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Protein

T-complex protein 1 subunit theta

Gene

cct-8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). Required for correct subcellular localization of pgl-1.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-CEL-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit theta
Short name:
TCP-1-theta
Alternative name(s):
CCT-theta
Gene namesi
Name:cct-8
ORF Names:Y55F3AR.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY55F3AR.3a; CE44228; WBGene00021934; cct-8.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Low and diffuse subcellular localization of pgl-1 in embryos rather than confined to granules in somatic cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548T-complex protein 1 subunit thetaPRO_0000239934Add
BLAST

Proteomic databases

EPDiQ9N358.
PaxDbiQ9N358.
PRIDEiQ9N358.

Expressioni

Gene expression databases

ExpressionAtlasiQ9N358. baseline.

Interactioni

Subunit structurei

Heterooligomeric complex.By similarity

Protein-protein interaction databases

IntActiQ9N358. 2 interactions.
STRINGi6239.Y55F3AR.3.

Structurei

3D structure databases

ProteinModelPortaliQ9N358.
SMRiQ9N358. Positions 12-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0362. Eukaryota.
ENOG410XPXR. LUCA.
GeneTreeiENSGT00550000074783.
InParanoidiQ9N358.
OMAiQSGTEDL.
OrthoDBiEOG7JQBN8.
PhylomeDBiQ9N358.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012721. Chap_CCT_theta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02346. chap_CCT_theta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9N358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMKIPKSGY NRFMKEGAQH FKGTDEAVQR NIEACTELAS QIRSAYGPNG
60 70 80 90 100
MNKMVINHIE KLFVTNDAAT ILKELEIQHP AARIIIMATE MQEKQIGDNT
110 120 130 140 150
NTVVILAAAL LEHAANLIHM GMTPQEVAAG YEQAAEKALE ILPTLVVKEA
160 170 180 190 200
TDMKNIEEVR QYIRSAITSK QYDNEDIIAD LVAKACVTTC PANSFNFNVD
210 220 230 240 250
NIRICKIIGS GVHTSTVMNG MVFKRGAEGE IREARDARIA VYTCPFDLTQ
260 270 280 290 300
TETKGTVLIE NADELRNFSK GEEAEVEEQV KAIADNGVKV VVAAGKFGDM
310 320 330 340 350
YLHFLNKYKI MAVRLTSKFD LRRLCRTVGA QPQARICAPA VNLLGHCDSV
360 370 380 390 400
AVQEIGDENV VVFDKKSETG KVATIIIRGS SQSRIDDVER AVDDAVNTYK
410 420 430 440 450
ALTKDGKLLA GAGAVEIELA KEIESFGAKA PGLEQYAIKK FAHALETLPK
460 470 480 490 500
AIAENAGMPT TETLTKLYAE HVAGKKNAGI DIWKRETMDA VVNNIFDLYA
510 520 530 540
GKRLAIKLAT DAASTILKVD QIIMSKQATG GPKPRGPKAQ DEDDDGMA
Length:548
Mass (Da):59,734
Last modified:June 15, 2010 - v3
Checksum:iDB26D85844C0EFDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080854 Genomic DNA. Translation: CCD67240.1.
RefSeqiNP_500035.3. NM_067634.4.
UniGeneiCel.11906.

Genome annotation databases

EnsemblMetazoaiY55F3AR.3a; Y55F3AR.3a; WBGene00021934.
GeneIDi176928.
KEGGicel:CELE_Y55F3AR.3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080854 Genomic DNA. Translation: CCD67240.1.
RefSeqiNP_500035.3. NM_067634.4.
UniGeneiCel.11906.

3D structure databases

ProteinModelPortaliQ9N358.
SMRiQ9N358. Positions 12-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9N358. 2 interactions.
STRINGi6239.Y55F3AR.3.

Proteomic databases

EPDiQ9N358.
PaxDbiQ9N358.
PRIDEiQ9N358.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY55F3AR.3a; Y55F3AR.3a; WBGene00021934.
GeneIDi176928.
KEGGicel:CELE_Y55F3AR.3.

Organism-specific databases

CTDi176928.
WormBaseiY55F3AR.3a; CE44228; WBGene00021934; cct-8.

Phylogenomic databases

eggNOGiKOG0362. Eukaryota.
ENOG410XPXR. LUCA.
GeneTreeiENSGT00550000074783.
InParanoidiQ9N358.
OMAiQSGTEDL.
OrthoDBiEOG7JQBN8.
PhylomeDBiQ9N358.

Enzyme and pathway databases

ReactomeiR-CEL-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-CEL-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiQ9N358.

Gene expression databases

ExpressionAtlasiQ9N358. baseline.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012721. Chap_CCT_theta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02346. chap_CCT_theta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. Bienvenut W.V.
    Submitted (MAR-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 62-73; 138-148; 255-266; 372-378 AND 508-518, IDENTIFICATION BY MASS SPECTROMETRY.
  3. "A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans."
    Updike D.L., Strome S.
    Genetics 183:1397-1419(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTCPQ_CAEEL
AccessioniPrimary (citable) accession number: Q9N358
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 15, 2010
Last modified: June 8, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.