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Q9N2V9

- PDE6_CAEEL

UniProt

Q9N2V9 - PDE6_CAEEL

Protein

Probable 3',5'-cyclic phosphodiesterase pde-6

Gene

pde-6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.By similarity

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei502 – 5021Proton donorBy similarity
    Metal bindingi506 – 5061Divalent metal cation 1By similarity
    Metal bindingi542 – 5421Divalent metal cation 1By similarity
    Metal bindingi543 – 5431Divalent metal cation 1By similarity
    Metal bindingi543 – 5431Divalent metal cation 2By similarity
    Metal bindingi656 – 6561Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: WormBase
    2. metal ion binding Source: UniProtKB-KW
    3. signal transducer activity Source: InterPro

    GO - Biological processi

    1. metabolic process Source: GOC
    2. negative regulation of oocyte maturation Source: WormBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 3',5'-cyclic phosphodiesterase pde-6 (EC:3.1.4.17)
    Gene namesi
    Name:pde-6
    ORF Names:Y95B8A.10
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiY95B8A.10a; CE23151; WBGene00022389; pde-6.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 760760Probable 3',5'-cyclic phosphodiesterase pde-6PRO_0000198849Add
    BLAST

    Proteomic databases

    PaxDbiQ9N2V9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9N2V9.
    SMRiQ9N2V9. Positions 230-277, 430-744.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclic nucleotide phosphodiesterase family.By similarity

    Phylogenomic databases

    eggNOGiNOG282089.
    GeneTreeiENSGT00730000110321.
    HOGENOMiHOG000272633.
    InParanoidiQ9N2V9.
    KOiK01120.
    OMAiALENDNC.
    PhylomeDBiQ9N2V9.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    InterProiIPR003607. HD/PDEase_dom.
    IPR000014. PAS.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55785. SSF55785. 1 hit.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9N2V9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDRSGVGGE EGEKSVLGAS AHSQAGRRQQ HTPAARRGAQ RAPAATAAAA    50
    SRPVFAMRWC CGGSYSENGG GGGGSRGAPP TPLLTVAATS SSTAHDTFGP 100
    MQVKMLKTAV IVTEGTGESV LLDSLRASGW ICTVSFPTQA TSDVESICPL 150
    AVFIDLRVPH PSQIAKDVSS VSTEEVLIVS IAEKHISEKR RRALAQSNII 200
    HHVTWNTRDV VLFDYVGRLA NRIRALPALF AVLDETDQAV EICDEQRVVQ 250
    YVNRAYENVT GCIRSEVIGQ PESEMRRKSL PRARGEEERR RSCDWKFIRV 300
    PFANNSQFVY MKRSNTTGDT AAIFRDVSLK SLKSQTGGIE APISEVLTML 350
    RDVSARVDGE PAQTIKDAMK VLSSHELYAP SINRFRDADR IATQYYDGLI 400
    RLHHPARQRK RSVVDAHREK RGSHGERRRV SADVKNALEN DNCWKFDILH 450
    LEKVSDHHAL SQVGMKVFER WKVCDVLGCS DDLLHRWILS IEAHYHAGNT 500
    YHNATHAADV LQATSFFLDS PSVAVHVNES HAVAALLAAA VHDLDHPGRG 550
    NAYLINTRQS LAILYNDNSI LENHHIALAF QLTLQHNANV NIFSSLSREE 600
    FIQMRHAMVE MVLATDISRH FEYLAKFNKM HVTDVPEEQR DTNSLTICDM 650
    LVKCADISNP AREWGLCQRW AHRIVEEYFE QTREEKEKGL PVTMEVFDRN 700
    TCNVPITQCG FIDMFAREAF ATFTEFAKLG ELSDQLESNY EKWKVMTSQW 750
    TPTHNTNLVL 760
    Length:760
    Mass (Da):84,881
    Last modified:October 1, 2000 - v1
    Checksum:i2BDD7274D30B34B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081787 Genomic DNA. Translation: CCD73546.1.
    RefSeqiNP_490787.1. NM_058386.1.
    UniGeneiCel.16242.

    Genome annotation databases

    EnsemblMetazoaiY95B8A.10a; Y95B8A.10a; WBGene00022389.
    GeneIDi190808.
    KEGGicel:CELE_Y95B8A.10.
    UCSCiY95B8A.10a. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081787 Genomic DNA. Translation: CCD73546.1 .
    RefSeqi NP_490787.1. NM_058386.1.
    UniGenei Cel.16242.

    3D structure databases

    ProteinModelPortali Q9N2V9.
    SMRi Q9N2V9. Positions 230-277, 430-744.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9N2V9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y95B8A.10a ; Y95B8A.10a ; WBGene00022389 .
    GeneIDi 190808.
    KEGGi cel:CELE_Y95B8A.10.
    UCSCi Y95B8A.10a. c. elegans.

    Organism-specific databases

    CTDi 190808.
    WormBasei Y95B8A.10a ; CE23151 ; WBGene00022389 ; pde-6.

    Phylogenomic databases

    eggNOGi NOG282089.
    GeneTreei ENSGT00730000110321.
    HOGENOMi HOG000272633.
    InParanoidi Q9N2V9.
    KOi K01120.
    OMAi ALENDNC.
    PhylomeDBi Q9N2V9.

    Miscellaneous databases

    NextBioi 947032.
    PROi Q9N2V9.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    InterProi IPR003607. HD/PDEase_dom.
    IPR000014. PAS.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55785. SSF55785. 1 hit.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPDE6_CAEEL
    AccessioniPrimary (citable) accession number: Q9N2V9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3