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Protein

Gastricsin

Gene

PGC

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes a variety of proteins.1 Publication

Catalytic activityi

More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.

Enzyme regulationi

Inhibited by pepstatin.1 Publication

pH dependencei

Optimum pH is about 2.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911PROSITE-ProRule annotation
Active sitei276 – 2761PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Keywords - Biological processi

Digestion

Protein family/group databases

MEROPSiA01.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastricsin (EC:3.4.23.3)
Alternative name(s):
Pepsinogen C
Gene namesi
Name:PGC
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
Proteomesi
  • UP000008225 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16161 PublicationAdd
BLAST
Propeptidei17 – 5943Activation peptideBy similarityPRO_0000026052Add
BLAST
Chaini60 – 388329GastricsinPRO_0000026053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi104 ↔ 109By similarity
Disulfide bondi267 ↔ 271By similarity
Disulfide bondi310 ↔ 343By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000007671.

Structurei

3D structure databases

ProteinModelPortaliQ9N2D3.
SMRiQ9N2D3. Positions 18-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 385313Peptidase A1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ9N2D3.
KOiK01377.
OMAiLSNNGYC.
OrthoDBiEOG091G0JP7.
TreeFamiTF314990.

Family and domain databases

CDDicd05477. gastricsin. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033735. Gastricsin.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF292. PTHR13683:SF292. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N2D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWMVVAFIC LQLLEATVVK VPLKKFKSIR ETMKEKGLLW EFLKTHKHDP
60 70 80 90 100
ARKYRVSDLS VSYEPMDYMD AAYFGEISIG TPPQNFLVLF DTGSSNLWVP
110 120 130 140 150
SVYCQSQACT SHSRFNPSAS STYSSNGQTF SLQYGSGSLT GFFGYDTLTV
160 170 180 190 200
QSIQVPNQEF GLSENEPGTN FVYAQFDGIM GLAYPALSMG GATTAMQGML
210 220 230 240 250
QEGALTSPVF SFYLSNQQGS SGGAVIFGGV DSSLYTGQIY WAPVTQELYW
260 270 280 290 300
QIGIEEFLIG GQASGWCSEG CQAIVDTGTS LLTVPQQYMS AFLEATGAQE
310 320 330 340 350
DEYGQFLVNC DSIQNLPTLT FIINGVEFPL PPSSYILSNN GYCTVGVEPT
360 370 380
YLSSQNSQPL WILGDVFLRS YYSVFDLGNN RVGFATAA
Length:388
Mass (Da):42,503
Last modified:October 1, 2000 - v1
Checksum:i0BC48DBD1F7D2D8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038385 mRNA. Translation: BAA90872.1.
PIRiJC7246.
RefSeqiXP_002746573.1. XM_002746527.2.

Genome annotation databases

EnsembliENSCJAT00000008109; ENSCJAP00000007671; ENSCJAG00000004226.
GeneIDi100404738.
KEGGicjc:100404738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038385 mRNA. Translation: BAA90872.1.
PIRiJC7246.
RefSeqiXP_002746573.1. XM_002746527.2.

3D structure databases

ProteinModelPortaliQ9N2D3.
SMRiQ9N2D3. Positions 18-388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000007671.

Protein family/group databases

MEROPSiA01.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCJAT00000008109; ENSCJAP00000007671; ENSCJAG00000004226.
GeneIDi100404738.
KEGGicjc:100404738.

Organism-specific databases

CTDi5225.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ9N2D3.
KOiK01377.
OMAiLSNNGYC.
OrthoDBiEOG091G0JP7.
TreeFamiTF314990.

Family and domain databases

CDDicd05477. gastricsin. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033735. Gastricsin.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF292. PTHR13683:SF292. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEPC_CALJA
AccessioniPrimary (citable) accession number: Q9N2D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.