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Q9MZV6

- CASP1_FELCA

UniProt

Q9MZV6 - CASP1_FELCA

Protein

Caspase-1

Gene

CASP1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis By similarity.By similarity

    Catalytic activityi

    Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei235 – 2351By similarity
    Active sitei284 – 2841By similarity

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. regulation of apoptotic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    BRENDAi3.4.22.36. 2240.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase-1 (EC:3.4.22.36)
    Short name:
    CASP-1
    Alternative name(s):
    Interleukin-1 beta convertase
    Short name:
    IL-1BC
    Interleukin-1 beta-converting enzyme
    Short name:
    ICE
    Short name:
    IL-1 beta-converting enzyme
    p45
    Cleaved into the following 2 chains:
    Gene namesi
    Name:CASP1
    Synonyms:IL1BC
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. AIM2 inflammasome complex Source: UniProtKB
    2. cytoplasm Source: UniProtKB-SubCell
    3. IPAF inflammasome complex Source: UniProtKB
    4. NLRP1 inflammasome complex Source: UniProtKB
    5. NLRP3 inflammasome complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 119119Sequence AnalysisPRO_0000004513Add
    BLAST
    Chaini120 – 296177Caspase-1 subunit p20PRO_0000004514Add
    BLAST
    Propeptidei297 – 32226Sequence AnalysisPRO_0000004515Add
    BLAST
    Chaini323 – 41088Caspase-1 subunit p10PRO_0000004516Add
    BLAST

    Post-translational modificationi

    The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

    Keywords - PTMi

    Zymogen

    Interactioni

    Subunit structurei

    Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17/INCA and CARD18 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9MZV6.
    SMRiQ9MZV6. Positions 2-90, 149-296, 323-410.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9191CARDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C14A family.Curated
    Contains 1 CARD domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG076981.
    KOiK01370.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProiIPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
    PRINTSiPR00376. IL1BCENZYME.
    SMARTiSM00114. CARD. 1 hit.
    SM00115. CASc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9MZV6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADKVLKGKR KQFINSVGMG TVNGLLDELF EKNVLNQEEM ERVKCENATV    50
    MDKARALIDS VLRKGPRACQ IFICHICEED THLAETLGLS SSPQSGNSQN 100
    TTDSEVAFPP LPASVNNMPG PAEPEESVDA LKLCPHENFV KLCKQRAEEI 150
    YPIKERKDRT RLALIICNTT FDHLSLRKGA DLDVAGMRRL LTDLGYSVHI 200
    KEELTAKDME SELRAFAARP EHKSSDSTFL VFMSHGILSG ICGTKYSAEG 250
    DPDVLAYDTI FQIFNNRNCL SLKDKPKVII VQACRGENLG ELLISDSPAA 300
    PMDSTSQMGS SLSQVGDNLE DDAIYKVHVE KDFIAFCSST PHHVSWRDVN 350
    KGSLFITQLI TCFQKYSWCF HLEEVFRKVQ QSFEKPNVRA QMPTIERLSM 400
    TRYFYLFPGH 410
    Length:410
    Mass (Da):46,052
    Last modified:October 1, 2000 - v1
    Checksum:i2B8BB99C007A40C5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti136 – 1361H → R.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135968 mRNA. Translation: AAF64389.1.
    RefSeqiNP_001009365.1. NM_001009365.1.

    Genome annotation databases

    GeneIDi493961.
    KEGGifca:493961.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135968 mRNA. Translation: AAF64389.1 .
    RefSeqi NP_001009365.1. NM_001009365.1.

    3D structure databases

    ProteinModelPortali Q9MZV6.
    SMRi Q9MZV6. Positions 2-90, 149-296, 323-410.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 493961.
    KEGGi fca:493961.

    Organism-specific databases

    CTDi 834.

    Phylogenomic databases

    HOVERGENi HBG076981.
    KOi K01370.

    Enzyme and pathway databases

    BRENDAi 3.4.22.36. 2240.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProi IPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
    PRINTSi PR00376. IL1BCENZYME.
    SMARTi SM00114. CARD. 1 hit.
    SM00115. CASc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of feline and canine ice-related cDNAs encoding hybrid caspase-1/caspase-13-like propeptides."
      Taylor S., Hanlon L., McGillivray C., Gault E.A., Argyle D.J., Onions D.E., Nicolson L.
      DNA Seq. 10:387-394(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCASP1_FELCA
    AccessioniPrimary (citable) accession number: Q9MZV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3