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Protein

Glutathione S-transferase Mu 1

Gene

GSTM1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalysed oxidative inactivation of enzymes.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50GlutathioneBy similarity1
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-BTA-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 1 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 1
GSTM1-1
Gene namesi
Name:GSTM1
Synonyms:GSTM
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406251 – 218Glutathione S-transferase Mu 1Add BLAST218

Proteomic databases

PaxDbiQ9N0V4.
PeptideAtlasiQ9N0V4.
PRIDEiQ9N0V4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017765.
ExpressionAtlasiQ9N0V4. baseline and differential.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023627.

Structurei

3D structure databases

ProteinModelPortaliQ9N0V4.
SMRiQ9N0V4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 88GST N-terminalAdd BLAST87
Domaini90 – 208GST C-terminalAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 8Glutathione bindingBy similarity2
Regioni43 – 46Glutathione bindingBy similarity4
Regioni59 – 60Glutathione bindingBy similarity2
Regioni72 – 73Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated

Phylogenomic databases

eggNOGiENOG410IN5J. Eukaryota.
ENOG4110YU0. LUCA.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiQ9N0V4.
KOiK00799.
OMAiFARICYS.
OrthoDBiEOG091G0K2E.
TreeFamiTF353040.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR036282. Glutathione-S-Trfase_C_sf.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9N0V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMILGYWDI RGLAHAIRLL LEYTDTNYEE RQYSVGDAPD YDRSQWLNEK
60 70 80 90 100
FKLGLDFPNL PYLIDGTHKL TQSNAILRYI ARKHNLCGET EEEMIRVDIL
110 120 130 140 150
ENQVMDVRLA MARICYSPDF EKLKPGFLKE IPEKIKLFSE FLGKRPWFAG
160 170 180 190 200
DKLTYVDFLV YDVLDMHRIF EPKCLDAFPN LKDFISRFEG LKKISAYMKS
210
SRFLPGPLFM KLAVWGNK
Length:218
Mass (Da):25,635
Last modified:January 23, 2007 - v3
Checksum:i3D02EA0F43C07B0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102050 mRNA. Translation: AAI02051.1.
AF249588 mRNA. Translation: AAF64308.1.
RefSeqiNP_787019.1. NM_175825.3.
UniGeneiBt.49673.

Genome annotation databases

EnsembliENSBTAT00000023627; ENSBTAP00000023627; ENSBTAG00000017765.
GeneIDi327709.
KEGGibta:327709.

Similar proteinsi

Entry informationi

Entry nameiGSTM1_BOVIN
AccessioniPrimary (citable) accession number: Q9N0V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families