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Q9N2V9

- PDE6_CAEEL

UniProt

Q9N2V9 - PDE6_CAEEL

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Protein
Probable 3',5'-cyclic phosphodiesterase pde-6
Gene
pde-6, Y95B8A.10
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei502 – 5021Proton donor By similarity
Metal bindingi506 – 5061Divalent metal cation 1 By similarity
Metal bindingi542 – 5421Divalent metal cation 1 By similarity
Metal bindingi543 – 5431Divalent metal cation 1 By similarity
Metal bindingi543 – 5431Divalent metal cation 2 By similarity
Metal bindingi656 – 6561Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: WormBase
  2. metal ion binding Source: UniProtKB-KW
  3. signal transducer activity Source: InterPro

GO - Biological processi

  1. metabolic process Source: GOC
  2. negative regulation of oocyte maturation Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-6 (EC:3.1.4.17)
Gene namesi
Name:pde-6
ORF Names:Y95B8A.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiY95B8A.10a; CE23151; WBGene00022389; pde-6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Probable 3',5'-cyclic phosphodiesterase pde-6
PRO_0000198849Add
BLAST

Proteomic databases

PaxDbiQ9N2V9.

Structurei

3D structure databases

ProteinModelPortaliQ9N2V9.
SMRiQ9N2V9. Positions 230-277, 430-744.

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.By similarity

Phylogenomic databases

eggNOGiNOG282089.
GeneTreeiENSGT00730000110321.
HOGENOMiHOG000272633.
InParanoidiQ9N2V9.
KOiK01120.
OMAiALENDNC.
PhylomeDBiQ9N2V9.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR000014. PAS.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9N2V9-1 [UniParc]FASTAAdd to Basket

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MGDRSGVGGE EGEKSVLGAS AHSQAGRRQQ HTPAARRGAQ RAPAATAAAA    50
SRPVFAMRWC CGGSYSENGG GGGGSRGAPP TPLLTVAATS SSTAHDTFGP 100
MQVKMLKTAV IVTEGTGESV LLDSLRASGW ICTVSFPTQA TSDVESICPL 150
AVFIDLRVPH PSQIAKDVSS VSTEEVLIVS IAEKHISEKR RRALAQSNII 200
HHVTWNTRDV VLFDYVGRLA NRIRALPALF AVLDETDQAV EICDEQRVVQ 250
YVNRAYENVT GCIRSEVIGQ PESEMRRKSL PRARGEEERR RSCDWKFIRV 300
PFANNSQFVY MKRSNTTGDT AAIFRDVSLK SLKSQTGGIE APISEVLTML 350
RDVSARVDGE PAQTIKDAMK VLSSHELYAP SINRFRDADR IATQYYDGLI 400
RLHHPARQRK RSVVDAHREK RGSHGERRRV SADVKNALEN DNCWKFDILH 450
LEKVSDHHAL SQVGMKVFER WKVCDVLGCS DDLLHRWILS IEAHYHAGNT 500
YHNATHAADV LQATSFFLDS PSVAVHVNES HAVAALLAAA VHDLDHPGRG 550
NAYLINTRQS LAILYNDNSI LENHHIALAF QLTLQHNANV NIFSSLSREE 600
FIQMRHAMVE MVLATDISRH FEYLAKFNKM HVTDVPEEQR DTNSLTICDM 650
LVKCADISNP AREWGLCQRW AHRIVEEYFE QTREEKEKGL PVTMEVFDRN 700
TCNVPITQCG FIDMFAREAF ATFTEFAKLG ELSDQLESNY EKWKVMTSQW 750
TPTHNTNLVL 760
Length:760
Mass (Da):84,881
Last modified:October 1, 2000 - v1
Checksum:i2BDD7274D30B34B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081787 Genomic DNA. Translation: CCD73546.1.
RefSeqiNP_490787.1. NM_058386.1.
UniGeneiCel.16242.

Genome annotation databases

EnsemblMetazoaiY95B8A.10a; Y95B8A.10a; WBGene00022389.
GeneIDi190808.
KEGGicel:CELE_Y95B8A.10.
UCSCiY95B8A.10a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081787 Genomic DNA. Translation: CCD73546.1 .
RefSeqi NP_490787.1. NM_058386.1.
UniGenei Cel.16242.

3D structure databases

ProteinModelPortali Q9N2V9.
SMRi Q9N2V9. Positions 230-277, 430-744.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9N2V9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y95B8A.10a ; Y95B8A.10a ; WBGene00022389 .
GeneIDi 190808.
KEGGi cel:CELE_Y95B8A.10.
UCSCi Y95B8A.10a. c. elegans.

Organism-specific databases

CTDi 190808.
WormBasei Y95B8A.10a ; CE23151 ; WBGene00022389 ; pde-6.

Phylogenomic databases

eggNOGi NOG282089.
GeneTreei ENSGT00730000110321.
HOGENOMi HOG000272633.
InParanoidi Q9N2V9.
KOi K01120.
OMAi ALENDNC.
PhylomeDBi Q9N2V9.

Miscellaneous databases

NextBioi 947032.
PROi Q9N2V9.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
InterProi IPR003607. HD/PDEase_dom.
IPR000014. PAS.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00471. HDc. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF55785. SSF55785. 1 hit.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPDE6_CAEEL
AccessioniPrimary (citable) accession number: Q9N2V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi