Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ornithine carbamoyltransferase, mitochondrial

Gene

OTC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Enzyme regulationi

Negatively regulated by lysine acetylation.By similarity

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-citrulline from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine carbamoyltransferase, mitochondrial (OTC)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-citrulline from L-ornithine and carbamoyl phosphate, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei263 – 2631By similarity
Active sitei303 – 3031By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle

Enzyme and pathway databases

SABIO-RKQ9N1U7.
UniPathwayiUPA00158; UER00271.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase, mitochondrial (EC:2.1.3.3)
Alternative name(s):
Ornithine transcarbamylase
Short name:
OTCase
Gene namesi
Name:OTC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232MitochondrionBy similarityAdd
BLAST
Chaini33 – 354322Ornithine carbamoyltransferase, mitochondrialPRO_0000245026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701N6-acetyllysine; alternateBy similarity
Modified residuei70 – 701N6-succinyllysine; alternateBy similarity
Modified residuei80 – 801N6-succinyllysineBy similarity
Modified residuei88 – 881N6-acetyllysine; alternateBy similarity
Modified residuei88 – 881N6-succinyllysine; alternateBy similarity
Modified residuei133 – 1331PhosphoserineBy similarity
Modified residuei144 – 1441N6-acetyllysine; alternateBy similarity
Modified residuei144 – 1441N6-succinyllysine; alternateBy similarity
Modified residuei221 – 2211N6-acetyllysine; alternateBy similarity
Modified residuei221 – 2211N6-succinyllysine; alternateBy similarity
Modified residuei231 – 2311N6-acetyllysine; alternateBy similarity
Modified residuei231 – 2311N6-succinyllysine; alternateBy similarity
Modified residuei238 – 2381N6-acetyllysine; alternateBy similarity
Modified residuei238 – 2381N6-succinyllysine; alternateBy similarity
Modified residuei243 – 2431N6-acetyllysineBy similarity
Modified residuei274 – 2741N6-succinyllysineBy similarity
Modified residuei289 – 2891N6-succinyllysineBy similarity
Modified residuei292 – 2921N6-acetyllysine; alternateBy similarity
Modified residuei292 – 2921N6-succinyllysine; alternateBy similarity
Modified residuei307 – 3071N6-acetyllysine; alternateBy similarity
Modified residuei307 – 3071N6-succinyllysine; alternateBy similarity

Post-translational modificationi

Acetylation at Lys-88 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9N1U7.
PeptideAtlasiQ9N1U7.
PRIDEiQ9N1U7.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001947.

Structurei

3D structure databases

ProteinModelPortaliQ9N1U7.
SMRiQ9N1U7. Positions 34-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1504. Eukaryota.
COG0078. LUCA.
HOGENOMiHOG000022686.
HOVERGENiHBG007881.
InParanoidiQ9N1U7.
KOiK00611.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N1U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFHLRTLLN NAALRNGHNF VVRNFRCGQP LQDKVQLKGR DLLTLKNFTG
60 70 80 90 100
EEIKYMLWLS ADLKFRIKQK GEYLPLLQGK SLGMIFEKRS TRTRLSTETG
110 120 130 140 150
FALLGGHPCF LTTDDIHLGV NESLTDTARV LSSMTDAVLA RVYKQSDLDL
160 170 180 190 200
LAKEASIPIV NGLSDLYHPI QILADYLTLQ EHYGSLKGLT LSWIGDGNNI
210 220 230 240 250
LHSIMMSAAK FGMHLQVATP KGYEPDPSIT KMAEQYAKEN GTKLSLTNDP
260 270 280 290 300
LEAACGGNVL ITDTWISMGQ EEEKKKRLQA FQGYQVTMKT AKVAAPDWTF
310 320 330 340 350
LHCLPRKPEE VDDEVFYSPR SLVSPEAENR KWTIMAVMVS LLTDYSPQLQ

KPKF
Length:354
Mass (Da):39,842
Last modified:October 1, 2000 - v1
Checksum:i30EAC2EF4AC1D71B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134841 mRNA. Translation: AAF61405.1.
RefSeqiNP_803453.1. NM_177487.2.
UniGeneiBt.4269.

Genome annotation databases

GeneIDi280887.
KEGGibta:280887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134841 mRNA. Translation: AAF61405.1.
RefSeqiNP_803453.1. NM_177487.2.
UniGeneiBt.4269.

3D structure databases

ProteinModelPortaliQ9N1U7.
SMRiQ9N1U7. Positions 34-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001947.

Proteomic databases

PaxDbiQ9N1U7.
PeptideAtlasiQ9N1U7.
PRIDEiQ9N1U7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280887.
KEGGibta:280887.

Organism-specific databases

CTDi5009.

Phylogenomic databases

eggNOGiKOG1504. Eukaryota.
COG0078. LUCA.
HOGENOMiHOG000022686.
HOVERGENiHBG007881.
InParanoidiQ9N1U7.
KOiK00611.

Enzyme and pathway databases

UniPathwayiUPA00158; UER00271.
SABIO-RKQ9N1U7.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Ornithine transcarbamylase is expressed in uricotelic animals."
    Shimogiri T., Koyanagi K., Mannen H., Tsuji S.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiOTC_BOVIN
AccessioniPrimary (citable) accession number: Q9N1U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.