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Q9N4M4

- ANC1_CAEEL

UniProt

Q9N4M4 - ANC1_CAEEL

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Protein
Nuclear anchorage protein 1
Gene
anc-1, ZK973.6
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a central role in nuclear and mitochondrial anchoring. Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus. Has a role in positioning of the cell body of the PVQ lumbar interneuron.3 Publications

GO - Molecular functioni

  1. actin binding Source: WormBase

GO - Biological processi

  1. cytoskeleton organization Source: UniProtKB
  2. localization Source: WormBase
  3. pronuclear migration Source: WormBase
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear anchorage protein 1
Short name:
Anchorage 1 protein
Alternative name(s):
Nesprin homolog
Gene namesi
Name:anc-1
ORF Names:ZK973.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiZK973.6; CE33588; WBGene00000140; anc-1.

Subcellular locationi

Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side Reviewed prediction. Cytoplasmcytoskeleton
Note: The largest part of the protein is cytoplasmic, while its C-terminal part is associated either with the nuclear envelope, most probably the outer nuclear membrane, or with mitochondrial membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 84948494Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei8495 – 851319Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST
Topological domaini8514 – 854532Perinuclear space Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. cytoskeleton Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. nuclear outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Nuclear anchorage is lost resulting in free-floating nuclei that often cluster as the animal flexes. An increase in PVQ cell bodies mispositioned to the anterior is apparent between three-fold embryos and L1 larvae. Pharyngeal cells show defects including mispositioned organelles.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 85458545Nuclear anchorage protein 1
PRO_0000163593Add
BLAST

Proteomic databases

PaxDbiQ9N4M4.
PRIDEiQ9N4M4.

Expressioni

Tissue specificityi

Ubiquitously expressed in all postembryonic cells.

Developmental stagei

First expressed in L1 larvae, and thereafter.

Interactioni

Subunit structurei

Interacts with F-actin via its N-terminal domain. Interacts indirectly with unc-84.1 Publication

Protein-protein interaction databases

BioGridi37504. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9N4M4.
SMRiQ9N4M4. Positions 20-131, 242-323.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 325325Actin-binding
Add
BLAST
Domaini23 – 130108CH 1
Add
BLAST
Domaini222 – 325104CH 2
Add
BLAST
Repeati3241 – 41439031
Add
BLAST
Repeati4144 – 50979542
Add
BLAST
Repeati5098 – 60009033
Add
BLAST
Repeati6001 – 69039034
Add
BLAST
Repeati6904 – 78069035
Add
BLAST
Repeati7807 – 81993936
Add
BLAST
Domaini8486 – 854560KASH
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni3241 – 819949596 X tandem repeat
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili754 – 77421 Reviewed prediction
Add
BLAST
Coiled coili1072 – 110130 Reviewed prediction
Add
BLAST
Coiled coili1215 – 123622 Reviewed prediction
Add
BLAST
Coiled coili1324 – 138461 Reviewed prediction
Add
BLAST
Coiled coili1574 – 162956 Reviewed prediction
Add
BLAST
Coiled coili1725 – 175430 Reviewed prediction
Add
BLAST
Coiled coili1950 – 198132 Reviewed prediction
Add
BLAST
Coiled coili2103 – 2580478 Reviewed prediction
Add
BLAST
Coiled coili2682 – 271231 Reviewed prediction
Add
BLAST
Coiled coili2852 – 294998 Reviewed prediction
Add
BLAST
Coiled coili3002 – 3119118 Reviewed prediction
Add
BLAST
Coiled coili3178 – 3295118 Reviewed prediction
Add
BLAST
Coiled coili3346 – 341772 Reviewed prediction
Add
BLAST
Coiled coili3482 – 355271 Reviewed prediction
Add
BLAST
Coiled coili3587 – 3703117 Reviewed prediction
Add
BLAST
Coiled coili3781 – 383959 Reviewed prediction
Add
BLAST
Coiled coili3902 – 4022121 Reviewed prediction
Add
BLAST
Coiled coili4114 – 419885 Reviewed prediction
Add
BLAST
Coiled coili4249 – 432072 Reviewed prediction
Add
BLAST
Coiled coili4436 – 450671 Reviewed prediction
Add
BLAST
Coiled coili4541 – 4657117 Reviewed prediction
Add
BLAST
Coiled coili4735 – 479359 Reviewed prediction
Add
BLAST
Coiled coili4856 – 4976121 Reviewed prediction
Add
BLAST
Coiled coili5035 – 5152118 Reviewed prediction
Add
BLAST
Coiled coili5203 – 527472 Reviewed prediction
Add
BLAST
Coiled coili5339 – 540971 Reviewed prediction
Add
BLAST
Coiled coili5444 – 5560117 Reviewed prediction
Add
BLAST
Coiled coili5638 – 569659 Reviewed prediction
Add
BLAST
Coiled coili5759 – 5879121 Reviewed prediction
Add
BLAST
Coiled coili5938 – 6055118 Reviewed prediction
Add
BLAST
Coiled coili6106 – 617772 Reviewed prediction
Add
BLAST
Coiled coili6242 – 631271 Reviewed prediction
Add
BLAST
Coiled coili6347 – 6463117 Reviewed prediction
Add
BLAST
Coiled coili6541 – 659959 Reviewed prediction
Add
BLAST
Coiled coili6662 – 6782121 Reviewed prediction
Add
BLAST
Coiled coili6841 – 6958118 Reviewed prediction
Add
BLAST
Coiled coili7009 – 708072 Reviewed prediction
Add
BLAST
Coiled coili7145 – 721571 Reviewed prediction
Add
BLAST
Coiled coili7250 – 7366117 Reviewed prediction
Add
BLAST
Coiled coili7444 – 750259 Reviewed prediction
Add
BLAST
Coiled coili7565 – 7685121 Reviewed prediction
Add
BLAST
Coiled coili7744 – 7861118 Reviewed prediction
Add
BLAST
Coiled coili7912 – 798372 Reviewed prediction
Add
BLAST
Coiled coili8048 – 811871 Reviewed prediction
Add
BLAST
Coiled coili8153 – 820452 Reviewed prediction
Add
BLAST
Coiled coili8273 – 832957 Reviewed prediction
Add
BLAST
Coiled coili8370 – 839021 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1655 – 16584Poly-Arg
Compositional biasi3021 – 30299Poly-Lys
Compositional biasi3924 – 39329Poly-Lys
Compositional biasi4878 – 48869Poly-Lys
Compositional biasi5781 – 57899Poly-Lys
Compositional biasi6684 – 66929Poly-Lys
Compositional biasi7587 – 75959Poly-Lys

Domaini

The large coiled coil domains are composed of 6 nearly exact repeats of 903 residues. The last repeat is partial. These repeats are conserved in Hawai (CB4856), Australia (AB4) and Germany (RC301) strains. The length of the repeat may be maintained because of a selective advantage to keep the protein large and allow a single molecule to extent more than 0,5 micrometers.
The KASH domain, which contains a potential transmembrane domain, is essential for the nuclear envelope targeting.

Sequence similaritiesi

Belongs to the nesprin family.
Contains 1 KASH domain.

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5069.
GeneTreeiENSGT00750000117361.
InParanoidiQ9N4M4.
OMAiTSVQIKN.
OrthoDBiEOG72JWF7.
PhylomeDBiQ9N4M4.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR012315. KASH.
[Graphical view]
PfamiPF00307. CH. 2 hits.
PF10541. KASH. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS51049. KASH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9N4M4-1 [UniParc]FASTAAdd to Basket

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MSSSPPARPC CVCFRFRPHE DEKAQKNTFT RWINFHLEEH SSSGRIEDLF     50
EDIRDGVLLC HLIEVLTGEA LAVHKGRVSK RVHHIANLTT ALTVLRRRGL 100
ELINNNAADI ADGNPRIVLG LIWQIILHFQ IETNMILLRE WGWAATGTEE 150
PTSSAQPEVV VTAPSPTPSS KKSHSKVSSL SGSKTSLASG EKAPSSPLRQ 200
RIASFLTPTK KAPKLTAQPV KQSVEQVFLR WINAEIGDLV GGRRVENMDK 250
QWRDGILFCA LVSRWRPDVI SMREVTNANP RDNLELAFNL AHQHLGVRRL 300
LAVEDMMIEK PDKRSVITYV SQFVRMFGER SPMQGREQHE IFLAWLEATY 350
LLCTRHELNS QECSRIRREF IEHRPLFNTI IVTKVNYDVE ELVEIEKKWD 400
CIRETLEKYA RRSERDLPEP FASIATWIAG AEHILSRPLD LDATDAKKTV 450
TMLQKLISEH QKYMEDLPKR QEDFEEAVKH GGLGGRPVAP EFSEPLRARF 500
AQIEEENEPR ISTLRILTTH YILLQYLQHI DEKIILWRTA DSVTLLLRWI 550
KEYTQLNAEN PQAKCASYIN KITLTMANDQ NSKLDKEAIL NTSNEKTAET 600
LKRFESLWIE LKLLKVEWVE WETHVSQLEE IIEERRRNGV PPTPEDEQAL 650
AVITAGADQL APKLGASARL SNNQRLDVLT HSFKKLTKTT IKIGGRLVVE 700
LEPSTSEQAS KISYSWQASD ELLKVEMQLR DRIQRDADSS DREQLEYRAE 750
TFRNIRDKLI ELERLNEIYD NHSRDQVDTP NRNLIRHDMG TIIYGLQAGQ 800
YANFVDLSCY AFVYDEYNQV PVNLTENVLS EDYVREIVNR KKAILTRREN 850
NEDEIRESIR DMEECDRIIE GWQSTEIEEL RAEWNIKLSE FESWHEMMQQ 900
VEVLSQTIQT RLDVTVIQTI WILKERSYDI KHSELGGTLR ESLEQLATTS 950
ETSVNRHLQN LELSNEQDCP DAIEFLEEVG RESVSKLSAA VDDRYIYTLH 1000
VLRTKMELFR RLQNFCDAVK ILRSQNTKWN GIKISQIDQV QSEIDTLIVR 1050
LDEEWTQDAN QLRAELASIH GSFFQLEFDR LNEKLNMLIH DKDKLRELMV 1100
HRRHYLTAAN ELITDSKTDL AQRATSSDHP DDILRATDEV TKALDIKGEE 1150
LRRLGELAEM NITDLVVVAL ILSFRRRQLG SEGEPEVEEL RRALREIIAR 1200
PITEPRDVSP DAIVADILRM KDEKKRDEKT IDEIQATTLT DEQRASFAPL 1250
IEDYRRRADR HRIVFEHLVM IYLDWLSRQF DELEDEIGMT IQTSRADDLR 1300
RMNSTEWNKW KTDLANIERQ VGPDTKKALS AELADLHRKR DSMEARINKY 1350
LTHSAKINAK LTQFEKWLNA IEEDIEQTER QFEDPERSYR FGSLHEVALA 1400
KQRLVAKLER LNVANKEEVL RLCERYHTIM HKLTPFQTAV GLPLHVSTNL 1450
DRNGPFQSQI SVSSIASSEL ERPESVMSLT SSIGVIPADV AELSPFEAKI 1500
NKLLQKLHII EDSYLKGPKP IDTVREDVKQ LEKYRNRGAE ILQQLSTSNI 1550
EDAEKEGLKH RFVLMLNNYD DILRSIENEI RDDNELTAKN QEILAELSNA 1600
EQTLQNSPLE DLDISAELDR LQMQLDLVKV MCNKPRKYVE CELIDSSREG 1650
SPQERRRRKK KVMVMVSNTI TTIIHVVEER LEASDISRNP DVQQKLVAVK 1700
ENLRELDTTT VTPHPPSIMS PLGTENRNDL EEVKRLAAEI DRAIDTASSM 1750
YEDAPTDEDA LKSAIHLLDD QKVTLNHLHV VLEGIPEKNE QDRTDAIDIA 1800
SSVGEKLGNL KSAVEEVYEE VLASTNPVKE DQPLQHIQEV QTTPAEQSNW 1850
DTDEFSRQPP VLSDERIELK TDPSAIDKFE VRSDEDPVPK IIDLFGQLQT 1900
AVNEASPLAC EGTDDVDALQ VASDKLTKQD RTIRKIHAIL DTIDDPVQKP 1950
AIIESLDKIK DQINNARDNI NRQIDNLNYN QTPVVVPKES TKTPLNEIED 2000
AVRQASTVVS DELCNTEKLL SARQTLANVK PQVDSVEANV WSNPETIETV 2050
TPILEEYTTL VDNIEKKLAN EIEVPTNDPS RQDLVQQLQD VILECEEVVV 2100
NCDNIEKLEE SKLKLEKARP LLDQIGDNVE KLSREQSPDT SDAIDALSNV 2150
HQQYNATIMS IDDKIDELKN PEEDTSAADQ LISELHVISE MPAVTIDLSM 2200
LNAIEEGLST LPAHQAENVQ AKIDELRQKK EVADQTEQIL SDLNAFGDMP 2250
AITLDLDLLK SVEDGIAVLP VEDSERIKAK IVDLRKKKED ADQAEALLQE 2300
LSVISDMPIS TLDLNMLQGI EDNLNSLPAE ESDEIREKLN ELRRRKQESD 2350
QAEALLQELS VISDMPISTL DLNMLQGVED NLNSLPTEEA DKIREKINDL 2400
RRRKQESDLA EALLQELSVI YDMPTSTIDL NMLQGIEDNL NSLPAEESDK 2450
IREKINDLRR RKQESDLAEA LLQELSVIYD MPTSTIDLNM LQGIEDNLNS 2500
LPAEESDKIR EKINDLRRRK QESDQAEALL QELSVVSDMP ASTIDINMLQ 2550
SIEDGLSTLL SEDRSKIQQA IDSLRKKKSD SDLAQHALEA LSVQSKLPSV 2600
SINLEELKKL EETLSTVPVE DSKVIRDKIA ELKTEKALAD HAENYLVELK 2650
KIEDMPISAV GSDVLATIED QILQMPVQYQ PSVKETLDKL KQAKEEDDKL 2700
AGVYDELEKI AKLPARDYDN KLLAKIDEKL NSLPKDQIAE THRKVEDIKV 2750
TKADIVAQID VLDKLPAKDI DEHLLNSIEE KLPTIPSDSS DQLQIAIGKL 2800
RDRKQANIDE GKKILNELAE IQKMPADSLN EHALNLLATE SDKFGSEISD 2850
KIMQEIDVLR EKQNNHEVAR LNAESVLQQL DKISEEPHLS LTEERLAPFL 2900
QNIDTVPACF VDKIRNKINE VQKLHDEAVQ DEKDELKEKL VAKVQNIGKT 2950
SIDDVNVSDF EEIEREINGS LEAFEAEPLL AKIQELREAK RVGDEARSAA 3000
HDQIVALEKE AEDVTAKESA KKKKKDKKKS PQEMIDELSA KVVEAKALIP 3050
KIEEAAKNEN LPADDKPKAE QLVSNLEAFV KDVETQVSEK QDELDKLNNA 3100
NDAIKRLGDA LDDAEKTVVP SSVPALSEFK DRIAPHLATL VEAVNDVPAS 3150
VEPSAVALRD RAAKFVSDLE KNIQKTGDDE KRADELKNDV GNAVKNVEDV 3200
VSKYQNQPQP LDVAKDDANK LKATVEQLTK LAESSDKIDP QVAKDIKDSK 3250
TKAKELLQAL EKAIPQEDAI RREQAEINDR LNNLEKELTK VDEFKPEDAL 3300
PIVDQLAANT NTLKTATDSN NEKAVAPSSL ISHDDLVVGL PEKVFQLQHA 3350
IDDKKQALNK AAAVNEIAPK LQLVSQQLQS VPQEVPASLD EQKQLLEDVE 3400
NQKHNLENLL ANLPENDPTA DELRQKSQWD LSRLKDLLKQ LGSAVGDKLA 3450
ALAAFNAARK NAEDALLDIT REDGGDDNKS PDELIDDLAK KEETVAKLLD 3500
TVSGVKPDEL DDKERAEYND LLARLATAAD VLKNKRAELE QAVKAKADEK 3550
SLHDSVDRIV SRLVPLVRES DELRHNAEAV PTQYAPKAEE LKKEVEAAKA 3600
VIANAPSSDA HVQQLEQAVA TAETLIPDLE ERARLWNEFL AARNDIDALI 3650
EQLQQPLDAV LAQPKRSAEE AAQDVENLRN NSQQLSDLDN KIANLQRISE 3700
LLDPLESAYA DVRFFDVDAE QTRHQYDDVL NDVAAELEDE TLLKQSASQV 3750
ANEIDDISKM IDSTDPERSI LDTIAKSDIP ALKAQINRIK DRIVNADASR 3800
KHVTTDPKIA EDLDNKLAKL QTELDDAIKT SDEHDKEQLI LSLKLNISQF 3850
EQIPLDQLKS DDLKTAEKEI TNSLKPEEAE PLLAKIQELR EAKRVGDEAR 3900
SAAHDQIVAL EKEAEDVTAK ESAKKKKKDK KKSPQEMIDE LSAKVVEAKA 3950
LIPKIEEAAK NENLPADDKP KAEQLVSNLE AFVKDVETQV SEKQDELDKL 4000
NNANDAIKRL GDALDDAEKT VVPSSVPALS EFKDRIAPHL ATLVEAVNDV 4050
PASVEPSAVA LRDRAAKFVS DLEKNIQKTG DDEKRADELK NDDGNAVKNV 4100
EDVVSKYQNQ PQPLDVAKDD ANKLKATVEQ LTKLAESSDK IDPQVAKDIK 4150
DSKTKAKELL QALEKAIPQE DAIRREQAEI NDRLNNLEKE LTKVDEFKPE 4200
DALPIVDQLA ANTNTLKTAT DSNNEKAVAP SSLISHDDLV VGLPEKVFQL 4250
QHAIDDKKQA LNKAAAVNEI APKLQLVSQQ LQSVPQEVPA SLDEQKQLLE 4300
DVENQKHNLE NLLANLPEND PTADELRQKS QWDLSRLKDL LKQLGSAVGD 4350
KLAALAAFNA ARKNAEDALL DITREDGGDD NKSPDELIDD RGRSTGSAVG 4400
DKLAALAAFN AARKNAEDAL LDITREDGGD DNKSPDELID DLAKKEETVA 4450
KLLDTVSGVK PDELDDKERA EYNDLLARLA TAADVLKNKR AELEQAVKAK 4500
ADEKSLHDSV DRIVSRLVPL VRESDELRHN AEAVPTQYAP KAEELKKEVE 4550
AAKAVIANAP SSDAHVQQLE QAVATAETLI PDLEERARLW NEFLAARNDI 4600
DALIEQLQQP LDAVLAQPKR SAEEAAQDVE NLRNNSQQLS DLDNKIANLQ 4650
RISELLDPLE SAYADVRFFD VDAEQTRHQY DDVLNDVAAE LEDETLLKQS 4700
ASQVANEIDD ISKMIDSTDP ERSILDTIAK SDIPALKAQI NRIKDRIVNA 4750
DASRKHVTTD PKIAEDLDNK LAKLQTELDD AIKTSDEHDK EQLILSLKLN 4800
ISQFEQIPLD QLKSDDLKTA EKEITNSLKP EEAEPLLAKI QELREAKRVG 4850
DEARSAAHDQ IVALEKEAED VTAKESAKKK KKDKKKSPQE MIDELSAKVV 4900
EAKALIPKIE EAAKNENLPA DDKPKAEQLV SNLEAFVKDV ETQVSEKQDE 4950
LDKLNNANDA IKRLGDALDD AEKTVVPSSV PALSEFKDRI APHLATLVEA 5000
VNDVPASVEP SAVALRDRAA KFVSDLEKNI QKTGDDEKRA DELKNDVGNA 5050
VKNVEDVVSK YQNQPQPLDV AKDDANKLKA TVEQLTKLAE SSDKIDPQVA 5100
KDIKDSKTKA KELLQALEKA IPQEDAIRRE QAEINDRLNN LEKELTKVDE 5150
FKPEDALPIV DQLAANTNTL KTATDSNNEK AVAPSSLISH DDLVVGLPEK 5200
VFQLQHAIDD KKQALNKAAA VNEIAPKLQL VSQQLQSVPQ EVPASLDEQK 5250
QLLEDVENQK HNLENLLANL PENDPTADEL RQKSQWDLSR LKDLLKQLGS 5300
AVGDKLAALA AFNAARKNAE DALLDITRED GGDDNKSPDE LIDDLAKKEE 5350
TVAKLLDTVS GVKPDELDDK ERAEYNDLLA RLATAADVLK NKRAELEQAV 5400
KAKADEKSLH DSVDRIVSRL VPLVRESDEL RHNAEAVPTQ YAPKAEELKK 5450
EVEAAKAVIA NAPSSDAHVQ QLEQAVATAE TLIPDLEERA RLWNEFLAAR 5500
NDIDALIEQL QQPLDAVLAQ PKRSAEEAAQ DVENLRNNSQ QLSDLDNKIA 5550
NLQRISELLD PLESAYADVR FFDVDAEQTR HQYDDVLNDV AAELEDETLL 5600
KQSASQVANE IDDISKMIDS TDPERSILDT IAKSDIPALK AQINRIKDRI 5650
VNADASRKHV TTDPKIAEDL DNKLAKLQTE LDDAIKTSDE HDKEQLILSL 5700
KLNISQFEQI PLDQLKSDDL KTAEKEITNS LKPEEAEPLL AKIQELREAK 5750
RVGDEARSAA HDQIVALEKE AEDVTAKESA KKKKKDKKKS PQEMIDELSA 5800
KVVEAKALIP KIEEAAKNEN LPADDKPKAE QLVSNLEAFV KDVETQVSEK 5850
QDELDKLNNA NDAIKRLGDA LDDAEKTVVP SSVPALSEFK DRIAPHLATL 5900
VEAVNDVPAS VEPSAVALRD RAAKFVSDLE KNIQKTGDDE KRADELKNDV 5950
GNAVKNVEDV VSKYQNQPQP LDVAKDDANK LKATVEQLTK LAESSDKIDP 6000
QVAKDIKDSK TKAKELLQAL EKAIPQEDAI RREQAEINDR LNNLEKELTK 6050
VDEFKPEDAL PIVDQLAANT NTLKTATDSN NEKAVAPSSL ISHDDLVVGL 6100
PEKVFQLQHA IDDKKQALNK AAAVNEIAPK LQLVSQQLQS VPQEVPASLD 6150
EQKQLLEDVE NQKHNLENLL ANLPENDPTA DELRQKSQWD LSRLKDLLKQ 6200
LGSAVGDKLA ALAAFNAARK NAEDALLDIT REDGGDDNKS PDELIDDLAK 6250
KEETVAKLLD TVSGVKPDEL DDKERAEYND LLARLATAAD VLKNKRAELE 6300
QAVKAKADEK SLHDSVDRIV SRLVPLVRES DELRHNAEAV PTQYAPKAEE 6350
LKKEVEAAKA VIANAPSSDA HVQQLEQAVA TAETLIPDLE ERARLWNEFL 6400
AARNDIDALI EQLQQPLDAV LAQPKRSAEE AAQDVENLRN NSQQLSDLDN 6450
KIANLQRISE LLDPLESAYA DVRFFDVDAE QTRHQYDDVL NDVAAELEDE 6500
TLLKQSASQV ANEIDDISKM IDSTDPERSI LDTIAKSDIP ALKAQINRIK 6550
DRIVNADASR KHVTTDPKIA EDLDNKLAKL QTELDDAIKT SDEHDKEQLI 6600
LSLKLNISQF EQIPLDQLKS DDLKTAEKEI TNSLKPEEAE PLLAKIQELR 6650
EAKRVGDEAR SAAHDQIVAL EKEAEDVTAK ESAKKKKKDK KKSPQEMIDE 6700
LSAKVVEAKA LIPKIEEAAK NENLPADDKP KAEQLVSNLE AFVKDVETQV 6750
SEKQDELDKL NNANDAIKRL GDALDDAEKT VVPSSVPALS EFKDRIAPHL 6800
ATLVEAVNDV PASVEPSAVA LRDRAAKFVS DLEKNIQKTG DDEKRADELK 6850
NDVGNAVKNV EDVVSKYQNQ PQPLDVAKDD ANKLKATVEQ LTKLAESSDK 6900
IDPQVAKDIK DSKTKAKELL QALEKAIPQE DAIRREQAEI NDRLNNLEKE 6950
LTKVDEFKPE DALPIVDQLA ANTNTLKTAT DSNNEKAVAP SSLISHDDLV 7000
VGLPEKVFQL QHAIDDKKQA LNKAAAVNEI APKLQLVSQQ LQSVPQEVPA 7050
SLDEQKQLLE DVENQKHNLE NLLANLPEND PTADELRQKS QWDLSRLKDL 7100
LKQLGSAVGD KLAALAAFNA ARKNAEDALL DITREDGGDD NKSPDELIDD 7150
LAKKEETVAK LLDTVSGVKP DELDDKERAE YNDLLARLAT AADVLKNKRA 7200
ELEQAVKAKA DEKSLHDSVD RIVSRLVPLV RESDELRHNA EAVPTQYAPK 7250
AEELKKEVEA AKAVIANAPS SDAHVQQLEQ AVATAETLIP DLEERARLWN 7300
EFLAARNDID ALIEQLQQPL DAVLAQPKRS AEEAAQDVEN LRNNSQQLSD 7350
LDNKIANLQR ISELLDPLES AYADVRFFDV DAEQTRHQYD DVLNDVAAEL 7400
EDETLLKQSA SQVANEIDDI SKMIDSTDPE RSILDTIAKS DIPALKAQIN 7450
RIKDRIVNAD ASRKHVTTDP KIAEDLDNKL AKLQTELDDA IKTSDEHDKE 7500
QLILSLKLNI SQFEQIPLDQ LKSDDLKTAE KEITNSLKPE EAEPLLAKIQ 7550
ELREAKRVGD EARSAAHDQI VALEKEAEDV TAKESAKKKK KDKKKSPQEM 7600
IDELSAKVVE AKALIPKIEE AAKNENLPAD DKPKAEQLVS NLEAFVKDVE 7650
TQVSEKQDEL DKLNNANDAI KRLGDALDDA EKTVVPSSVP ALSEFKDRIA 7700
PHLATLVEAV NDVPASVEPS AVALRDRAAK FVSDLEKNIQ KTGDDEKRAD 7750
ELKNDVGNAV KNVEDVVSKY QNQPQPLDVA KDDANKLKAT VEQLTKLAES 7800
SDKIDPQVAK DIKDSKTKAK ELLQALEKAI PQEDAIRREQ AEINDRLNKL 7850
EKELTKVDEF KPEDALPIVD QLAANTNTLK TATDSNNEKA VAPSSLISHD 7900
DLVVGLPEKV FQLQHAIDDK KQALNKAAAV NEIAPKLQLV SQQLQSVPQE 7950
VPASLDEQKQ LLEDVENQKH NLENLLANLP ENDPTADELR QKSQWDLSRL 8000
KDLLKQLGSA VGEKLAALAA FNAARKNAED ALLDITREDG GDDNKSPDEL 8050
IDDLAKKEET VAKLLDTVSG VKPDELDDKE RAEYNDLLAR LATAADVLKN 8100
KRAELEQAVK AKADEKSLHD SVDRIVSRLV PLVRESDELR HNAEAVPTQY 8150
APKAEELKKE VEAAKAVIAN APSSDAHVQQ LEQAVATAET LIPDLEERAS 8200
IWERFVKAKD DLYDYLEKLE NNVSDVLNRP RLPVSQAQQR FNKLKEQSYL 8250
LDRIRDLKID FDDLGEALLP LTVAEDELRF MHVHVESIER QYEDTMDKLN 8300
AEITAEVELL RTLDILSNEL SQCKEDINNP SVDVDELSRA TMLNDAIAHL 8350
ENQKVVVARS EKDRKFVESS TSIDLDQLLA EAKRLLKEIE PRLQLAQPDH 8400
DNEDDEDEEK GSDEKPYDVR AAAEVLSALY PDEHPHNVLR NIGFEELPSD 8450
SESRSEFDSL DSRSDGLLSP IPDDSTLSEE QLRRQRSRWR RVLRTALPLQ 8500
ALLVLLMGAA CLVPHCDDEY CCQLLNNFAK SFDPSLEFVN GPPPF 8545
Length:8,545
Mass (Da):956,482
Last modified:March 28, 2003 - v3
Checksum:i02A94D994BEE19E3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7849 – 78491K → N in DAA04553. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY157938 mRNA. Translation: AAN35200.1.
BK000642 mRNA. Translation: DAA04553.1.
FO081700 Genomic DNA. Translation: CCD73568.1.
AY126454 mRNA. Translation: AAM95163.1.
PIRiT33140.
T33141.
RefSeqiNP_491353.2. NM_058952.3.
UniGeneiCel.22568.

Genome annotation databases

EnsemblMetazoaiZK973.6; ZK973.6; WBGene00000140.
GeneIDi172034.
KEGGicel:CELE_ZK973.6.
UCSCiZK973.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY157938 mRNA. Translation: AAN35200.1 .
BK000642 mRNA. Translation: DAA04553.1 .
FO081700 Genomic DNA. Translation: CCD73568.1 .
AY126454 mRNA. Translation: AAM95163.1 .
PIRi T33140.
T33141.
RefSeqi NP_491353.2. NM_058952.3.
UniGenei Cel.22568.

3D structure databases

ProteinModelPortali Q9N4M4.
SMRi Q9N4M4. Positions 20-131, 242-323.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 37504. 2 interactions.

Proteomic databases

PaxDbi Q9N4M4.
PRIDEi Q9N4M4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZK973.6 ; ZK973.6 ; WBGene00000140 .
GeneIDi 172034.
KEGGi cel:CELE_ZK973.6.
UCSCi ZK973.6. c. elegans.

Organism-specific databases

CTDi 172034.
WormBasei ZK973.6 ; CE33588 ; WBGene00000140 ; anc-1.

Phylogenomic databases

eggNOGi COG5069.
GeneTreei ENSGT00750000117361.
InParanoidi Q9N4M4.
OMAi TSVQIKN.
OrthoDBi EOG72JWF7.
PhylomeDBi Q9N4M4.

Miscellaneous databases

NextBioi 873759.
PROi Q9N4M4.

Family and domain databases

Gene3Di 1.10.418.10. 2 hits.
InterProi IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR012315. KASH.
[Graphical view ]
Pfami PF00307. CH. 2 hits.
PF10541. KASH. 1 hit.
[Graphical view ]
SMARTi SM00033. CH. 2 hits.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 2 hits.
PROSITEi PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS51049. KASH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Role of ANC-1 in tethering nuclei to the actin cytoskeleton."
    Starr D.A., Han M.
    Science 298:406-409(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1751, IDENTIFICATION OF COMPLETE SEQUENCE, FUNCTION, CHARACTERIZATION, INTERACTION WITH F-ACTIN AND UNC-84.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300."
    Zhang Q., Ragnauth C., Greener M.J., Shanahan C.M., Roberts R.G.
    Genomics 80:473-481(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 689-1243.
  4. "A gene required for nuclear and mitochondrial attachment in the nematode Caenorhabditis elegans."
    Hedgecock E.M., Thomson J.N.
    Cell 30:321-330(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. "Neural maintenance roles for the matrix receptor dystroglycan and the nuclear anchorage complex in Caenorhabditis elegans."
    Johnson R.P., Kramer J.M.
    Genetics 190:1365-1377(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiANC1_CAEEL
AccessioniPrimary (citable) accession number: Q9N4M4
Secondary accession number(s): O61841, O61842, Q6IMP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: July 9, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3