Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-7

Gene

IL7

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7
Short name:
IL-7
Gene namesi
Name:IL7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 176151Interleukin-7PRO_0000326172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 165By similarity
Disulfide bondi58 ↔ 153By similarity
Disulfide bondi71 ↔ 116By similarity
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence analysis
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9N2G6.

Expressioni

Gene expression databases

BgeeiENSSSCG00000006161.
ExpressionAtlasiQ9N2G6. differential.
GenevisibleiQ9N2G6. SS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006572.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW6Q. Eukaryota.
ENOG41114MI. LUCA.
HOGENOMiHOG000036891.
HOVERGENiHBG004609.
InParanoidiQ9N2G6.
KOiK05431.
OMAiNNEPNFF.
OrthoDBiEOG091G0VZI.
TreeFamiTF338065.

Family and domain databases

InterProiIPR001181. IL-7.
IPR000226. IL-7/IL-9_fam.
[Graphical view]
PANTHERiPTHR10526. PTHR10526. 1 hit.
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PIRSFiPIRSF001942. IL-7. 1 hit.
PRINTSiPR00435. INTERLEUKIN7.
SMARTiSM00127. IL7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N2G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHVSFRYIF GIPPLILVLL PVASSDCDIE GKDGGVYQNV LMVSIDDLDR
60 70 80 90 100
MIDFDSNCLN NEPNFLKKHS CDDNKEASFL YRAARKLKQF IKMNISEEFN
110 120 130 140 150
HHLSTVSQGT LTLFNCTSKV KGRKPPSLGE AQLTKNLEEN KSLKEQKRQG
160 170
DLCFLKILLQ KIKTCWNKIL RGAKEY
Length:176
Mass (Da):20,161
Last modified:October 1, 2000 - v1
Checksum:i9FB75E272BDCBBEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035380 mRNA. Translation: BAA96385.1.
AB040441 mRNA. Translation: BAB39170.1.
AB049332 Genomic DNA. Translation: BAB39172.1.
EU364895 mRNA. Translation: ABY66141.1.
RefSeqiNP_999300.1. NM_214135.2.
UniGeneiSsc.15904.

Genome annotation databases

EnsembliENSSSCT00000006755; ENSSSCP00000006572; ENSSSCG00000006161.
GeneIDi397253.
KEGGissc:397253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035380 mRNA. Translation: BAA96385.1.
AB040441 mRNA. Translation: BAB39170.1.
AB049332 Genomic DNA. Translation: BAB39172.1.
EU364895 mRNA. Translation: ABY66141.1.
RefSeqiNP_999300.1. NM_214135.2.
UniGeneiSsc.15904.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006572.

Proteomic databases

PaxDbiQ9N2G6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000006755; ENSSSCP00000006572; ENSSSCG00000006161.
GeneIDi397253.
KEGGissc:397253.

Organism-specific databases

CTDi3574.

Phylogenomic databases

eggNOGiENOG410IW6Q. Eukaryota.
ENOG41114MI. LUCA.
HOGENOMiHOG000036891.
HOVERGENiHBG004609.
InParanoidiQ9N2G6.
KOiK05431.
OMAiNNEPNFF.
OrthoDBiEOG091G0VZI.
TreeFamiTF338065.

Gene expression databases

BgeeiENSSSCG00000006161.
ExpressionAtlasiQ9N2G6. differential.
GenevisibleiQ9N2G6. SS.

Family and domain databases

InterProiIPR001181. IL-7.
IPR000226. IL-7/IL-9_fam.
[Graphical view]
PANTHERiPTHR10526. PTHR10526. 1 hit.
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PIRSFiPIRSF001942. IL-7. 1 hit.
PRINTSiPR00435. INTERLEUKIN7.
SMARTiSM00127. IL7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL7_PIG
AccessioniPrimary (citable) accession number: Q9N2G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.