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Q9N0V4

- GSTM1_BOVIN

UniProt

Q9N0V4 - GSTM1_BOVIN

Protein

Glutathione S-transferase Mu 1

Gene

GSTM1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalysed oxidative inactivation of enzymes.1 Publication

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei116 – 1161SubstrateBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase Mu 1 (EC:2.5.1.18)
    Alternative name(s):
    GST class-mu 1
    GSTM1-1
    Gene namesi
    Name:GSTM1
    Synonyms:GSTM
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 218217Glutathione S-transferase Mu 1PRO_0000240625Add
    BLAST

    Proteomic databases

    PaxDbiQ9N0V4.
    PRIDEiQ9N0V4.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000023627.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9N0V4.
    SMRiQ9N0V4. Positions 1-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8887GST N-terminalAdd
    BLAST
    Domaini90 – 208119GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni7 – 82Glutathione bindingBy similarity
    Regioni46 – 505Glutathione bindingBy similarity
    Regioni59 – 602Glutathione bindingBy similarity
    Regioni72 – 732Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Mu family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG300089.
    GeneTreeiENSGT00550000074559.
    HOGENOMiHOG000115735.
    HOVERGENiHBG106842.
    InParanoidiQ9N0V4.
    KOiK00799.
    OMAiWDIRGLV.
    OrthoDBiEOG7KH9M3.
    TreeFamiTF353040.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01267. GSTRNSFRASEM.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9N0V4-1 [UniParc]FASTAAdd to Basket

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    MPMILGYWDI RGLAHAIRLL LEYTDTNYEE RQYSVGDAPD YDRSQWLNEK    50
    FKLGLDFPNL PYLIDGTHKL TQSNAILRYI ARKHNLCGET EEEMIRVDIL 100
    ENQVMDVRLA MARICYSPDF EKLKPGFLKE IPEKIKLFSE FLGKRPWFAG 150
    DKLTYVDFLV YDVLDMHRIF EPKCLDAFPN LKDFISRFEG LKKISAYMKS 200
    SRFLPGPLFM KLAVWGNK 218
    Length:218
    Mass (Da):25,635
    Last modified:January 23, 2007 - v3
    Checksum:i3D02EA0F43C07B0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102050 mRNA. Translation: AAI02051.1.
    AF249588 mRNA. Translation: AAF64308.1.
    RefSeqiNP_787019.1. NM_175825.3.
    UniGeneiBt.49673.

    Genome annotation databases

    EnsembliENSBTAT00000023627; ENSBTAP00000023627; ENSBTAG00000017765.
    GeneIDi327709.
    KEGGibta:327709.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102050 mRNA. Translation: AAI02051.1 .
    AF249588 mRNA. Translation: AAF64308.1 .
    RefSeqi NP_787019.1. NM_175825.3.
    UniGenei Bt.49673.

    3D structure databases

    ProteinModelPortali Q9N0V4.
    SMRi Q9N0V4. Positions 1-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000023627.

    Proteomic databases

    PaxDbi Q9N0V4.
    PRIDEi Q9N0V4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000023627 ; ENSBTAP00000023627 ; ENSBTAG00000017765 .
    GeneIDi 327709.
    KEGGi bta:327709.

    Organism-specific databases

    CTDi 2944.

    Phylogenomic databases

    eggNOGi NOG300089.
    GeneTreei ENSGT00550000074559.
    HOGENOMi HOG000115735.
    HOVERGENi HBG106842.
    InParanoidi Q9N0V4.
    KOi K00799.
    OMAi WDIRGLV.
    OrthoDBi EOG7KH9M3.
    TreeFami TF353040.

    Miscellaneous databases

    NextBioi 20810173.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01267. GSTRNSFRASEM.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A lens glutathione S-transferase, class mu, with thiol-specific antioxidant activity."
      Jimenez-Asensio J., Garland D.
      Exp. Eye Res. 71:255-265(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, FUNCTION, SUBUNIT.
      Tissue: Lens.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiGSTM1_BOVIN
    AccessioniPrimary (citable) accession number: Q9N0V4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3