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Q9N0Z6

- AT1A1_RABIT

UniProt

Q9N0Z6 - AT1A1_RABIT

Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

ATP1A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients By similarity. May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na+/H+ exchange.By similarity1 Publication

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei376 – 37614-aspartylphosphate intermediateBy similarity
    Binding sitei487 – 4871ATPBy similarity
    Metal bindingi717 – 7171MagnesiumBy similarity
    Metal bindingi721 – 7211MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro
    2. regulation of sodium ion transport Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha-1 subunit
    Alternative name(s):
    Sodium pump subunit alpha-1
    Gene namesi
    Name:ATP1A1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 55By similarityPRO_0000305979
    Chaini6 – 10231018Sodium/potassium-transporting ATPase subunit alpha-1By similarityPRO_0000305980Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91N6-acetyllysineBy similarity
    Modified residuei10 – 101PhosphotyrosineBy similarity
    Modified residuei16 – 161Phosphoserine; by PKCBy similarity
    Modified residuei21 – 211N6-acetyllysineBy similarity
    Modified residuei260 – 2601PhosphotyrosineBy similarity
    Modified residuei542 – 5421PhosphotyrosineBy similarity
    Modified residuei661 – 6611N6-succinyllysineBy similarity
    Modified residuei943 – 9431Phosphoserine; by PKABy similarity

    Post-translational modificationi

    Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ9N0Z6.

    Expressioni

    Tissue specificityi

    Expressed in endocardial endothelial cells.1 Publication

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma. Interacts with SIK1 By similarity. Interacts with SLC35G1 and STIM1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000024821.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9N0Z6.
    SMRiQ9N0Z6. Positions 26-1023.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini6 – 8782CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini109 – 13123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini153 – 288136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini309 – 32012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini339 – 772434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini793 – 80210ExtracellularSequence Analysis
    Topological domaini824 – 84320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini867 – 91852ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini939 – 95113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini971 – 98515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1007 – 102317CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei289 – 30820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei321 – 33818HelicalSequence AnalysisAdd
    BLAST
    Transmembranei773 – 79220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei803 – 82321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei844 – 86623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei919 – 93820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei952 – 97019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei986 – 100621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni82 – 843Phosphoinositide-3 kinase bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOGENOMiHOG000265622.
    HOVERGENiHBG004298.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9N0Z6-1 [UniParc]FASTAAdd to Basket

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    MGKGVGRDKY EPAAVSEHGD KKGKKAKKER DMDELKKEVS MDDHKLSLDE     50
    LHRKYGTDLS RGLTTARAAE ILARDGPNAL TPPPTTPEWV KFCRQLFGGF 100
    SMLLWIGAIL CFLAYGILAA TEEDFDNDNL YLGVVLAAVV IITGCFSYYQ 150
    EAKSSKIMES FKNMVPQQAL VIRNGEKMSI NAEDVVVGDL VEVKGGDRIP 200
    ADLRIISANG CKVDNSSLTG ESEPQTRSPD FTNENPLETR NIAFFSTNCV 250
    EGTARGIVIY TGDRTVMGRI ATLASGLEGG QTPIAAEIEH FIHIITGVAV 300
    FLGVSFFILS LILEYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR 350
    MARKNCLVKN LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA 400
    DTTENQSGVS FDKTSATWLA LSRIAGLCNR AVFQANQENL PILKRAVAGD 450
    ASESALLKCI ELCCGSVKEM RERYTKIVEI PFNSTNKYQL SIHKNLNANE 500
    PRHLLVMKGA PERILDRCSS ILLHGKEQPL DEELKDAFQN AYLELGGLGE 550
    RVLGFCHLLL PDEQFPEGFQ FDTDEVNFPV DNLCFIGLIS MIDPPRAAVP 600
    DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI 650
    PVSQVNPRDA KACVVHGSDL KDMTSEQLDD ILKYHTEIVF ARTSPQQKLI 700
    IVEGCQRQGA IVAVTGDGVN DSPALKKADI GVAMGIAGSD VSKQAADMIL 750
    LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEITPF LIFIIANIPL 800
    PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK TDKLVNERLI 850
    SMAYGQIGMI QALGGFFTYF VILAENGFLP FHLLGIRVDW DDRWINDVED 900
    SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR RNSVFQQGMK 950
    NKILIFGLFE ETALAAFLSY CPGMGVALRM YPLKPTWWFC AFPYSLLIFV 1000
    YDEIRKLIIR RRPGGWVEKE TYY 1023
    Length:1,023
    Mass (Da):112,994
    Last modified:March 1, 2004 - v2
    Checksum:iF6BA59C8979F574D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF235024 mRNA. Translation: AAF60310.2.
    RefSeqiNP_001156546.1. NM_001163074.1.
    UniGeneiOcu.2457.

    Genome annotation databases

    GeneIDi100302415.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF235024 mRNA. Translation: AAF60310.2 .
    RefSeqi NP_001156546.1. NM_001163074.1.
    UniGenei Ocu.2457.

    3D structure databases

    ProteinModelPortali Q9N0Z6.
    SMRi Q9N0Z6. Positions 26-1023.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000024821.

    Proteomic databases

    PRIDEi Q9N0Z6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100302415.

    Organism-specific databases

    CTDi 476.

    Phylogenomic databases

    eggNOGi COG0474.
    HOGENOMi HOG000265622.
    HOVERGENi HBG004298.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distribution and role of Na(+)/K(+) ATPase in endocardial endothelium."
      Fransen P., Hendrickx J., Brutsaert D.L., Sys S.U.
      Cardiovasc. Res. 52:487-499(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiAT1A1_RABIT
    AccessioniPrimary (citable) accession number: Q9N0Z6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3