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Q9N0C5

- KITM_MACFA

UniProt

Q9N0C5 - KITM_MACFA

Protein

Thymidine kinase 2, mitochondrial

Gene

TK2

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs By similarity.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei81 – 811SubstrateBy similarity
    Binding sitei99 – 991SubstrateBy similarity
    Binding sitei110 – 1101SubstrateBy similarity
    Active sitei133 – 1331Proton acceptorSequence Analysis
    Binding sitei134 – 1341SubstrateBy similarity
    Binding sitei201 – 2011SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi57 – 659ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphotransferase activity, alcohol group as acceptor Source: InterPro
    3. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase 2, mitochondrial (EC:2.7.1.21)
    Alternative name(s):
    Mt-TK
    Gene namesi
    Name:TK2
    ORF Names:QccE-13136
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3333MitochondrionBy similarityAdd
    BLAST
    Chaini34 – 265232Thymidine kinase 2, mitochondrialPRO_0000016843Add
    BLAST

    Proteomic databases

    PRIDEiQ9N0C5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9N0C5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DCK/DGK family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG006216.
    KOiK00857.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR002624. DNK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10513. PTHR10513. 1 hit.
    PfamiPF01712. dNK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000705. DNK. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9N0C5-1 [UniParc]FASTAAdd to Basket

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    MLLRPLRGWA ALALRCFEPG SPGSPASGPG SRRVQRGAWP SDKEREKEKK    50
    SVICVEGNIA SGKTTCLEFF SNATDIEVLT EPVSKWRNVR GHNPLGLMYQ 100
    DASRWGLTLQ TYVQLTMLDR HTCPQVSSVR LMERSIHSAR YIFVENLYRS 150
    GKMPEVDYVV LSEWFDWILR NMDVSIDLIV YLRTNPETCY QRLKRRCREE 200
    EKVIPLEYLE AIHHLHEEWL IKGSLFPVAA PVLVIEADHH MERMLQLFEQ 250
    NRDRILTPEN RKLGP 265
    Length:265
    Mass (Da):30,744
    Last modified:October 1, 2000 - v1
    Checksum:i6104E608C0E809A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046005 mRNA. Translation: BAB01587.1.
    RefSeqiNP_001272031.1. NM_001285102.1.
    UniGeneiMfa.1376.

    Genome annotation databases

    GeneIDi102139352.
    KEGGimcf:102139352.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046005 mRNA. Translation: BAB01587.1 .
    RefSeqi NP_001272031.1. NM_001285102.1.
    UniGenei Mfa.1376.

    3D structure databases

    ProteinModelPortali Q9N0C5.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9N0C5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102139352.
    KEGGi mcf:102139352.

    Organism-specific databases

    CTDi 7084.

    Phylogenomic databases

    HOVERGENi HBG006216.
    KOi K00857.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR002624. DNK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10513. PTHR10513. 1 hit.
    Pfami PF01712. dNK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000705. DNK. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of full-length cDNA clones from macaque brain cDNA libraries."
      Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiKITM_MACFA
    AccessioniPrimary (citable) accession number: Q9N0C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3