Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcium-binding protein 5

Gene

CABP5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi41 – 52121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi118 – 129122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi155 – 166123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 5
Short name:
CaBP5
Gene namesi
Name:CABP5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Calcium-binding protein 5PRO_0000073523Add
BLAST

Proteomic databases

PaxDbiQ9N1Q8.

Interactioni

Subunit structurei

Interacts with CACNA1C (via C-terminal CDB motif) in a calcium-dependent manner.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021449.

Structurei

3D structure databases

ProteinModelPortaliQ9N1Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 6336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini64 – 9936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini105 – 14036EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini142 – 17332EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9N1Q8.
OMAiTEMELTE.
OrthoDBiEOG7XM303.
TreeFamiTF334804.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9N1Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFPMGPACI FLRKGIAEKQ RERPLGPDEI EELREAFLEF DKDRDGFISC
60 70 80 90 100
KDLGNLMRTM GYMPTEMELI ELGQQIRMNL GGRVDFDDFV ELMTPKLLAE
110 120 130 140 150
TAGMIGVQEM RDAFKEFDAN GDGEITLGEL QQAMQRLLGD KLTSQEISEV
160 170
VQEADINGDG TVDFEEFVKM MSR
Length:173
Mass (Da):19,628
Last modified:October 1, 2000 - v1
Checksum:iC76D75BF4D3214A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169160 mRNA. Translation: AAF25794.1.
RefSeqiNP_777153.1. NM_174728.2.
UniGeneiBt.245.

Genome annotation databases

EnsembliENSBTAT00000021449; ENSBTAP00000021449; ENSBTAG00000016114.
GeneIDi282715.
KEGGibta:282715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169160 mRNA. Translation: AAF25794.1.
RefSeqiNP_777153.1. NM_174728.2.
UniGeneiBt.245.

3D structure databases

ProteinModelPortaliQ9N1Q8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021449.

Proteomic databases

PaxDbiQ9N1Q8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021449; ENSBTAP00000021449; ENSBTAG00000016114.
GeneIDi282715.
KEGGibta:282715.

Organism-specific databases

CTDi56344.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9N1Q8.
OMAiTEMELTE.
OrthoDBiEOG7XM303.
TreeFamiTF334804.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin."
    Haeseleer F., Sokal I., Verlinde C.L.M.J., Erdjument-Bromage H., Tempst P., Pronin A.N., Benovic J.L., Fariss R.N., Palczewski K.
    J. Biol. Chem. 275:1247-1260(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Retina.

Entry informationi

Entry nameiCABP5_BOVIN
AccessioniPrimary (citable) accession number: Q9N1Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.