEK AVAPSSLISH DDLVVGLPEK VFQLQHAIDD KKQALNKAAA 5230 5240 5250 5260 5270 5280 VNEIAPKLQL VSQQLQSVPQ EVPASLDEQK QLLEDVENQK HNLENLLANL PENDPTADEL 5290 5300 5310 5320 5330 5340 RQKSQWDLSR LKDLLKQLGS AVGDKLAALA AFNAARKNAE DALLDITRED GGDDNKSPDE 5350 5360 5370 5380 5390 5400 LIDDLAKKEE TVAKLLDTVS GVKPDELDDK ERAEYNDLLA RLATAADVLK NKRAELEQAV 5410 5420 5430 5440 5450 5460 KAKADEKSLH DSVDRIVSRL VPLVRESDEL RHNAEAVPTQ YAPKAEELKK EVEAAKAVIA 5470 5480 5490 5500 5510 5520 NAPSSDAHVQ QLEQAVATAE TLIPDLEERA RLWNEFLAAR NDIDALIEQL QQPLDAVLAQ 5530 5540 5550 5560 5570 5580 PKRSAEEAAQ DVENLRNNSQ QLSDLDNKIA NLQRISELLD PLESAYADVR FFDVDAEQTR 5590 5600 5610 5620 5630 5640 HQYDDVLNDV AAELEDETLL KQSASQVANE IDDISKMIDS TDPERSILDT IAKSDIPALK 5650 5660 5670 5680 5690 5700 AQINRIKDRI VNADASRKHV TTDPKIAEDL DNKLAKLQTE LDDAIKTSDE HDKEQLILSL 5710 5720 5730 5740 5750 5760 KLNISQFEQI PLDQLKSDDL KTAEKEITNS LKPEEAEPLL AKIQELREAK RVGDEARSAA 5770 5780 5790 5800 5810 5820 HDQIVALEKE AEDVTAKESA KKKKKDKKKS PQEMIDELSA KVVEAKALIP KIEEAAKNEN 5830 5840 5850 5860 5870 5880 LPADDKPKAE QLVSNLEAFV KDVETQVSEK QDELDKLNNA NDAIKRLGDA LDDAEKTVVP 5890 5900 5910 5920 5930 5940 SSVPALSEFK DRIAPHLATL VEAVNDVPAS VEPSAVALRD RAAKFVSDLE KNIQKTGDDE 5950 5960 5970 5980 5990 6000 KRADELKNDV GNAVKNVEDV VSKYQNQPQP LDVAKDDANK LKATVEQLTK LAESSDKIDP 6010 6020 6030 6040 6050 6060 QVAKDIKDSK TKAKELLQAL EKAIPQEDAI RREQAEINDR LNNLEKELTK VDEFKPEDAL 6070 6080 6090 6100 6110 6120 PIVDQLAANT NTLKTATDSN NEKAVAPSSL ISHDDLVVGL PEKVFQLQHA IDDKKQALNK 6130 6140 6150 6160 6170 6180 AAAVNEIAPK LQLVSQQLQS VPQEVPASLD EQKQLLEDVE NQKHNLENLL ANLPENDPTA 6190 6200 6210 6220 6230 6240 DELRQKSQWD LSRLKDLLKQ LGSAVGDKLA ALAAFNAARK NAEDALLDIT REDGGDDNKS 6250 6260 6270 6280 6290 6300 PDELIDDLAK KEETVAKLLD TVSGVKPDEL DDKERAEYND LLARLATAAD VLKNKRAELE 6310 6320 6330 6340 6350 6360 QAVKAKADEK SLHDSVDRIV SRLVPLVRES DELRHNAEAV PTQYAPKAEE LKKEVEAAKA 6370 6380 6390 6400 6410 6420 VIANAPSSDA HVQQLEQAVA TAETLIPDLE ERARLWNEFL AARNDIDALI EQLQQPLDAV 6430 6440 6450 6460 6470 6480 LAQPKRSAEE AAQDVENLRN NSQQLSDLDN KIANLQRISE LLDPLESAYA DVRFFDVDAE 6490 6500 6510 6520 6530 6540 QTRHQYDDVL NDVAAELEDE TLLKQSASQV ANEIDDISKM IDSTDPERSI LDTIAKSDIP 6550 6560 6570 6580 6590 6600 ALKAQINRIK DRIVNADASR KHVTTDPKIA EDLDNKLAKL QTELDDAIKT SDEHDKEQLI 6610 6620 6630 6640 6650 6660 LSLKLNISQF EQIPLDQLKS DDLKTAEKEI TNSLKPEEAE PLLAKIQELR EAKRVGDEAR 6670 6680 6690 6700 6710 6720 SAAHDQIVAL EKEAEDVTAK ESAKKKKKDK KKSPQEMIDE LSAKVVEAKA LIPKIEEAAK 6730 6740 6750 6760 6770 6780 NENLPADDKP KAEQLVSNLE AFVKDVETQV SEKQDELDKL NNANDAIKRL GDALDDAEKT 6790 6800 6810 6820 6830 6840 VVPSSVPALS EFKDRIAPHL ATLVEAVNDV PASVEPSAVA LRDRAAKFVS DLEKNIQKTG 6850 6860 6870 6880 6890 6900 DDEKRADELK NDVGNAVKNV EDVVSKYQNQ PQPLDVAKDD ANKLKATVEQ LTKLAESSDK 6910 6920 6930 6940 6950 6960 IDPQVAKDIK DSKTKAKELL QALEKAIPQE DAIRREQAEI NDRLNNLEKE LTKVDEFKPE 6970 6980 6990 7000 7010 7020 DALPIVDQLA ANTNTLKTAT DSNNEKAVAP SSLISHDDLV VGLPEKVFQL QHAIDDKKQA 7030 7040 7050 7060 7070 7080 LNKAAAVNEI APKLQLVSQQ LQSVPQEVPA SLDEQKQLLE DVENQKHNLE NLLANLPEND 7090 7100 7110 7120 7130 7140 PTADELRQKS QWDLSRLKDL LKQLGSAVGD KLAALAAFNA ARKNAEDALL DITREDGGDD 7150 7160 7170 7180 7190 7200 NKSPDELIDD LAKKEETVAK LLDTVSGVKP DELDDKERAE YNDLLARLAT AADVLKNKRA 7210 7220 7230 7240 7250 7260 ELEQAVKAKA DEKSLHDSVD RIVSRLVPLV RESDELRHNA EAVPTQYAPK AEELKKEVEA 7270 7280 7290 7300 7310 7320 AKAVIANAPS SDAHVQQLEQ AVATAETLIP DLEERARLWN EFLAARNDID ALIEQLQQPL 7330 7340 7350 7360 7370 7380 DAVLAQPKRS AEEAAQDVEN LRNNSQQLSD LDNKIANLQR ISELLDPLES AYADVRFFDV 7390 7400 7410 7420 7430 7440 DAEQTRHQYD DVLNDVAAEL EDETLLKQSA SQVANEIDDI SKMIDSTDPE RSILDTIAKS 7450 7460 7470 7480 7490 7500 DIPALKAQIN RIKDRIVNAD ASRKHVTTDP KIAEDLDNKL AKLQTELDDA IKTSDEHDKE 7510 7520 7530 7540 7550 7560 QLILSLKLNI SQFEQIPLDQ LKSDDLKTAE KEITNSLKPE EAEPLLAKIQ ELREAKRVGD 7570 7580 7590 7600 7610 7620 EARSAAHDQI VALEKEAEDV TAKESAKKKK KDKKKSPQEM IDELSAKVVE AKALIPKIEE 7630 7640 7650 7660 7670 7680 AAKNENLPAD DKPKAEQLVS NLEAFVKDVE TQVSEKQDEL DKLNNANDAI KRLGDALDDA 7690 7700 7710 7720 7730 7740 EKTVVPSSVP ALSEFKDRIA PHLATLVEAV NDVPASVEPS AVALRDRAAK FVSDLEKNIQ 7750 7760 7770 7780 7790 7800 KTGDDEKRAD ELKNDVGNAV KNVEDVVSKY QNQPQPLDVA KDDANKLKAT VEQLTKLAES 7810 7820 7830 7840 7850 7860 SDKIDPQVAK DIKDSKTKAK ELLQALEKAI PQEDAIRREQ AEINDRLNKL EKELTKVDEF 7870 7880 7890 7900 7910 7920 KPEDALPIVD QLAANTNTLK TATDSNNEKA VAPSSLISHD DLVVGLPEKV FQLQHAIDDK 7930 7940 7950 7960 7970 7980 KQALNKAAAV NEIAPKLQLV SQQLQSVPQE VPASLDEQKQ LLEDVENQKH NLENLLANLP 7990 8000 8010 8020 8030 8040 ENDPTADELR QKSQWDLSRL KDLLKQLGSA VGEKLAALAA FNAARKNAED ALLDITREDG 8050 8060 8070 8080 8090 8100 GDDNKSPDEL IDDLAKKEET VAKLLDTVSG VKPDELDDKE RAEYNDLLAR LATAADVLKN 8110 8120 8130 8140 8150 8160 KRAELEQAVK AKADEKSLHD SVDRIVSRLV PLVRESDELR HNAEAVPTQY APKAEELKKE 8170 8180 8190 8200 8210 8220 VEAAKAVIAN APSSDAHVQQ LEQAVATAET LIPDLEERAS IWERFVKAKD DLYDYLEKLE 8230 8240 8250 8260 8270 8280 NNVSDVLNRP RLPVSQAQQR FNKLKEQSYL LDRIRDLKID FDDLGEALLP LTVAEDELRF 8290 8300 8310 8320 8330 8340 MHVHVESIER QYEDTMDKLN AEITAEVELL RTLDILSNEL SQCKEDINNP SVDVDELSRA 8350 8360 8370 8380 8390 8400 TMLNDAIAHL ENQKVVVARS EKDRKFVESS TSIDLDQLLA EAKRLLKEIE PRLQLAQPDH 8410 8420 8430 8440 8450 8460 DNEDDEDEEK GSDEKPYDVR AAAEVLSALY PDEHPHNVLR NIGFEELPSD SESRSEFDSL 8470 8480 8490 8500 8510 8520 DSRSDGLLSP IPDDSTLSEE QLRRQRSRWR RVLRTALPLQ ALLVLLMGAA CLVPHCDDEY 8530 8540 CCQLLNNFAK SFDPSLEFVN GPPPF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Role of ANC-1 in tethering nuclei to the actin cytoskeleton." Starr D.A., Han M. Science 298:406-409(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1751, FUNCTION, CHARACTERIZATION, INTERACTION WITH F-ACTIN AND UNC-84. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[3]	"The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300." Zhang Q., Ragnauth C., Greener M.J., Shanahan C.M., Roberts R.G. Genomics 80:473-481(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 689-1243.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY157938 mRNA. Translation: AAN35200.1. FO081700 Genomic DNA. Translation: CCD73568.1. AY126454 mRNA. Translation: AAM95163.1.
PIR	T33140. T33141.
RefSeq	NP_491353.2. NM_058952.3.
3D structure databases
ProteinModelPortal	Q9N4M4.
SMR	Q9N4M4. Positions 20-131, 242-323.
ModBase	Search...
Proteomic databases
PaxDb	Q9N4M4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ZK973.6; ZK973.6; ZK973.6.
GeneID	172034.
KEGG	cel:CELE_ZK973.6.
UCSC	ZK973.6. c. elegans.
Organism-specific databases
CTD	172034.
WormBase	ZK973.6; CE33588; WBGene00000140; anc-1.
Phylogenomic databases
eggNOG	COG5069.
GeneTree	ENSGT00550000074593.
InParanoid	Q9N4M4.
OMA	TSVQIKN.
Gene expression databases
ArrayExpress	Q9N4M4.
Family and domain databases
Gene3D	1.10.418.10. 2 hits.
InterPro	IPR001589. Actinin_actin-bd_CS. IPR001715. CH-domain. IPR012315. KASH. [Graphical view]
Pfam	PF00307. CH. 2 hits. PF10541. KASH. 1 hit. [Graphical view]
SMART	SM00033. CH. 2 hits. [Graphical view]
SUPFAM	SSF47576. Calponin-homology. 1 hit.
PROSITE	PS00019. ACTININ_1. 1 hit. PS00020. ACTININ_2. 1 hit. PS50021. CH. 2 hits. PS51049. KASH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	873759.

Entry information

Entry name

ANC1_CAEEL

Accession

Primary (citable) accession number: Q9N4M4
Secondary accession number(s): O61841, O61842

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	March 28, 2003
Last modified:	May 1, 2013
This is version 105 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project