Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9N0C5 (KITM_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase 2, mitochondrial

EC=2.7.1.21
Alternative name(s):
Mt-TK
Gene names
Name:TK2
ORF Names:QccE-13136
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the DCK/DGK family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphotransferase activity, alcohol group as acceptor

Inferred from electronic annotation. Source: InterPro

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3333Mitochondrion By similarity
Chain34 – 265232Thymidine kinase 2, mitochondrial
PRO_0000016843

Regions

Nucleotide binding57 – 659ATP By similarity

Sites

Active site1331Proton acceptor Potential
Binding site811Substrate By similarity
Binding site991Substrate By similarity
Binding site1101Substrate By similarity
Binding site1341Substrate By similarity
Binding site2011Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9N0C5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 6104E608C0E809A0

FASTA26530,744
        10         20         30         40         50         60 
MLLRPLRGWA ALALRCFEPG SPGSPASGPG SRRVQRGAWP SDKEREKEKK SVICVEGNIA 

        70         80         90        100        110        120 
SGKTTCLEFF SNATDIEVLT EPVSKWRNVR GHNPLGLMYQ DASRWGLTLQ TYVQLTMLDR 

       130        140        150        160        170        180 
HTCPQVSSVR LMERSIHSAR YIFVENLYRS GKMPEVDYVV LSEWFDWILR NMDVSIDLIV 

       190        200        210        220        230        240 
YLRTNPETCY QRLKRRCREE EKVIPLEYLE AIHHLHEEWL IKGSLFPVAA PVLVIEADHH 

       250        260 
MERMLQLFEQ NRDRILTPEN RKLGP 

« Hide

References

[1]"Isolation of full-length cDNA clones from macaque brain cDNA libraries."
Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB046005 mRNA. Translation: BAB01587.1.
RefSeqNP_001272031.1. NM_001285102.1.
UniGeneMfa.1376.

3D structure databases

ProteinModelPortalQ9N0C5.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9N0C5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102139352.
KEGGmcf:102139352.

Organism-specific databases

CTD7084.

Phylogenomic databases

HOVERGENHBG006216.
KOK00857.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR002624. Deoxynucleoside_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10513. PTHR10513. 1 hit.
PfamPF01712. dNK. 1 hit.
[Graphical view]
PIRSFPIRSF000705. DNK. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITM_MACFA
AccessionPrimary (citable) accession number: Q9N0C5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families