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Q9N2V9 (PDE6_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 3',5'-cyclic phosphodiesterase pde-6

EC=3.1.4.17
Gene names
Name:pde-6
ORF Names:Y95B8A.10
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length760 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. UniProtKB P54750

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. UniProtKB P54750

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 760760Probable 3',5'-cyclic phosphodiesterase pde-6
PRO_0000198849

Sites

Active site5021Proton donor By similarity
Metal binding5061Divalent metal cation 1 By similarity
Metal binding5421Divalent metal cation 1 By similarity
Metal binding5431Divalent metal cation 1 By similarity
Metal binding5431Divalent metal cation 2 By similarity
Metal binding6561Divalent metal cation 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9N2V9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 2BDD7274D30B34B5

FASTA76084,881
        10         20         30         40         50         60 
MGDRSGVGGE EGEKSVLGAS AHSQAGRRQQ HTPAARRGAQ RAPAATAAAA SRPVFAMRWC 

        70         80         90        100        110        120 
CGGSYSENGG GGGGSRGAPP TPLLTVAATS SSTAHDTFGP MQVKMLKTAV IVTEGTGESV 

       130        140        150        160        170        180 
LLDSLRASGW ICTVSFPTQA TSDVESICPL AVFIDLRVPH PSQIAKDVSS VSTEEVLIVS 

       190        200        210        220        230        240 
IAEKHISEKR RRALAQSNII HHVTWNTRDV VLFDYVGRLA NRIRALPALF AVLDETDQAV 

       250        260        270        280        290        300 
EICDEQRVVQ YVNRAYENVT GCIRSEVIGQ PESEMRRKSL PRARGEEERR RSCDWKFIRV 

       310        320        330        340        350        360 
PFANNSQFVY MKRSNTTGDT AAIFRDVSLK SLKSQTGGIE APISEVLTML RDVSARVDGE 

       370        380        390        400        410        420 
PAQTIKDAMK VLSSHELYAP SINRFRDADR IATQYYDGLI RLHHPARQRK RSVVDAHREK 

       430        440        450        460        470        480 
RGSHGERRRV SADVKNALEN DNCWKFDILH LEKVSDHHAL SQVGMKVFER WKVCDVLGCS 

       490        500        510        520        530        540 
DDLLHRWILS IEAHYHAGNT YHNATHAADV LQATSFFLDS PSVAVHVNES HAVAALLAAA 

       550        560        570        580        590        600 
VHDLDHPGRG NAYLINTRQS LAILYNDNSI LENHHIALAF QLTLQHNANV NIFSSLSREE 

       610        620        630        640        650        660 
FIQMRHAMVE MVLATDISRH FEYLAKFNKM HVTDVPEEQR DTNSLTICDM LVKCADISNP 

       670        680        690        700        710        720 
AREWGLCQRW AHRIVEEYFE QTREEKEKGL PVTMEVFDRN TCNVPITQCG FIDMFAREAF 

       730        740        750        760 
ATFTEFAKLG ELSDQLESNY EKWKVMTSQW TPTHNTNLVL 

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081787 Genomic DNA. Translation: CCD73546.1.
RefSeqNP_490787.1. NM_058386.1.
UniGeneCel.16242.

3D structure databases

ProteinModelPortalQ9N2V9.
SMRQ9N2V9. Positions 230-277, 430-744.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9N2V9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaY95B8A.10a; Y95B8A.10a; Y95B8A.10.
GeneID190808.
KEGGcel:CELE_Y95B8A.10.
UCSCY95B8A.10a. c. elegans.

Organism-specific databases

CTD190808.
WormBaseY95B8A.10a; CE23151; WBGene00022389; pde-6.

Phylogenomic databases

eggNOGNOG282089.
HOGENOMHOG000272633.
InParanoidQ9N2V9.
KOK01120.
OMAALENDNC.
PhylomeDBQ9N2V9.

Family and domain databases

Gene3D1.10.1300.10. 1 hit.
InterProIPR003607. HD/PDEase_dom.
IPR000014. PAS.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00471. HDc. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMSSF55785. SSF55785. 1 hit.
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio947032.
PROQ9N2V9.

Entry information

Entry namePDE6_CAEEL
AccessionPrimary (citable) accession number: Q9N2V9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase