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Protein

Retinol dehydrogenase 8

Gene

RDH8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.1 Publication

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143SubstrateSequence analysis1
Active sitei156Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 18NADPBy similarity10

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-BTA-2453902. The canonical retinoid cycle in rods (twilight vision).

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 8 (EC:1.1.1.300)
Alternative name(s):
Photoreceptor outer segment all-trans retinol dehydrogenase
Gene namesi
Name:RDH8
Synonyms:PRRDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003059711 – 312Retinol dehydrogenase 8Add BLAST312

Proteomic databases

PaxDbiQ9N126.
PRIDEiQ9N126.

Expressioni

Tissue specificityi

Detected in photoreceptor outer segments in the retina (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013443.

Structurei

3D structure databases

ProteinModelPortaliQ9N126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00860000133667.
HOVERGENiHBG014077.
InParanoidiQ9N126.
KOiK11150.
OMAiQRYQVVA.
OrthoDBiEOG091G0BYI.
TreeFamiTF105451.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011348. 17beta_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9N126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAPRTVLI SGCSSGIGLE LAVQLAHDPR QRYQVVATMR DLGKKGTLET
60 70 80 90 100
AAGEALGQTL TVAQLDVCSD ESVAQCLNCI QGGEVDVLVN NAGVGLVGPL
110 120 130 140 150
EGLSLAAMQN VFDTNFFGAV RLVKAVLPSM KRRRQGHIVV VSSVMGLQGV
160 170 180 190 200
VFNEVYAASK FAMEGFFESL AVQLLQFNIF ISLVEPGPVV TEFEGKLLEQ
210 220 230 240 250
VSTAEFPGTD PDTLSYFRDL YLPASRELFH NVGQSPQDVA KVIVKVIGSA
260 270 280 290 300
RPPLRRRTNT RYTPLIALKA MDPSGSLYVR TSHCLLFRWP RLLNLGLRCL
310
ACSCFRTPVW PR
Length:312
Mass (Da):33,956
Last modified:October 1, 2000 - v1
Checksum:i36481039FF71874D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229846 mRNA. Translation: AAF63161.1.
RefSeqiNP_776592.1. NM_174167.2.
UniGeneiBt.266.

Genome annotation databases

EnsembliENSBTAT00000013443; ENSBTAP00000013443; ENSBTAG00000010188.
GeneIDi281449.
KEGGibta:281449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229846 mRNA. Translation: AAF63161.1.
RefSeqiNP_776592.1. NM_174167.2.
UniGeneiBt.266.

3D structure databases

ProteinModelPortaliQ9N126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013443.

Proteomic databases

PaxDbiQ9N126.
PRIDEiQ9N126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013443; ENSBTAP00000013443; ENSBTAG00000010188.
GeneIDi281449.
KEGGibta:281449.

Organism-specific databases

CTDi50700.

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00860000133667.
HOVERGENiHBG014077.
InParanoidiQ9N126.
KOiK11150.
OMAiQRYQVVA.
OrthoDBiEOG091G0BYI.
TreeFamiTF105451.

Enzyme and pathway databases

ReactomeiR-BTA-2453902. The canonical retinoid cycle in rods (twilight vision).

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011348. 17beta_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRDH8_BOVIN
AccessioniPrimary (citable) accession number: Q9N126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.