Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gastricsin

Gene

PGC

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes a variety of proteins.1 Publication

Catalytic activityi

More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.

Enzyme regulationi

Inhibited by pepstatin.1 Publication

pH dependencei

Optimum pH is about 2.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91PROSITE-ProRule annotation1
Active sitei276PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease
Biological processDigestion

Protein family/group databases

MEROPSiA01.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastricsin (EC:3.4.23.3)
Alternative name(s):
Pepsinogen C
Gene namesi
Name:PGC
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
PropeptideiPRO_000002605217 – 59Activation peptideBy similarityAdd BLAST43
ChainiPRO_000002605360 – 388GastricsinAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi104 ↔ 109By similarity
Disulfide bondi267 ↔ 271By similarity
Disulfide bondi310 ↔ 343By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000007671.

Structurei

3D structure databases

ProteinModelPortaliQ9N2D3.
SMRiQ9N2D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 385Peptidase A1PROSITE-ProRule annotationAdd BLAST313

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ9N2D3.
KOiK01377.
OMAiHARFNPS.
OrthoDBiEOG091G0JP7.
TreeFamiTF314990.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033735. Gastricsin.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF471. PTHR13683:SF471. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N2D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWMVVAFIC LQLLEATVVK VPLKKFKSIR ETMKEKGLLW EFLKTHKHDP
60 70 80 90 100
ARKYRVSDLS VSYEPMDYMD AAYFGEISIG TPPQNFLVLF DTGSSNLWVP
110 120 130 140 150
SVYCQSQACT SHSRFNPSAS STYSSNGQTF SLQYGSGSLT GFFGYDTLTV
160 170 180 190 200
QSIQVPNQEF GLSENEPGTN FVYAQFDGIM GLAYPALSMG GATTAMQGML
210 220 230 240 250
QEGALTSPVF SFYLSNQQGS SGGAVIFGGV DSSLYTGQIY WAPVTQELYW
260 270 280 290 300
QIGIEEFLIG GQASGWCSEG CQAIVDTGTS LLTVPQQYMS AFLEATGAQE
310 320 330 340 350
DEYGQFLVNC DSIQNLPTLT FIINGVEFPL PPSSYILSNN GYCTVGVEPT
360 370 380
YLSSQNSQPL WILGDVFLRS YYSVFDLGNN RVGFATAA
Length:388
Mass (Da):42,503
Last modified:October 1, 2000 - v1
Checksum:i0BC48DBD1F7D2D8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038385 mRNA. Translation: BAA90872.1.
PIRiJC7246.
RefSeqiXP_002746573.1. XM_002746527.2.

Genome annotation databases

EnsembliENSCJAT00000008109; ENSCJAP00000007671; ENSCJAG00000004226.
GeneIDi100404738.
KEGGicjc:100404738.

Similar proteinsi

Entry informationi

Entry nameiPEPC_CALJA
AccessioniPrimary (citable) accession number: Q9N2D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families