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Protein

Interferon-induced GTP-binding protein Mx1

Gene

MX1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Interferon-induced dynamin-like GTPase with antiviral activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 80GTPSequence analysis8
Nucleotide bindingi174 – 178GTPSequence analysis5
Nucleotide bindingi243 – 246GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CFA-1169408 ISG15 antiviral mechanism

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx1
Alternative name(s):
Myxoma resistance protein 1
Myxovirus resistance protein 1
Gene namesi
Name:MX1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 31

Organism-specific databases

VGNCiVGNC:43511 MX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065911 – 657Interferon-induced GTP-binding protein Mx1Add BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PaxDbiQ9N0Y3

Expressioni

Inductioni

By type I and type III interferons.1 Publication

Gene expression databases

BgeeiENSCAFG00000010172

Interactioni

Subunit structurei

Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014941

Structurei

3D structure databases

ProteinModelPortaliQ9N0Y3
SMRiQ9N0Y3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 336Dynamin-type GAdd BLAST274
Domaini569 – 657GEDPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 336GTPase domainBy similarityAdd BLAST272
Regioni337 – 362Bundle signaling element (BSE)By similarityAdd BLAST26
Regioni362 – 529Middle domainBy similarityAdd BLAST168
Regioni363 – 627StalkBy similarityAdd BLAST265
Regioni550 – 553Critical for lipid-bindingBy similarity4

Domaini

The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.By similarity
The middle domain mediates self-assembly and oligomerization.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOGENOMiHOG000063238
HOVERGENiHBG008788
InParanoidiQ9N0Y3
KOiK14754
OMAiAVDMLHT
OrthoDBiEOG091G080G
TreeFamiTF331484

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequencei

Sequence statusi: Complete.

Q9N0Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNSQGKITD SNPVPNHVLL NGLTDKAEKN QGIGNSLCSQ YEEKVRPCID
60 70 80 90 100
LIDSLRALGV EQDLALPAIA VIGDQSSGKS SVLEALSGVA LPRGSGIVTR
110 120 130 140 150
CPLVLKLKKL INEDEWRGKV SYQDTEMEIS DPSEVEVEIN KAQDAIAGEG
160 170 180 190 200
QGISHELISL EVSSPHVPDL TLIDLPGITR VAVGNQPADI GRQTKQLIRK
210 220 230 240 250
YILKQETINL VVVPCNVDIA TTEALSMAQE VDPDGDRTIG ILTKPDLVDR
260 270 280 290 300
GTEGKVVDVA QNLVCHLKKG YMIVKCRGQQ DIQDQVSLAE ALQKEKDFFE
310 320 330 340 350
DHPHFRVLLE EGRATVPNLA EKLTSELITH ICKTLPLLEN QIKENHEKIT
360 370 380 390 400
EELQKYGSDV PEDEHEKMFF LIDKLNAFNQ DISSLIQGEE SVGEDESRLF
410 420 430 440 450
TKIRNEFHKW SAVIEKKFQR GYKAIYKQME KFENRYRGRE LPGFVNYKTF
460 470 480 490 500
EIIIKQQIKE LEEPAVDMLH TITDMVQVAF GDISKANFDE FFNLYRTTKS
510 520 530 540 550
KIEDIKFELE KEAEKSIRLH FQMEQIVYCQ DHVYQRALQR VREKDSDEEK
560 570 580 590 600
KKKTSSMSHD EVSSVNISLS EILEHLLAYR QEATNRISSH IPLIIQYFIL
610 620 630 640 650
QVYGQKLQNG MLQLLQDKDT YSWLLKERSD TSDKRKFLKE RLARLAQARR

RLAKFPG
Length:657
Mass (Da):74,801
Last modified:October 1, 2000 - v1
Checksum:i25EA43329BFF7C70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239823 mRNA Translation: AAF44684.1
RefSeqiNP_001003134.1, NM_001003134.1
XP_005638792.1, XM_005638735.2
UniGeneiCfa.3610

Genome annotation databases

EnsembliENSCAFT00000016155; ENSCAFP00000014941; ENSCAFG00000010172
GeneIDi403745
KEGGicfa:403745

Similar proteinsi

Entry informationi

Entry nameiMX1_CANLF
AccessioniPrimary (citable) accession number: Q9N0Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome