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Q9N4M4 (ANC1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nuclear anchorage protein 1

Short name=Anchorage 1 protein
Alternative name(s):
Nesprin homolog
Gene names
Name:anc-1
ORF Names:ZK973.6
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length8545 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a central role in nuclear and mitochondrial anchoring. Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus. Has a role in positioning of the cell body of the PVQ lumbar interneuron. Ref.1 Ref.4 Ref.5

Subunit structure

Interacts with F-actin via its N-terminal domain. Interacts indirectly with unc-84. Ref.1

Subcellular location

Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side Potential. Cytoplasmcytoskeleton. Note: The largest part of the protein is cytoplasmic, while its C-terminal part is associated either with the nuclear envelope, most probably the outer nuclear membrane, or with mitochondrial membrane.

Tissue specificity

Ubiquitously expressed in all postembryonic cells.

Developmental stage

First expressed in L1 larvae, and thereafter.

Domain

The large coiled coil domains are composed of 6 nearly exact repeats of 903 residues. The last repeat is partial. These repeats are conserved in Hawai (CB4856), Australia (AB4) and Germany (RC301) strains. The length of the repeat may be maintained because of a selective advantage to keep the protein large and allow a single molecule to extent more than 0,5 micrometers.

The KASH domain, which contains a potential transmembrane domain, is essential for the nuclear envelope targeting.

Disruption phenotype

Nuclear anchorage is lost resulting in free-floating nuclei that often cluster as the animal flexes. An increase in PVQ cell bodies mispositioned to the anterior is apparent between three-fold embryos and L1 larvae. Pharyngeal cells show defects including mispositioned organelles. Ref.4 Ref.5

Sequence similarities

Belongs to the nesprin family.

Contains 1 actin-binding domain.

Contains 2 CH (calponin-homology) domains.

Contains 1 KASH domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 85458545Nuclear anchorage protein 1
PRO_0000163593

Regions

Topological domain1 – 84948494Cytoplasmic Potential
Transmembrane8495 – 851319Helical; Anchor for type IV membrane protein; Potential
Topological domain8514 – 854532Perinuclear space Potential
Domain1 – 325325Actin-binding
Domain23 – 130108CH 1
Domain222 – 325104CH 2
Repeat3241 – 41439031
Repeat4144 – 50979542
Repeat5098 – 60009033
Repeat6001 – 69039034
Repeat6904 – 78069035
Repeat7807 – 81993936
Domain8486 – 854560KASH
Region3241 – 819949596 X tandem repeat
Coiled coil754 – 77421 Potential
Coiled coil1072 – 110130 Potential
Coiled coil1215 – 123622 Potential
Coiled coil1324 – 138461 Potential
Coiled coil1574 – 162956 Potential
Coiled coil1725 – 175430 Potential
Coiled coil1950 – 198132 Potential
Coiled coil2103 – 2580478 Potential
Coiled coil2682 – 271231 Potential
Coiled coil2852 – 294998 Potential
Coiled coil3002 – 3119118 Potential
Coiled coil3178 – 3295118 Potential
Coiled coil3346 – 341772 Potential
Coiled coil3482 – 355271 Potential
Coiled coil3587 – 3703117 Potential
Coiled coil3781 – 383959 Potential
Coiled coil3902 – 4022121 Potential
Coiled coil4114 – 419885 Potential
Coiled coil4249 – 432072 Potential
Coiled coil4436 – 450671 Potential
Coiled coil4541 – 4657117 Potential
Coiled coil4735 – 479359 Potential
Coiled coil4856 – 4976121 Potential
Coiled coil5035 – 5152118 Potential
Coiled coil5203 – 527472 Potential
Coiled coil5339 – 540971 Potential
Coiled coil5444 – 5560117 Potential
Coiled coil5638 – 569659 Potential
Coiled coil5759 – 5879121 Potential
Coiled coil5938 – 6055118 Potential
Coiled coil6106 – 617772 Potential
Coiled coil6242 – 631271 Potential
Coiled coil6347 – 6463117 Potential
Coiled coil6541 – 659959 Potential
Coiled coil6662 – 6782121 Potential
Coiled coil6841 – 6958118 Potential
Coiled coil7009 – 708072 Potential
Coiled coil7145 – 721571 Potential
Coiled coil7250 – 7366117 Potential
Coiled coil7444 – 750259 Potential
Coiled coil7565 – 7685121 Potential
Coiled coil7744 – 7861118 Potential
Coiled coil7912 – 798372 Potential
Coiled coil8048 – 811871 Potential
Coiled coil8153 – 820452 Potential
Coiled coil8273 – 832957 Potential
Coiled coil8370 – 839021 Potential
Compositional bias1655 – 16584Poly-Arg
Compositional bias3021 – 30299Poly-Lys
Compositional bias3924 – 39329Poly-Lys
Compositional bias4878 – 48869Poly-Lys
Compositional bias5781 – 57899Poly-Lys
Compositional bias6684 – 66929Poly-Lys
Compositional bias7587 – 75959Poly-Lys

Experimental info

Sequence conflict78491K → N in DAA04553. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9N4M4 [UniParc].

Last modified March 28, 2003. Version 3.
Checksum: 02A94D994BEE19E3

FASTA8,545956,482
        10         20         30         40         50         60 
MSSSPPARPC CVCFRFRPHE DEKAQKNTFT RWINFHLEEH SSSGRIEDLF EDIRDGVLLC 

        70         80         90        100        110        120 
HLIEVLTGEA LAVHKGRVSK RVHHIANLTT ALTVLRRRGL ELINNNAADI ADGNPRIVLG 

       130        140        150        160        170        180 
LIWQIILHFQ IETNMILLRE WGWAATGTEE PTSSAQPEVV VTAPSPTPSS KKSHSKVSSL 

       190        200        210        220        230        240 
SGSKTSLASG EKAPSSPLRQ RIASFLTPTK KAPKLTAQPV KQSVEQVFLR WINAEIGDLV 

       250        260        270        280        290        300 
GGRRVENMDK QWRDGILFCA LVSRWRPDVI SMREVTNANP RDNLELAFNL AHQHLGVRRL 

       310        320        330        340        350        360 
LAVEDMMIEK PDKRSVITYV SQFVRMFGER SPMQGREQHE IFLAWLEATY LLCTRHELNS 

       370        380        390        400        410        420 
QECSRIRREF IEHRPLFNTI IVTKVNYDVE ELVEIEKKWD CIRETLEKYA RRSERDLPEP 

       430        440        450        460        470        480 
FASIATWIAG AEHILSRPLD LDATDAKKTV TMLQKLISEH QKYMEDLPKR QEDFEEAVKH 

       490        500        510        520        530        540 
GGLGGRPVAP EFSEPLRARF AQIEEENEPR ISTLRILTTH YILLQYLQHI DEKIILWRTA 

       550        560        570        580        590        600 
DSVTLLLRWI KEYTQLNAEN PQAKCASYIN KITLTMANDQ NSKLDKEAIL NTSNEKTAET 

       610        620        630        640        650        660 
LKRFESLWIE LKLLKVEWVE WETHVSQLEE IIEERRRNGV PPTPEDEQAL AVITAGADQL 

       670        680        690        700        710        720 
APKLGASARL SNNQRLDVLT HSFKKLTKTT IKIGGRLVVE LEPSTSEQAS KISYSWQASD 

       730        740        750        760        770        780 
ELLKVEMQLR DRIQRDADSS DREQLEYRAE TFRNIRDKLI ELERLNEIYD NHSRDQVDTP 

       790        800        810        820        830        840 
NRNLIRHDMG TIIYGLQAGQ YANFVDLSCY AFVYDEYNQV PVNLTENVLS EDYVREIVNR 

       850        860        870        880        890        900 
KKAILTRREN NEDEIRESIR DMEECDRIIE GWQSTEIEEL RAEWNIKLSE FESWHEMMQQ 

       910        920        930        940        950        960 
VEVLSQTIQT RLDVTVIQTI WILKERSYDI KHSELGGTLR ESLEQLATTS ETSVNRHLQN 

       970        980        990       1000       1010       1020 
LELSNEQDCP DAIEFLEEVG RESVSKLSAA VDDRYIYTLH VLRTKMELFR RLQNFCDAVK 

      1030       1040       1050       1060       1070       1080 
ILRSQNTKWN GIKISQIDQV QSEIDTLIVR LDEEWTQDAN QLRAELASIH GSFFQLEFDR 

      1090       1100       1110       1120       1130       1140 
LNEKLNMLIH DKDKLRELMV HRRHYLTAAN ELITDSKTDL AQRATSSDHP DDILRATDEV 

      1150       1160       1170       1180       1190       1200 
TKALDIKGEE LRRLGELAEM NITDLVVVAL ILSFRRRQLG SEGEPEVEEL RRALREIIAR 

      1210       1220       1230       1240       1250       1260 
PITEPRDVSP DAIVADILRM KDEKKRDEKT IDEIQATTLT DEQRASFAPL IEDYRRRADR 

      1270       1280       1290       1300       1310       1320 
HRIVFEHLVM IYLDWLSRQF DELEDEIGMT IQTSRADDLR RMNSTEWNKW KTDLANIERQ 

      1330       1340       1350       1360       1370       1380 
VGPDTKKALS AELADLHRKR DSMEARINKY LTHSAKINAK LTQFEKWLNA IEEDIEQTER 

      1390       1400       1410       1420       1430       1440 
QFEDPERSYR FGSLHEVALA KQRLVAKLER LNVANKEEVL RLCERYHTIM HKLTPFQTAV 

      1450       1460       1470       1480       1490       1500 
GLPLHVSTNL DRNGPFQSQI SVSSIASSEL ERPESVMSLT SSIGVIPADV AELSPFEAKI 

      1510       1520       1530       1540       1550       1560 
NKLLQKLHII EDSYLKGPKP IDTVREDVKQ LEKYRNRGAE ILQQLSTSNI EDAEKEGLKH 

      1570       1580       1590       1600       1610       1620 
RFVLMLNNYD DILRSIENEI RDDNELTAKN QEILAELSNA EQTLQNSPLE DLDISAELDR 

      1630       1640       1650       1660       1670       1680 
LQMQLDLVKV MCNKPRKYVE CELIDSSREG SPQERRRRKK KVMVMVSNTI TTIIHVVEER 

      1690       1700       1710       1720       1730       1740 
LEASDISRNP DVQQKLVAVK ENLRELDTTT VTPHPPSIMS PLGTENRNDL EEVKRLAAEI 

      1750       1760       1770       1780       1790       1800 
DRAIDTASSM YEDAPTDEDA LKSAIHLLDD QKVTLNHLHV VLEGIPEKNE QDRTDAIDIA 

      1810       1820       1830       1840       1850       1860 
SSVGEKLGNL KSAVEEVYEE VLASTNPVKE DQPLQHIQEV QTTPAEQSNW DTDEFSRQPP 

      1870       1880       1890       1900       1910       1920 
VLSDERIELK TDPSAIDKFE VRSDEDPVPK IIDLFGQLQT AVNEASPLAC EGTDDVDALQ 

      1930       1940       1950       1960       1970       1980 
VASDKLTKQD RTIRKIHAIL DTIDDPVQKP AIIESLDKIK DQINNARDNI NRQIDNLNYN 

      1990       2000       2010       2020       2030       2040 
QTPVVVPKES TKTPLNEIED AVRQASTVVS DELCNTEKLL SARQTLANVK PQVDSVEANV 

      2050       2060       2070       2080       2090       2100 
WSNPETIETV TPILEEYTTL VDNIEKKLAN EIEVPTNDPS RQDLVQQLQD VILECEEVVV 

      2110       2120       2130       2140       2150       2160 
NCDNIEKLEE SKLKLEKARP LLDQIGDNVE KLSREQSPDT SDAIDALSNV HQQYNATIMS 

      2170       2180       2190       2200       2210       2220 
IDDKIDELKN PEEDTSAADQ LISELHVISE MPAVTIDLSM LNAIEEGLST LPAHQAENVQ 

      2230       2240       2250       2260       2270       2280 
AKIDELRQKK EVADQTEQIL SDLNAFGDMP AITLDLDLLK SVEDGIAVLP VEDSERIKAK 

      2290       2300       2310       2320       2330       2340 
IVDLRKKKED ADQAEALLQE LSVISDMPIS TLDLNMLQGI EDNLNSLPAE ESDEIREKLN 

      2350       2360       2370       2380       2390       2400 
ELRRRKQESD QAEALLQELS VISDMPISTL DLNMLQGVED NLNSLPTEEA DKIREKINDL 

      2410       2420       2430       2440       2450       2460 
RRRKQESDLA EALLQELSVI YDMPTSTIDL NMLQGIEDNL NSLPAEESDK IREKINDLRR 

      2470       2480       2490       2500       2510       2520 
RKQESDLAEA LLQELSVIYD MPTSTIDLNM LQGIEDNLNS LPAEESDKIR EKINDLRRRK 

      2530       2540       2550       2560       2570       2580 
QESDQAEALL QELSVVSDMP ASTIDINMLQ SIEDGLSTLL SEDRSKIQQA IDSLRKKKSD 

      2590       2600       2610       2620       2630       2640 
SDLAQHALEA LSVQSKLPSV SINLEELKKL EETLSTVPVE DSKVIRDKIA ELKTEKALAD 

      2650       2660       2670       2680       2690       2700 
HAENYLVELK KIEDMPISAV GSDVLATIED QILQMPVQYQ PSVKETLDKL KQAKEEDDKL 

      2710       2720       2730       2740       2750       2760 
AGVYDELEKI AKLPARDYDN KLLAKIDEKL NSLPKDQIAE THRKVEDIKV TKADIVAQID 

      2770       2780       2790       2800       2810       2820 
VLDKLPAKDI DEHLLNSIEE KLPTIPSDSS DQLQIAIGKL RDRKQANIDE GKKILNELAE 

      2830       2840       2850       2860       2870       2880 
IQKMPADSLN EHALNLLATE SDKFGSEISD KIMQEIDVLR EKQNNHEVAR LNAESVLQQL 

      2890       2900       2910       2920       2930       2940 
DKISEEPHLS LTEERLAPFL QNIDTVPACF VDKIRNKINE VQKLHDEAVQ DEKDELKEKL 

      2950       2960       2970       2980       2990       3000 
VAKVQNIGKT SIDDVNVSDF EEIEREINGS LEAFEAEPLL AKIQELREAK RVGDEARSAA 

      3010       3020       3030       3040       3050       3060 
HDQIVALEKE AEDVTAKESA KKKKKDKKKS PQEMIDELSA KVVEAKALIP KIEEAAKNEN 

      3070       3080       3090       3100       3110       3120 
LPADDKPKAE QLVSNLEAFV KDVETQVSEK QDELDKLNNA NDAIKRLGDA LDDAEKTVVP 

      3130       3140       3150       3160       3170       3180 
SSVPALSEFK DRIAPHLATL VEAVNDVPAS VEPSAVALRD RAAKFVSDLE KNIQKTGDDE 

      3190       3200       3210       3220       3230       3240 
KRADELKNDV GNAVKNVEDV VSKYQNQPQP LDVAKDDANK LKATVEQLTK LAESSDKIDP 

      3250       3260       3270       3280       3290       3300 
QVAKDIKDSK TKAKELLQAL EKAIPQEDAI RREQAEINDR LNNLEKELTK VDEFKPEDAL 

      3310       3320       3330       3340       3350       3360 
PIVDQLAANT NTLKTATDSN NEKAVAPSSL ISHDDLVVGL PEKVFQLQHA IDDKKQALNK 

      3370       3380       3390       3400       3410       3420 
AAAVNEIAPK LQLVSQQLQS VPQEVPASLD EQKQLLEDVE NQKHNLENLL ANLPENDPTA 

      3430       3440       3450       3460       3470       3480 
DELRQKSQWD LSRLKDLLKQ LGSAVGDKLA ALAAFNAARK NAEDALLDIT REDGGDDNKS 

      3490       3500       3510       3520       3530       3540 
PDELIDDLAK KEETVAKLLD TVSGVKPDEL DDKERAEYND LLARLATAAD VLKNKRAELE 

      3550       3560       3570       3580       3590       3600 
QAVKAKADEK SLHDSVDRIV SRLVPLVRES DELRHNAEAV PTQYAPKAEE LKKEVEAAKA 

      3610       3620       3630       3640       3650       3660 
VIANAPSSDA HVQQLEQAVA TAETLIPDLE ERARLWNEFL AARNDIDALI EQLQQPLDAV 

      3670       3680       3690       3700       3710       3720 
LAQPKRSAEE AAQDVENLRN NSQQLSDLDN KIANLQRISE LLDPLESAYA DVRFFDVDAE 

      3730       3740       3750       3760       3770       3780 
QTRHQYDDVL NDVAAELEDE TLLKQSASQV ANEIDDISKM IDSTDPERSI LDTIAKSDIP 

      3790       3800       3810       3820       3830       3840 
ALKAQINRIK DRIVNADASR KHVTTDPKIA EDLDNKLAKL QTELDDAIKT SDEHDKEQLI 

      3850       3860       3870       3880       3890       3900 
LSLKLNISQF EQIPLDQLKS DDLKTAEKEI TNSLKPEEAE PLLAKIQELR EAKRVGDEAR 

      3910       3920       3930       3940       3950       3960 
SAAHDQIVAL EKEAEDVTAK ESAKKKKKDK KKSPQEMIDE LSAKVVEAKA LIPKIEEAAK 

      3970       3980       3990       4000       4010       4020 
NENLPADDKP KAEQLVSNLE AFVKDVETQV SEKQDELDKL NNANDAIKRL GDALDDAEKT 

      4030       4040       4050       4060       4070       4080 
VVPSSVPALS EFKDRIAPHL ATLVEAVNDV PASVEPSAVA LRDRAAKFVS DLEKNIQKTG 

      4090       4100       4110       4120       4130       4140 
DDEKRADELK NDDGNAVKNV EDVVSKYQNQ PQPLDVAKDD ANKLKATVEQ LTKLAESSDK 

      4150       4160       4170       4180       4190       4200 
IDPQVAKDIK DSKTKAKELL QALEKAIPQE DAIRREQAEI NDRLNNLEKE LTKVDEFKPE 

      4210       4220       4230       4240       4250       4260 
DALPIVDQLA ANTNTLKTAT DSNNEKAVAP SSLISHDDLV VGLPEKVFQL QHAIDDKKQA 

      4270       4280       4290       4300       4310       4320 
LNKAAAVNEI APKLQLVSQQ LQSVPQEVPA SLDEQKQLLE DVENQKHNLE NLLANLPEND 

      4330       4340       4350       4360       4370       4380 
PTADELRQKS QWDLSRLKDL LKQLGSAVGD KLAALAAFNA ARKNAEDALL DITREDGGDD 

      4390       4400       4410       4420       4430       4440 
NKSPDELIDD RGRSTGSAVG DKLAALAAFN AARKNAEDAL LDITREDGGD DNKSPDELID 

      4450       4460       4470       4480       4490       4500 
DLAKKEETVA KLLDTVSGVK PDELDDKERA EYNDLLARLA TAADVLKNKR AELEQAVKAK 

      4510       4520       4530       4540       4550       4560 
ADEKSLHDSV DRIVSRLVPL VRESDELRHN AEAVPTQYAP KAEELKKEVE AAKAVIANAP 

      4570       4580       4590       4600       4610       4620 
SSDAHVQQLE QAVATAETLI PDLEERARLW NEFLAARNDI DALIEQLQQP LDAVLAQPKR 

      4630       4640       4650       4660       4670       4680 
SAEEAAQDVE NLRNNSQQLS DLDNKIANLQ RISELLDPLE SAYADVRFFD VDAEQTRHQY 

      4690       4700       4710       4720       4730       4740 
DDVLNDVAAE LEDETLLKQS ASQVANEIDD ISKMIDSTDP ERSILDTIAK SDIPALKAQI 

      4750       4760       4770       4780       4790       4800 
NRIKDRIVNA DASRKHVTTD PKIAEDLDNK LAKLQTELDD AIKTSDEHDK EQLILSLKLN 

      4810       4820       4830       4840       4850       4860 
ISQFEQIPLD QLKSDDLKTA EKEITNSLKP EEAEPLLAKI QELREAKRVG DEARSAAHDQ 

      4870       4880       4890       4900       4910       4920 
IVALEKEAED VTAKESAKKK KKDKKKSPQE MIDELSAKVV EAKALIPKIE EAAKNENLPA 

      4930       4940       4950       4960       4970       4980 
DDKPKAEQLV SNLEAFVKDV ETQVSEKQDE LDKLNNANDA IKRLGDALDD AEKTVVPSSV 

      4990       5000       5010       5020       5030       5040 
PALSEFKDRI APHLATLVEA VNDVPASVEP SAVALRDRAA KFVSDLEKNI QKTGDDEKRA 

      5050       5060       5070       5080       5090       5100 
DELKNDVGNA VKNVEDVVSK YQNQPQPLDV AKDDANKLKA TVEQLTKLAE SSDKIDPQVA 

      5110       5120       5130       5140       5150       5160 
KDIKDSKTKA KELLQALEKA IPQEDAIRRE QAEINDRLNN LEKELTKVDE FKPEDALPIV 

      5170       5180       5190       5200       5210       5220 
DQLAANTNTL KTATDSNNEK AVAPSSLISH DDLVVGLPEK VFQLQHAIDD KKQALNKAAA 

      5230       5240       5250       5260       5270       5280 
VNEIAPKLQL VSQQLQSVPQ EVPASLDEQK QLLEDVENQK HNLENLLANL PENDPTADEL 

      5290       5300       5310       5320       5330       5340 
RQKSQWDLSR LKDLLKQLGS AVGDKLAALA AFNAARKNAE DALLDITRED GGDDNKSPDE 

      5350       5360       5370       5380       5390       5400 
LIDDLAKKEE TVAKLLDTVS GVKPDELDDK ERAEYNDLLA RLATAADVLK NKRAELEQAV 

      5410       5420       5430       5440       5450       5460 
KAKADEKSLH DSVDRIVSRL VPLVRESDEL RHNAEAVPTQ YAPKAEELKK EVEAAKAVIA 

      5470       5480       5490       5500       5510       5520 
NAPSSDAHVQ QLEQAVATAE TLIPDLEERA RLWNEFLAAR NDIDALIEQL QQPLDAVLAQ 

      5530       5540       5550       5560       5570       5580 
PKRSAEEAAQ DVENLRNNSQ QLSDLDNKIA NLQRISELLD PLESAYADVR FFDVDAEQTR 

      5590       5600       5610       5620       5630       5640 
HQYDDVLNDV AAELEDETLL KQSASQVANE IDDISKMIDS TDPERSILDT IAKSDIPALK 

      5650       5660       5670       5680       5690       5700 
AQINRIKDRI VNADASRKHV TTDPKIAEDL DNKLAKLQTE LDDAIKTSDE HDKEQLILSL 

      5710       5720       5730       5740       5750       5760 
KLNISQFEQI PLDQLKSDDL KTAEKEITNS LKPEEAEPLL AKIQELREAK RVGDEARSAA 

      5770       5780       5790       5800       5810       5820 
HDQIVALEKE AEDVTAKESA KKKKKDKKKS PQEMIDELSA KVVEAKALIP KIEEAAKNEN 

      5830       5840       5850       5860       5870       5880 
LPADDKPKAE QLVSNLEAFV KDVETQVSEK QDELDKLNNA NDAIKRLGDA LDDAEKTVVP 

      5890       5900       5910       5920       5930       5940 
SSVPALSEFK DRIAPHLATL VEAVNDVPAS VEPSAVALRD RAAKFVSDLE KNIQKTGDDE 

      5950       5960       5970       5980       5990       6000 
KRADELKNDV GNAVKNVEDV VSKYQNQPQP LDVAKDDANK LKATVEQLTK LAESSDKIDP 

      6010       6020       6030       6040       6050       6060 
QVAKDIKDSK TKAKELLQAL EKAIPQEDAI RREQAEINDR LNNLEKELTK VDEFKPEDAL 

      6070       6080       6090       6100       6110       6120 
PIVDQLAANT NTLKTATDSN NEKAVAPSSL ISHDDLVVGL PEKVFQLQHA IDDKKQALNK 

      6130       6140       6150       6160       6170       6180 
AAAVNEIAPK LQLVSQQLQS VPQEVPASLD EQKQLLEDVE NQKHNLENLL ANLPENDPTA 

      6190       6200       6210       6220       6230       6240 
DELRQKSQWD LSRLKDLLKQ LGSAVGDKLA ALAAFNAARK NAEDALLDIT REDGGDDNKS 

      6250       6260       6270       6280       6290       6300 
PDELIDDLAK KEETVAKLLD TVSGVKPDEL DDKERAEYND LLARLATAAD VLKNKRAELE 

      6310       6320       6330       6340       6350       6360 
QAVKAKADEK SLHDSVDRIV SRLVPLVRES DELRHNAEAV PTQYAPKAEE LKKEVEAAKA 

      6370       6380       6390       6400       6410       6420 
VIANAPSSDA HVQQLEQAVA TAETLIPDLE ERARLWNEFL AARNDIDALI EQLQQPLDAV 

      6430       6440       6450       6460       6470       6480 
LAQPKRSAEE AAQDVENLRN NSQQLSDLDN KIANLQRISE LLDPLESAYA DVRFFDVDAE 

      6490       6500       6510       6520       6530       6540 
QTRHQYDDVL NDVAAELEDE TLLKQSASQV ANEIDDISKM IDSTDPERSI LDTIAKSDIP 

      6550       6560       6570       6580       6590       6600 
ALKAQINRIK DRIVNADASR KHVTTDPKIA EDLDNKLAKL QTELDDAIKT SDEHDKEQLI 

      6610       6620       6630       6640       6650       6660 
LSLKLNISQF EQIPLDQLKS DDLKTAEKEI TNSLKPEEAE PLLAKIQELR EAKRVGDEAR 

      6670       6680       6690       6700       6710       6720 
SAAHDQIVAL EKEAEDVTAK ESAKKKKKDK KKSPQEMIDE LSAKVVEAKA LIPKIEEAAK 

      6730       6740       6750       6760       6770       6780 
NENLPADDKP KAEQLVSNLE AFVKDVETQV SEKQDELDKL NNANDAIKRL GDALDDAEKT 

      6790       6800       6810       6820       6830       6840 
VVPSSVPALS EFKDRIAPHL ATLVEAVNDV PASVEPSAVA LRDRAAKFVS DLEKNIQKTG 

      6850       6860       6870       6880       6890       6900 
DDEKRADELK NDVGNAVKNV EDVVSKYQNQ PQPLDVAKDD ANKLKATVEQ LTKLAESSDK 

      6910       6920       6930       6940       6950       6960 
IDPQVAKDIK DSKTKAKELL QALEKAIPQE DAIRREQAEI NDRLNNLEKE LTKVDEFKPE 

      6970       6980       6990       7000       7010       7020 
DALPIVDQLA ANTNTLKTAT DSNNEKAVAP SSLISHDDLV VGLPEKVFQL QHAIDDKKQA 

      7030       7040       7050       7060       7070       7080 
LNKAAAVNEI APKLQLVSQQ LQSVPQEVPA SLDEQKQLLE DVENQKHNLE NLLANLPEND 

      7090       7100       7110       7120       7130       7140 
PTADELRQKS QWDLSRLKDL LKQLGSAVGD KLAALAAFNA ARKNAEDALL DITREDGGDD 

      7150       7160       7170       7180       7190       7200 
NKSPDELIDD LAKKEETVAK LLDTVSGVKP DELDDKERAE YNDLLARLAT AADVLKNKRA 

      7210       7220       7230       7240       7250       7260 
ELEQAVKAKA DEKSLHDSVD RIVSRLVPLV RESDELRHNA EAVPTQYAPK AEELKKEVEA 

      7270       7280       7290       7300       7310       7320 
AKAVIANAPS SDAHVQQLEQ AVATAETLIP DLEERARLWN EFLAARNDID ALIEQLQQPL 

      7330       7340       7350       7360       7370       7380 
DAVLAQPKRS AEEAAQDVEN LRNNSQQLSD LDNKIANLQR ISELLDPLES AYADVRFFDV 

      7390       7400       7410       7420       7430       7440 
DAEQTRHQYD DVLNDVAAEL EDETLLKQSA SQVANEIDDI SKMIDSTDPE RSILDTIAKS 

      7450       7460       7470       7480       7490       7500 
DIPALKAQIN RIKDRIVNAD ASRKHVTTDP KIAEDLDNKL AKLQTELDDA IKTSDEHDKE 

      7510       7520       7530       7540       7550       7560 
QLILSLKLNI SQFEQIPLDQ LKSDDLKTAE KEITNSLKPE EAEPLLAKIQ ELREAKRVGD 

      7570       7580       7590       7600       7610       7620 
EARSAAHDQI VALEKEAEDV TAKESAKKKK KDKKKSPQEM IDELSAKVVE AKALIPKIEE 

      7630       7640       7650       7660       7670       7680 
AAKNENLPAD DKPKAEQLVS NLEAFVKDVE TQVSEKQDEL DKLNNANDAI KRLGDALDDA 

      7690       7700       7710       7720       7730       7740 
EKTVVPSSVP ALSEFKDRIA PHLATLVEAV NDVPASVEPS AVALRDRAAK FVSDLEKNIQ 

      7750       7760       7770       7780       7790       7800 
KTGDDEKRAD ELKNDVGNAV KNVEDVVSKY QNQPQPLDVA KDDANKLKAT VEQLTKLAES 

      7810       7820       7830       7840       7850       7860 
SDKIDPQVAK DIKDSKTKAK ELLQALEKAI PQEDAIRREQ AEINDRLNKL EKELTKVDEF 

      7870       7880       7890       7900       7910       7920 
KPEDALPIVD QLAANTNTLK TATDSNNEKA VAPSSLISHD DLVVGLPEKV FQLQHAIDDK 

      7930       7940       7950       7960       7970       7980 
KQALNKAAAV NEIAPKLQLV SQQLQSVPQE VPASLDEQKQ LLEDVENQKH NLENLLANLP 

      7990       8000       8010       8020       8030       8040 
ENDPTADELR QKSQWDLSRL KDLLKQLGSA VGEKLAALAA FNAARKNAED ALLDITREDG 

      8050       8060       8070       8080       8090       8100 
GDDNKSPDEL IDDLAKKEET VAKLLDTVSG VKPDELDDKE RAEYNDLLAR LATAADVLKN 

      8110       8120       8130       8140       8150       8160 
KRAELEQAVK AKADEKSLHD SVDRIVSRLV PLVRESDELR HNAEAVPTQY APKAEELKKE 

      8170       8180       8190       8200       8210       8220 
VEAAKAVIAN APSSDAHVQQ LEQAVATAET LIPDLEERAS IWERFVKAKD DLYDYLEKLE 

      8230       8240       8250       8260       8270       8280 
NNVSDVLNRP RLPVSQAQQR FNKLKEQSYL LDRIRDLKID FDDLGEALLP LTVAEDELRF 

      8290       8300       8310       8320       8330       8340 
MHVHVESIER QYEDTMDKLN AEITAEVELL RTLDILSNEL SQCKEDINNP SVDVDELSRA 

      8350       8360       8370       8380       8390       8400 
TMLNDAIAHL ENQKVVVARS EKDRKFVESS TSIDLDQLLA EAKRLLKEIE PRLQLAQPDH 

      8410       8420       8430       8440       8450       8460 
DNEDDEDEEK GSDEKPYDVR AAAEVLSALY PDEHPHNVLR NIGFEELPSD SESRSEFDSL 

      8470       8480       8490       8500       8510       8520 
DSRSDGLLSP IPDDSTLSEE QLRRQRSRWR RVLRTALPLQ ALLVLLMGAA CLVPHCDDEY 

      8530       8540 
CCQLLNNFAK SFDPSLEFVN GPPPF 

« Hide

References

« Hide 'large scale' references
[1]"Role of ANC-1 in tethering nuclei to the actin cytoskeleton."
Starr D.A., Han M.
Science 298:406-409(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1751, IDENTIFICATION OF COMPLETE SEQUENCE, FUNCTION, CHARACTERIZATION, INTERACTION WITH F-ACTIN AND UNC-84.
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300."
Zhang Q., Ragnauth C., Greener M.J., Shanahan C.M., Roberts R.G.
Genomics 80:473-481(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 689-1243.
[4]"A gene required for nuclear and mitochondrial attachment in the nematode Caenorhabditis elegans."
Hedgecock E.M., Thomson J.N.
Cell 30:321-330(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[5]"Neural maintenance roles for the matrix receptor dystroglycan and the nuclear anchorage complex in Caenorhabditis elegans."
Johnson R.P., Kramer J.M.
Genetics 190:1365-1377(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY157938 mRNA. Translation: AAN35200.1.
BK000642 mRNA. Translation: DAA04553.1.
FO081700 Genomic DNA. Translation: CCD73568.1.
AY126454 mRNA. Translation: AAM95163.1.
PIRT33140.
T33141.
RefSeqNP_491353.2. NM_058952.3.
UniGeneCel.22568.

3D structure databases

ProteinModelPortalQ9N4M4.
SMRQ9N4M4. Positions 20-328.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid37504. 2 interactions.

Proteomic databases

PaxDbQ9N4M4.
PRIDEQ9N4M4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK973.6; ZK973.6; ZK973.6.
GeneID172034.
KEGGcel:CELE_ZK973.6.
UCSCZK973.6. c. elegans.

Organism-specific databases

CTD172034.
WormBaseZK973.6; CE33588; WBGene00000140; anc-1.

Phylogenomic databases

eggNOGCOG5069.
InParanoidQ9N4M4.
OMATSVQIKN.
OrthoDBEOG72JWF7.
PhylomeDBQ9N4M4.

Family and domain databases

Gene3D1.10.418.10. 2 hits.
InterProIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR012315. KASH.
[Graphical view]
PfamPF00307. CH. 2 hits.
PF10541. KASH. 1 hit.
[Graphical view]
SMARTSM00033. CH. 2 hits.
[Graphical view]
SUPFAMSSF47576. SSF47576. 2 hits.
PROSITEPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS51049. KASH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio873759.
PROQ9N4M4.

Entry information

Entry nameANC1_CAEEL
AccessionPrimary (citable) accession number: Q9N4M4
Secondary accession number(s): O61841, O61842, Q6IMP3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: April 16, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase