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Protein

Calcium-binding protein 5

Gene

CABP5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi41 – 521PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi118 – 1292PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi155 – 1663PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 5
Short name:
CaBP5
Gene namesi
Name:CABP5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:26667 CABP5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735231 – 173Calcium-binding protein 5Add BLAST173

Proteomic databases

PaxDbiQ9N1Q8
PRIDEiQ9N1Q8

Interactioni

Subunit structurei

Interacts with CACNA1C (via C-terminal CDB motif) in a calcium-dependent manner.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021449

Structurei

3D structure databases

ProteinModelPortaliQ9N1Q8
SMRiQ9N1Q8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 63EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini64 – 99EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini105 – 140EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini142 – 173EF-hand 4PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ9N1Q8
OMAiAFNEFDK
OrthoDBiEOG091G0PB4
TreeFamiTF334804

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q9N1Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFPMGPACI FLRKGIAEKQ RERPLGPDEI EELREAFLEF DKDRDGFISC
60 70 80 90 100
KDLGNLMRTM GYMPTEMELI ELGQQIRMNL GGRVDFDDFV ELMTPKLLAE
110 120 130 140 150
TAGMIGVQEM RDAFKEFDAN GDGEITLGEL QQAMQRLLGD KLTSQEISEV
160 170
VQEADINGDG TVDFEEFVKM MSR
Length:173
Mass (Da):19,628
Last modified:October 1, 2000 - v1
Checksum:iC76D75BF4D3214A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169160 mRNA Translation: AAF25794.1
RefSeqiNP_777153.1, NM_174728.2
UniGeneiBt.245

Genome annotation databases

EnsembliENSBTAT00000021449; ENSBTAP00000021449; ENSBTAG00000016114
GeneIDi282715
KEGGibta:282715

Similar proteinsi

Entry informationi

Entry nameiCABP5_BOVIN
AccessioniPrimary (citable) accession number: Q9N1Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health