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Protein

Voltage-dependent L-type calcium channel subunit beta-2

Gene

CACNB2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei492 – 4921Required for CaMK2D-bindingBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-BTA-112308. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
R-BTA-422356. Regulation of insulin secretion.
R-BTA-5576892. Phase 0 - rapid depolarisation.
R-BTA-5576893. Phase 2 - plateau phase.
R-BTA-5576894. Phase 1 - inactivation of fast Na+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit beta-2
Short name:
CAB2
Alternative name(s):
Calcium channel voltage-dependent subunit beta 2
Gene namesi
Name:CACNB2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 603603Voltage-dependent L-type calcium channel subunit beta-2PRO_0000144050Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491PhosphoserineBy similarity
Modified residuei152 – 1521PhosphoserineBy similarity
Modified residuei163 – 1631PhosphoserineBy similarity
Modified residuei493 – 4931PhosphoserineBy similarity
Modified residuei497 – 4971Phosphothreonine; by CaMK2DBy similarity

Post-translational modificationi

Regulated through phosphorylation at Thr-497 by CaMK2D.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9MZL5.
PRIDEiQ9MZL5.

Interactioni

Subunit structurei

The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane. Interacts with CAMK2D. Interacts with CBARP (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9MZL5. 2 interactions.
STRINGi9913.ENSBTAP00000029344.

Chemistry

BindingDBiQ9MZL5.

Structurei

3D structure databases

ProteinModelPortaliQ9MZL5.
SMRiQ9MZL5. Positions 33-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 12870SH3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG3812. Eukaryota.
ENOG410XRDI. LUCA.
GeneTreeiENSGT00390000002740.
HOVERGENiHBG050765.
InParanoidiQ9MZL5.
KOiK04863.
OMAiSAPHHNH.
OrthoDBiEOG7966G4.
TreeFamiTF316195.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
IPR005444. VDCC_L_b2su.
IPR000584. VDCC_L_bsu.
[Graphical view]
PANTHERiPTHR11824. PTHR11824. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF12052. VGCC_beta4Aa_N. 1 hit.
[Graphical view]
PRINTSiPR01626. LCACHANNELB.
PR01628. LCACHANNELB2.
SMARTiSM00072. GuKc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MZL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQCCGLVHRR RARVSYGSAD SYTSRPSDSD VSLEEDREAV RREAERQAQA
60 70 80 90 100
QLEKAKTKPV AFAVRTNVSY SAAHEDDVPV PGMAISFEAK DFLHVKEKFN
110 120 130 140 150
NDWWIGRLVK EGCEIGFIPS PVKLENMRLQ HEQRAKQGKF YSSKSGGNSS
160 170 180 190 200
SSLGDIVPSS RKSTPPSSAI DIDATGLDAE DNDIPANHRS PKPSANSVTS
210 220 230 240 250
PHSKEKRMPF FKKTEHTPPY DVVPSMRPVV LVGPSLKGYE VTDMMQKALF
260 270 280 290 300
DFLKHRFEGR ISITRVTADI SLAKRSVLNN PSKHAIIERS NTRSSLAEVQ
310 320 330 340 350
SEIERIFELA RTLQLVVLDA DTINHPAQLS KTSLAPIIVY VKISSPKVLQ
360 370 380 390 400
RLIKSRGKSQ AKHLNVQMVA ADKLAQCPPE LFDVILDENQ LEDACEHLAD
410 420 430 440 450
YLEAYWKATH PPSSSLPNPL LSRTLATSTL PVSPTLASNS QGSQGDQRTD
460 470 480 490 500
RGAPGRSASQ AEEEHCPEPV KKAQHRSSTQ HHNHRSGTSR GLSRQETLDS
510 520 530 540 550
ETQESRDSAY AEPKEEYSHE HADHYAPHRD HNHREEPHGG GEHRHREPRH
560 570 580 590 600
RSRDPDREQD HNESNKQRSR HKSKDRYCDK DGEGLSRRRN EAADWNRDVY

IRQ
Length:603
Mass (Da):67,842
Last modified:October 1, 2000 - v1
Checksum:i217E10D1FA91B314
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174417 mRNA. Translation: AAF26681.1.
RefSeqiNP_786983.1. NM_175789.2.
UniGeneiBt.91412.

Genome annotation databases

EnsembliENSBTAT00000029344; ENSBTAP00000029344; ENSBTAG00000022000.
GeneIDi327667.
KEGGibta:327667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174417 mRNA. Translation: AAF26681.1.
RefSeqiNP_786983.1. NM_175789.2.
UniGeneiBt.91412.

3D structure databases

ProteinModelPortaliQ9MZL5.
SMRiQ9MZL5. Positions 33-410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9MZL5. 2 interactions.
STRINGi9913.ENSBTAP00000029344.

Chemistry

BindingDBiQ9MZL5.

Proteomic databases

PaxDbiQ9MZL5.
PRIDEiQ9MZL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000029344; ENSBTAP00000029344; ENSBTAG00000022000.
GeneIDi327667.
KEGGibta:327667.

Organism-specific databases

CTDi783.

Phylogenomic databases

eggNOGiKOG3812. Eukaryota.
ENOG410XRDI. LUCA.
GeneTreeiENSGT00390000002740.
HOVERGENiHBG050765.
InParanoidiQ9MZL5.
KOiK04863.
OMAiSAPHHNH.
OrthoDBiEOG7966G4.
TreeFamiTF316195.

Enzyme and pathway databases

ReactomeiR-BTA-112308. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
R-BTA-422356. Regulation of insulin secretion.
R-BTA-5576892. Phase 0 - rapid depolarisation.
R-BTA-5576893. Phase 2 - plateau phase.
R-BTA-5576894. Phase 1 - inactivation of fast Na+ channels.

Miscellaneous databases

NextBioi20810132.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
IPR005444. VDCC_L_b2su.
IPR000584. VDCC_L_bsu.
[Graphical view]
PANTHERiPTHR11824. PTHR11824. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF12052. VGCC_beta4Aa_N. 1 hit.
[Graphical view]
PRINTSiPR01626. LCACHANNELB.
PR01628. LCACHANNELB2.
SMARTiSM00072. GuKc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Coexpression of cloned alpha(1B), beta(2a), and alpha(2)/delta subunits produces non-inactivating calcium currents similar to those found in bovine chromaffin cells."
    Cahill A.L., Hurley J.H., Fox A.P.
    J. Neurosci. 20:1685-1693(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCACB2_BOVIN
AccessioniPrimary (citable) accession number: Q9MZL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.