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Q9N0C5

- KITM_MACFA

UniProt

Q9N0C5 - KITM_MACFA

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Protein
Thymidine kinase 2, mitochondrial
Gene
TK2, QccE-13136
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs By similarity.

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei81 – 811Substrate By similarity
Binding sitei99 – 991Substrate By similarity
Binding sitei110 – 1101Substrate By similarity
Active sitei133 – 1331Proton acceptor Reviewed prediction
Binding sitei134 – 1341Substrate By similarity
Binding sitei201 – 2011Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi57 – 659ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphotransferase activity, alcohol group as acceptor Source: InterPro
  3. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase 2, mitochondrial (EC:2.7.1.21)
Alternative name(s):
Mt-TK
Gene namesi
Name:TK2
ORF Names:QccE-13136
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333Mitochondrion By similarity
Add
BLAST
Chaini34 – 265232Thymidine kinase 2, mitochondrial
PRO_0000016843Add
BLAST

Proteomic databases

PRIDEiQ9N0C5.

Structurei

3D structure databases

ProteinModelPortaliQ9N0C5.

Family & Domainsi

Sequence similaritiesi

Belongs to the DCK/DGK family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG006216.
KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000705. DNK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N0C5-1 [UniParc]FASTAAdd to Basket

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MLLRPLRGWA ALALRCFEPG SPGSPASGPG SRRVQRGAWP SDKEREKEKK    50
SVICVEGNIA SGKTTCLEFF SNATDIEVLT EPVSKWRNVR GHNPLGLMYQ 100
DASRWGLTLQ TYVQLTMLDR HTCPQVSSVR LMERSIHSAR YIFVENLYRS 150
GKMPEVDYVV LSEWFDWILR NMDVSIDLIV YLRTNPETCY QRLKRRCREE 200
EKVIPLEYLE AIHHLHEEWL IKGSLFPVAA PVLVIEADHH MERMLQLFEQ 250
NRDRILTPEN RKLGP 265
Length:265
Mass (Da):30,744
Last modified:October 1, 2000 - v1
Checksum:i6104E608C0E809A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB046005 mRNA. Translation: BAB01587.1.
RefSeqiNP_001272031.1. NM_001285102.1.
UniGeneiMfa.1376.

Genome annotation databases

GeneIDi102139352.
KEGGimcf:102139352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB046005 mRNA. Translation: BAB01587.1 .
RefSeqi NP_001272031.1. NM_001285102.1.
UniGenei Mfa.1376.

3D structure databases

ProteinModelPortali Q9N0C5.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9N0C5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 102139352.
KEGGi mcf:102139352.

Organism-specific databases

CTDi 7084.

Phylogenomic databases

HOVERGENi HBG006216.
KOi K00857.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10513. PTHR10513. 1 hit.
Pfami PF01712. dNK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000705. DNK. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation of full-length cDNA clones from macaque brain cDNA libraries."
    Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiKITM_MACFA
AccessioniPrimary (citable) accession number: Q9N0C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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