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Q9N4M4

- ANC1_CAEEL

UniProt

Q9N4M4 - ANC1_CAEEL

Protein

Nuclear anchorage protein 1

Gene

anc-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 3 (28 Mar 2003)
      Previous versions | rss
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    Functioni

    Plays a central role in nuclear and mitochondrial anchoring. Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus. Has a role in positioning of the cell body of the PVQ lumbar interneuron.3 Publications

    GO - Molecular functioni

    1. actin binding Source: WormBase

    GO - Biological processi

    1. cytoskeleton organization Source: UniProtKB
    2. localization Source: WormBase
    3. pronuclear migration Source: WormBase

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear anchorage protein 1
    Short name:
    Anchorage 1 protein
    Alternative name(s):
    Nesprin homolog
    Gene namesi
    Name:anc-1
    ORF Names:ZK973.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiZK973.6; CE33588; WBGene00000140; anc-1.

    Subcellular locationi

    Nucleus outer membrane Curated; Single-pass type IV membrane protein Curated; Cytoplasmic side Curated. Cytoplasmcytoskeleton
    Note: The largest part of the protein is cytoplasmic, while its C-terminal part is associated either with the nuclear envelope, most probably the outer nuclear membrane, or with mitochondrial membrane.

    GO - Cellular componenti

    1. cytoplasm Source: WormBase
    2. cytoskeleton Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. nuclear outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Membrane, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Nuclear anchorage is lost resulting in free-floating nuclei that often cluster as the animal flexes. An increase in PVQ cell bodies mispositioned to the anterior is apparent between three-fold embryos and L1 larvae. Pharyngeal cells show defects including mispositioned organelles.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 85458545Nuclear anchorage protein 1PRO_0000163593Add
    BLAST

    Proteomic databases

    PaxDbiQ9N4M4.
    PRIDEiQ9N4M4.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed in all postembryonic cells.

    Developmental stagei

    First expressed in L1 larvae, and thereafter.

    Interactioni

    Subunit structurei

    Interacts with F-actin via its N-terminal domain. Interacts indirectly with unc-84.1 Publication

    Protein-protein interaction databases

    BioGridi37504. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9N4M4.
    SMRiQ9N4M4. Positions 20-131, 242-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 84948494CytoplasmicPROSITE-ProRule annotationAdd
    BLAST
    Topological domaini8514 – 854532Perinuclear spacePROSITE-ProRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8495 – 851319Helical; Anchor for type IV membrane proteinPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 325325Actin-bindingAdd
    BLAST
    Domaini23 – 130108CH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini222 – 325104CH 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati3241 – 41439031Add
    BLAST
    Repeati4144 – 50979542Add
    BLAST
    Repeati5098 – 60009033Add
    BLAST
    Repeati6001 – 69039034Add
    BLAST
    Repeati6904 – 78069035Add
    BLAST
    Repeati7807 – 81993936Add
    BLAST
    Domaini8486 – 854560KASHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni3241 – 819949596 X tandem repeatAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili754 – 77421Sequence AnalysisAdd
    BLAST
    Coiled coili1072 – 110130Sequence AnalysisAdd
    BLAST
    Coiled coili1215 – 123622Sequence AnalysisAdd
    BLAST
    Coiled coili1324 – 138461Sequence AnalysisAdd
    BLAST
    Coiled coili1574 – 162956Sequence AnalysisAdd
    BLAST
    Coiled coili1725 – 175430Sequence AnalysisAdd
    BLAST
    Coiled coili1950 – 198132Sequence AnalysisAdd
    BLAST
    Coiled coili2103 – 2580478Sequence AnalysisAdd
    BLAST
    Coiled coili2682 – 271231Sequence AnalysisAdd
    BLAST
    Coiled coili2852 – 294998Sequence AnalysisAdd
    BLAST
    Coiled coili3002 – 3119118Sequence AnalysisAdd
    BLAST
    Coiled coili3178 – 3295118Sequence AnalysisAdd
    BLAST
    Coiled coili3346 – 341772Sequence AnalysisAdd
    BLAST
    Coiled coili3482 – 355271Sequence AnalysisAdd
    BLAST
    Coiled coili3587 – 3703117Sequence AnalysisAdd
    BLAST
    Coiled coili3781 – 383959Sequence AnalysisAdd
    BLAST
    Coiled coili3902 – 4022121Sequence AnalysisAdd
    BLAST
    Coiled coili4114 – 419885Sequence AnalysisAdd
    BLAST
    Coiled coili4249 – 432072Sequence AnalysisAdd
    BLAST
    Coiled coili4436 – 450671Sequence AnalysisAdd
    BLAST
    Coiled coili4541 – 4657117Sequence AnalysisAdd
    BLAST
    Coiled coili4735 – 479359Sequence AnalysisAdd
    BLAST
    Coiled coili4856 – 4976121Sequence AnalysisAdd
    BLAST
    Coiled coili5035 – 5152118Sequence AnalysisAdd
    BLAST
    Coiled coili5203 – 527472Sequence AnalysisAdd
    BLAST
    Coiled coili5339 – 540971Sequence AnalysisAdd
    BLAST
    Coiled coili5444 – 5560117Sequence AnalysisAdd
    BLAST
    Coiled coili5638 – 569659Sequence AnalysisAdd
    BLAST
    Coiled coili5759 – 5879121Sequence AnalysisAdd
    BLAST
    Coiled coili5938 – 6055118Sequence AnalysisAdd
    BLAST
    Coiled coili6106 – 617772Sequence AnalysisAdd
    BLAST
    Coiled coili6242 – 631271Sequence AnalysisAdd
    BLAST
    Coiled coili6347 – 6463117Sequence AnalysisAdd
    BLAST
    Coiled coili6541 – 659959Sequence AnalysisAdd
    BLAST
    Coiled coili6662 – 6782121Sequence AnalysisAdd
    BLAST
    Coiled coili6841 – 6958118Sequence AnalysisAdd
    BLAST
    Coiled coili7009 – 708072Sequence AnalysisAdd
    BLAST
    Coiled coili7145 – 721571Sequence AnalysisAdd
    BLAST
    Coiled coili7250 – 7366117Sequence AnalysisAdd
    BLAST
    Coiled coili7444 – 750259Sequence AnalysisAdd
    BLAST
    Coiled coili7565 – 7685121Sequence AnalysisAdd
    BLAST
    Coiled coili7744 – 7861118Sequence AnalysisAdd
    BLAST
    Coiled coili7912 – 798372Sequence AnalysisAdd
    BLAST
    Coiled coili8048 – 811871Sequence AnalysisAdd
    BLAST
    Coiled coili8153 – 820452Sequence AnalysisAdd
    BLAST
    Coiled coili8273 – 832957Sequence AnalysisAdd
    BLAST
    Coiled coili8370 – 839021Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1655 – 16584Poly-Arg
    Compositional biasi3021 – 30299Poly-Lys
    Compositional biasi3924 – 39329Poly-Lys
    Compositional biasi4878 – 48869Poly-Lys
    Compositional biasi5781 – 57899Poly-Lys
    Compositional biasi6684 – 66929Poly-Lys
    Compositional biasi7587 – 75959Poly-Lys

    Domaini

    The large coiled coil domains are composed of 6 nearly exact repeats of 903 residues. The last repeat is partial. These repeats are conserved in Hawai (CB4856), Australia (AB4) and Germany (RC301) strains. The length of the repeat may be maintained because of a selective advantage to keep the protein large and allow a single molecule to extent more than 0,5 micrometers.
    The KASH domain, which contains a potential transmembrane domain, is essential for the nuclear envelope targeting.

    Sequence similaritiesi

    Belongs to the nesprin family.Curated
    Contains 1 actin-binding domain.Curated
    Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation
    Contains 1 KASH domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5069.
    GeneTreeiENSGT00750000117361.
    InParanoidiQ9N4M4.
    OMAiTSVQIKN.
    OrthoDBiEOG72JWF7.
    PhylomeDBiQ9N4M4.

    Family and domain databases

    Gene3Di1.10.418.10. 2 hits.
    InterProiIPR001589. Actinin_actin-bd_CS.
    IPR001715. CH-domain.
    IPR012315. KASH.
    [Graphical view]
    PfamiPF00307. CH. 2 hits.
    PF10541. KASH. 1 hit.
    [Graphical view]
    SMARTiSM00033. CH. 2 hits.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 2 hits.
    PROSITEiPS00019. ACTININ_1. 1 hit.
    PS00020. ACTININ_2. 1 hit.
    PS50021. CH. 2 hits.
    PS51049. KASH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9N4M4-1 [UniParc]FASTAAdd to Basket

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    MSSSPPARPC CVCFRFRPHE DEKAQKNTFT RWINFHLEEH SSSGRIEDLF     50
    EDIRDGVLLC HLIEVLTGEA LAVHKGRVSK RVHHIANLTT ALTVLRRRGL 100
    ELINNNAADI ADGNPRIVLG LIWQIILHFQ IETNMILLRE WGWAATGTEE 150
    PTSSAQPEVV VTAPSPTPSS KKSHSKVSSL SGSKTSLASG EKAPSSPLRQ 200
    RIASFLTPTK KAPKLTAQPV KQSVEQVFLR WINAEIGDLV GGRRVENMDK 250
    QWRDGILFCA LVSRWRPDVI SMREVTNANP RDNLELAFNL AHQHLGVRRL 300
    LAVEDMMIEK PDKRSVITYV SQFVRMFGER SPMQGREQHE IFLAWLEATY 350
    LLCTRHELNS QECSRIRREF IEHRPLFNTI IVTKVNYDVE ELVEIEKKWD 400
    CIRETLEKYA RRSERDLPEP FASIATWIAG AEHILSRPLD LDATDAKKTV 450
    TMLQKLISEH QKYMEDLPKR QEDFEEAVKH GGLGGRPVAP EFSEPLRARF 500
    AQIEEENEPR ISTLRILTTH YILLQYLQHI DEKIILWRTA DSVTLLLRWI 550
    KEYTQLNAEN PQAKCASYIN KITLTMANDQ NSKLDKEAIL NTSNEKTAET 600
    LKRFESLWIE LKLLKVEWVE WETHVSQLEE IIEERRRNGV PPTPEDEQAL 650
    AVITAGADQL APKLGASARL SNNQRLDVLT HSFKKLTKTT IKIGGRLVVE 700
    LEPSTSEQAS KISYSWQASD ELLKVEMQLR DRIQRDADSS DREQLEYRAE 750
    TFRNIRDKLI ELERLNEIYD NHSRDQVDTP NRNLIRHDMG TIIYGLQAGQ 800
    YANFVDLSCY AFVYDEYNQV PVNLTENVLS EDYVREIVNR KKAILTRREN 850
    NEDEIRESIR DMEECDRIIE GWQSTEIEEL RAEWNIKLSE FESWHEMMQQ 900
    VEVLSQTIQT RLDVTVIQTI WILKERSYDI KHSELGGTLR ESLEQLATTS 950
    ETSVNRHLQN LELSNEQDCP DAIEFLEEVG RESVSKLSAA VDDRYIYTLH 1000
    VLRTKMELFR RLQNFCDAVK ILRSQNTKWN GIKISQIDQV QSEIDTLIVR 1050
    LDEEWTQDAN QLRAELASIH GSFFQLEFDR LNEKLNMLIH DKDKLRELMV 1100
    HRRHYLTAAN ELITDSKTDL AQRATSSDHP DDILRATDEV TKALDIKGEE 1150
    LRRLGELAEM NITDLVVVAL ILSFRRRQLG SEGEPEVEEL RRALREIIAR 1200
    PITEPRDVSP DAIVADILRM KDEKKRDEKT IDEIQATTLT DEQRASFAPL 1250
    IEDYRRRADR HRIVFEHLVM IYLDWLSRQF DELEDEIGMT IQTSRADDLR 1300
    RMNSTEWNKW KTDLANIERQ VGPDTKKALS AELADLHRKR DSMEARINKY 1350
    LTHSAKINAK LTQFEKWLNA IEEDIEQTER QFEDPERSYR FGSLHEVALA 1400
    KQRLVAKLER LNVANKEEVL RLCERYHTIM HKLTPFQTAV GLPLHVSTNL 1450
    DRNGPFQSQI SVSSIASSEL ERPESVMSLT SSIGVIPADV AELSPFEAKI 1500
    NKLLQKLHII EDSYLKGPKP IDTVREDVKQ LEKYRNRGAE ILQQLSTSNI 1550
    EDAEKEGLKH RFVLMLNNYD DILRSIENEI RDDNELTAKN QEILAELSNA 1600
    EQTLQNSPLE DLDISAELDR LQMQLDLVKV MCNKPRKYVE CELIDSSREG 1650
    SPQERRRRKK KVMVMVSNTI TTIIHVVEER LEASDISRNP DVQQKLVAVK 1700
    ENLRELDTTT VTPHPPSIMS PLGTENRNDL EEVKRLAAEI DRAIDTASSM 1750
    YEDAPTDEDA LKSAIHLLDD QKVTLNHLHV VLEGIPEKNE QDRTDAIDIA 1800
    SSVGEKLGNL KSAVEEVYEE VLASTNPVKE DQPLQHIQEV QTTPAEQSNW 1850
    DTDEFSRQPP VLSDERIELK TDPSAIDKFE VRSDEDPVPK IIDLFGQLQT 1900
    AVNEASPLAC EGTDDVDALQ VASDKLTKQD RTIRKIHAIL DTIDDPVQKP 1950
    AIIESLDKIK DQINNARDNI NRQIDNLNYN QTPVVVPKES TKTPLNEIED 2000
    AVRQASTVVS DELCNTEKLL SARQTLANVK PQVDSVEANV WSNPETIETV 2050
    TPILEEYTTL VDNIEKKLAN EIEVPTNDPS RQDLVQQLQD VILECEEVVV 2100
    NCDNIEKLEE SKLKLEKARP LLDQIGDNVE KLSREQSPDT SDAIDALSNV 2150
    HQQYNATIMS IDDKIDELKN PEEDTSAADQ LISELHVISE MPAVTIDLSM 2200
    LNAIEEGLST LPAHQAENVQ AKIDELRQKK EVADQTEQIL SDLNAFGDMP 2250
    AITLDLDLLK SVEDGIAVLP VEDSERIKAK IVDLRKKKED ADQAEALLQE 2300
    LSVISDMPIS TLDLNMLQGI EDNLNSLPAE ESDEIREKLN ELRRRKQESD 2350
    QAEALLQELS VISDMPISTL DLNMLQGVED NLNSLPTEEA DKIREKINDL 2400
    RRRKQESDLA EALLQELSVI YDMPTSTIDL NMLQGIEDNL NSLPAEESDK 2450
    IREKINDLRR RKQESDLAEA LLQELSVIYD MPTSTIDLNM LQGIEDNLNS 2500
    LPAEESDKIR EKINDLRRRK QESDQAEALL QELSVVSDMP ASTIDINMLQ 2550
    SIEDGLSTLL SEDRSKIQQA IDSLRKKKSD SDLAQHALEA LSVQSKLPSV 2600
    SINLEELKKL EETLSTVPVE DSKVIRDKIA ELKTEKALAD HAENYLVELK 2650
    KIEDMPISAV GSDVLATIED QILQMPVQYQ PSVKETLDKL KQAKEEDDKL 2700
    AGVYDELEKI AKLPARDYDN KLLAKIDEKL NSLPKDQIAE THRKVEDIKV 2750
    TKADIVAQID VLDKLPAKDI DEHLLNSIEE KLPTIPSDSS DQLQIAIGKL 2800
    RDRKQANIDE GKKILNELAE IQKMPADSLN EHALNLLATE SDKFGSEISD 2850
    KIMQEIDVLR EKQNNHEVAR LNAESVLQQL DKISEEPHLS LTEERLAPFL 2900
    QNIDTVPACF VDKIRNKINE VQKLHDEAVQ DEKDELKEKL VAKVQNIGKT 2950
    SIDDVNVSDF EEIEREINGS LEAFEAEPLL AKIQELREAK RVGDEARSAA 3000
    HDQIVALEKE AEDVTAKESA KKKKKDKKKS PQEMIDELSA KVVEAKALIP 3050
    KIEEAAKNEN LPADDKPKAE QLVSNLEAFV KDVETQVSEK QDELDKLNNA 3100
    NDAIKRLGDA LDDAEKTVVP SSVPALSEFK DRIAPHLATL VEAVNDVPAS 3150
    VEPSAVALRD RAAKFVSDLE KNIQKTGDDE KRADELKNDV GNAVKNVEDV 3200
    VSKYQNQPQP LDVAKDDANK LKATVEQLTK LAESSDKIDP QVAKDIKDSK 3250
    TKAKELLQAL EKAIPQEDAI RREQAEINDR LNNLEKELTK VDEFKPEDAL 3300
    PIVDQLAANT NTLKTATDSN NEKAVAPSSL ISHDDLVVGL PEKVFQLQHA 3350
    IDDKKQALNK AAAVNEIAPK LQLVSQQLQS VPQEVPASLD EQKQLLEDVE 3400
    NQKHNLENLL ANLPENDPTA DELRQKSQWD LSRLKDLLKQ LGSAVGDKLA 3450
    ALAAFNAARK NAEDALLDIT REDGGDDNKS PDELIDDLAK KEETVAKLLD 3500
    TVSGVKPDEL DDKERAEYND LLARLATAAD VLKNKRAELE QAVKAKADEK 3550
    SLHDSVDRIV SRLVPLVRES DELRHNAEAV PTQYAPKAEE LKKEVEAAKA 3600
    VIANAPSSDA HVQQLEQAVA TAETLIPDLE ERARLWNEFL AARNDIDALI 3650
    EQLQQPLDAV LAQPKRSAEE AAQDVENLRN NSQQLSDLDN KIANLQRISE 3700
    LLDPLESAYA DVRFFDVDAE QTRHQYDDVL NDVAAELEDE TLLKQSASQV 3750
    ANEIDDISKM IDSTDPERSI LDTIAKSDIP ALKAQINRIK DRIVNADASR 3800
    KHVTTDPKIA EDLDNKLAKL QTELDDAIKT SDEHDKEQLI LSLKLNISQF 3850
    EQIPLDQLKS DDLKTAEKEI TNSLKPEEAE PLLAKIQELR EAKRVGDEAR 3900
    SAAHDQIVAL EKEAEDVTAK ESAKKKKKDK KKSPQEMIDE LSAKVVEAKA 3950
    LIPKIEEAAK NENLPADDKP KAEQLVSNLE AFVKDVETQV SEKQDELDKL 4000
    NNANDAIKRL GDALDDAEKT VVPSSVPALS EFKDRIAPHL ATLVEAVNDV 4050
    PASVEPSAVA LRDRAAKFVS DLEKNIQKTG DDEKRADELK NDDGNAVKNV 4100
    EDVVSKYQNQ PQPLDVAKDD ANKLKATVEQ LTKLAESSDK IDPQVAKDIK 4150
    DSKTKAKELL QALEKAIPQE DAIRREQAEI NDRLNNLEKE LTKVDEFKPE 4200
    DALPIVDQLA ANTNTLKTAT DSNNEKAVAP SSLISHDDLV VGLPEKVFQL 4250
    QHAIDDKKQA LNKAAAVNEI APKLQLVSQQ LQSVPQEVPA SLDEQKQLLE 4300
    DVENQKHNLE NLLANLPEND PTADELRQKS QWDLSRLKDL LKQLGSAVGD 4350
    KLAALAAFNA ARKNAEDALL DITREDGGDD NKSPDELIDD RGRSTGSAVG 4400
    DKLAALAAFN AARKNAEDAL LDITREDGGD DNKSPDELID DLAKKEETVA 4450
    KLLDTVSGVK PDELDDKERA EYNDLLARLA TAADVLKNKR AELEQAVKAK 4500
    ADEKSLHDSV DRIVSRLVPL VRESDELRHN AEAVPTQYAP KAEELKKEVE 4550
    AAKAVIANAP SSDAHVQQLE QAVATAETLI PDLEERARLW NEFLAARNDI 4600
    DALIEQLQQP LDAVLAQPKR SAEEAAQDVE NLRNNSQQLS DLDNKIANLQ 4650
    RISELLDPLE SAYADVRFFD VDAEQTRHQY DDVLNDVAAE LEDETLLKQS 4700
    ASQVANEIDD ISKMIDSTDP ERSILDTIAK SDIPALKAQI NRIKDRIVNA 4750
    DASRKHVTTD PKIAEDLDNK LAKLQTELDD AIKTSDEHDK EQLILSLKLN 4800
    ISQFEQIPLD QLKSDDLKTA EKEITNSLKP EEAEPLLAKI QELREAKRVG 4850
    DEARSAAHDQ IVALEKEAED VTAKESAKKK KKDKKKSPQE MIDELSAKVV 4900
    EAKALIPKIE EAAKNENLPA DDKPKAEQLV SNLEAFVKDV ETQVSEKQDE 4950
    LDKLNNANDA IKRLGDALDD AEKTVVPSSV PALSEFKDRI APHLATLVEA 5000
    VNDVPASVEP SAVALRDRAA KFVSDLEKNI QKTGDDEKRA DELKNDVGNA 5050
    VKNVEDVVSK YQNQPQPLDV AKDDANKLKA TVEQLTKLAE SSDKIDPQVA 5100
    KDIKDSKTKA KELLQALEKA IPQEDAIRRE QAEINDRLNN LEKELTKVDE 5150
    FKPEDALPIV DQLAANTNTL KTATDSNNEK AVAPSSLISH DDLVVGLPEK 5200
    VFQLQHAIDD KKQALNKAAA VNEIAPKLQL VSQQLQSVPQ EVPASLDEQK 5250
    QLLEDVENQK HNLENLLANL PENDPTADEL RQKSQWDLSR LKDLLKQLGS 5300
    AVGDKLAALA AFNAARKNAE DALLDITRED GGDDNKSPDE LIDDLAKKEE 5350
    TVAKLLDTVS GVKPDELDDK ERAEYNDLLA RLATAADVLK NKRAELEQAV 5400
    KAKADEKSLH DSVDRIVSRL VPLVRESDEL RHNAEAVPTQ YAPKAEELKK 5450
    EVEAAKAVIA NAPSSDAHVQ QLEQAVATAE TLIPDLEERA RLWNEFLAAR 5500
    NDIDALIEQL QQPLDAVLAQ PKRSAEEAAQ DVENLRNNSQ QLSDLDNKIA 5550
    NLQRISELLD PLESAYADVR FFDVDAEQTR HQYDDVLNDV AAELEDETLL 5600
    KQSASQVANE IDDISKMIDS TDPERSILDT IAKSDIPALK AQINRIKDRI 5650
    VNADASRKHV TTDPKIAEDL DNKLAKLQTE LDDAIKTSDE HDKEQLILSL 5700
    KLNISQFEQI PLDQLKSDDL KTAEKEITNS LKPEEAEPLL AKIQELREAK 5750
    RVGDEARSAA HDQIVALEKE AEDVTAKESA KKKKKDKKKS PQEMIDELSA 5800
    KVVEAKALIP KIEEAAKNEN LPADDKPKAE QLVSNLEAFV KDVETQVSEK 5850
    QDELDKLNNA NDAIKRLGDA LDDAEKTVVP SSVPALSEFK DRIAPHLATL 5900
    VEAVNDVPAS VEPSAVALRD RAAKFVSDLE KNIQKTGDDE KRADELKNDV 5950
    GNAVKNVEDV VSKYQNQPQP LDVAKDDANK LKATVEQLTK LAESSDKIDP 6000
    QVAKDIKDSK TKAKELLQAL EKAIPQEDAI RREQAEINDR LNNLEKELTK 6050
    VDEFKPEDAL PIVDQLAANT NTLKTATDSN NEKAVAPSSL ISHDDLVVGL 6100
    PEKVFQLQHA IDDKKQALNK AAAVNEIAPK LQLVSQQLQS VPQEVPASLD 6150
    EQKQLLEDVE NQKHNLENLL ANLPENDPTA DELRQKSQWD LSRLKDLLKQ 6200
    LGSAVGDKLA ALAAFNAARK NAEDALLDIT REDGGDDNKS PDELIDDLAK 6250
    KEETVAKLLD TVSGVKPDEL DDKERAEYND LLARLATAAD VLKNKRAELE 6300
    QAVKAKADEK SLHDSVDRIV SRLVPLVRES DELRHNAEAV PTQYAPKAEE 6350
    LKKEVEAAKA VIANAPSSDA HVQQLEQAVA TAETLIPDLE ERARLWNEFL 6400
    AARNDIDALI EQLQQPLDAV LAQPKRSAEE AAQDVENLRN NSQQLSDLDN 6450
    KIANLQRISE LLDPLESAYA DVRFFDVDAE QTRHQYDDVL NDVAAELEDE 6500
    TLLKQSASQV ANEIDDISKM IDSTDPERSI LDTIAKSDIP ALKAQINRIK 6550
    DRIVNADASR KHVTTDPKIA EDLDNKLAKL QTELDDAIKT SDEHDKEQLI 6600
    LSLKLNISQF EQIPLDQLKS DDLKTAEKEI TNSLKPEEAE PLLAKIQELR 6650
    EAKRVGDEAR SAAHDQIVAL EKEAEDVTAK ESAKKKKKDK KKSPQEMIDE 6700
    LSAKVVEAKA LIPKIEEAAK NENLPADDKP KAEQLVSNLE AFVKDVETQV 6750
    SEKQDELDKL NNANDAIKRL GDALDDAEKT VVPSSVPALS EFKDRIAPHL 6800
    ATLVEAVNDV PASVEPSAVA LRDRAAKFVS DLEKNIQKTG DDEKRADELK 6850
    NDVGNAVKNV EDVVSKYQNQ PQPLDVAKDD ANKLKATVEQ LTKLAESSDK 6900
    IDPQVAKDIK DSKTKAKELL QALEKAIPQE DAIRREQAEI NDRLNNLEKE 6950
    LTKVDEFKPE DALPIVDQLA ANTNTLKTAT DSNNEKAVAP SSLISHDDLV 7000
    VGLPEKVFQL QHAIDDKKQA LNKAAAVNEI APKLQLVSQQ LQSVPQEVPA 7050
    SLDEQKQLLE DVENQKHNLE NLLANLPEND PTADELRQKS QWDLSRLKDL 7100
    LKQLGSAVGD KLAALAAFNA ARKNAEDALL DITREDGGDD NKSPDELIDD 7150
    LAKKEETVAK LLDTVSGVKP DELDDKERAE YNDLLARLAT AADVLKNKRA 7200
    ELEQAVKAKA DEKSLHDSVD RIVSRLVPLV RESDELRHNA EAVPTQYAPK 7250
    AEELKKEVEA AKAVIANAPS SDAHVQQLEQ AVATAETLIP DLEERARLWN 7300
    EFLAARNDID ALIEQLQQPL DAVLAQPKRS AEEAAQDVEN LRNNSQQLSD 7350
    LDNKIANLQR ISELLDPLES AYADVRFFDV DAEQTRHQYD DVLNDVAAEL 7400
    EDETLLKQSA SQVANEIDDI SKMIDSTDPE RSILDTIAKS DIPALKAQIN 7450
    RIKDRIVNAD ASRKHVTTDP KIAEDLDNKL AKLQTELDDA IKTSDEHDKE 7500
    QLILSLKLNI SQFEQIPLDQ LKSDDLKTAE KEITNSLKPE EAEPLLAKIQ 7550
    ELREAKRVGD EARSAAHDQI VALEKEAEDV TAKESAKKKK KDKKKSPQEM 7600
    IDELSAKVVE AKALIPKIEE AAKNENLPAD DKPKAEQLVS NLEAFVKDVE 7650
    TQVSEKQDEL DKLNNANDAI KRLGDALDDA EKTVVPSSVP ALSEFKDRIA 7700
    PHLATLVEAV NDVPASVEPS AVALRDRAAK FVSDLEKNIQ KTGDDEKRAD 7750
    ELKNDVGNAV KNVEDVVSKY QNQPQPLDVA KDDANKLKAT VEQLTKLAES 7800
    SDKIDPQVAK DIKDSKTKAK ELLQALEKAI PQEDAIRREQ AEINDRLNKL 7850
    EKELTKVDEF KPEDALPIVD QLAANTNTLK TATDSNNEKA VAPSSLISHD 7900
    DLVVGLPEKV FQLQHAIDDK KQALNKAAAV NEIAPKLQLV SQQLQSVPQE 7950
    VPASLDEQKQ LLEDVENQKH NLENLLANLP ENDPTADELR QKSQWDLSRL 8000
    KDLLKQLGSA VGEKLAALAA FNAARKNAED ALLDITREDG GDDNKSPDEL 8050
    IDDLAKKEET VAKLLDTVSG VKPDELDDKE RAEYNDLLAR LATAADVLKN 8100
    KRAELEQAVK AKADEKSLHD SVDRIVSRLV PLVRESDELR HNAEAVPTQY 8150
    APKAEELKKE VEAAKAVIAN APSSDAHVQQ LEQAVATAET LIPDLEERAS 8200
    IWERFVKAKD DLYDYLEKLE NNVSDVLNRP RLPVSQAQQR FNKLKEQSYL 8250
    LDRIRDLKID FDDLGEALLP LTVAEDELRF MHVHVESIER QYEDTMDKLN 8300
    AEITAEVELL RTLDILSNEL SQCKEDINNP SVDVDELSRA TMLNDAIAHL 8350
    ENQKVVVARS EKDRKFVESS TSIDLDQLLA EAKRLLKEIE PRLQLAQPDH 8400
    DNEDDEDEEK GSDEKPYDVR AAAEVLSALY PDEHPHNVLR NIGFEELPSD 8450
    SESRSEFDSL DSRSDGLLSP IPDDSTLSEE QLRRQRSRWR RVLRTALPLQ 8500
    ALLVLLMGAA CLVPHCDDEY CCQLLNNFAK SFDPSLEFVN GPPPF 8545
    Length:8,545
    Mass (Da):956,482
    Last modified:March 28, 2003 - v3
    Checksum:i02A94D994BEE19E3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7849 – 78491K → N in DAA04553. (PubMed:12169658)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY157938 mRNA. Translation: AAN35200.1.
    BK000642 mRNA. Translation: DAA04553.1.
    FO081700 Genomic DNA. Translation: CCD73568.1.
    AY126454 mRNA. Translation: AAM95163.1.
    PIRiT33140.
    T33141.
    RefSeqiNP_491353.2. NM_058952.3.
    UniGeneiCel.22568.

    Genome annotation databases

    EnsemblMetazoaiZK973.6; ZK973.6; WBGene00000140.
    GeneIDi172034.
    KEGGicel:CELE_ZK973.6.
    UCSCiZK973.6. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY157938 mRNA. Translation: AAN35200.1 .
    BK000642 mRNA. Translation: DAA04553.1 .
    FO081700 Genomic DNA. Translation: CCD73568.1 .
    AY126454 mRNA. Translation: AAM95163.1 .
    PIRi T33140.
    T33141.
    RefSeqi NP_491353.2. NM_058952.3.
    UniGenei Cel.22568.

    3D structure databases

    ProteinModelPortali Q9N4M4.
    SMRi Q9N4M4. Positions 20-131, 242-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 37504. 2 interactions.

    Proteomic databases

    PaxDbi Q9N4M4.
    PRIDEi Q9N4M4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZK973.6 ; ZK973.6 ; WBGene00000140 .
    GeneIDi 172034.
    KEGGi cel:CELE_ZK973.6.
    UCSCi ZK973.6. c. elegans.

    Organism-specific databases

    CTDi 172034.
    WormBasei ZK973.6 ; CE33588 ; WBGene00000140 ; anc-1.

    Phylogenomic databases

    eggNOGi COG5069.
    GeneTreei ENSGT00750000117361.
    InParanoidi Q9N4M4.
    OMAi TSVQIKN.
    OrthoDBi EOG72JWF7.
    PhylomeDBi Q9N4M4.

    Miscellaneous databases

    NextBioi 873759.
    PROi Q9N4M4.

    Family and domain databases

    Gene3Di 1.10.418.10. 2 hits.
    InterProi IPR001589. Actinin_actin-bd_CS.
    IPR001715. CH-domain.
    IPR012315. KASH.
    [Graphical view ]
    Pfami PF00307. CH. 2 hits.
    PF10541. KASH. 1 hit.
    [Graphical view ]
    SMARTi SM00033. CH. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 2 hits.
    PROSITEi PS00019. ACTININ_1. 1 hit.
    PS00020. ACTININ_2. 1 hit.
    PS50021. CH. 2 hits.
    PS51049. KASH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role of ANC-1 in tethering nuclei to the actin cytoskeleton."
      Starr D.A., Han M.
      Science 298:406-409(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1751, IDENTIFICATION OF COMPLETE SEQUENCE, FUNCTION, CHARACTERIZATION, INTERACTION WITH F-ACTIN AND UNC-84.
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    3. "The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300."
      Zhang Q., Ragnauth C., Greener M.J., Shanahan C.M., Roberts R.G.
      Genomics 80:473-481(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 689-1243.
    4. "A gene required for nuclear and mitochondrial attachment in the nematode Caenorhabditis elegans."
      Hedgecock E.M., Thomson J.N.
      Cell 30:321-330(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    5. "Neural maintenance roles for the matrix receptor dystroglycan and the nuclear anchorage complex in Caenorhabditis elegans."
      Johnson R.P., Kramer J.M.
      Genetics 190:1365-1377(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiANC1_CAEEL
    AccessioniPrimary (citable) accession number: Q9N4M4
    Secondary accession number(s): O61841, O61842, Q6IMP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: March 28, 2003
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3