Reviewed, UniProtKB/Swiss-Prot Q9N2V9 (PDE6_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable 3',5'-cyclic phosphodiesterase pde-6
    EC=3.1.4.17

Gene names

Name:	pde-6
ORF Names:	Y95B8A.10

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	760 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. UniProtKB P54750
Cofactor	Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family.

Ontologies

Keywords
Ligand	Metal-binding cGMP
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	axon guidance Inferred from mutant phenotype. Source: WormBase signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 760	760	Probable 3',5'-cyclic phosphodiesterase pde-6		PRO_0000198849
Sites
	Active site	502	1	Proton donor By similarity
	Metal binding	506	1	Divalent metal cation 1 By similarity
	Metal binding	542	1	Divalent metal cation 1 By similarity
	Metal binding	543	1	Divalent metal cation 1 By similarity
	Metal binding	543	1	Divalent metal cation 2 By similarity
	Metal binding	656	1	Divalent metal cation 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9N2V9-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 2BDD7274D30B34B5	FASTA	760	84,881
	10 20 30 40 50 60 MGDRSGVGGE EGEKSVLGAS AHSQAGRRQQ HTPAARRGAQ RAPAATAAAA SRPVFAMRWC 70 80 90 100 110 120 CGGSYSENGG GGGGSRGAPP TPLLTVAATS SSTAHDTFGP MQVKMLKTAV IVTEGTGESV 130 140 150 160 170 180 LLDSLRASGW ICTVSFPTQA TSDVESICPL AVFIDLRVPH PSQIAKDVSS VSTEEVLIVS 190 200 210 220 230 240 IAEKHISEKR RRALAQSNII HHVTWNTRDV VLFDYVGRLA NRIRALPALF AVLDETDQAV 250 260 270 280 290 300 EICDEQRVVQ YVNRAYENVT GCIRSEVIGQ PESEMRRKSL PRARGEEERR RSCDWKFIRV 310 320 330 340 350 360 PFANNSQFVY MKRSNTTGDT AAIFRDVSLK SLKSQTGGIE APISEVLTML RDVSARVDGE 370 380 390 400 410 420 PAQTIKDAMK VLSSHELYAP SINRFRDADR IATQYYDGLI RLHHPARQRK RSVVDAHREK 430 440 450 460 470 480 RGSHGERRRV SADVKNALEN DNCWKFDILH LEKVSDHHAL SQVGMKVFER WKVCDVLGCS 490 500 510 520 530 540 DDLLHRWILS IEAHYHAGNT YHNATHAADV LQATSFFLDS PSVAVHVNES HAVAALLAAA 550 560 570 580 590 600 VHDLDHPGRG NAYLINTRQS LAILYNDNSI LENHHIALAF QLTLQHNANV NIFSSLSREE 610 620 630 640 650 660 FIQMRHAMVE MVLATDISRH FEYLAKFNKM HVTDVPEEQR DTNSLTICDM LVKCADISNP 670 680 690 700 710 720 AREWGLCQRW AHRIVEEYFE QTREEKEKGL PVTMEVFDRN TCNVPITQCG FIDMFAREAF 730 740 750 760 ATFTEFAKLG ELSDQLESNY EKWKVMTSQW TPTHNTNLVL

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC024877 Genomic DNA. Translation: AAF60898.1.
RefSeq	NP_490787.1.
UniGene	Cel.16242
3D structure databases
SMR	Q9N2V9. Positions 433-746.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9N2V9.
Genome annotation databases
Ensembl	Y95B8A.10a; Y95B8A.10a; Y95B8A.10; Caenorhabditis elegans. [Genome view]
GeneID	190808.
NMPDR	fig|6239.3.peg.153.
UCSC	Y95B8A.10a. c. elegans.
Organism-specific databases
CTD	190808.
WormBase	WBGene00022389. pde-6.
WormPep	Y95B8A.10. CE23151. [WorfDB]
Phylogenomic databases
eggNOG	meNOG05714.
HOGENOM	HBG379297.
InParanoid	Q9N2V9.
OMA	ALENDNC.
PhylomeDB	Q9N2V9.
Enzyme and pathway databases
BRENDA	3.1.4.17. 672.
Gene expression databases
ArrayExpress	Q9N2V9.
Family and domain databases
InterPro	IPR003607. Metal-dep_PHydrolase_HD_dom. IPR000014. PAS. IPR002073. PDEase. [Graphical view]
Pfam	PF00233. PDEase_I. 1 hit. [Graphical view]
PRINTS	PR00387. PDIESTERASE1.
SMART	SM00471. HDc. 1 hit. SM00091. PAS. 1 hit. [Graphical view]
PROSITE	PS00126. PDEASE_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	947032.

Entry information

Entry name

PDE6_CAEEL

Accession

Primary (citable) accession number: Q9N2V9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project