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Q9N2C1 (LEP_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leptin
Alternative name(s):
Obesity factor
Gene names
Name:LEP
Synonyms:OB
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass By similarity.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the leptin family.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseObesity
   DomainSignal
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadipose tissue development

Inferred from electronic annotation. Source: Ensembl

adult feeding behavior

Inferred from sequence or structural similarity. Source: HGNC

bile acid metabolic process

Inferred from electronic annotation. Source: Ensembl

central nervous system neuron development

Inferred from electronic annotation. Source: Ensembl

cholesterol metabolic process

Inferred from electronic annotation. Source: Ensembl

eating behavior

Inferred from electronic annotation. Source: Ensembl

glucose metabolic process

Inferred from electronic annotation. Source: Ensembl

hormone metabolic process

Inferred from electronic annotation. Source: Ensembl

insulin secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of appetite

Inferred from sequence or structural similarity. Source: HGNC

negative regulation of glucagon secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

placenta development

Inferred from electronic annotation. Source: Ensembl

positive regulation of STAT protein import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of developmental growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of myeloid cell differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of fat cell differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of gluconeogenesis

Inferred from electronic annotation. Source: Ensembl

regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

regulation of intestinal cholesterol absorption

Inferred from electronic annotation. Source: Ensembl

regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

regulation of steroid biosynthetic process

Inferred from electronic annotation. Source: Ensembl

response to dietary excess

Inferred from electronic annotation. Source: Ensembl

response to insulin

Inferred from electronic annotation. Source: Ensembl

tyrosine phosphorylation of STAT protein

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from sequence or structural similarity. Source: HGNC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 167146Leptin
PRO_0000017682

Amino acid modifications

Disulfide bond117 ↔ 167 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9N2C1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 643720DBB0AB4B95

FASTA16718,584
        10         20         30         40         50         60 
MLCGPLCRFL WLWPYLSYVE AVPIRKVQDD TKTLIKTIVT RINDISHTQS VSSKQRVAGL 

        70         80         90        100        110        120 
DFIPGLHPVL SLSKMDQTLA IYQQILTGLP SRNVVQISND LENLRDLLHL LASSKNCPLP 

       130        140        150        160 
RARGLETLES LGGALEASLY STEVVALSRL QASLQDMLWR LDLSPGC 

« Hide

References

[1]"Molecular cloning of feline leptin cDNA."
Sasaki N., Iwase M., Kimura K., Ohishi I., Saito M.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: White adipose tissue.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB041360 mRNA. Translation: BAA95481.1.
RefSeqNP_001009850.1. NM_001009850.1.

3D structure databases

ProteinModelPortalQ9N2C1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9685.ENSFCAP00000005951.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSFCAT00000006404; ENSFCAP00000005951; ENSFCAG00000006402.
GeneID493838.
KEGGfca:493838.

Organism-specific databases

CTD3952.

Phylogenomic databases

eggNOGNOG45133.
GeneTreeENSGT00390000011772.
HOGENOMHOG000252923.
HOVERGENHBG007860.
KOK05424.
OMAKTIVTRI.
OrthoDBEOG77Q4Z3.
TreeFamTF105086.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000065. Leptin.
[Graphical view]
PANTHERPTHR11724. PTHR11724. 1 hit.
PfamPF02024. Leptin. 1 hit.
[Graphical view]
PIRSFPIRSF001837. Leptin. 1 hit.
PRINTSPR00495. LEPTIN.
ProDomPD005698. Leptin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLEP_FELCA
AccessionPrimary (citable) accession number: Q9N2C1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families