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Q9MZV6

- CASP1_FELCA

UniProt

Q9MZV6 - CASP1_FELCA

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Protein

Caspase-1

Gene

CASP1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity).By similarity

Catalytic activityi

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei235 – 2351By similarity
Active sitei284 – 2841By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. regulation of apoptotic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BRENDAi3.4.22.36. 2240.

Protein family/group databases

MEROPSiC14.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-1 (EC:3.4.22.36)
Short name:
CASP-1
Alternative name(s):
Interleukin-1 beta convertase
Short name:
IL-1BC
Interleukin-1 beta-converting enzyme
Short name:
ICE
Short name:
IL-1 beta-converting enzyme
p45
Cleaved into the following 2 chains:
Gene namesi
Name:CASP1
Synonyms:IL1BC
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. AIM2 inflammasome complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB-KW
  3. IPAF inflammasome complex Source: UniProtKB
  4. NLRP1 inflammasome complex Source: UniProtKB
  5. NLRP3 inflammasome complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 119119Sequence AnalysisPRO_0000004513Add
BLAST
Chaini120 – 296177Caspase-1 subunit p20PRO_0000004514Add
BLAST
Propeptidei297 – 32226Sequence AnalysisPRO_0000004515Add
BLAST
Chaini323 – 41088Caspase-1 subunit p10PRO_0000004516Add
BLAST

Post-translational modificationi

The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

Keywords - PTMi

Zymogen

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17/INCA and CARD18 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9MZV6.
SMRiQ9MZV6. Positions 2-90, 149-296, 323-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated
Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG076981.
InParanoidiQ9MZV6.
KOiK01370.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9MZV6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADKVLKGKR KQFINSVGMG TVNGLLDELF EKNVLNQEEM ERVKCENATV
60 70 80 90 100
MDKARALIDS VLRKGPRACQ IFICHICEED THLAETLGLS SSPQSGNSQN
110 120 130 140 150
TTDSEVAFPP LPASVNNMPG PAEPEESVDA LKLCPHENFV KLCKQRAEEI
160 170 180 190 200
YPIKERKDRT RLALIICNTT FDHLSLRKGA DLDVAGMRRL LTDLGYSVHI
210 220 230 240 250
KEELTAKDME SELRAFAARP EHKSSDSTFL VFMSHGILSG ICGTKYSAEG
260 270 280 290 300
DPDVLAYDTI FQIFNNRNCL SLKDKPKVII VQACRGENLG ELLISDSPAA
310 320 330 340 350
PMDSTSQMGS SLSQVGDNLE DDAIYKVHVE KDFIAFCSST PHHVSWRDVN
360 370 380 390 400
KGSLFITQLI TCFQKYSWCF HLEEVFRKVQ QSFEKPNVRA QMPTIERLSM
410
TRYFYLFPGH
Length:410
Mass (Da):46,052
Last modified:October 1, 2000 - v1
Checksum:i2B8BB99C007A40C5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361H → R.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135968 mRNA. Translation: AAF64389.1.
RefSeqiNP_001009365.1. NM_001009365.1.

Genome annotation databases

GeneIDi493961.
KEGGifca:493961.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135968 mRNA. Translation: AAF64389.1 .
RefSeqi NP_001009365.1. NM_001009365.1.

3D structure databases

ProteinModelPortali Q9MZV6.
SMRi Q9MZV6. Positions 2-90, 149-296, 323-410.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C14.017.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493961.
KEGGi fca:493961.

Organism-specific databases

CTDi 834.

Phylogenomic databases

HOVERGENi HBG076981.
InParanoidi Q9MZV6.
KOi K01370.

Enzyme and pathway databases

BRENDAi 3.4.22.36. 2240.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProi IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
PRINTSi PR00376. IL1BCENZYME.
SMARTi SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of feline and canine ice-related cDNAs encoding hybrid caspase-1/caspase-13-like propeptides."
    Taylor S., Hanlon L., McGillivray C., Gault E.A., Argyle D.J., Onions D.E., Nicolson L.
    DNA Seq. 10:387-394(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCASP1_FELCA
AccessioniPrimary (citable) accession number: Q9MZV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3