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Protein

Tropomyosin

Gene
N/A
Organism
Charybdis feriata (Crucifix crab) (Cancer feriatus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
Alternative name(s):
Allergen Cha f I
Allergen: Cha f 1
OrganismiCharybdis feriata (Crucifix crab) (Cancer feriatus)
Taxonomic identifieri65693 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeCharybdis

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei196. Cha f 1.
3185. Cha f 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›264›264TropomyosinPRO_0000205673Add
BLAST

Proteomic databases

PRIDEiQ9N2R3.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9N2R3.
SMRiQ9N2R3. Positions 1-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – ›264›264By similarityAdd
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9N2R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIKKKMQA MKLEKDNAMD RADTLEQQNK EANLRAEKTE EEIRATQKKM
60 70 80 90 100
QQVENELDQA QEQLSAANTK LDEKEKALQN AEGEVAALNR RIQLPEEDLE
110 120 130 140 150
RSEERLNTAT TKLAEASQAA DESERMRKVL ENRSLSDEER MDALENQLKE
160 170 180 190 200
ARFLAEEADR KYDEVARKLA MVEADLERAE ERAESGESKI VELEEELRVV
210 220 230 240 250
GNNLKSLEVS EEKANQREET YKEQIKTLAN KLKAAEARAE FAERSVQKLQ
260
KEVDRLEDEL VNEK
Length:264
Mass (Da):30,436
Last modified:October 1, 2000 - v1
Checksum:i9A376620B2D36910
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei264 – 2641

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061783 mRNA. Translation: AAF35431.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061783 mRNA. Translation: AAF35431.1.

3D structure databases

ProteinModelPortaliQ9N2R3.
SMRiQ9N2R3. Positions 1-262.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei196. Cha f 1.
3185. Cha f 1.0101.

Proteomic databases

PRIDEiQ9N2R3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and molecular characterization of Charybdis feriatus tropomyosin, the major crab allergen."
    Leung P.S.C., Chen Y.C., Gershwin M.E., Wong S.H., Kwan H.S., Chu K.H.
    J. Allergy Clin. Immunol. 102:847-852(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiTPM_CHAFE
AccessioniPrimary (citable) accession number: Q9N2R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: October 14, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.