Reviewed, UniProtKB/Swiss-Prot Q9N181 (NMT2_BOVIN)

Names and origin

Protein names

Recommended name:
    Glycylpeptide N-tetradecanoyltransferase 2
    EC=2.3.1.97
Alternative name(s):
    Peptide N-myristoyltransferase 2
    Myristoyl-CoA:protein N-myristoyltransferase 2
      Short name=NMT 2
    Type II N-myristoyltransferase

Gene names

Name:

NMT2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins By similarity.
Catalytic activity	Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NMT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	N-terminal protein myristoylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycylpeptide N-tetradecanoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 498	498	Glycylpeptide N-tetradecanoyltransferase 2		PRO_0000064225
Regions
	Compositional bias	46 – 56	11	Poly-Lys
Amino acid modifications
	Modified residue	66	1	Phosphoserine By similarity
	Modified residue	68	1	Phosphoserine By similarity
	Modified residue	70	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9N181-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D3ECB34B98CA4D67	FASTA	498	56,803
	10 20 30 40 50 60 MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GDLGAKKKKK KQKRKKEKPN 70 80 90 100 110 120 SGGTKSDSAS DSQEIKIQPP SKNSTIPVQK LQDIQRAMEL LSACQGPARN IDEAAKHRYQ 130 140 150 160 170 180 FWDTQPVPKL NEVITSHGAI EADKENVRQE PYSLPQGFMW DTLDLGNAEV LRELYTLLNE 190 200 210 220 230 240 NYVEDDDNMF RFDYSPEFLL WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS 250 260 270 280 290 300 VKKMVEINFL CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPVATCRYWH 310 320 330 340 350 360 RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDATKTSGL RPMEPRDIKA VQELTNTYLK 370 380 390 400 410 420 QFHLAPVMDE EEVAHWFLPQ EHIIDTFVVE NSSGKLTDFL SFYTLPSTVM HHPAHKSLKA 430 440 450 460 470 480 AYSFYNIHTE TPLLDLMSDA LIIAKLKGFD VFNALDLMEN KTFLEKLKFG IGDGNLQYYL 490 YNWRCPGTES EKVGLVLQ

References

[1]	"Bovine retina type II N-myristoyltransferase." Rundle D.R., Alvarez R.A., Anderson R.E. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF222687 mRNA. Translation: AAF31456.1.
IPI	IPI00686656.
RefSeq	NP_776881.1.
UniGene	Bt.249
3D structure databases
HSSP	HSSP built from PDB template 1NMT based on UniProtKB P30418.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000050460; ENSBTAP00000047156; ENSBTAG00000007703; Bos taurus. [Genome view]
GeneID	282049.
KEGG	bta:282049.
Organism-specific databases
CTD	282049.
Phylogenomic databases
HOVERGEN	Q9N181.
Enzyme and pathway databases
BRENDA	2.3.1.97. 251.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000903. Myristoyl_trans. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 2 hits.
PANTHER	PTHR11377. Myristoyl_trans. 1 hit.
Pfam	PF01233. NMT. 1 hit. PF02799. NMT_C. 1 hit. [Graphical view]
PIRSF	PIRSF015892. N-myristl_transf. 1 hit.
PROSITE	PS00975. NMT_1. 1 hit. PS00976. NMT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NMT2_BOVIN

Accession

Primary (citable) accession number: Q9N181

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	October 1, 2000
Last modified:	September 1, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)