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Q9N4G4

- MED1_CAEEL

UniProt

Q9N4G4 - MED1_CAEEL

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Protein
Mediator of RNA polymerase II transcription subunit 1.1
Gene
sop-3, mdt-1.1, Y71F9B.10
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.

GO - Molecular functioni

  1. RNA polymerase II transcription cofactor activity Source: InterPro
  2. protein binding Source: IntAct
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ9N4G4.

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 1.1
Alternative name(s):
Mediator complex subunit 1.1
Suppressor of pal-1 protein 3
Gene namesi
Name:sop-3
Synonyms:mdt-1.1
ORF Names:Y71F9B.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiY71F9B.10a; CE28808; WBGene00004946; sop-3.
Y71F9B.10b; CE29912; WBGene00004946; sop-3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. mediator complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14751475Mediator of RNA polymerase II transcription subunit 1.1
PRO_0000302025Add
BLAST

Proteomic databases

PaxDbiQ9N4G4.
PRIDEiQ9N4G4.

Interactioni

Subunit structurei

Component of the Mediator complex By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
T04C9.1Q8MPT26EBI-2315681,EBI-2315635

Protein-protein interaction databases

BioGridi37321. 3 interactions.
IntActiQ9N4G4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9N4G4.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1098 – 113538 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi755 – 79945Gln-rich
Add
BLAST
Compositional biasi820 – 88263Pro-rich
Add
BLAST
Compositional biasi1280 – 1441162Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG270356.
GeneTreeiENSGT00750000118762.
HOGENOMiHOG000113532.
InParanoidiQ9N4G4.
OMAiVGLASHQ.
OrthoDBiEOG7R830S.

Family and domain databases

InterProiIPR019680. Mediator_Med1_met/fun.
[Graphical view]
PfamiPF10744. Med1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q9N4G4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MIIEERKNHE LNLESIDRDL RMENVRQSAE KLGWEHFARS VRRNLLEKRQ     50
TLDARTRLDV LGSLVFMKEH LPIDNDATIA RKVQQLSEGL GEHCVFSTQN 100
SGFSIRNPDV TIDIGVAEDQ ISTCKIGYFG QPLTDAPGAL ALMKNGEFSK 150
LRDSITAILS SLPKEITLSE KNACKEAFRA LDQLLIRDAA DSSFTAINTG 200
KYGFYAPRNE LRSGRIYYVA EPVLIRLAEK EGKTKADASY LDLLPYIEIS 250
FFKHDKPSKL PVFTQTGEWS TFNDANVCIC VRFNQGFLLS QQTIRKLSHI 300
VPKSPLVRNY VNFYRYMTGR VGVKSNLKLL TQFPDEGDIQ QQYQVDSKML 350
TKEDDVVAME MYLSDFRDLS KLIETLRSEW KHASLWESIL AICESSKGEQ 400
KEVNAVDMQL VLRRTEFFLQ FDTDYGSMTM QIFEKSPSNY VVKTTSQITG 450
ESPSLDFDKM LTEKLNSTWS IPATLTFAIT DLKCRINSVL NCVISFDSSS 500
SSDKQHQNYW SISNNNTQLM QSAAQKSAAK CTKKKVTVLE VGPAIEPTQL 550
VYTRENDEEF QGSLLSSFGE VDDYYVKTST IGRTRPQPRP KREPNQLTSM 600
DMMSAELDKS RHTMEGSMRD AQTSSFLDAA RVRMKQSIGA AHAVGLASHQ 650
PPASPVAAAA AAPGGPMRHN SYPSGFEPPP SVAPYDFPAD PSKKQRKQRA 700
KKQPGEEPPA GRGKGGKKGR GAGAVGAAAA GGRKSAGGAG ENPFGMDPMR 750
PPMLQRSSSE QHNPNPHQMS QYQMQQYQQN QQFRMHQMQQ QQQQQFQMQS 800
PKNPLVPAYT DEDSDEECDP PPPPKPQVST SSRMSSVPSH PPPPPQQLGN 850
PMVGYPGMPL QSPNHLPLTP SPLSAPPKPF SPEQQHHFGM KMRETSYWKE 900
LERLETKPDV EKLKQQLSSS SSSSQAEASD PPSTSTEAQD PPKPSSSSAP 950
PPPKKKLGLE AAISKIRGQQ EQALQKQLQQ QESVESELAT PHPGSSGAPP 1000
LAPHQVNRAR NLNDIFDDEA DDSSPTADIK PSLQALQKPT DTSSQSTSSE 1050
PPPKKEPADE QPEREKEKLI LKIPKMLKPV VDDRREDRKE RDRDRDRDRD 1100
RDEDREKVRD KEDKAQREKD KKEKERERRR QRDRDRTEQK KSDREKEPSK 1150
KRKLEKKDEK EKDRREPERK KGKSDGKEYS KASTTSLIPT LSLKNFRIPK 1200
KDTVEEEKKD VKEEAPGPSS STESKKEPPS AAPITRKEST TAPVAPAVQQ 1250
QQQRKESFTA LPSLPEQQQH HREPLLKKKP PLQPPPPPQM TGPPIGIYPG 1300
PPAPGNLPGS SRPSGNRKQP LPPPPPMIRG PPPDQMYRDR SGGGGGSMRG 1350
GFPPASHYHG GTSGVNKQVA SYAQGLPPGM GPPVVKPHGN NYQASQWVRP 1400
PTHRDSSHSY HGMPSLGPPQ LQREPPAPPP PQMIPLPKDP PVLREHPREH 1450
RAHRGGADDD GPDSPEEGTL RIDDE 1475
Length:1,475
Mass (Da):164,547
Last modified:October 1, 2001 - v2
Checksum:iC0A80E70DE9CC98B
GO
Isoform b (identifier: Q9N4G4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     536-544: VTVLEVGPA → ELYALTTSK
     545-1475: Missing.

Note: No experimental confirmation available.

Show »
Length:544
Mass (Da):61,840
Checksum:i478ADA6030DDA18D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei536 – 5449VTVLEVGPA → ELYALTTSK in isoform b.
VSP_027908
Alternative sequencei545 – 1475931Missing in isoform b.
VSP_027909Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF308860 mRNA. Translation: AAG45416.1.
FO081276 Genomic DNA. Translation: CCD70417.1.
FO081276 Genomic DNA. Translation: CCD70418.1.
RefSeqiNP_001021811.1. NM_001026640.3. [Q9N4G4-2]
NP_740821.1. NM_170837.3. [Q9N4G4-1]
UniGeneiCel.17584.

Genome annotation databases

EnsemblMetazoaiY71F9B.10a; Y71F9B.10a; WBGene00004946. [Q9N4G4-1]
GeneIDi171840.
KEGGicel:CELE_Y71F9B.10.
UCSCiY71F9B.10a.1. c. elegans. [Q9N4G4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF308860 mRNA. Translation: AAG45416.1 .
FO081276 Genomic DNA. Translation: CCD70417.1 .
FO081276 Genomic DNA. Translation: CCD70418.1 .
RefSeqi NP_001021811.1. NM_001026640.3. [Q9N4G4-2 ]
NP_740821.1. NM_170837.3. [Q9N4G4-1 ]
UniGenei Cel.17584.

3D structure databases

ProteinModelPortali Q9N4G4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 37321. 3 interactions.
IntActi Q9N4G4. 1 interaction.

Proteomic databases

PaxDbi Q9N4G4.
PRIDEi Q9N4G4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y71F9B.10a ; Y71F9B.10a ; WBGene00004946 . [Q9N4G4-1 ]
GeneIDi 171840.
KEGGi cel:CELE_Y71F9B.10.
UCSCi Y71F9B.10a.1. c. elegans. [Q9N4G4-1 ]

Organism-specific databases

CTDi 171840.
WormBasei Y71F9B.10a ; CE28808 ; WBGene00004946 ; sop-3.
Y71F9B.10b ; CE29912 ; WBGene00004946 ; sop-3.

Phylogenomic databases

eggNOGi NOG270356.
GeneTreei ENSGT00750000118762.
HOGENOMi HOG000113532.
InParanoidi Q9N4G4.
OMAi VGLASHQ.
OrthoDBi EOG7R830S.

Enzyme and pathway databases

SignaLinki Q9N4G4.

Miscellaneous databases

NextBioi 872925.
PROi Q9N4G4.

Family and domain databases

InterProi IPR019680. Mediator_Med1_met/fun.
[Graphical view ]
Pfami PF10744. Med1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression."
    Zhang H., Emmons S.W.
    Development 128:767-777(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiMED1_CAEEL
AccessioniPrimary (citable) accession number: Q9N4G4
Secondary accession number(s): Q95Y43, Q9GPV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2001
Last modified: June 11, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi