Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9N2I1

- CASP1_PIG

UniProt

Q9N2I1 - CASP1_PIG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Caspase-1

Gene

CASP1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity).By similarity

Catalytic activityi

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei237 – 2371By similarity
Active sitei285 – 2851By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. regulation of apoptotic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BRENDAi3.4.22.36. 6170.

Protein family/group databases

MEROPSiC14.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-1 (EC:3.4.22.36)
Short name:
CASP-1
Alternative name(s):
Interleukin-1 beta convertase
Short name:
IL-1BC
Interleukin-1 beta-converting enzyme
Short name:
ICE
Short name:
IL-1 beta-converting enzyme
p45
Cleaved into the following 2 chains:
Gene namesi
Name:CASP1
Synonyms:IL1BC
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. AIM2 inflammasome complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB-KW
  3. IPAF inflammasome complex Source: UniProtKB
  4. NLRP1 inflammasome complex Source: UniProtKB
  5. NLRP3 inflammasome complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 119119Sequence AnalysisPRO_0000004529Add
BLAST
Chaini120 – 297178Caspase-1 subunit p20PRO_0000004530Add
BLAST
Propeptidei298 – 31619Sequence AnalysisPRO_0000004531Add
BLAST
Chaini317 – 40488Caspase-1 subunit p10PRO_0000004532Add
BLAST

Post-translational modificationi

The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

Keywords - PTMi

Zymogen

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17/INCA and CARD18 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015922.

Structurei

3D structure databases

ProteinModelPortaliQ9N2I1.
SMRiQ9N2I1. Positions 2-89, 120-297, 317-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated
Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG326166.
HOVERGENiHBG076981.
InParanoidiQ9N2I1.
KOiK01370.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N2I1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADKVLKEKR RLFVRSVAMG TINGLLDELL ETRVLNQEEV EIVRGENATV
60 70 80 90 100
MDKARALIDS VIRKGPQACQ ICINHICGDD PHLAGVLELS TGSQSGKCLT
110 120 130 140 150
VQESQAVVPP FPAPQTVQDN PVKPASSEPR GSLKLCPPDI AQRLWKEKSA
160 170 180 190 200
EIYPIMGKSI RTRLALIICN TEFENLPRRD GADVDIRDMK ILLEDLGYSV
210 220 230 240 250
DVRENLTASD MAIELKAFAA RPEHKSSDST FLVLMSHGIQ AGICGKKYSE
260 270 280 290 300
EVPDVLEVNT VFQILNTLNC PSLKDKPKVI IIQACRGEKQ GVVWIKDSVG
310 320 330 340 350
PSGNSSLLAA EDFEYDAIKK AHIEKDFIAF CSSTPDNVSW RHPLLGSLFI
360 370 380 390 400
IKLIKILQEH AWSCGLEEIF RKVRFSFELA DGRAQMPTAE RVTLTRSFYL

FPGH
Length:404
Mass (Da):44,882
Last modified:October 1, 2000 - v1
Checksum:i437DC787E85FB449
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027296 mRNA. Translation: BAA89531.1.
RefSeqiNP_999327.1. NM_214162.1.
UniGeneiSsc.16012.

Genome annotation databases

GeneIDi397319.
KEGGissc:397319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027296 mRNA. Translation: BAA89531.1 .
RefSeqi NP_999327.1. NM_214162.1.
UniGenei Ssc.16012.

3D structure databases

ProteinModelPortali Q9N2I1.
SMRi Q9N2I1. Positions 2-89, 120-297, 317-404.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000015922.

Protein family/group databases

MEROPSi C14.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397319.
KEGGi ssc:397319.

Organism-specific databases

CTDi 834.

Phylogenomic databases

eggNOGi NOG326166.
HOVERGENi HBG076981.
InParanoidi Q9N2I1.
KOi K01370.

Enzyme and pathway databases

BRENDAi 3.4.22.36. 6170.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProi IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
PRINTSi PR00376. IL1BCENZYME.
SMARTi SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of porcine interleukin-1beta converting enzyme and differential gene expression of IL-1beta converting enzyme, IL-1beta, and IL-18 in porcine alveolar macrophages."
    Muneta Y., Shimoji Y., Yokomizo Y., Mori Y.
    J. Interferon Cytokine Res. 19:1289-1296(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCASP1_PIG
AccessioniPrimary (citable) accession number: Q9N2I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3