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Q9N4G4

- MED1_CAEEL

UniProt

Q9N4G4 - MED1_CAEEL

Protein

Mediator of RNA polymerase II transcription subunit 1.1

Gene

sop-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. RNA polymerase II transcription cofactor activity Source: InterPro

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    SignaLinkiQ9N4G4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 1.1
    Alternative name(s):
    Mediator complex subunit 1.1
    Suppressor of pal-1 protein 3
    Gene namesi
    Name:sop-3
    Synonyms:mdt-1.1
    ORF Names:Y71F9B.10
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiY71F9B.10a; CE28808; WBGene00004946; sop-3.
    Y71F9B.10b; CE29912; WBGene00004946; sop-3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. mediator complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14751475Mediator of RNA polymerase II transcription subunit 1.1PRO_0000302025Add
    BLAST

    Proteomic databases

    PaxDbiQ9N4G4.
    PRIDEiQ9N4G4.

    Interactioni

    Subunit structurei

    Component of the Mediator complex.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    T04C9.1Q8MPT26EBI-2315681,EBI-2315635

    Protein-protein interaction databases

    BioGridi37321. 3 interactions.
    IntActiQ9N4G4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9N4G4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1098 – 113538Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi755 – 79945Gln-richAdd
    BLAST
    Compositional biasi820 – 88263Pro-richAdd
    BLAST
    Compositional biasi1280 – 1441162Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Mediator complex subunit 1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG270356.
    GeneTreeiENSGT00750000118762.
    HOGENOMiHOG000113532.
    InParanoidiQ9N4G4.
    OMAiVGLASHQ.
    OrthoDBiEOG7R830S.

    Family and domain databases

    InterProiIPR019680. Mediator_Med1_met/fun.
    [Graphical view]
    PfamiPF10744. Med1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q9N4G4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIIEERKNHE LNLESIDRDL RMENVRQSAE KLGWEHFARS VRRNLLEKRQ     50
    TLDARTRLDV LGSLVFMKEH LPIDNDATIA RKVQQLSEGL GEHCVFSTQN 100
    SGFSIRNPDV TIDIGVAEDQ ISTCKIGYFG QPLTDAPGAL ALMKNGEFSK 150
    LRDSITAILS SLPKEITLSE KNACKEAFRA LDQLLIRDAA DSSFTAINTG 200
    KYGFYAPRNE LRSGRIYYVA EPVLIRLAEK EGKTKADASY LDLLPYIEIS 250
    FFKHDKPSKL PVFTQTGEWS TFNDANVCIC VRFNQGFLLS QQTIRKLSHI 300
    VPKSPLVRNY VNFYRYMTGR VGVKSNLKLL TQFPDEGDIQ QQYQVDSKML 350
    TKEDDVVAME MYLSDFRDLS KLIETLRSEW KHASLWESIL AICESSKGEQ 400
    KEVNAVDMQL VLRRTEFFLQ FDTDYGSMTM QIFEKSPSNY VVKTTSQITG 450
    ESPSLDFDKM LTEKLNSTWS IPATLTFAIT DLKCRINSVL NCVISFDSSS 500
    SSDKQHQNYW SISNNNTQLM QSAAQKSAAK CTKKKVTVLE VGPAIEPTQL 550
    VYTRENDEEF QGSLLSSFGE VDDYYVKTST IGRTRPQPRP KREPNQLTSM 600
    DMMSAELDKS RHTMEGSMRD AQTSSFLDAA RVRMKQSIGA AHAVGLASHQ 650
    PPASPVAAAA AAPGGPMRHN SYPSGFEPPP SVAPYDFPAD PSKKQRKQRA 700
    KKQPGEEPPA GRGKGGKKGR GAGAVGAAAA GGRKSAGGAG ENPFGMDPMR 750
    PPMLQRSSSE QHNPNPHQMS QYQMQQYQQN QQFRMHQMQQ QQQQQFQMQS 800
    PKNPLVPAYT DEDSDEECDP PPPPKPQVST SSRMSSVPSH PPPPPQQLGN 850
    PMVGYPGMPL QSPNHLPLTP SPLSAPPKPF SPEQQHHFGM KMRETSYWKE 900
    LERLETKPDV EKLKQQLSSS SSSSQAEASD PPSTSTEAQD PPKPSSSSAP 950
    PPPKKKLGLE AAISKIRGQQ EQALQKQLQQ QESVESELAT PHPGSSGAPP 1000
    LAPHQVNRAR NLNDIFDDEA DDSSPTADIK PSLQALQKPT DTSSQSTSSE 1050
    PPPKKEPADE QPEREKEKLI LKIPKMLKPV VDDRREDRKE RDRDRDRDRD 1100
    RDEDREKVRD KEDKAQREKD KKEKERERRR QRDRDRTEQK KSDREKEPSK 1150
    KRKLEKKDEK EKDRREPERK KGKSDGKEYS KASTTSLIPT LSLKNFRIPK 1200
    KDTVEEEKKD VKEEAPGPSS STESKKEPPS AAPITRKEST TAPVAPAVQQ 1250
    QQQRKESFTA LPSLPEQQQH HREPLLKKKP PLQPPPPPQM TGPPIGIYPG 1300
    PPAPGNLPGS SRPSGNRKQP LPPPPPMIRG PPPDQMYRDR SGGGGGSMRG 1350
    GFPPASHYHG GTSGVNKQVA SYAQGLPPGM GPPVVKPHGN NYQASQWVRP 1400
    PTHRDSSHSY HGMPSLGPPQ LQREPPAPPP PQMIPLPKDP PVLREHPREH 1450
    RAHRGGADDD GPDSPEEGTL RIDDE 1475
    Length:1,475
    Mass (Da):164,547
    Last modified:October 1, 2001 - v2
    Checksum:iC0A80E70DE9CC98B
    GO
    Isoform b (identifier: Q9N4G4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         536-544: VTVLEVGPA → ELYALTTSK
         545-1475: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:544
    Mass (Da):61,840
    Checksum:i478ADA6030DDA18D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei536 – 5449VTVLEVGPA → ELYALTTSK in isoform b. CuratedVSP_027908
    Alternative sequencei545 – 1475931Missing in isoform b. CuratedVSP_027909Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF308860 mRNA. Translation: AAG45416.1.
    FO081276 Genomic DNA. Translation: CCD70417.1.
    FO081276 Genomic DNA. Translation: CCD70418.1.
    RefSeqiNP_001021811.1. NM_001026640.3. [Q9N4G4-2]
    NP_740821.1. NM_170837.3. [Q9N4G4-1]
    UniGeneiCel.17584.

    Genome annotation databases

    EnsemblMetazoaiY71F9B.10a; Y71F9B.10a; WBGene00004946. [Q9N4G4-1]
    GeneIDi171840.
    KEGGicel:CELE_Y71F9B.10.
    UCSCiY71F9B.10a.1. c. elegans. [Q9N4G4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF308860 mRNA. Translation: AAG45416.1 .
    FO081276 Genomic DNA. Translation: CCD70417.1 .
    FO081276 Genomic DNA. Translation: CCD70418.1 .
    RefSeqi NP_001021811.1. NM_001026640.3. [Q9N4G4-2 ]
    NP_740821.1. NM_170837.3. [Q9N4G4-1 ]
    UniGenei Cel.17584.

    3D structure databases

    ProteinModelPortali Q9N4G4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 37321. 3 interactions.
    IntActi Q9N4G4. 1 interaction.

    Proteomic databases

    PaxDbi Q9N4G4.
    PRIDEi Q9N4G4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y71F9B.10a ; Y71F9B.10a ; WBGene00004946 . [Q9N4G4-1 ]
    GeneIDi 171840.
    KEGGi cel:CELE_Y71F9B.10.
    UCSCi Y71F9B.10a.1. c. elegans. [Q9N4G4-1 ]

    Organism-specific databases

    CTDi 171840.
    WormBasei Y71F9B.10a ; CE28808 ; WBGene00004946 ; sop-3.
    Y71F9B.10b ; CE29912 ; WBGene00004946 ; sop-3.

    Phylogenomic databases

    eggNOGi NOG270356.
    GeneTreei ENSGT00750000118762.
    HOGENOMi HOG000113532.
    InParanoidi Q9N4G4.
    OMAi VGLASHQ.
    OrthoDBi EOG7R830S.

    Enzyme and pathway databases

    SignaLinki Q9N4G4.

    Miscellaneous databases

    NextBioi 872925.
    PROi Q9N4G4.

    Family and domain databases

    InterProi IPR019680. Mediator_Med1_met/fun.
    [Graphical view ]
    Pfami PF10744. Med1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression."
      Zhang H., Emmons S.W.
      Development 128:767-777(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiMED1_CAEEL
    AccessioniPrimary (citable) accession number: Q9N4G4
    Secondary accession number(s): Q95Y43, Q9GPV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3