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Protein
Submitted name:

Ferret 5-HT3A receptor

Gene

HTR3A

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ferret 5-HT3A receptorImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:HTR3AImported
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei248 – 271HelicalSequence analysisAdd BLAST24
Transmembranei283 – 304HelicalSequence analysisAdd BLAST22
Transmembranei310 – 332HelicalSequence analysisAdd BLAST23
Transmembranei457 – 480HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500818030224 – 483Sequence analysisAdd BLAST460

Interactioni

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000003893.

Structurei

3D structure databases

ProteinModelPortaliQ9N0F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 247Neur_chan_LBDInterPro annotationAdd BLAST207
Domaini254 – 473Neur_chan_membInterPro annotationAdd BLAST220

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOVERGENiHBG106638.
OMAiHGEVQNY.
OrthoDBiEOG091G06Q8.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR008132. 5HT3_rcpt.
IPR008133. 5HT3_rcpt_A.
IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01709. 5HT3ARECEPTR.
PR01708. 5HT3RECEPTOR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9N0F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLWVPRALL ALLLPMLLAQ GEAKHWRPLQ AQNSSRPALL RLSEHLMANY
60 70 80 90 100
EKGVRPVRDW RKPTTVAIDV IIYAILSVDE KNQVLTTYIW YRQYWTDEFL
110 120 130 140 150
QWNPEDFDNI TKLSVPTDNI WVPDILINEF VDVGKSPSIP YVYVGHHGEV
160 170 180 190 200
QNYKPLQVMT ACSLDIYNFP FDVQNCSLTF TSWLHTIQDI NISLWRLPEK
210 220 230 240 250
VKLDKTVFMN QGEWELLGVL TQFREFSLED SSHYAEMKFY VVIRRRPLFY
260 270 280 290 300
AVSLLLPSIF LMLMDIVGFY LPPDSGERVS FKITLLLGYS VFLIIVSDTL
310 320 330 340 350
PATAIGTPLI GVYFVVCMAL LVMSLAETIF IVRLVHKQDL QQPVPAWLRH
360 370 380 390 400
LVLERVAPLL CLGEQPASRR PLVISPATKT DDCTDVGNHC SHLGDPWDLE
410 420 430 440 450
KTPRGRDSPP PPPREASLAV RGLLQELASI RRFLEKRDES REVAREWLRV
460 470 480
GSVLDRLLFR VYLVAVLAYS VTLIALWSIW QYS
Length:483
Mass (Da):55,563
Last modified:October 1, 2000 - v1
Checksum:i54695AC794E30206
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01026722 Genomic DNA. No translation available.
AB029898 mRNA. Translation: BAA96417.1.
RefSeqiNP_001297113.1. NM_001310184.1.

Genome annotation databases

EnsembliENSMPUT00000003963; ENSMPUP00000003893; ENSMPUG00000003924.
GeneIDi101680756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01026722 Genomic DNA. No translation available.
AB029898 mRNA. Translation: BAA96417.1.
RefSeqiNP_001297113.1. NM_001310184.1.

3D structure databases

ProteinModelPortaliQ9N0F4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000003893.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMPUT00000003963; ENSMPUP00000003893; ENSMPUG00000003924.
GeneIDi101680756.

Organism-specific databases

CTDi3359.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOVERGENiHBG106638.
OMAiHGEVQNY.
OrthoDBiEOG091G06Q8.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR008132. 5HT3_rcpt.
IPR008133. 5HT3_rcpt_A.
IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01709. 5HT3ARECEPTR.
PR01708. 5HT3RECEPTOR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9N0F4_MUSPF
AccessioniPrimary (citable) accession number: Q9N0F4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.