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Q9N2I1

- CASP1_PIG

UniProt

Q9N2I1 - CASP1_PIG

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Protein
Caspase-1
Gene
CASP1, IL1BC
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis By similarity.

Catalytic activityi

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei237 – 2371 By similarity
Active sitei285 – 2851 By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. regulation of apoptotic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BRENDAi3.4.22.36. 6170.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-1 (EC:3.4.22.36)
Short name:
CASP-1
Alternative name(s):
Interleukin-1 beta convertase
Short name:
IL-1BC
Interleukin-1 beta-converting enzyme
Short name:
ICE
Short name:
IL-1 beta-converting enzyme
p45
Cleaved into the following 2 chains:
Gene namesi
Name:CASP1
Synonyms:IL1BC
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. AIM2 inflammasome complex Source: UniProtKB
  2. IPAF inflammasome complex Source: UniProtKB
  3. NLRP1 inflammasome complex Source: UniProtKB
  4. NLRP3 inflammasome complex Source: UniProtKB
  5. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 119119 Reviewed prediction
PRO_0000004529Add
BLAST
Chaini120 – 297178Caspase-1 subunit p20
PRO_0000004530Add
BLAST
Propeptidei298 – 31619 Reviewed prediction
PRO_0000004531Add
BLAST
Chaini317 – 40488Caspase-1 subunit p10
PRO_0000004532Add
BLAST

Post-translational modificationi

The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

Keywords - PTMi

Zymogen

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17/INCA and CARD18 By similarity.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015922.

Structurei

3D structure databases

ProteinModelPortaliQ9N2I1.
SMRiQ9N2I1. Positions 2-89, 120-297, 317-404.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191CARD
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.
Contains 1 CARD domain.

Phylogenomic databases

eggNOGiNOG326166.
HOVERGENiHBG076981.
KOiK01370.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N2I1-1 [UniParc]FASTAAdd to Basket

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MADKVLKEKR RLFVRSVAMG TINGLLDELL ETRVLNQEEV EIVRGENATV    50
MDKARALIDS VIRKGPQACQ ICINHICGDD PHLAGVLELS TGSQSGKCLT 100
VQESQAVVPP FPAPQTVQDN PVKPASSEPR GSLKLCPPDI AQRLWKEKSA 150
EIYPIMGKSI RTRLALIICN TEFENLPRRD GADVDIRDMK ILLEDLGYSV 200
DVRENLTASD MAIELKAFAA RPEHKSSDST FLVLMSHGIQ AGICGKKYSE 250
EVPDVLEVNT VFQILNTLNC PSLKDKPKVI IIQACRGEKQ GVVWIKDSVG 300
PSGNSSLLAA EDFEYDAIKK AHIEKDFIAF CSSTPDNVSW RHPLLGSLFI 350
IKLIKILQEH AWSCGLEEIF RKVRFSFELA DGRAQMPTAE RVTLTRSFYL 400
FPGH 404
Length:404
Mass (Da):44,882
Last modified:October 1, 2000 - v1
Checksum:i437DC787E85FB449
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027296 mRNA. Translation: BAA89531.1.
RefSeqiNP_999327.1. NM_214162.1.
UniGeneiSsc.16012.

Genome annotation databases

GeneIDi397319.
KEGGissc:397319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027296 mRNA. Translation: BAA89531.1 .
RefSeqi NP_999327.1. NM_214162.1.
UniGenei Ssc.16012.

3D structure databases

ProteinModelPortali Q9N2I1.
SMRi Q9N2I1. Positions 2-89, 120-297, 317-404.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000015922.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397319.
KEGGi ssc:397319.

Organism-specific databases

CTDi 834.

Phylogenomic databases

eggNOGi NOG326166.
HOVERGENi HBG076981.
KOi K01370.

Enzyme and pathway databases

BRENDAi 3.4.22.36. 6170.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProi IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
PRINTSi PR00376. IL1BCENZYME.
SMARTi SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of porcine interleukin-1beta converting enzyme and differential gene expression of IL-1beta converting enzyme, IL-1beta, and IL-18 in porcine alveolar macrophages."
    Muneta Y., Shimoji Y., Yokomizo Y., Mori Y.
    J. Interferon Cytokine Res. 19:1289-1296(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCASP1_PIG
AccessioniPrimary (citable) accession number: Q9N2I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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