Reviewed, UniProtKB/Swiss-Prot Q9N2I7 (DPP4_FELCA)

Names and origin

Protein names

Recommended name:
    Dipeptidyl peptidase 4
    EC=3.4.14.5
Alternative name(s):
    Dipeptidyl peptidase IV
      Short name=DPP IV
    T-cell activation antigen CD26
    CD_antigen=CD26
Cleaved into the following 2 chains:
    1- Recommended name:
            Dipeptidyl peptidase 4 membrane form
        Alternative name(s):
            Dipeptidyl peptidase IV membrane form
    2- Recommended name:
            Dipeptidyl peptidase 4 soluble form
        Alternative name(s):
            Dipeptidyl peptidase IV soluble form

Gene names

Name:	DPP4
Synonyms:	CD26

Organism

Felis catus (Cat) (Felis silvestris catus)

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	765 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.
Catalytic activity	Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Subunit structure	Homodimer By similarity.
Subcellular location	Cell membrane; Single-pass type II membrane protein By similarity. Dipeptidyl peptidase 4 soluble form: Secreted By similarity.
Post-translational modification	The soluble form (SDPP) derives from the membrane form (MDPP) by proteolytic processing By similarity.
Sequence similarities	Belongs to the peptidase S9B family. DPPIV subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Domain	Signal-anchor Transmembrane
Molecular function	Aminopeptidase Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 765	765	Dipeptidyl peptidase 4 membrane form		PRO_0000027211
	Chain	38 – 765	728	Dipeptidyl peptidase 4 soluble form By similarity		PRO_0000027212
Regions
	Topological domain	1 – 6	6	Cytoplasmic Potential
	Transmembrane	7 – 29	23	Signal-anchor for type II membrane protein Potential
	Topological domain	30 – 765	736	Extracellular Potential
Sites
	Active site	629	1	Charge relay system By similarity
	Active site	707	1	Charge relay system By similarity
	Active site	739	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	84	1	N-linked (GlcNAc...) By similarity
	Glycosylation	91	1	N-linked (GlcNAc...) By similarity
	Glycosylation	149	1	N-linked (GlcNAc...) By similarity
	Glycosylation	178	1	N-linked (GlcNAc...) Potential
	Glycosylation	228	1	N-linked (GlcNAc...) By similarity
	Glycosylation	280	1	N-linked (GlcNAc...) By similarity
	Glycosylation	320	1	N-linked (GlcNAc...) By similarity
	Glycosylation	330	1	N-linked (GlcNAc...) Potential
	Glycosylation	331	1	N-linked (GlcNAc...) Potential
	Glycosylation	519	1	N-linked (GlcNAc...) By similarity
	Glycosylation	684	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	384 ↔ 393		By similarity
	Disulfide bond	443 ↔ 446		By similarity
	Disulfide bond	453 ↔ 471		By similarity
	Disulfide bond	648 ↔ 761		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9N2I7-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3EFCE98A22B175D9	FASTA	765	88,213
	10 20 30 40 50 60 MKTPWKVLLG LLGLAALITI ITVPVVLLNK GNDAAADSRR TYTLTDYLKN TFRVKFYSLR 70 80 90 100 110 120 WVSDHDYLYK QDNNILLFNA EYGNSSIFLE NSTFDEFEHS INDYSVSPDG QFILLEYNYV 130 140 150 160 170 180 KQWRHSYTAS YDIYDLNKRQ LITEEKIPNN TQWITWSPEG HKLAYVWKND VYVKNEPNSS 190 200 210 220 230 240 SHRITWTGEE NAIYNGIADW VYEEEIFSAY SALWWSPKGT FLAYAQFNDT QVPLIEYSFY 250 260 270 280 290 300 SDESLQYPMT MRIPYPKAGA ANPTVKLFVI KTDNLNPNTN ATSVEITPPA AMLTGDYYLC 310 320 330 340 350 360 DVTWANEERI SLQWLRRIQN YSVMDIRDYN NSTGKWISSA AQEHIEMSTT GWVGRFRPAE 370 380 390 400 410 420 PHFTSDGRNF YKIISNEDGY KHICRFQIDK KDCTFITKGA WEVIGIEALT TDYLYYISNE 430 440 450 460 470 480 YKGMPGGRNL YKIQLNDYTK VACLSCELKP ERCQYYSVSF SKEAKYYQLR CSGPGLPLYT 490 500 510 520 530 540 LHRSSNDEEL RVLEDNSALD KMLQEVQMPS KKLDFIILNE TKFWYQMILP PHFDTSKKYP 550 560 570 580 590 600 LLIDVYAGPC SQKADAIFRL NWATYLASTE NIIVASFDGR GSGYQGDKIM HAVNRRLGTF 610 620 630 640 650 660 EVEDQIEAAR QFSKMGFVDD KRIAIWGWSY GGYVTSMVLG AGSGVFKCGI AVAPVSRWEY 670 680 690 700 710 720 YDSVYTERYM GLPTPQDNLD YYKNSTVMSR AENFKQVEYL LIHGTADDNV HFQQSAQISK 730 740 750 760 ALVDAGVDFQ AMWYTDEDHG IASGPAHQHI YTHMSHFIKQ CFSLP

References

[1]

"Molecular cloning and sequencing of a cDNA encoding the feline T-cell activation antigen CD26 homologue." Nishimura Y., Miyazawa T., Ikeda Y., Izumiya Y., Nakamura K., Sato E., Mikami T., Takahashi E. Immunogenetics 50:366-368(1999) [PubMed: 10630304] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peripheral blood.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB023952 mRNA. Translation: BAA92344.1.
RefSeq	NP_001009838.1.
3D structure databases
HSSP	HSSP built from PDB template 1PFQ based on UniProtKB P27487.
SMR	Q9N2I7. Positions 38-765.
ModBase	Search...
Protein family/group databases
MEROPS	S09.003.
Genome annotation databases
GeneID	493787.
Organism-specific databases
CTD	493787.
Phylogenomic databases
HOVERGEN	Q9N2I7.
Enzyme and pathway databases
BRENDA	3.4.14.5. 273949.
Family and domain databases
InterPro	IPR002471. Pept_S9_AS. IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view]
Pfam	PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view]
PROSITE	PS00708. PRO_ENDOPEP_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPP4_FELCA

Accession

Primary (citable) accession number: Q9N2I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 26, 2002
Last sequence update:	October 1, 2000
Last modified:	October 13, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)