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Protein

Cytochrome P450 2E1

Gene

CYP2E1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites.By similarity

Catalytic activityi

4-nitrophenol + NADPH + O2 = 4-nitrocatechol + NADP+ + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiR-CFA-211999. CYP2E1 reactions.
SABIO-RKQ9MZY0.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2E1 (EC:1.14.13.-)
Alternative name(s):
4-nitrophenol 2-hydroxylase (EC:1.14.13.n7)
CYPIIE1
Gene namesi
Name:CYP2E1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 28

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 494493Cytochrome P450 2E1PRO_0000289585Add
BLAST

Proteomic databases

PaxDbiQ9MZY0.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000034940.

Structurei

3D structure databases

ProteinModelPortaliQ9MZY0.
SMRiQ9MZY0. Positions 33-493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni298 – 3036Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ9MZY0.
KOiK07415.
OMAiRGITFNN.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008070. Cyt_P450_E_grp-I_CYP2E-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01687. EP450ICYP2E.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9MZY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALGITVAL LVWMATLMLI SIWKQIYSRW KLPPGPFPLP IIGNILQVDI
60 70 80 90 100
KNVPKSLAKL AEQYGPVFTL YLGSQRTVVL HGYKAVKEVL LDHKNDLSGR
110 120 130 140 150
GEVFAFQSHK DRGITFNNGP GWKDTRRLSL STLRDYGMGK RGNEERIQRE
160 170 180 190 200
IPFLLEALRG TRGQPFDPTF LLGFAPFNVI ADILFHKHFD YSDQTGLRIQ
210 220 230 240 250
KLFNENFHLL STGWLQLYNI FPSYLHYLPG SHRKVLRNVA ELKDYSLERV
260 270 280 290 300
KEHQESLDPT CSRDFTDCLL QELQKERYGT EPWYTLDNIA VTVADLFFAG
310 320 330 340 350
TETTSTTLRY GLLILMKYPE VEEKLHEEID RVIGPSRVPA IKDRLEMPYM
360 370 380 390 400
DAVVHEIQRF IDLLPSNLPH VANQDTMFRG YVIPKGTVVI PTLDSVLFDK
410 420 430 440 450
QEFPDPEKFK PEHFLNENGK FKYSDYFKAF SAGKRVCVGE GLARMELFLF
460 470 480 490
LSAILQHFNL KSLVDPKDID LSPCTIGFAK IPPHYKLCVV PRSG
Length:494
Mass (Da):56,599
Last modified:October 1, 2000 - v1
Checksum:iF3F891371B65A36D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti485 – 4851Y → H in minor allele. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029978 mRNA. Translation: AAF88144.1.
AF029979 mRNA. Translation: AAF88145.1.
RefSeqiNP_001003339.1. NM_001003339.1.
UniGeneiCfa.28355.

Genome annotation databases

EnsembliENSCAFT00000039127; ENSCAFP00000034940; ENSCAFG00000013318.
GeneIDi415128.
KEGGicfa:415128.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029978 mRNA. Translation: AAF88144.1.
AF029979 mRNA. Translation: AAF88145.1.
RefSeqiNP_001003339.1. NM_001003339.1.
UniGeneiCfa.28355.

3D structure databases

ProteinModelPortaliQ9MZY0.
SMRiQ9MZY0. Positions 33-493.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000034940.

Proteomic databases

PaxDbiQ9MZY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000039127; ENSCAFP00000034940; ENSCAFG00000013318.
GeneIDi415128.
KEGGicfa:415128.

Organism-specific databases

CTDi1571.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ9MZY0.
KOiK07415.
OMAiRGITFNN.
OrthoDBiEOG7RBZ85.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiR-CFA-211999. CYP2E1 reactions.
SABIO-RKQ9MZY0.

Miscellaneous databases

NextBioi20818807.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008070. Cyt_P450_E_grp-I_CYP2E-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01687. EP450ICYP2E.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of canine cytochrome P450 2E1 cDNA: identification and characterization of two variant alleles."
    Lankford S.M., Bai S.A., Goldstein J.A.
    Drug Metab. Dispos. 28:981-986(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-485.

Entry informationi

Entry nameiCP2E1_CANLF
AccessioniPrimary (citable) accession number: Q9MZY0
Secondary accession number(s): Q9MZY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: March 16, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.