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Protein

Serine/threonine-protein kinase ATM

Gene

atm-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Serine/threonine protein kinase which activates checkpoint signaling in the presence of DNA double strand breaks (DSBs) and other forms of DNA damage induced by ionizing radiation and other genotoxic stresses such as UV. Plays a role in maintaining genome stability.3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • DNA repair Source: GO_Central
  • response to ionizing radiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, DNA damage

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-CEL-3371453. Regulation of HSF1-mediated heat shock response.
R-CEL-5693548. Sensing of DNA Double Strand Breaks.
R-CEL-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-CEL-6804756. Regulation of TP53 Activity through Phosphorylation.
R-CEL-6804760. Regulation of TP53 Activity through Methylation.
SignaLinkiQ9N3Q4.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ATMBy similarity (EC:2.7.11.1)
Gene namesi
Name:atm-1
ORF Names:Y48G1BL.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY48G1BL.2a; CE49304; WBGene00000227; atm-1.
Y48G1BL.2b; CE49311; WBGene00000227; atm-1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • chromatin Source: WormBase
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Increased sensitivity to ionizing radiation with reduced survival compared to wild-type animals. Loss of induction of apoptosis following UV-C or ionizing radiation treatment but no effect on apoptotic response induced by X-ray exposure. Low brood size, reduced viability and sterility, appearance of a high-incidence-of-males (Him) phenotype, and reduced chromosome number due to chromosome fusions.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23782378Serine/threonine-protein kinase ATMPRO_0000396514Add
BLAST

Proteomic databases

PaxDbiQ9N3Q4.
PeptideAtlasiQ9N3Q4.
PRIDEiQ9N3Q4.

Interactioni

Protein-protein interaction databases

STRINGi6239.K10E9.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2070 – 2378309PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini2346 – 237833FATCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Sequence analysis
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0892. Eukaryota.
ENOG410XNPY. LUCA.
GeneTreeiENSGT00670000098061.
HOGENOMiHOG000153269.
InParanoidiQ9N3Q4.
KOiK04728.
OrthoDBiEOG789C9F.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
InterProiIPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
[Graphical view]
PfamiPF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q9N3Q4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVTQLKNLK HAIAQLLEWD GTKTARKKIV DEVVLLYHAL GAEALSEDNQ
60 70 80 90 100
EIYDLYDLSA RIFNLAKKEI EEANQQFEKE RKKGTRRSEK PVPTPLFELS
110 120 130 140 150
IQHLKRCCQQ GIDHNQVPWI AYCLKLLEFP ITITEKSIEN EISNVLLLSS
160 170 180 190 200
NASQLHWAEH AHLSSLWKWI WSRVETADIG ALAMRNYMEL AANLLENVDY
210 220 230 240 250
VVFEKSPIDL MAKVMGTLKK SVEMGNPKEY WCHYRKFSVV HILSYIVHRW
260 270 280 290 300
GLEARDFILR EIFELTGSLS NLISVAHKDG EQSKKCIMRL IDDLVKLAMI
310 320 330 340 350
ETVHGHRTMN EVTRGNIQKL VKTGIQESLK SAHRNFSRSS TFSISEECVR
360 370 380 390 400
YLTRWLLAER RLEQPSAAMN ESFELTGDSS SKKKDDATFD SLIDLSFGST
410 420 430 440 450
ISGKHKLNAW NGVMQILNEL LKSRRLELQV TEKIVTILWE KRKSYTTEPL
460 470 480 490 500
RTVFCSILST VVCQADVRFG HRKVPTIDSI LKYSLSLMPN VASLPSAAAL
510 520 530 540 550
TETIVRFRTV SREGLRNTWD TVSRTSSGSF EVVRLISALI SVTEFDENSR
560 570 580 590 600
FANDERVRSW SFRKDIIEWV LLDPNAHSHK LLYQLCQYHP TYCYESEASS
610 620 630 640 650
SDDSLLQTLK LCKLACSPAP PSAPKALRPL EASIEEIVRY VHDKLKSILA
660 670 680 690 700
TEITLPAFVL CHEFALKYPD RSYEFNKMYK KLYQIMEDQE EDEFLQSARH
710 720 730 740 750
FSKWPQNLTL PIQKQTINCM AVFFEANLDN QLVDLCQWSD RRKVLVEMLA
760 770 780 790 800
ELAATRSEIR DKLQKSMPFN KFVKECIMEN RGDLYEMTKR FEKYSFLLSI
810 820 830 840 850
RNLIVTRMII TNEAARLLGD GETISETDIF IIEKRTLSTC IRNVSEGKEL
860 870 880 890 900
SGYTLDPYTV AANVHNVHFD HINVEIYLEL LKKSPFFAQN IVRHLLRQNG
910 920 930 940 950
KEAEEETWHL HATVLKIVMK DEKLLAVCVA TIPNMVRYLK VYQIHFSPKS
960 970 980 990 1000
NAAKFLHLDM ESISHCQSYL RKPTKSSNLI TAANFLTLFG CEKRTWKRPI
1010 1020 1030 1040 1050
LRFWSIFKQQ PAMCCEKLLI FAEECVELGL NHRIACLLRA LTTSEFCRKA
1060 1070 1080 1090 1100
LCDEYLKIAF QLTYRSIFLI LSKNECRPEI VELCDDMNLR YDLLQHQIKH
1110 1120 1130 1140 1150
VAAHHLEHFE RFETKIAFSV EKFLKSGIDG IDFEDLGLVE FYKQLNENLT
1160 1170 1180 1190 1200
EDAIRSNEAR NIYIVDILST IWLQLPSIRP QILPILARFK HISPAWTNFP
1210 1220 1230 1240 1250
QPPHISTNEK SFLQHLRFHL YLKMMNISKS MTQGEYATCI MMLLTSYDSS
1260 1270 1280 1290 1300
HFVADLIEKK QLGKLKLQQR RNVLCILSRL LKDQAVMGDE DETIIDPILF
1310 1320 1330 1340 1350
KAITKASAVF EDTAACIVPF LFKICVDFKG KYDKCVINLL GCLKGVNAED
1360 1370 1380 1390 1400
EIVVRCLAEC VDSIGLNVIA RYERLNIETH SEFGVKWFFK LSRLFLKHGF
1410 1420 1430 1440 1450
TTHSFAIANI LFDRLSARKR NTMMIDRTSL DRIDRSQELI NLLVEIYVAE
1460 1470 1480 1490 1500
GNSVALSSLP PAVQNRPDVR QVMNKSSKEW LKLLSSNQMD SWELTIVQWM
1510 1520 1530 1540 1550
CGIQFNAITG DKYLNSILRC NFNEYTKKID SPLKFVYFQL FHLSTSTLEI
1560 1570 1580 1590 1600
EEAISSMPLA PTIDQMRLMI IANATASFEP QSVEEHVVRA VRELRETSNR
1610 1620 1630 1640 1650
RKSGGNVKGI NEKTTRMVKL AEMLTENKAY DAAINLLDTW EHECLQWTSV
1660 1670 1680 1690 1700
AAESIDIDLI RICKQHVTCR SGDPRMADIN LRTMHPRVPV MSDLAIAEWS
1710 1720 1730 1740 1750
LALSKITIEY RNDMEEGIRI LEFGCKHLQN KDSVETRLKV LLKLHSVCIG
1760 1770 1780 1790 1800
QLSKLEEYRE TRTYRMKQQA VTAFEQQIQN SCRTSLARGN SGDEWTKKTV
1810 1820 1830 1840 1850
QRVRKEHQFE KNDLEKVDNS LNSAARKAVS SGFDALLCIS QLEDDDEAIR
1860 1870 1880 1890 1900
ASSLIIFPLI DVIYKYETDV GVIALLKEHT KSKLPSKLWI SATSHIASKC
1910 1920 1930 1940 1950
FSIEKSQITR HLSQILCHLI YDYPYHVLHT ILMYDDEKNA SKVKGFLKTI
1960 1970 1980 1990 2000
FDARADQRDS SKLKEIVITI REAHQAYREI AMLDVRGNVR IQRVEINGKT
2010 2020 2030 2040 2050
MYRWPHDLKI FKCKLRQLPI PTISQKIGCP GDYSTTDLIT WKRWKDVFTI
2060 2070 2080 2090 2100
ADGISTPKIW EIEGSDGKWY KTVWKKDDVR QDVLVEQMFD VTNNMLEKAM
2110 2120 2130 2140 2150
LRTYNVVPLD TECGVIEFCG GTVSLKEVMC GVTREGGLHR EFNSEEVSAS
2160 2170 2180 2190 2200
KVSSMMRQVQ TESTETRRQV FVEICQQYSP VFRHFFYTNF STAQIWRQKI
2210 2220 2230 2240 2250
INYRQSLATW SIVCYIVGLG DRHASNILFD QKLCTFVHID LGMILEYSKR
2260 2270 2280 2290 2300
TLPVPEQVPF RITRDVLDPI LIEGIENGQL AEECTQIMEK LKENGKVILG
2310 2320 2330 2340 2350
VASALLRETM TNFREAEQAA GRPSYISEMA IGRLREKLRG TDDGVTAQSS
2360 2370
NLQIRRLLRE ATSADNLSRM FCGWMPFL
Length:2,378
Mass (Da):273,957
Last modified:July 9, 2014 - v3
Checksum:iBB646EBBB3B1D8E2
GO
Isoform b (identifier: Q9N3Q4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-677: Missing.

Note: No experimental confirmation available.
Show »
Length:1,701
Mass (Da):196,422
Checksum:iE90CE71BD649A678
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 677677Missing in isoform b. CuratedVSP_055333Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081620, FO081456, FO081488 Genomic DNA. Translation: CDK13475.1.
FO081620, FO081488 Genomic DNA. Translation: CDK13476.1.
RefSeqiNP_001293214.1. NM_001306285.1. [Q9N3Q4-1]
NP_001293215.1. NM_001306286.1. [Q9N3Q4-2]

Genome annotation databases

EnsemblMetazoaiY48G1BL.2a; Y48G1BL.2a; WBGene00000227. [Q9N3Q4-1]
GeneIDi3565793.
KEGGicel:CELE_Y48G1BL.2.
UCSCiY48G1BL.2. c. elegans. [Q9N3Q4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081620, FO081456, FO081488 Genomic DNA. Translation: CDK13475.1.
FO081620, FO081488 Genomic DNA. Translation: CDK13476.1.
RefSeqiNP_001293214.1. NM_001306285.1. [Q9N3Q4-1]
NP_001293215.1. NM_001306286.1. [Q9N3Q4-2]

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K10E9.1.

Proteomic databases

PaxDbiQ9N3Q4.
PeptideAtlasiQ9N3Q4.
PRIDEiQ9N3Q4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY48G1BL.2a; Y48G1BL.2a; WBGene00000227. [Q9N3Q4-1]
GeneIDi3565793.
KEGGicel:CELE_Y48G1BL.2.
UCSCiY48G1BL.2. c. elegans. [Q9N3Q4-1]

Organism-specific databases

CTDi3565793.
WormBaseiY48G1BL.2a; CE49304; WBGene00000227; atm-1.
Y48G1BL.2b; CE49311; WBGene00000227; atm-1.

Phylogenomic databases

eggNOGiKOG0892. Eukaryota.
ENOG410XNPY. LUCA.
GeneTreeiENSGT00670000098061.
HOGENOMiHOG000153269.
InParanoidiQ9N3Q4.
KOiK04728.
OrthoDBiEOG789C9F.

Enzyme and pathway databases

ReactomeiR-CEL-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-CEL-3371453. Regulation of HSF1-mediated heat shock response.
R-CEL-5693548. Sensing of DNA Double Strand Breaks.
R-CEL-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-CEL-6804756. Regulation of TP53 Activity through Phosphorylation.
R-CEL-6804760. Regulation of TP53 Activity through Methylation.
SignaLinkiQ9N3Q4.

Miscellaneous databases

PROiQ9N3Q4.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
InterProiIPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
[Graphical view]
PfamiPF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi."
    van Haaften G., Romeijn R., Pothof J., Koole W., Mullenders L.H., Pastink A., Plasterk R.H., Tijsterman M.
    Curr. Biol. 16:1344-1350(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "The nucleotide excision repair pathway is required for UV-C-induced apoptosis in Caenorhabditis elegans."
    Stergiou L., Doukoumetzidis K., Sendoel A., Hengartner M.O.
    Cell Death Differ. 14:1129-1138(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. "The atm-1 gene is required for genome stability in Caenorhabditis elegans."
    Jones M.R., Huang J.C., Chua S.Y., Baillie D.L., Rose A.M.
    Mol. Genet. Genomics 287:325-335(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL, FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiATM_CAEEL
AccessioniPrimary (citable) accession number: Q9N3Q4
Secondary accession number(s): V6CJ63, V6CKB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 9, 2014
Last modified: July 6, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.