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Protein

Retinol dehydrogenase 8

Gene

RDH8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.1 Publication

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143SubstrateSequence analysis1
Active sitei156Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 18NADPBy similarity10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processSensory transduction, Vision
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 8 (EC:1.1.1.300)
Alternative name(s):
Photoreceptor outer segment all-trans retinol dehydrogenase
Gene namesi
Name:RDH8
Synonyms:PRRDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:52817 RDH8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003059711 – 312Retinol dehydrogenase 8Add BLAST312

Proteomic databases

PaxDbiQ9N126
PRIDEiQ9N126

Expressioni

Tissue specificityi

Detected in photoreceptor outer segments in the retina (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013443

Structurei

3D structure databases

ProteinModelPortaliQ9N126
SMRiQ9N126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00920000148940
HOVERGENiHBG014077
InParanoidiQ9N126
KOiK11150
OMAiQRYQVVA
OrthoDBiEOG091G0BYI
TreeFamiTF105451

Family and domain databases

InterProiView protein in InterPro
IPR011348 17beta_DH
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PIRSFiPIRSF000095 17beta-HSD, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9N126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAPRTVLI SGCSSGIGLE LAVQLAHDPR QRYQVVATMR DLGKKGTLET
60 70 80 90 100
AAGEALGQTL TVAQLDVCSD ESVAQCLNCI QGGEVDVLVN NAGVGLVGPL
110 120 130 140 150
EGLSLAAMQN VFDTNFFGAV RLVKAVLPSM KRRRQGHIVV VSSVMGLQGV
160 170 180 190 200
VFNEVYAASK FAMEGFFESL AVQLLQFNIF ISLVEPGPVV TEFEGKLLEQ
210 220 230 240 250
VSTAEFPGTD PDTLSYFRDL YLPASRELFH NVGQSPQDVA KVIVKVIGSA
260 270 280 290 300
RPPLRRRTNT RYTPLIALKA MDPSGSLYVR TSHCLLFRWP RLLNLGLRCL
310
ACSCFRTPVW PR
Length:312
Mass (Da):33,956
Last modified:October 1, 2000 - v1
Checksum:i36481039FF71874D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229846 mRNA Translation: AAF63161.1
RefSeqiNP_776592.1, NM_174167.2
UniGeneiBt.266

Genome annotation databases

EnsembliENSBTAT00000013443; ENSBTAP00000013443; ENSBTAG00000010188
GeneIDi281449
KEGGibta:281449

Similar proteinsi

Entry informationi

Entry nameiRDH8_BOVIN
AccessioniPrimary (citable) accession number: Q9N126
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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