Reviewed,
UniProtKB/Swiss-Prot Q9N2V9 (PDE6_CAEEL)
Last modified
February 9, 2010.
Version 54.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable 3',5'-cyclic phosphodiesterase pde-6 EC=3.1.4.17 | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 760 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. UniProtKB P54750 |
| Cofactor | Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity. |
| Sequence similarities | Belongs to the cyclic nucleotide phosphodiesterase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding cGMP |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | axon guidance Inferred from mutant phenotype. Source: WormBase signal transductionInferred from electronic annotation. Source: InterPro |
| Molecular function | 3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC signal transducer activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 760 | 760 | Probable 3',5'-cyclic phosphodiesterase pde-6 | PRO_0000198849 | |||||
Sites | |||||||||
| Active site | 502 | 1 | Proton donor By similarity | ||||||
| Metal binding | 506 | 1 | Divalent metal cation 1 By similarity | ||||||
| Metal binding | 542 | 1 | Divalent metal cation 1 By similarity | ||||||
| Metal binding | 543 | 1 | Divalent metal cation 1 By similarity | ||||||
| Metal binding | 543 | 1 | Divalent metal cation 2 By similarity | ||||||
| Metal binding | 656 | 1 | Divalent metal cation 1 By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AC024877 Genomic DNA. Translation: AAF60898.1. |
| RefSeq | NP_490787.1. |
| UniGene | Cel.16242 |
3D structure databases | |
| SMR | Q9N2V9. Positions 433-746. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9N2V9. |
Genome annotation databases | |
| Ensembl | Y95B8A.10a; Y95B8A.10a; Y95B8A.10; Caenorhabditis elegans. [Genome view] |
| GeneID | 190808. |
| NMPDR | fig|6239.3.peg.153. |
| UCSC | Y95B8A.10a. c. elegans. |
Organism-specific databases | |
| CTD | 190808. |
| WormBase | WBGene00022389. pde-6. |
| WormPep | Y95B8A.10. CE23151. [WorfDB] |
Phylogenomic databases | |
| eggNOG | meNOG05714. |
| HOGENOM | HBG379297. |
| InParanoid | Q9N2V9. |
| OMA | ALENDNC. |
| PhylomeDB | Q9N2V9. |
Enzyme and pathway databases | |
| BRENDA | 3.1.4.17. 672. |
Gene expression databases | |
| ArrayExpress | Q9N2V9. |
Family and domain databases | |
| InterPro | IPR003607. Metal-dep_PHydrolase_HD_dom. IPR000014. PAS. IPR002073. PDEase. [Graphical view] |
| Pfam | PF00233. PDEase_I. 1 hit. [Graphical view] |
| PRINTS | PR00387. PDIESTERASE1. |
| SMART | SM00471. HDc. 1 hit. SM00091. PAS. 1 hit. [Graphical view] |
| PROSITE | PS00126. PDEASE_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 947032. |
Entry information
| Entry name | PDE6_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q9N2V9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

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