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Q9N2C1

- LEP_FELCA

UniProt

Q9N2C1 - LEP_FELCA

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Protein

Leptin

Gene
LEP, OB
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass By similarity.

GO - Biological processi

  1. adipose tissue development Source: Ensembl
  2. adult feeding behavior Source: HGNC
  3. bile acid metabolic process Source: Ensembl
  4. central nervous system neuron development Source: Ensembl
  5. cholesterol metabolic process Source: Ensembl
  6. eating behavior Source: Ensembl
  7. glucose metabolic process Source: Ensembl
  8. hormone metabolic process Source: Ensembl
  9. insulin secretion Source: Ensembl
  10. negative regulation of appetite Source: HGNC
  11. negative regulation of glucagon secretion Source: Ensembl
  12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. placenta development Source: Ensembl
  14. positive regulation of developmental growth Source: Ensembl
  15. positive regulation of myeloid cell differentiation Source: Ensembl
  16. positive regulation of STAT protein import into nucleus Source: Ensembl
  17. regulation of fat cell differentiation Source: Ensembl
  18. regulation of gluconeogenesis Source: Ensembl
  19. regulation of insulin secretion Source: Ensembl
  20. regulation of intestinal cholesterol absorption Source: Ensembl
  21. regulation of protein phosphorylation Source: Ensembl
  22. regulation of steroid biosynthetic process Source: Ensembl
  23. response to dietary excess Source: Ensembl
  24. response to insulin Source: Ensembl
  25. tyrosine phosphorylation of STAT protein Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin
Alternative name(s):
Obesity factor
Gene namesi
Name:LEP
Synonyms:OB
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Chromosome A2

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 167146LeptinPRO_0000017682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi117 ↔ 167 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000005951.

Structurei

3D structure databases

ProteinModelPortaliQ9N2C1.

Family & Domainsi

Sequence similaritiesi

Belongs to the leptin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45133.
GeneTreeiENSGT00390000011772.
HOGENOMiHOG000252923.
HOVERGENiHBG007860.
KOiK05424.
OMAiTIVTRIN.
OrthoDBiEOG77Q4Z3.
TreeFamiTF105086.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000065. Leptin.
[Graphical view]
PANTHERiPTHR11724. PTHR11724. 1 hit.
PfamiPF02024. Leptin. 1 hit.
[Graphical view]
PIRSFiPIRSF001837. Leptin. 1 hit.
PRINTSiPR00495. LEPTIN.
ProDomiPD005698. Leptin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N2C1-1 [UniParc]FASTAAdd to Basket

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MLCGPLCRFL WLWPYLSYVE AVPIRKVQDD TKTLIKTIVT RINDISHTQS    50
VSSKQRVAGL DFIPGLHPVL SLSKMDQTLA IYQQILTGLP SRNVVQISND 100
LENLRDLLHL LASSKNCPLP RARGLETLES LGGALEASLY STEVVALSRL 150
QASLQDMLWR LDLSPGC 167
Length:167
Mass (Da):18,584
Last modified:October 1, 2000 - v1
Checksum:i643720DBB0AB4B95
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041360 mRNA. Translation: BAA95481.1.
RefSeqiNP_001009850.1. NM_001009850.1.
XP_006929412.1. XM_006929350.1.
XP_006929413.1. XM_006929351.1.
XP_006929414.1. XM_006929352.1.

Genome annotation databases

EnsembliENSFCAT00000006404; ENSFCAP00000005951; ENSFCAG00000006402.
GeneIDi493838.
KEGGifca:493838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041360 mRNA. Translation: BAA95481.1 .
RefSeqi NP_001009850.1. NM_001009850.1.
XP_006929412.1. XM_006929350.1.
XP_006929413.1. XM_006929351.1.
XP_006929414.1. XM_006929352.1.

3D structure databases

ProteinModelPortali Q9N2C1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000005951.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSFCAT00000006404 ; ENSFCAP00000005951 ; ENSFCAG00000006402 .
GeneIDi 493838.
KEGGi fca:493838.

Organism-specific databases

CTDi 3952.

Phylogenomic databases

eggNOGi NOG45133.
GeneTreei ENSGT00390000011772.
HOGENOMi HOG000252923.
HOVERGENi HBG007860.
KOi K05424.
OMAi TIVTRIN.
OrthoDBi EOG77Q4Z3.
TreeFami TF105086.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000065. Leptin.
[Graphical view ]
PANTHERi PTHR11724. PTHR11724. 1 hit.
Pfami PF02024. Leptin. 1 hit.
[Graphical view ]
PIRSFi PIRSF001837. Leptin. 1 hit.
PRINTSi PR00495. LEPTIN.
ProDomi PD005698. Leptin. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of feline leptin cDNA."
    Sasaki N., Iwase M., Kimura K., Ohishi I., Saito M.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: White adipose tissue.

Entry informationi

Entry nameiLEP_FELCA
AccessioniPrimary (citable) accession number: Q9N2C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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