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Q9N2D9 (5HT1F_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 1F

Short name=5-HT-1F
Short name=5-HT1F
Alternative name(s):
Serotonin receptor 1F
Gene names
Name:HTR1F
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length365 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›365›3655-hydroxytryptamine receptor 1F
PRO_0000068939

Regions

Topological domain1 – 2929Extracellular By similarity
Transmembrane30 – 5021Helical; Name=1; By similarity
Topological domain51 – 6010Cytoplasmic By similarity
Transmembrane61 – 8323Helical; Name=2; By similarity
Topological domain84 – 9714Extracellular By similarity
Transmembrane98 – 11821Helical; Name=3; By similarity
Topological domain119 – 14022Cytoplasmic By similarity
Transmembrane141 – 16121Helical; Name=4; By similarity
Topological domain162 – 17817Extracellular By similarity
Transmembrane179 – 20123Helical; Name=5; By similarity
Topological domain202 – 29089Cytoplasmic By similarity
Transmembrane291 – 31121Helical; Name=6; By similarity
Topological domain312 – 32918Extracellular By similarity
Transmembrane330 – 35021Helical; Name=7; By similarity
Topological domain351 – ›365›15Cytoplasmic By similarity
Region99 – 10810Agonist binding By similarity
Region306 – 3105Agonist binding By similarity
Motif120 – 1223DRY motif; important for ligand-induced conformation changes By similarity
Motif343 – 3475NPxxY motif; important for ligand-induced conformation changes and signaling By similarity

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 172 By similarity

Experimental info

Non-terminal residue3651

Sequences

Sequence LengthMass (Da)Tools
Q9N2D9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 86BB944230134CFE

FASTA36541,605
        10         20         30         40         50         60 
MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV TRKLHHPANY 

        70         80         90        100        110        120 
LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVVCDIWL SVDITCCTCS ILHLSAIALD 

       130        140        150        160        170        180 
RYRAITDAVE YARKRTPKHA GIMITIVWII SVFISMPPLF WRHQGTSRDD ECIIKHBHIV 

       190        200        210        220        230        240 
STIYSTFGAF YIPLALILIL YYKIYRAAKT LYHKRQASRI AKEEVNGQVL LESGEKSTKS 

       250        260        270        280        290        300 
VSTSYVLEKS LSDPSTDFDK IHSTVRSLRS EFKHEKSWRR QKISGTRERK AATTLGLILG 

       310        320        330        340        350        360 
AFVICWLPFF VKELVVNVCD KCKISEEMSN FLAWLGYLNS LINPLIYTIF NEDFKKAFQK 


LVRCR 

« Hide

References

[1]"Human-specific amino acid changes found in 103 protein-coding genes."
Kitano T., Liu Y.-H., Ueda S., Saitou N.
Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Isolate 220.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB037534 Genomic DNA. Translation: BAA90454.2.
UniGenePtr.6299.

3D structure databases

ProteinModelPortalQ9N2D9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9598.ENSPTRP00000026109.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG249628.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidQ9N2D9.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000450. 5HT1F_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24247:SF34. PTHR24247:SF34. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00515. 5HT1FRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name5HT1F_PANTR
AccessionPrimary (citable) accession number: Q9N2D9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries