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Protein

Sodium- and chloride-dependent taurine transporter

Gene

SLC6A6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-dependent taurine and beta-alanine transporter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent taurine transporter
Alternative name(s):
Solute carrier family 6 member 6
Gene namesi
Name:SLC6A6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949CytoplasmicSequence analysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei78 – 9720Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei122 – 14221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini143 – 21775ExtracellularSequence analysisAdd
BLAST
Transmembranei218 – 23619Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei245 – 26218Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei298 – 31518Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei327 – 34822Helical; Name=7Sequence analysisAdd
BLAST
Transmembranei381 – 40020Helical; Name=8Sequence analysisAdd
BLAST
Transmembranei430 – 44819Helical; Name=9Sequence analysisAdd
BLAST
Transmembranei465 – 48521Helical; Name=10Sequence analysisAdd
BLAST
Transmembranei506 – 52520Helical; Name=11Sequence analysisAdd
BLAST
Transmembranei545 – 56319Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini564 – 62057CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Sodium- and chloride-dependent taurine transporterPRO_0000214765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Modified residuei322 – 3221PhosphoserineBy similarity

Post-translational modificationi

Down-regulated upon Ser-322 phosphorylation.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9MZ34.
PRIDEiQ9MZ34.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014720.

Structurei

3D structure databases

ProteinModelPortaliQ9MZ34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ9MZ34.
KOiK05039.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002434. Na/ntran_symport_taurine.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01200. TAUTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MZ34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEAEGKPPQ REKWASRIDF
60 70 80 90 100
VLSVAGGFVG LGNVWRFPYL CYKNGGGAFL IPYFIFLFGG GLPVFFLEVI
110 120 130 140 150
IGQYTSEGGI TCWEKICPLF AGIGYASIVI VSLLNIYYII ILAWAMYYLF
160 170 180 190 200
QSFQSELPWA KCNHSWNTPH CLEDTLRRNR SLWISNSTAN FTSPVTEFWE
210 220 230 240 250
RKVLSLSSGI DEPGALKWDL ALCLLLVWLV CFFCIWKGVK STGKVVYFTA
260 270 280 290 300
TFPFAMLLVL LVRGLTLPGA GAGIKFYLYP DISRLEDPQV WIDAGTQIFF
310 320 330 340 350
SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF
360 370 380 390 400
MAQEQGVDIA DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL
410 420 430 440 450
DSQFVEVEGQ ITSLVDLHPS LLRKGFHREI FIASICCVTY LLGLTMVTEG
460 470 480 490 500
GMYVFQLFDY YAASGVCLLW VAFFECFAIA WIYGSDNFYD GIEDMIGYRP
510 520 530 540 550
GPWMKYCWAV VTPLLCTGCF IFSLVKYVPL TYNKVYTYPT WAIGLGWCLA
560 570 580 590 600
LSSMVCVPLV MVIRLAQTEG PFLVRLKYLL TPREPNRWAV EHEGAMPYSS
610 620
RMAVNNTLRK PTHIIVETMM
Length:620
Mass (Da):69,751
Last modified:October 1, 2000 - v1
Checksum:i3D5E8F79D336FDA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260239 mRNA. Translation: AAF76147.1.
RefSeqiNP_777035.1. NM_174610.2.
UniGeneiBt.276.

Genome annotation databases

GeneIDi282366.
KEGGibta:282366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260239 mRNA. Translation: AAF76147.1.
RefSeqiNP_777035.1. NM_174610.2.
UniGeneiBt.276.

3D structure databases

ProteinModelPortaliQ9MZ34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014720.

Proteomic databases

PaxDbiQ9MZ34.
PRIDEiQ9MZ34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282366.
KEGGibta:282366.

Organism-specific databases

CTDi6533.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ9MZ34.
KOiK05039.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002434. Na/ntran_symport_taurine.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01200. TAUTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of taurine transport in bovine aortic endothelial cells."
    Qian X., Vinnakota S., Edwards C., Sarkar H.K.
    Biochim. Biophys. Acta 1509:324-334(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSC6A6_BOVIN
AccessioniPrimary (citable) accession number: Q9MZ34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.