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Q9N4M4

- ANC1_CAEEL

UniProt

Q9N4M4 - ANC1_CAEEL

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Protein

Nuclear anchorage protein 1

Gene

anc-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a central role in nuclear and mitochondrial anchoring. Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus. Has a role in positioning of the cell body of the PVQ lumbar interneuron.3 Publications

GO - Molecular functioni

  1. actin binding Source: WormBase

GO - Biological processi

  1. cytoskeleton organization Source: UniProtKB
  2. localization Source: WormBase
  3. pronuclear migration Source: WormBase
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear anchorage protein 1
Short name:
Anchorage 1 protein
Alternative name(s):
Nesprin homolog
Gene namesi
Name:anc-1
ORF Names:ZK973.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiZK973.6; CE33588; WBGene00000140; anc-1.

Subcellular locationi

Nucleus outer membrane Curated; Single-pass type IV membrane protein Curated; Cytoplasmic side Curated. Cytoplasmcytoskeleton
Note: The largest part of the protein is cytoplasmic, while its C-terminal part is associated either with the nuclear envelope, most probably the outer nuclear membrane, or with mitochondrial membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 84948494CytoplasmicPROSITE-ProRule annotationAdd
BLAST
Transmembranei8495 – 851319Helical; Anchor for type IV membrane proteinPROSITE-ProRule annotationAdd
BLAST
Topological domaini8514 – 854532Perinuclear spacePROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. cytoskeleton Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Nuclear anchorage is lost resulting in free-floating nuclei that often cluster as the animal flexes. An increase in PVQ cell bodies mispositioned to the anterior is apparent between three-fold embryos and L1 larvae. Pharyngeal cells show defects including mispositioned organelles.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 85458545Nuclear anchorage protein 1PRO_0000163593Add
BLAST

Proteomic databases

PaxDbiQ9N4M4.
PRIDEiQ9N4M4.

Expressioni

Tissue specificityi

Ubiquitously expressed in all postembryonic cells.

Developmental stagei

First expressed in L1 larvae, and thereafter.

Gene expression databases

ExpressionAtlasiQ9N4M4. baseline and differential.

Interactioni

Subunit structurei

Interacts with F-actin via its N-terminal domain. Interacts indirectly with unc-84.1 Publication

Protein-protein interaction databases

BioGridi37504. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9N4M4.
SMRiQ9N4M4. Positions 20-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 325325Actin-bindingAdd
BLAST
Domaini23 – 130108CH 1PROSITE-ProRule annotationAdd
BLAST
Domaini222 – 325104CH 2PROSITE-ProRule annotationAdd
BLAST
Repeati3241 – 41439031Add
BLAST
Repeati4144 – 50979542Add
BLAST
Repeati5098 – 60009033Add
BLAST
Repeati6001 – 69039034Add
BLAST
Repeati6904 – 78069035Add
BLAST
Repeati7807 – 81993936Add
BLAST
Domaini8486 – 854560KASHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni3241 – 819949596 X tandem repeatAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili754 – 77421Sequence AnalysisAdd
BLAST
Coiled coili1072 – 110130Sequence AnalysisAdd
BLAST
Coiled coili1215 – 123622Sequence AnalysisAdd
BLAST
Coiled coili1324 – 138461Sequence AnalysisAdd
BLAST
Coiled coili1574 – 162956Sequence AnalysisAdd
BLAST
Coiled coili1725 – 175430Sequence AnalysisAdd
BLAST
Coiled coili1950 – 198132Sequence AnalysisAdd
BLAST
Coiled coili2103 – 2580478Sequence AnalysisAdd
BLAST
Coiled coili2682 – 271231Sequence AnalysisAdd
BLAST
Coiled coili2852 – 294998Sequence AnalysisAdd
BLAST
Coiled coili3002 – 3119118Sequence AnalysisAdd
BLAST
Coiled coili3178 – 3295118Sequence AnalysisAdd
BLAST
Coiled coili3346 – 341772Sequence AnalysisAdd
BLAST
Coiled coili3482 – 355271Sequence AnalysisAdd
BLAST
Coiled coili3587 – 3703117Sequence AnalysisAdd
BLAST
Coiled coili3781 – 383959Sequence AnalysisAdd
BLAST
Coiled coili3902 – 4022121Sequence AnalysisAdd
BLAST
Coiled coili4114 – 419885Sequence AnalysisAdd
BLAST
Coiled coili4249 – 432072Sequence AnalysisAdd
BLAST
Coiled coili4436 – 450671Sequence AnalysisAdd
BLAST
Coiled coili4541 – 4657117Sequence AnalysisAdd
BLAST
Coiled coili4735 – 479359Sequence AnalysisAdd
BLAST
Coiled coili4856 – 4976121Sequence AnalysisAdd
BLAST
Coiled coili5035 – 5152118Sequence AnalysisAdd
BLAST
Coiled coili5203 – 527472Sequence AnalysisAdd
BLAST
Coiled coili5339 – 540971Sequence AnalysisAdd
BLAST
Coiled coili5444 – 5560117Sequence AnalysisAdd
BLAST
Coiled coili5638 – 569659Sequence AnalysisAdd
BLAST
Coiled coili5759 – 5879121Sequence AnalysisAdd
BLAST
Coiled coili5938 – 6055118Sequence AnalysisAdd
BLAST
Coiled coili6106 – 617772Sequence AnalysisAdd
BLAST
Coiled coili6242 – 631271Sequence AnalysisAdd
BLAST
Coiled coili6347 – 6463117Sequence AnalysisAdd
BLAST
Coiled coili6541 – 659959Sequence AnalysisAdd
BLAST
Coiled coili6662 – 6782121Sequence AnalysisAdd
BLAST
Coiled coili6841 – 6958118Sequence AnalysisAdd
BLAST
Coiled coili7009 – 708072Sequence AnalysisAdd
BLAST
Coiled coili7145 – 721571Sequence AnalysisAdd
BLAST
Coiled coili7250 – 7366117Sequence AnalysisAdd
BLAST
Coiled coili7444 – 750259Sequence AnalysisAdd
BLAST
Coiled coili7565 – 7685121Sequence AnalysisAdd
BLAST
Coiled coili7744 – 7861118Sequence AnalysisAdd
BLAST
Coiled coili7912 – 798372Sequence AnalysisAdd
BLAST
Coiled coili8048 – 811871Sequence AnalysisAdd
BLAST
Coiled coili8153 – 820452Sequence AnalysisAdd
BLAST
Coiled coili8273 – 832957Sequence AnalysisAdd
BLAST
Coiled coili8370 – 839021Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1655 – 16584Poly-Arg
Compositional biasi3021 – 30299Poly-Lys
Compositional biasi3924 – 39329Poly-Lys
Compositional biasi4878 – 48869Poly-Lys
Compositional biasi5781 – 57899Poly-Lys
Compositional biasi6684 – 66929Poly-Lys
Compositional biasi7587 – 75959Poly-Lys

Domaini

The large coiled coil domains are composed of 6 nearly exact repeats of 903 residues. The last repeat is partial. These repeats are conserved in Hawai (CB4856), Australia (AB4) and Germany (RC301) strains. The length of the repeat may be maintained because of a selective advantage to keep the protein large and allow a single molecule to extent more than 0,5 micrometers.
The KASH domain, which contains a potential transmembrane domain, is essential for the nuclear envelope targeting.

Sequence similaritiesi

Belongs to the nesprin family.Curated
Contains 1 actin-binding domain.Curated
Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 1 KASH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5069.
GeneTreeiENSGT00760000118813.
InParanoidiQ9N4M4.
OMAiTSVQIKN.
OrthoDBiEOG72JWF7.
PhylomeDBiQ9N4M4.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR012315. KASH.
[Graphical view]
PfamiPF00307. CH. 2 hits.
PF10541. KASH. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS51049. KASH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9N4M4-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSSSPPARPC CVCFRFRPHE DEKAQKNTFT RWINFHLEEH SSSGRIEDLF
60 70 80 90 100
EDIRDGVLLC HLIEVLTGEA LAVHKGRVSK RVHHIANLTT ALTVLRRRGL
110 120 130 140 150
ELINNNAADI ADGNPRIVLG LIWQIILHFQ IETNMILLRE WGWAATGTEE
160 170 180 190 200
PTSSAQPEVV VTAPSPTPSS KKSHSKVSSL SGSKTSLASG EKAPSSPLRQ
210 220 230 240 250
RIASFLTPTK KAPKLTAQPV KQSVEQVFLR WINAEIGDLV GGRRVENMDK
260 270 280 290 300
QWRDGILFCA LVSRWRPDVI SMREVTNANP RDNLELAFNL AHQHLGVRRL
310 320 330 340 350
LAVEDMMIEK PDKRSVITYV SQFVRMFGER SPMQGREQHE IFLAWLEATY
360 370 380 390 400
LLCTRHELNS QECSRIRREF IEHRPLFNTI IVTKVNYDVE ELVEIEKKWD
410 420 430 440 450
CIRETLEKYA RRSERDLPEP FASIATWIAG AEHILSRPLD LDATDAKKTV
460 470 480 490 500
TMLQKLISEH QKYMEDLPKR QEDFEEAVKH GGLGGRPVAP EFSEPLRARF
510 520 530 540 550
AQIEEENEPR ISTLRILTTH YILLQYLQHI DEKIILWRTA DSVTLLLRWI
560 570 580 590 600
KEYTQLNAEN PQAKCASYIN KITLTMANDQ NSKLDKEAIL NTSNEKTAET
610 620 630 640 650
LKRFESLWIE LKLLKVEWVE WETHVSQLEE IIEERRRNGV PPTPEDEQAL
660 670 680 690 700
AVITAGADQL APKLGASARL SNNQRLDVLT HSFKKLTKTT IKIGGRLVVE
710 720 730 740 750
LEPSTSEQAS KISYSWQASD ELLKVEMQLR DRIQRDADSS DREQLEYRAE
760 770 780 790 800
TFRNIRDKLI ELERLNEIYD NHSRDQVDTP NRNLIRHDMG TIIYGLQAGQ
810 820 830 840 850
YANFVDLSCY AFVYDEYNQV PVNLTENVLS EDYVREIVNR KKAILTRREN
860 870 880 890 900
NEDEIRESIR DMEECDRIIE GWQSTEIEEL RAEWNIKLSE FESWHEMMQQ
910 920 930 940 950
VEVLSQTIQT RLDVTVIQTI WILKERSYDI KHSELGGTLR ESLEQLATTS
960 970 980 990 1000
ETSVNRHLQN LELSNEQDCP DAIEFLEEVG RESVSKLSAA VDDRYIYTLH
1010 1020 1030 1040 1050
VLRTKMELFR RLQNFCDAVK ILRSQNTKWN GIKISQIDQV QSEIDTLIVR
1060 1070 1080 1090 1100
LDEEWTQDAN QLRAELASIH GSFFQLEFDR LNEKLNMLIH DKDKLRELMV
1110 1120 1130 1140 1150
HRRHYLTAAN ELITDSKTDL AQRATSSDHP DDILRATDEV TKALDIKGEE
1160 1170 1180 1190 1200
LRRLGELAEM NITDLVVVAL ILSFRRRQLG SEGEPEVEEL RRALREIIAR
1210 1220 1230 1240 1250
PITEPRDVSP DAIVADILRM KDEKKRDEKT IDEIQATTLT DEQRASFAPL
1260 1270 1280 1290 1300
IEDYRRRADR HRIVFEHLVM IYLDWLSRQF DELEDEIGMT IQTSRADDLR
1310 1320 1330 1340 1350
RMNSTEWNKW KTDLANIERQ VGPDTKKALS AELADLHRKR DSMEARINKY
1360 1370 1380 1390 1400
LTHSAKINAK LTQFEKWLNA IEEDIEQTER QFEDPERSYR FGSLHEVALA
1410 1420 1430 1440 1450
KQRLVAKLER LNVANKEEVL RLCERYHTIM HKLTPFQTAV GLPLHVSTNL
1460 1470 1480 1490 1500
DRNGPFQSQI SVSSIASSEL ERPESVMSLT SSIGVIPADV AELSPFEAKI
1510 1520 1530 1540 1550
NKLLQKLHII EDSYLKGPKP IDTVREDVKQ LEKYRNRGAE ILQQLSTSNI
1560 1570 1580 1590 1600
EDAEKEGLKH RFVLMLNNYD DILRSIENEI RDDNELTAKN QEILAELSNA
1610 1620 1630 1640 1650
EQTLQNSPLE DLDISAELDR LQMQLDLVKV MCNKPRKYVE CELIDSSREG
1660 1670 1680 1690 1700
SPQERRRRKK KVMVMVSNTI TTIIHVVEER LEASDISRNP DVQQKLVAVK
1710 1720 1730 1740 1750
ENLRELDTTT VTPHPPSIMS PLGTENRNDL EEVKRLAAEI DRAIDTASSM
1760 1770 1780 1790 1800
YEDAPTDEDA LKSAIHLLDD QKVTLNHLHV VLEGIPEKNE QDRTDAIDIA
1810 1820 1830 1840 1850
SSVGEKLGNL KSAVEEVYEE VLASTNPVKE DQPLQHIQEV QTTPAEQSNW
1860 1870 1880 1890 1900
DTDEFSRQPP VLSDERIELK TDPSAIDKFE VRSDEDPVPK IIDLFGQLQT
1910 1920 1930 1940 1950
AVNEASPLAC EGTDDVDALQ VASDKLTKQD RTIRKIHAIL DTIDDPVQKP
1960 1970 1980 1990 2000
AIIESLDKIK DQINNARDNI NRQIDNLNYN QTPVVVPKES TKTPLNEIED
2010 2020 2030 2040 2050
AVRQASTVVS DELCNTEKLL SARQTLANVK PQVDSVEANV WSNPETIETV
2060 2070 2080 2090 2100
TPILEEYTTL VDNIEKKLAN EIEVPTNDPS RQDLVQQLQD VILECEEVVV
2110 2120 2130 2140 2150
NCDNIEKLEE SKLKLEKARP LLDQIGDNVE KLSREQSPDT SDAIDALSNV
2160 2170 2180 2190 2200
HQQYNATIMS IDDKIDELKN PEEDTSAADQ LISELHVISE MPAVTIDLSM
2210 2220 2230 2240 2250
LNAIEEGLST LPAHQAENVQ AKIDELRQKK EVADQTEQIL SDLNAFGDMP
2260 2270 2280 2290 2300
AITLDLDLLK SVEDGIAVLP VEDSERIKAK IVDLRKKKED ADQAEALLQE
2310 2320 2330 2340 2350
LSVISDMPIS TLDLNMLQGI EDNLNSLPAE ESDEIREKLN ELRRRKQESD
2360 2370 2380 2390 2400
QAEALLQELS VISDMPISTL DLNMLQGVED NLNSLPTEEA DKIREKINDL
2410 2420 2430 2440 2450
RRRKQESDLA EALLQELSVI YDMPTSTIDL NMLQGIEDNL NSLPAEESDK
2460 2470 2480 2490 2500
IREKINDLRR RKQESDLAEA LLQELSVIYD MPTSTIDLNM LQGIEDNLNS
2510 2520 2530 2540 2550
LPAEESDKIR EKINDLRRRK QESDQAEALL QELSVVSDMP ASTIDINMLQ
2560 2570 2580 2590 2600
SIEDGLSTLL SEDRSKIQQA IDSLRKKKSD SDLAQHALEA LSVQSKLPSV
2610 2620 2630 2640 2650
SINLEELKKL EETLSTVPVE DSKVIRDKIA ELKTEKALAD HAENYLVELK
2660 2670 2680 2690 2700
KIEDMPISAV GSDVLATIED QILQMPVQYQ PSVKETLDKL KQAKEEDDKL
2710 2720 2730 2740 2750
AGVYDELEKI AKLPARDYDN KLLAKIDEKL NSLPKDQIAE THRKVEDIKV
2760 2770 2780 2790 2800
TKADIVAQID VLDKLPAKDI DEHLLNSIEE KLPTIPSDSS DQLQIAIGKL
2810 2820 2830 2840 2850
RDRKQANIDE GKKILNELAE IQKMPADSLN EHALNLLATE SDKFGSEISD
2860 2870 2880 2890 2900
KIMQEIDVLR EKQNNHEVAR LNAESVLQQL DKISEEPHLS LTEERLAPFL
2910 2920 2930 2940 2950
QNIDTVPACF VDKIRNKINE VQKLHDEAVQ DEKDELKEKL VAKVQNIGKT
2960 2970 2980 2990 3000
SIDDVNVSDF EEIEREINGS LEAFEAEPLL AKIQELREAK RVGDEARSAA
3010 3020 3030 3040 3050
HDQIVALEKE AEDVTAKESA KKKKKDKKKS PQEMIDELSA KVVEAKALIP
3060 3070 3080 3090 3100
KIEEAAKNEN LPADDKPKAE QLVSNLEAFV KDVETQVSEK QDELDKLNNA
3110 3120 3130 3140 3150
NDAIKRLGDA LDDAEKTVVP SSVPALSEFK DRIAPHLATL VEAVNDVPAS
3160 3170 3180 3190 3200
VEPSAVALRD RAAKFVSDLE KNIQKTGDDE KRADELKNDV GNAVKNVEDV
3210 3220 3230 3240 3250
VSKYQNQPQP LDVAKDDANK LKATVEQLTK LAESSDKIDP QVAKDIKDSK
3260 3270 3280 3290 3300
TKAKELLQAL EKAIPQEDAI RREQAEINDR LNNLEKELTK VDEFKPEDAL
3310 3320 3330 3340 3350
PIVDQLAANT NTLKTATDSN NEKAVAPSSL ISHDDLVVGL PEKVFQLQHA
3360 3370 3380 3390 3400
IDDKKQALNK AAAVNEIAPK LQLVSQQLQS VPQEVPASLD EQKQLLEDVE
3410 3420 3430 3440 3450
NQKHNLENLL ANLPENDPTA DELRQKSQWD LSRLKDLLKQ LGSAVGDKLA
3460 3470 3480 3490 3500
ALAAFNAARK NAEDALLDIT REDGGDDNKS PDELIDDLAK KEETVAKLLD
3510 3520 3530 3540 3550
TVSGVKPDEL DDKERAEYND LLARLATAAD VLKNKRAELE QAVKAKADEK
3560 3570 3580 3590 3600
SLHDSVDRIV SRLVPLVRES DELRHNAEAV PTQYAPKAEE LKKEVEAAKA
3610 3620 3630 3640 3650
VIANAPSSDA HVQQLEQAVA TAETLIPDLE ERARLWNEFL AARNDIDALI
3660 3670 3680 3690 3700
EQLQQPLDAV LAQPKRSAEE AAQDVENLRN NSQQLSDLDN KIANLQRISE
3710 3720 3730 3740 3750
LLDPLESAYA DVRFFDVDAE QTRHQYDDVL NDVAAELEDE TLLKQSASQV
3760 3770 3780 3790 3800
ANEIDDISKM IDSTDPERSI LDTIAKSDIP ALKAQINRIK DRIVNADASR
3810 3820 3830 3840 3850
KHVTTDPKIA EDLDNKLAKL QTELDDAIKT SDEHDKEQLI LSLKLNISQF
3860 3870 3880 3890 3900
EQIPLDQLKS DDLKTAEKEI TNSLKPEEAE PLLAKIQELR EAKRVGDEAR
3910 3920 3930 3940 3950
SAAHDQIVAL EKEAEDVTAK ESAKKKKKDK KKSPQEMIDE LSAKVVEAKA
3960 3970 3980 3990 4000
LIPKIEEAAK NENLPADDKP KAEQLVSNLE AFVKDVETQV SEKQDELDKL
4010 4020 4030 4040 4050
NNANDAIKRL GDALDDAEKT VVPSSVPALS EFKDRIAPHL ATLVEAVNDV
4060 4070 4080 4090 4100
PASVEPSAVA LRDRAAKFVS DLEKNIQKTG DDEKRADELK NDDGNAVKNV
4110 4120 4130 4140 4150
EDVVSKYQNQ PQPLDVAKDD ANKLKATVEQ LTKLAESSDK IDPQVAKDIK
4160 4170 4180 4190 4200
DSKTKAKELL QALEKAIPQE DAIRREQAEI NDRLNNLEKE LTKVDEFKPE
4210 4220 4230 4240 4250
DALPIVDQLA ANTNTLKTAT DSNNEKAVAP SSLISHDDLV VGLPEKVFQL
4260 4270 4280 4290 4300
QHAIDDKKQA LNKAAAVNEI APKLQLVSQQ LQSVPQEVPA SLDEQKQLLE
4310 4320 4330 4340 4350
DVENQKHNLE NLLANLPEND PTADELRQKS QWDLSRLKDL LKQLGSAVGD
4360 4370 4380 4390 4400
KLAALAAFNA ARKNAEDALL DITREDGGDD NKSPDELIDD RGRSTGSAVG
4410 4420 4430 4440 4450
DKLAALAAFN AARKNAEDAL LDITREDGGD DNKSPDELID DLAKKEETVA
4460 4470 4480 4490 4500
KLLDTVSGVK PDELDDKERA EYNDLLARLA TAADVLKNKR AELEQAVKAK
4510 4520 4530 4540 4550
ADEKSLHDSV DRIVSRLVPL VRESDELRHN AEAVPTQYAP KAEELKKEVE
4560 4570 4580 4590 4600
AAKAVIANAP SSDAHVQQLE QAVATAETLI PDLEERARLW NEFLAARNDI
4610 4620 4630 4640 4650
DALIEQLQQP LDAVLAQPKR SAEEAAQDVE NLRNNSQQLS DLDNKIANLQ
4660 4670 4680 4690 4700
RISELLDPLE SAYADVRFFD VDAEQTRHQY DDVLNDVAAE LEDETLLKQS
4710 4720 4730 4740 4750
ASQVANEIDD ISKMIDSTDP ERSILDTIAK SDIPALKAQI NRIKDRIVNA
4760 4770 4780 4790 4800
DASRKHVTTD PKIAEDLDNK LAKLQTELDD AIKTSDEHDK EQLILSLKLN
4810 4820 4830 4840 4850
ISQFEQIPLD QLKSDDLKTA EKEITNSLKP EEAEPLLAKI QELREAKRVG
4860 4870 4880 4890 4900
DEARSAAHDQ IVALEKEAED VTAKESAKKK KKDKKKSPQE MIDELSAKVV
4910 4920 4930 4940 4950
EAKALIPKIE EAAKNENLPA DDKPKAEQLV SNLEAFVKDV ETQVSEKQDE
4960 4970 4980 4990 5000
LDKLNNANDA IKRLGDALDD AEKTVVPSSV PALSEFKDRI APHLATLVEA
5010 5020 5030 5040 5050
VNDVPASVEP SAVALRDRAA KFVSDLEKNI QKTGDDEKRA DELKNDVGNA
5060 5070 5080 5090 5100
VKNVEDVVSK YQNQPQPLDV AKDDANKLKA TVEQLTKLAE SSDKIDPQVA
5110 5120 5130 5140 5150
KDIKDSKTKA KELLQALEKA IPQEDAIRRE QAEINDRLNN LEKELTKVDE
5160 5170 5180 5190 5200
FKPEDALPIV DQLAANTNTL KTATDSNNEK AVAPSSLISH DDLVVGLPEK
5210 5220 5230 5240 5250
VFQLQHAIDD KKQALNKAAA VNEIAPKLQL VSQQLQSVPQ EVPASLDEQK
5260 5270 5280 5290 5300
QLLEDVENQK HNLENLLANL PENDPTADEL RQKSQWDLSR LKDLLKQLGS
5310 5320 5330 5340 5350
AVGDKLAALA AFNAARKNAE DALLDITRED GGDDNKSPDE LIDDLAKKEE
5360 5370 5380 5390 5400
TVAKLLDTVS GVKPDELDDK ERAEYNDLLA RLATAADVLK NKRAELEQAV
5410 5420 5430 5440 5450
KAKADEKSLH DSVDRIVSRL VPLVRESDEL RHNAEAVPTQ YAPKAEELKK
5460 5470 5480 5490 5500
EVEAAKAVIA NAPSSDAHVQ QLEQAVATAE TLIPDLEERA RLWNEFLAAR
5510 5520 5530 5540 5550
NDIDALIEQL QQPLDAVLAQ PKRSAEEAAQ DVENLRNNSQ QLSDLDNKIA
5560 5570 5580 5590 5600
NLQRISELLD PLESAYADVR FFDVDAEQTR HQYDDVLNDV AAELEDETLL
5610 5620 5630 5640 5650
KQSASQVANE IDDISKMIDS TDPERSILDT IAKSDIPALK AQINRIKDRI
5660 5670 5680 5690 5700
VNADASRKHV TTDPKIAEDL DNKLAKLQTE LDDAIKTSDE HDKEQLILSL
5710 5720 5730 5740 5750
KLNISQFEQI PLDQLKSDDL KTAEKEITNS LKPEEAEPLL AKIQELREAK
5760 5770 5780 5790 5800
RVGDEARSAA HDQIVALEKE AEDVTAKESA KKKKKDKKKS PQEMIDELSA
5810 5820 5830 5840 5850
KVVEAKALIP KIEEAAKNEN LPADDKPKAE QLVSNLEAFV KDVETQVSEK
5860 5870 5880 5890 5900
QDELDKLNNA NDAIKRLGDA LDDAEKTVVP SSVPALSEFK DRIAPHLATL
5910 5920 5930 5940 5950
VEAVNDVPAS VEPSAVALRD RAAKFVSDLE KNIQKTGDDE KRADELKNDV
5960 5970 5980 5990 6000
GNAVKNVEDV VSKYQNQPQP LDVAKDDANK LKATVEQLTK LAESSDKIDP
6010 6020 6030 6040 6050
QVAKDIKDSK TKAKELLQAL EKAIPQEDAI RREQAEINDR LNNLEKELTK
6060 6070 6080 6090 6100
VDEFKPEDAL PIVDQLAANT NTLKTATDSN NEKAVAPSSL ISHDDLVVGL
6110 6120 6130 6140 6150
PEKVFQLQHA IDDKKQALNK AAAVNEIAPK LQLVSQQLQS VPQEVPASLD
6160 6170 6180 6190 6200
EQKQLLEDVE NQKHNLENLL ANLPENDPTA DELRQKSQWD LSRLKDLLKQ
6210 6220 6230 6240 6250
LGSAVGDKLA ALAAFNAARK NAEDALLDIT REDGGDDNKS PDELIDDLAK
6260 6270 6280 6290 6300
KEETVAKLLD TVSGVKPDEL DDKERAEYND LLARLATAAD VLKNKRAELE
6310 6320 6330 6340 6350
QAVKAKADEK SLHDSVDRIV SRLVPLVRES DELRHNAEAV PTQYAPKAEE
6360 6370 6380 6390 6400
LKKEVEAAKA VIANAPSSDA HVQQLEQAVA TAETLIPDLE ERARLWNEFL
6410 6420 6430 6440 6450
AARNDIDALI EQLQQPLDAV LAQPKRSAEE AAQDVENLRN NSQQLSDLDN
6460 6470 6480 6490 6500
KIANLQRISE LLDPLESAYA DVRFFDVDAE QTRHQYDDVL NDVAAELEDE
6510 6520 6530 6540 6550
TLLKQSASQV ANEIDDISKM IDSTDPERSI LDTIAKSDIP ALKAQINRIK
6560 6570 6580 6590 6600
DRIVNADASR KHVTTDPKIA EDLDNKLAKL QTELDDAIKT SDEHDKEQLI
6610 6620 6630 6640 6650
LSLKLNISQF EQIPLDQLKS DDLKTAEKEI TNSLKPEEAE PLLAKIQELR
6660 6670 6680 6690 6700
EAKRVGDEAR SAAHDQIVAL EKEAEDVTAK ESAKKKKKDK KKSPQEMIDE
6710 6720 6730 6740 6750
LSAKVVEAKA LIPKIEEAAK NENLPADDKP KAEQLVSNLE AFVKDVETQV
6760 6770 6780 6790 6800
SEKQDELDKL NNANDAIKRL GDALDDAEKT VVPSSVPALS EFKDRIAPHL
6810 6820 6830 6840 6850
ATLVEAVNDV PASVEPSAVA LRDRAAKFVS DLEKNIQKTG DDEKRADELK
6860 6870 6880 6890 6900
NDVGNAVKNV EDVVSKYQNQ PQPLDVAKDD ANKLKATVEQ LTKLAESSDK
6910 6920 6930 6940 6950
IDPQVAKDIK DSKTKAKELL QALEKAIPQE DAIRREQAEI NDRLNNLEKE
6960 6970 6980 6990 7000
LTKVDEFKPE DALPIVDQLA ANTNTLKTAT DSNNEKAVAP SSLISHDDLV
7010 7020 7030 7040 7050
VGLPEKVFQL QHAIDDKKQA LNKAAAVNEI APKLQLVSQQ LQSVPQEVPA
7060 7070 7080 7090 7100
SLDEQKQLLE DVENQKHNLE NLLANLPEND PTADELRQKS QWDLSRLKDL
7110 7120 7130 7140 7150
LKQLGSAVGD KLAALAAFNA ARKNAEDALL DITREDGGDD NKSPDELIDD
7160 7170 7180 7190 7200
LAKKEETVAK LLDTVSGVKP DELDDKERAE YNDLLARLAT AADVLKNKRA
7210 7220 7230 7240 7250
ELEQAVKAKA DEKSLHDSVD RIVSRLVPLV RESDELRHNA EAVPTQYAPK
7260 7270 7280 7290 7300
AEELKKEVEA AKAVIANAPS SDAHVQQLEQ AVATAETLIP DLEERARLWN
7310 7320 7330 7340 7350
EFLAARNDID ALIEQLQQPL DAVLAQPKRS AEEAAQDVEN LRNNSQQLSD
7360 7370 7380 7390 7400
LDNKIANLQR ISELLDPLES AYADVRFFDV DAEQTRHQYD DVLNDVAAEL
7410 7420 7430 7440 7450
EDETLLKQSA SQVANEIDDI SKMIDSTDPE RSILDTIAKS DIPALKAQIN
7460 7470 7480 7490 7500
RIKDRIVNAD ASRKHVTTDP KIAEDLDNKL AKLQTELDDA IKTSDEHDKE
7510 7520 7530 7540 7550
QLILSLKLNI SQFEQIPLDQ LKSDDLKTAE KEITNSLKPE EAEPLLAKIQ
7560 7570 7580 7590 7600
ELREAKRVGD EARSAAHDQI VALEKEAEDV TAKESAKKKK KDKKKSPQEM
7610 7620 7630 7640 7650
IDELSAKVVE AKALIPKIEE AAKNENLPAD DKPKAEQLVS NLEAFVKDVE
7660 7670 7680 7690 7700
TQVSEKQDEL DKLNNANDAI KRLGDALDDA EKTVVPSSVP ALSEFKDRIA
7710 7720 7730 7740 7750
PHLATLVEAV NDVPASVEPS AVALRDRAAK FVSDLEKNIQ KTGDDEKRAD
7760 7770 7780 7790 7800
ELKNDVGNAV KNVEDVVSKY QNQPQPLDVA KDDANKLKAT VEQLTKLAES
7810 7820 7830 7840 7850
SDKIDPQVAK DIKDSKTKAK ELLQALEKAI PQEDAIRREQ AEINDRLNKL
7860 7870 7880 7890 7900
EKELTKVDEF KPEDALPIVD QLAANTNTLK TATDSNNEKA VAPSSLISHD
7910 7920 7930 7940 7950
DLVVGLPEKV FQLQHAIDDK KQALNKAAAV NEIAPKLQLV SQQLQSVPQE
7960 7970 7980 7990 8000
VPASLDEQKQ LLEDVENQKH NLENLLANLP ENDPTADELR QKSQWDLSRL
8010 8020 8030 8040 8050
KDLLKQLGSA VGEKLAALAA FNAARKNAED ALLDITREDG GDDNKSPDEL
8060 8070 8080 8090 8100
IDDLAKKEET VAKLLDTVSG VKPDELDDKE RAEYNDLLAR LATAADVLKN
8110 8120 8130 8140 8150
KRAELEQAVK AKADEKSLHD SVDRIVSRLV PLVRESDELR HNAEAVPTQY
8160 8170 8180 8190 8200
APKAEELKKE VEAAKAVIAN APSSDAHVQQ LEQAVATAET LIPDLEERAS
8210 8220 8230 8240 8250
IWERFVKAKD DLYDYLEKLE NNVSDVLNRP RLPVSQAQQR FNKLKEQSYL
8260 8270 8280 8290 8300
LDRIRDLKID FDDLGEALLP LTVAEDELRF MHVHVESIER QYEDTMDKLN
8310 8320 8330 8340 8350
AEITAEVELL RTLDILSNEL SQCKEDINNP SVDVDELSRA TMLNDAIAHL
8360 8370 8380 8390 8400
ENQKVVVARS EKDRKFVESS TSIDLDQLLA EAKRLLKEIE PRLQLAQPDH
8410 8420 8430 8440 8450
DNEDDEDEEK GSDEKPYDVR AAAEVLSALY PDEHPHNVLR NIGFEELPSD
8460 8470 8480 8490 8500
SESRSEFDSL DSRSDGLLSP IPDDSTLSEE QLRRQRSRWR RVLRTALPLQ
8510 8520 8530 8540
ALLVLLMGAA CLVPHCDDEY CCQLLNNFAK SFDPSLEFVN GPPPF
Length:8,545
Mass (Da):956,482
Last modified:March 28, 2003 - v3
Checksum:i02A94D994BEE19E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7849 – 78491K → N in DAA04553. (PubMed:12169658)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157938 mRNA. Translation: AAN35200.1.
BK000642 mRNA. Translation: DAA04553.1.
FO081700 Genomic DNA. Translation: CCD73568.1.
AY126454 mRNA. Translation: AAM95163.1.
PIRiT33140.
T33141.
RefSeqiNP_491353.2. NM_058952.3.
UniGeneiCel.22568.

Genome annotation databases

EnsemblMetazoaiZK973.6; ZK973.6; WBGene00000140.
GeneIDi172034.
KEGGicel:CELE_ZK973.6.
UCSCiZK973.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157938 mRNA. Translation: AAN35200.1 .
BK000642 mRNA. Translation: DAA04553.1 .
FO081700 Genomic DNA. Translation: CCD73568.1 .
AY126454 mRNA. Translation: AAM95163.1 .
PIRi T33140.
T33141.
RefSeqi NP_491353.2. NM_058952.3.
UniGenei Cel.22568.

3D structure databases

ProteinModelPortali Q9N4M4.
SMRi Q9N4M4. Positions 20-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 37504. 2 interactions.

Proteomic databases

PaxDbi Q9N4M4.
PRIDEi Q9N4M4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZK973.6 ; ZK973.6 ; WBGene00000140 .
GeneIDi 172034.
KEGGi cel:CELE_ZK973.6.
UCSCi ZK973.6. c. elegans.

Organism-specific databases

CTDi 172034.
WormBasei ZK973.6 ; CE33588 ; WBGene00000140 ; anc-1.

Phylogenomic databases

eggNOGi COG5069.
GeneTreei ENSGT00760000118813.
InParanoidi Q9N4M4.
OMAi TSVQIKN.
OrthoDBi EOG72JWF7.
PhylomeDBi Q9N4M4.

Miscellaneous databases

NextBioi 873759.
PROi Q9N4M4.

Gene expression databases

ExpressionAtlasi Q9N4M4. baseline and differential.

Family and domain databases

Gene3Di 1.10.418.10. 2 hits.
InterProi IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR012315. KASH.
[Graphical view ]
Pfami PF00307. CH. 2 hits.
PF10541. KASH. 1 hit.
[Graphical view ]
SMARTi SM00033. CH. 2 hits.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 2 hits.
PROSITEi PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS51049. KASH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Role of ANC-1 in tethering nuclei to the actin cytoskeleton."
    Starr D.A., Han M.
    Science 298:406-409(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1751, IDENTIFICATION OF COMPLETE SEQUENCE, FUNCTION, CHARACTERIZATION, INTERACTION WITH F-ACTIN AND UNC-84.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300."
    Zhang Q., Ragnauth C., Greener M.J., Shanahan C.M., Roberts R.G.
    Genomics 80:473-481(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 689-1243.
  4. "A gene required for nuclear and mitochondrial attachment in the nematode Caenorhabditis elegans."
    Hedgecock E.M., Thomson J.N.
    Cell 30:321-330(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. "Neural maintenance roles for the matrix receptor dystroglycan and the nuclear anchorage complex in Caenorhabditis elegans."
    Johnson R.P., Kramer J.M.
    Genetics 190:1365-1377(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiANC1_CAEEL
AccessioniPrimary (citable) accession number: Q9N4M4
Secondary accession number(s): O61841, O61842, Q6IMP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: November 26, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3