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Q9MZV7

- CASP1_CANFA

UniProt

Q9MZV7 - CASP1_CANFA

Protein

Caspase-1

Gene

CASP1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis By similarity.By similarity

    Catalytic activityi

    Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei237 – 2371By similarity
    Active sitei285 – 2851By similarity

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. regulation of apoptotic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    BRENDAi3.4.22.36. 1154.

    Protein family/group databases

    MEROPSiC14.024.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase-1 (EC:3.4.22.36)
    Short name:
    CASP-1
    Alternative name(s):
    Interleukin-1 beta convertase
    Short name:
    IL-1BC
    Interleukin-1 beta-converting enzyme
    Short name:
    ICE
    Short name:
    IL-1 beta-converting enzyme
    p45
    Cleaved into the following 2 chains:
    Gene namesi
    Name:CASP1
    Synonyms:IL1BC
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. AIM2 inflammasome complex Source: UniProtKB
    2. cytoplasm Source: UniProtKB-SubCell
    3. IPAF inflammasome complex Source: UniProtKB
    4. NLRP1 inflammasome complex Source: UniProtKB
    5. NLRP3 inflammasome complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 119119Sequence AnalysisPRO_0000004509Add
    BLAST
    Chaini120 – 297178Caspase-1 subunit p20PRO_0000004510Add
    BLAST
    Propeptidei298 – 31619Sequence AnalysisPRO_0000004511Add
    BLAST
    Chaini317 – 40488Caspase-1 subunit p10PRO_0000004512Add
    BLAST

    Post-translational modificationi

    The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

    Keywords - PTMi

    Zymogen

    Interactioni

    Subunit structurei

    Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17/INCA and CARD18 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9MZV7.
    SMRiQ9MZV7. Positions 2-90, 151-297, 317-404.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9191CARDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C14A family.Curated
    Contains 1 CARD domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG326166.
    HOGENOMiHOG000234399.
    HOVERGENiHBG076981.
    KOiK04394.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProiIPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
    PRINTSiPR00376. IL1BCENZYME.
    SMARTiSM00114. CARD. 1 hit.
    SM00115. CASc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9MZV7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADKVLKDKR RLFVRSVDMG TINGLLDELF EKRVLNHEEM ERVRCAHSTV    50
    MDQARVLIDS VLRKGPNACQ IFISNICNED IHLAQTLGLS SGSPSGNDHT 100
    KLDSQVEVPS LPAFVENMPG PTIPDSEEST DTLKLCPPET FVKMYKEKAE 150
    EIYPIKERKD RTRLALIICN IEFDHLSTRD GAELDIAGME SLLEGLGYSV 200
    VVKRKLTAKG MESVLREFAA RPEHKSSDST FLVLMSHGIL NGICGTAHSV 250
    ENPDVLAYDT IFQIFNNRHC LNLKDKPKVI IIQACRGENP GELWVSDSPK 300
    ASTDSWTHQP LMLQSDAIHK VHVEKDFIAF CSSTPHNVSW RHITKGSLFI 350
    AQLITCFQKY SWCCHLEGVF RKVQQSFEKP DVKAQMPTIE RVSMTRYFYL 400
    FPGH 404
    Length:404
    Mass (Da):45,662
    Last modified:October 1, 2000 - v1
    Checksum:iBC5A505CD7DBDFDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135967 mRNA. Translation: AAF64388.1.
    RefSeqiNP_001003125.1. NM_001003125.1.
    UniGeneiCfa.3589.

    Genome annotation databases

    GeneIDi403724.
    KEGGicfa:403724.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135967 mRNA. Translation: AAF64388.1 .
    RefSeqi NP_001003125.1. NM_001003125.1.
    UniGenei Cfa.3589.

    3D structure databases

    ProteinModelPortali Q9MZV7.
    SMRi Q9MZV7. Positions 2-90, 151-297, 317-404.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C14.024.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403724.
    KEGGi cfa:403724.

    Organism-specific databases

    CTDi 837.

    Phylogenomic databases

    eggNOGi NOG326166.
    HOGENOMi HOG000234399.
    HOVERGENi HBG076981.
    KOi K04394.

    Enzyme and pathway databases

    BRENDAi 3.4.22.36. 1154.

    Miscellaneous databases

    NextBioi 20817227.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProi IPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
    PRINTSi PR00376. IL1BCENZYME.
    SMARTi SM00114. CARD. 1 hit.
    SM00115. CASc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of feline and canine ice-related cDNAs encoding hybrid caspase-1/caspase-13-like propeptides."
      Taylor S., Hanlon L., McGillivray C., Gault E.A., Argyle D.J., Onions D.E., Nicolson L.
      DNA Seq. 10:387-394(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCASP1_CANFA
    AccessioniPrimary (citable) accession number: Q9MZV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3