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Protein

C-X-C chemokine receptor type 6

Gene

CXCR6

Organism
Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 6
Short name:
CXC-R6
Short name:
CXCR-6
Alternative name(s):
G-protein coupled receptor STRL33
G-protein coupled receptor bonzo
CD_antigen: CD186
Gene namesi
Name:CXCR6
Synonyms:BONZO, STRL33
OrganismiCercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
Taxonomic identifieri9531 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeCercocebus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence analysisAdd
BLAST
Transmembranei34 – 6027Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini61 – 699CytoplasmicSequence analysis
Transmembranei70 – 9021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 10414ExtracellularSequence analysisAdd
BLAST
Transmembranei105 – 12622Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini127 – 14418CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini166 – 18823ExtracellularSequence analysisAdd
BLAST
Transmembranei189 – 21628Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 23216CytoplasmicSequence analysisAdd
BLAST
Transmembranei233 – 26028Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27616ExtracellularSequence analysisAdd
BLAST
Transmembranei277 – 29418Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini295 – 34349CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343C-X-C chemokine receptor type 6PRO_0000069364Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi103 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9N0Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106917.

Family and domain databases

InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9N0Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEYDHYEDD EFFNSFNDSS QKEHQDFLQF SKVFLPCMYL VVFVCGLVGN
60 70 80 90 100
SLVLVISIFY HKLQSLTDVF LVNLPLADLV FVCTLPFWAY AGIHEWIFGQ
110 120 130 140 150
VMCKTLLGVY TINFYTSMLI LTCITVDRFI VVVKATKAYN QQAKRMTWGK
160 170 180 190 200
VICLLIWVIS LLVSLPQIIY GNVFNLDKLI CRYHDEEIST VVLATQMTLG
210 220 230 240 250
FFLPLLTMIV CYSVIIKTLL HAGGFQKHRS LKIIFLVMAV FLLTQTPFNL
260 270 280 290 300
VKLIRSTHWE YYAMTSFHYT IIVTEAIAYL RACLNPVLYA FVSLKFRKNF
310 320 330 340
WKLVKDIGCL PYLGVSHQWK SSEDNSKTFS ASHNVEATSM FQL
Length:343
Mass (Da):39,589
Last modified:October 1, 2000 - v1
Checksum:iA75B7A0751C13455
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237559 Genomic DNA. Translation: AAF68392.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237559 Genomic DNA. Translation: AAF68392.1.

3D structure databases

ProteinModelPortaliQ9N0Z0.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106917.

Family and domain databases

InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR6_CERAT
AccessioniPrimary (citable) accession number: Q9N0Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2000
Last modified: November 11, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.