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Protein

Calcium-binding protein 1

Gene

CABP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi94MagnesiumBy similarity1
Metal bindingi96MagnesiumBy similarity1
Metal bindingi98MagnesiumBy similarity1
Metal bindingi100Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi171Calcium 1By similarity1
Metal bindingi173Calcium 1By similarity1
Metal bindingi175Calcium 1By similarity1
Metal bindingi177Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi182Calcium 1By similarity1
Metal bindingi208Calcium 2By similarity1
Metal bindingi209Calcium 2; via amide nitrogenBy similarity1
Metal bindingi210Calcium 2By similarity1
Metal bindingi212Calcium 2By similarity1
Metal bindingi213Calcium 2; via amide nitrogenBy similarity1
Metal bindingi214Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi216Calcium 2By similarity1
Metal bindingi219Calcium 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi94 – 1051PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi171 – 1822PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi208 – 2193PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSensory transduction, Vision
LigandCalcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 1
Short name:
CaBP1
Gene namesi
Name:CABP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:53893 CABP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000735122 – 226Calcium-binding protein 1Add BLAST225
Isoform S-CaBP1 (identifier: Q9N1R0-2)
Initiator methionineiRemovedBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi4S-palmitoyl cysteineBy similarity1
Modified residuei179PhosphoserineBy similarity1
Isoform S-CaBP1 (identifier: Q9N1R0-2)
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi4S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Phosphorylated. The phosphorylation regulates the activity (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ9N1R0
PRIDEiQ9N1R0

Expressioni

Gene expression databases

BgeeiENSBTAG00000020049

Interactioni

Subunit structurei

Homodimer. Interacts (via C-terminus) with ITPR1, ITPR2 and ITPR3. This binding is calcium dependent and the interaction correlates with calcium concentration. An additional calcium-independent interaction with the N-terminus of ITPR1 results in a decreased InsP3 binding to the receptor (By similarity). Interacts with CACNA1A (via C-terminal CDB motif) in the pre- and postsynaptic membranes (By similarity). Interacts with CACNA1C (via C-terminal C and IQ motifs). Interacts with CACNA1D (By similarity). The binding to the C motif is calcium independent whereas the binding to IQ requires the presence of calcium and is mutually exclusive with calmodulin binding (By similarity). Interacts with TRPC5 (via C-terminus) (By similarity). Interacts (via EF-hands 1 and 2) at microtubules with MAP1LC3B (By similarity). Interacts with MYO1C (By similarity). Interacts (via EF-hands 1 and 2) with NSMF (via the central NLS-containing motif region), the interaction occurs in a calcium dependent manner after synaptic NMDA receptor stimulation and prevents nuclear import of NSMF. Interacts with SPACA9 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026714

Structurei

3D structure databases

ProteinModelPortaliQ9N1R0
SMRiQ9N1R0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 116EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 152EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini158 – 193EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini195 – 226EF-hand 4PROSITE-ProRule annotationAdd BLAST32

Domaini

EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively and EF-2 binds neither calcium nor magnesium.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ9N1R0
OMAiNVLGPAC
OrthoDBiEOG091G0PB4
TreeFamiTF334804

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform L-CaBP1 (identifier: Q9N1R0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNCVKSPLR NLSRKMRQEE TSYTVVQTSE EGLAASGELP GPLLMLAQNC
60 70 80 90 100
AVMHNLLGPA CIFLRKGFAE NRQPDRSLRP EEIEELREAF REFDKDKDGY
110 120 130 140 150
INCRDLGNCM RTMGYMPTEM ELIELSQQIN MNLGGHVDFD DFVELMGPKL
160 170 180 190 200
LAETADMIGV KELRDAFREF DTNGDGEIST SELREAMRKL LGHQVGHRDI
210 220
EEIIRDVDLN GDGRVDFEEF VRMMSR
Length:226
Mass (Da):25,755
Last modified:January 23, 2007 - v3
Checksum:iBC1AF2D62FDF9F02
GO
Isoform S-CaBP1 (identifier: Q9N1R0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-74: Missing.

Show »
Length:167
Mass (Da):19,354
Checksum:i3C65D1F2C4338AF3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00073016 – 74Missing in isoform S-CaBP1. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169151 mRNA Translation: AAF25785.1
AF169150 mRNA Translation: AAF25784.1
RefSeqiNP_776679.1, NM_174254.2 [Q9N1R0-1]
UniGeneiBt.243

Genome annotation databases

EnsembliENSBTAT00000026714; ENSBTAP00000026714; ENSBTAG00000020049 [Q9N1R0-1]
ENSBTAT00000044919; ENSBTAP00000042361; ENSBTAG00000020049 [Q9N1R0-2]
GeneIDi281653
KEGGibta:281653

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCABP1_BOVIN
AccessioniPrimary (citable) accession number: Q9N1R0
Secondary accession number(s): Q9N1R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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