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Protein

Probable 3',5'-cyclic phosphodiesterase pde-6

Gene

pde-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei502 – 5021Proton donorBy similarity
Metal bindingi506 – 5061Divalent metal cation 1By similarity
Metal bindingi542 – 5421Divalent metal cation 1By similarity
Metal bindingi543 – 5431Divalent metal cation 1By similarity
Metal bindingi543 – 5431Divalent metal cation 2By similarity
Metal bindingi656 – 6561Divalent metal cation 1By similarity

GO - Molecular functioni

  • 3',5'-cyclic-AMP phosphodiesterase activity Source: WormBase
  • metal ion binding Source: UniProtKB-KW
  • signal transducer activity Source: InterPro

GO - Biological processi

  • metabolic process Source: GOC
  • negative regulation of oocyte maturation Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_354932. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-6 (EC:3.1.4.17)
Gene namesi
Name:pde-6
ORF Names:Y95B8A.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY95B8A.10a; CE23151; WBGene00022389; pde-6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Probable 3',5'-cyclic phosphodiesterase pde-6PRO_0000198849Add
BLAST

Proteomic databases

PaxDbiQ9N2V9.

Expressioni

Gene expression databases

ExpressionAtlasiQ9N2V9. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y95B8A.10a.

Structurei

3D structure databases

ProteinModelPortaliQ9N2V9.
SMRiQ9N2V9. Positions 242-278, 430-744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.By similarity

Phylogenomic databases

eggNOGiNOG282089.
GeneTreeiENSGT00760000118889.
HOGENOMiHOG000272633.
InParanoidiQ9N2V9.
OMAiCGGSYSE.
PhylomeDBiQ9N2V9.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR000014. PAS.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9N2V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRSGVGGE EGEKSVLGAS AHSQAGRRQQ HTPAARRGAQ RAPAATAAAA
60 70 80 90 100
SRPVFAMRWC CGGSYSENGG GGGGSRGAPP TPLLTVAATS SSTAHDTFGP
110 120 130 140 150
MQVKMLKTAV IVTEGTGESV LLDSLRASGW ICTVSFPTQA TSDVESICPL
160 170 180 190 200
AVFIDLRVPH PSQIAKDVSS VSTEEVLIVS IAEKHISEKR RRALAQSNII
210 220 230 240 250
HHVTWNTRDV VLFDYVGRLA NRIRALPALF AVLDETDQAV EICDEQRVVQ
260 270 280 290 300
YVNRAYENVT GCIRSEVIGQ PESEMRRKSL PRARGEEERR RSCDWKFIRV
310 320 330 340 350
PFANNSQFVY MKRSNTTGDT AAIFRDVSLK SLKSQTGGIE APISEVLTML
360 370 380 390 400
RDVSARVDGE PAQTIKDAMK VLSSHELYAP SINRFRDADR IATQYYDGLI
410 420 430 440 450
RLHHPARQRK RSVVDAHREK RGSHGERRRV SADVKNALEN DNCWKFDILH
460 470 480 490 500
LEKVSDHHAL SQVGMKVFER WKVCDVLGCS DDLLHRWILS IEAHYHAGNT
510 520 530 540 550
YHNATHAADV LQATSFFLDS PSVAVHVNES HAVAALLAAA VHDLDHPGRG
560 570 580 590 600
NAYLINTRQS LAILYNDNSI LENHHIALAF QLTLQHNANV NIFSSLSREE
610 620 630 640 650
FIQMRHAMVE MVLATDISRH FEYLAKFNKM HVTDVPEEQR DTNSLTICDM
660 670 680 690 700
LVKCADISNP AREWGLCQRW AHRIVEEYFE QTREEKEKGL PVTMEVFDRN
710 720 730 740 750
TCNVPITQCG FIDMFAREAF ATFTEFAKLG ELSDQLESNY EKWKVMTSQW
760
TPTHNTNLVL
Length:760
Mass (Da):84,881
Last modified:October 1, 2000 - v1
Checksum:i2BDD7274D30B34B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081787 Genomic DNA. Translation: CCD73546.1.
RefSeqiNP_490787.1. NM_058386.1.
UniGeneiCel.16242.

Genome annotation databases

EnsemblMetazoaiY95B8A.10a; Y95B8A.10a; WBGene00022389.
GeneIDi190808.
UCSCiY95B8A.10a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081787 Genomic DNA. Translation: CCD73546.1.
RefSeqiNP_490787.1. NM_058386.1.
UniGeneiCel.16242.

3D structure databases

ProteinModelPortaliQ9N2V9.
SMRiQ9N2V9. Positions 242-278, 430-744.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y95B8A.10a.

Proteomic databases

PaxDbiQ9N2V9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY95B8A.10a; Y95B8A.10a; WBGene00022389.
GeneIDi190808.
UCSCiY95B8A.10a. c. elegans.

Organism-specific databases

CTDi190808.
WormBaseiY95B8A.10a; CE23151; WBGene00022389; pde-6.

Phylogenomic databases

eggNOGiNOG282089.
GeneTreeiENSGT00760000118889.
HOGENOMiHOG000272633.
InParanoidiQ9N2V9.
OMAiCGGSYSE.
PhylomeDBiQ9N2V9.

Enzyme and pathway databases

ReactomeiREACT_354932. G alpha (s) signalling events.

Miscellaneous databases

NextBioi947032.
PROiQ9N2V9.

Gene expression databases

ExpressionAtlasiQ9N2V9. baseline.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR000014. PAS.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPDE6_CAEEL
AccessioniPrimary (citable) accession number: Q9N2V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.