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Q9N2C1

- LEP_FELCA

UniProt

Q9N2C1 - LEP_FELCA

Protein

Leptin

Gene

LEP

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass By similarity.By similarity

    GO - Biological processi

    1. adipose tissue development Source: Ensembl
    2. adult feeding behavior Source: HGNC
    3. bile acid metabolic process Source: Ensembl
    4. central nervous system neuron development Source: Ensembl
    5. cholesterol metabolic process Source: Ensembl
    6. eating behavior Source: Ensembl
    7. glucose metabolic process Source: Ensembl
    8. hormone metabolic process Source: Ensembl
    9. insulin secretion Source: Ensembl
    10. negative regulation of appetite Source: HGNC
    11. negative regulation of glucagon secretion Source: Ensembl
    12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    13. placenta development Source: Ensembl
    14. positive regulation of developmental growth Source: Ensembl
    15. positive regulation of myeloid cell differentiation Source: Ensembl
    16. positive regulation of STAT protein import into nucleus Source: Ensembl
    17. regulation of fat cell differentiation Source: Ensembl
    18. regulation of gluconeogenesis Source: Ensembl
    19. regulation of insulin secretion Source: Ensembl
    20. regulation of intestinal cholesterol absorption Source: Ensembl
    21. regulation of protein phosphorylation Source: Ensembl
    22. regulation of steroid biosynthetic process Source: Ensembl
    23. response to dietary excess Source: Ensembl
    24. response to insulin Source: Ensembl
    25. tyrosine phosphorylation of STAT protein Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leptin
    Alternative name(s):
    Obesity factor
    Gene namesi
    Name:LEP
    Synonyms:OB
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Chromosome A2

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: HGNC

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Obesity

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 167146LeptinPRO_0000017682Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi117 ↔ 167By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000005951.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9N2C1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the leptin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45133.
    GeneTreeiENSGT00390000011772.
    HOGENOMiHOG000252923.
    HOVERGENiHBG007860.
    KOiK05424.
    OMAiTIVTRIN.
    OrthoDBiEOG77Q4Z3.
    TreeFamiTF105086.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000065. Leptin.
    [Graphical view]
    PANTHERiPTHR11724. PTHR11724. 1 hit.
    PfamiPF02024. Leptin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001837. Leptin. 1 hit.
    PRINTSiPR00495. LEPTIN.
    ProDomiPD005698. Leptin. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9N2C1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLCGPLCRFL WLWPYLSYVE AVPIRKVQDD TKTLIKTIVT RINDISHTQS    50
    VSSKQRVAGL DFIPGLHPVL SLSKMDQTLA IYQQILTGLP SRNVVQISND 100
    LENLRDLLHL LASSKNCPLP RARGLETLES LGGALEASLY STEVVALSRL 150
    QASLQDMLWR LDLSPGC 167
    Length:167
    Mass (Da):18,584
    Last modified:October 1, 2000 - v1
    Checksum:i643720DBB0AB4B95
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041360 mRNA. Translation: BAA95481.1.
    RefSeqiNP_001009850.1. NM_001009850.1.
    XP_006929412.1. XM_006929350.1.
    XP_006929413.1. XM_006929351.1.
    XP_006929414.1. XM_006929352.1.

    Genome annotation databases

    EnsembliENSFCAT00000006404; ENSFCAP00000005951; ENSFCAG00000006402.
    GeneIDi493838.
    KEGGifca:493838.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041360 mRNA. Translation: BAA95481.1 .
    RefSeqi NP_001009850.1. NM_001009850.1.
    XP_006929412.1. XM_006929350.1.
    XP_006929413.1. XM_006929351.1.
    XP_006929414.1. XM_006929352.1.

    3D structure databases

    ProteinModelPortali Q9N2C1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000005951.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSFCAT00000006404 ; ENSFCAP00000005951 ; ENSFCAG00000006402 .
    GeneIDi 493838.
    KEGGi fca:493838.

    Organism-specific databases

    CTDi 3952.

    Phylogenomic databases

    eggNOGi NOG45133.
    GeneTreei ENSGT00390000011772.
    HOGENOMi HOG000252923.
    HOVERGENi HBG007860.
    KOi K05424.
    OMAi TIVTRIN.
    OrthoDBi EOG77Q4Z3.
    TreeFami TF105086.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000065. Leptin.
    [Graphical view ]
    PANTHERi PTHR11724. PTHR11724. 1 hit.
    Pfami PF02024. Leptin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001837. Leptin. 1 hit.
    PRINTSi PR00495. LEPTIN.
    ProDomi PD005698. Leptin. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of feline leptin cDNA."
      Sasaki N., Iwase M., Kimura K., Ohishi I., Saito M.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: White adipose tissue.

    Entry informationi

    Entry nameiLEP_FELCA
    AccessioniPrimary (citable) accession number: Q9N2C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3