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Protein

Interferon-induced GTP-binding protein Mx1

Gene

MX1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Interferon-induced dynamin-like GTPase with antiviral activity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 808GTPSequence analysis
Nucleotide bindingi174 – 1785GTPSequence analysis
Nucleotide bindingi243 – 2464GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx1
Alternative name(s):
Myxoma resistance protein 1
Myxovirus resistance protein 1
Cleaved into the following chain:
Gene namesi
Name:MX1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 31

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Interferon-induced GTP-binding protein Mx1PRO_0000206591Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 657656Interferon-induced GTP-binding protein Mx1, N-terminally processedPRO_0000382940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PaxDbiQ9N0Y3.

Expressioni

Inductioni

By type I and type III interferons.1 Publication

Interactioni

Subunit structurei

Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014941.

Structurei

3D structure databases

ProteinModelPortaliQ9N0Y3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 336274Dynamin-type GAdd
BLAST
Domaini569 – 65789GEDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni65 – 336272GTPase domainBy similarityAdd
BLAST
Regioni337 – 36226Bundle signaling element (BSE)By similarityAdd
BLAST
Regioni362 – 529168Middle domainBy similarityAdd
BLAST
Regioni363 – 627265StalkBy similarityAdd
BLAST
Regioni550 – 5534Critical for lipid-bindingBy similarity

Domaini

The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.By similarity
The middle domain mediates self-assembly and oligomerization.By similarity

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000063238.
HOVERGENiHBG008788.
InParanoidiQ9N0Y3.
KOiK14754.
OMAiLHTVTDM.
OrthoDBiEOG7034GF.
TreeFamiTF331484.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N0Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNSQGKITD SNPVPNHVLL NGLTDKAEKN QGIGNSLCSQ YEEKVRPCID
60 70 80 90 100
LIDSLRALGV EQDLALPAIA VIGDQSSGKS SVLEALSGVA LPRGSGIVTR
110 120 130 140 150
CPLVLKLKKL INEDEWRGKV SYQDTEMEIS DPSEVEVEIN KAQDAIAGEG
160 170 180 190 200
QGISHELISL EVSSPHVPDL TLIDLPGITR VAVGNQPADI GRQTKQLIRK
210 220 230 240 250
YILKQETINL VVVPCNVDIA TTEALSMAQE VDPDGDRTIG ILTKPDLVDR
260 270 280 290 300
GTEGKVVDVA QNLVCHLKKG YMIVKCRGQQ DIQDQVSLAE ALQKEKDFFE
310 320 330 340 350
DHPHFRVLLE EGRATVPNLA EKLTSELITH ICKTLPLLEN QIKENHEKIT
360 370 380 390 400
EELQKYGSDV PEDEHEKMFF LIDKLNAFNQ DISSLIQGEE SVGEDESRLF
410 420 430 440 450
TKIRNEFHKW SAVIEKKFQR GYKAIYKQME KFENRYRGRE LPGFVNYKTF
460 470 480 490 500
EIIIKQQIKE LEEPAVDMLH TITDMVQVAF GDISKANFDE FFNLYRTTKS
510 520 530 540 550
KIEDIKFELE KEAEKSIRLH FQMEQIVYCQ DHVYQRALQR VREKDSDEEK
560 570 580 590 600
KKKTSSMSHD EVSSVNISLS EILEHLLAYR QEATNRISSH IPLIIQYFIL
610 620 630 640 650
QVYGQKLQNG MLQLLQDKDT YSWLLKERSD TSDKRKFLKE RLARLAQARR

RLAKFPG
Length:657
Mass (Da):74,801
Last modified:October 1, 2000 - v1
Checksum:i25EA43329BFF7C70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239823 mRNA. Translation: AAF44684.1.
RefSeqiNP_001003134.1. NM_001003134.1.
XP_005638792.1. XM_005638735.2.
UniGeneiCfa.3610.

Genome annotation databases

EnsembliENSCAFT00000016155; ENSCAFP00000014941; ENSCAFG00000010172.
GeneIDi403745.
KEGGicfa:403745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239823 mRNA. Translation: AAF44684.1.
RefSeqiNP_001003134.1. NM_001003134.1.
XP_005638792.1. XM_005638735.2.
UniGeneiCfa.3610.

3D structure databases

ProteinModelPortaliQ9N0Y3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014941.

Proteomic databases

PaxDbiQ9N0Y3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000016155; ENSCAFP00000014941; ENSCAFG00000010172.
GeneIDi403745.
KEGGicfa:403745.

Organism-specific databases

CTDi4599.

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
GeneTreeiENSGT00760000119213.
HOGENOMiHOG000063238.
HOVERGENiHBG008788.
InParanoidiQ9N0Y3.
KOiK14754.
OMAiLHTVTDM.
OrthoDBiEOG7034GF.
TreeFamiTF331484.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Vice S.J., Gordy P.W., Bowen R.A.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  2. "Intracellular localization and antiviral property of canine Mx proteins."
    Nakamura T., Asano A., Okano S., Ko J.H., Kon Y., Watanabe T., Agui T.
    J. Interferon Cytokine Res. 25:169-173(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  3. "The Mx GTPase family of interferon-induced antiviral proteins."
    Haller O., Stertz S., Kochs G.
    Microbes Infect. 9:1636-1643(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, INDUCTION.

Entry informationi

Entry nameiMX1_CANLF
AccessioniPrimary (citable) accession number: Q9N0Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.