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Protein

Thymidine kinase 2, mitochondrial

Gene

TK2

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs (By similarity).By similarity

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei81 – 811SubstrateBy similarity
Binding sitei99 – 991SubstrateBy similarity
Binding sitei110 – 1101SubstrateBy similarity
Active sitei133 – 1331Proton acceptorSequence Analysis
Binding sitei134 – 1341SubstrateBy similarity
Binding sitei201 – 2011SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi57 – 659ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase 2, mitochondrial (EC:2.7.1.21)
Alternative name(s):
Mt-TK
Gene namesi
Name:TK2
ORF Names:QccE-13136
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333MitochondrionBy similarityAdd
BLAST
Chaini34 – 265232Thymidine kinase 2, mitochondrialPRO_0000016843Add
BLAST

Proteomic databases

PRIDEiQ9N0C5.

Structurei

3D structure databases

ProteinModelPortaliQ9N0C5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCK/DGK family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG006216.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000705. DNK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N0C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLRPLRGWA ALALRCFEPG SPGSPASGPG SRRVQRGAWP SDKEREKEKK
60 70 80 90 100
SVICVEGNIA SGKTTCLEFF SNATDIEVLT EPVSKWRNVR GHNPLGLMYQ
110 120 130 140 150
DASRWGLTLQ TYVQLTMLDR HTCPQVSSVR LMERSIHSAR YIFVENLYRS
160 170 180 190 200
GKMPEVDYVV LSEWFDWILR NMDVSIDLIV YLRTNPETCY QRLKRRCREE
210 220 230 240 250
EKVIPLEYLE AIHHLHEEWL IKGSLFPVAA PVLVIEADHH MERMLQLFEQ
260
NRDRILTPEN RKLGP
Length:265
Mass (Da):30,744
Last modified:October 1, 2000 - v1
Checksum:i6104E608C0E809A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046005 mRNA. Translation: BAB01587.1.
RefSeqiNP_001272031.1. NM_001285102.1.
UniGeneiMfa.1376.

Genome annotation databases

GeneIDi102139352.
KEGGimcf:102139352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046005 mRNA. Translation: BAB01587.1.
RefSeqiNP_001272031.1. NM_001285102.1.
UniGeneiMfa.1376.

3D structure databases

ProteinModelPortaliQ9N0C5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9N0C5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102139352.
KEGGimcf:102139352.

Organism-specific databases

CTDi7084.

Phylogenomic databases

HOVERGENiHBG006216.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000705. DNK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Isolation of full-length cDNA clones from macaque brain cDNA libraries."
    Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiKITM_MACFA
AccessioniPrimary (citable) accession number: Q9N0C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: April 1, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.