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Q9MZ08 (BCAM_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Basal cell adhesion molecule
Alternative name(s):
B-CAM cell surface glycoprotein
Lutheran antigen
CD_antigen=CD239
Gene names
Name:BCAM
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Laminin alpha-5 receptor. May mediate intracellular signaling By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 2 Ig-like V-type (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 By similarity
Chain32 – 628597Basal cell adhesion molecule
PRO_0000383337

Regions

Topological domain32 – 547516Extracellular Potential
Transmembrane548 – 56821Helical; Potential
Topological domain569 – 62860Cytoplasmic Potential
Domain32 – 142111Ig-like V-type 1
Domain150 – 253104Ig-like V-type 2
Domain254 – 355102Ig-like C2-type 1
Domain355 – 44187Ig-like C2-type 2
Domain448 – 53891Ig-like C2-type 3

Amino acid modifications

Modified residue5961Phosphoserine By similarity
Modified residue5981Phosphoserine By similarity
Modified residue6211Phosphoserine By similarity
Glycosylation3211N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation3781N-linked (GlcNAc...) Potential
Disulfide bond53 ↔ 125 By similarity
Disulfide bond172 ↔ 237 By similarity
Disulfide bond291 ↔ 337 By similarity
Disulfide bond384 ↔ 424 By similarity
Disulfide bond473 ↔ 522 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9MZ08 [UniParc].

Last modified December 1, 2001. Version 2.
Checksum: 2128B1F1B73E6A93

FASTA62868,003
        10         20         30         40         50         60 
MEPPDARAGA RRAPRLLVLA LLLAAPPGSK AEVRLSVPPL VEVMRGESVT LDCSPLGTHD 

        70         80         90        100        110        120 
YFMLEWFLVD RSGARHRLAS AELRGSELRD KELNSRGRSP PYQLDSQGRL VLPEAQVGDE 

       130        140        150        160        170        180 
RDYVCVVKAG AAGTAEATAR LKVFAKPEAP EVSPNKGILS VMDDFAQEIA TCSSRNGNPA 

       190        200        210        220        230        240 
PQIMWYRNGQ PLAVPLEVNS EGYMTTRTVR EASGLLSLTS TLYLRLHKPD REASFHCSVH 

       250        260        270        280        290        300 
YYLPAGQHGR LDGPSFSLTL HYPTEHVLFW LGSQSTAEGW VREGDSVQLL CQGDGSPTPE 

       310        320        330        340        350        360 
YTFFWLQDKQ EDVLKTSLEG NLTLERVQRN QSGTYGCRVE DFDVPEDAEL SKTLELRVAY 

       370        380        390        400        410        420 
LDSLELSAGE ELSLPLHNST TVTCSARGLP TPTLYWTKDS APMGEDPTLS LHSVTFDSAG 

       430        440        450        460        470        480 
TYTCEAYMPR IPLLSRTRSF RLLVQGTPEL KAKETQPKAE GSWTEGDEVT LICYARGYPK 

       490        500        510        520        530        540 
PKLTWSQLGG SPTEPAPGGQ GWVSSSLTLK VTSALSQDGV SCEASNPLGN THHVFHFGTV 

       550        560        570        580        590        600 
APQTSQAGVA VMAVAISVAL LLLVVAVFYC MRRKGRPGCC QWGEKGSPPP GEPKLSHSGS 

       610        620 
QRPEQTGLLM GSASGGAKHG SGGFGDEC 

« Hide

References

« Hide 'large scale' references
[1]"Vascular proteomics and subtractive antibody expression cloning."
Shusta E.V., Boado R.J., Pardridge W.M.
Mol. Cell. Proteomics 1:75-82(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal skin.
[3]"Selective Lutheran glycoprotein gene expression at the blood-brain barrier in normal brain and in human brain tumors."
Boado R.J., Li J.Y., Pardridge W.M.
J. Cereb. Blood Flow Metab. 20:1096-1102(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF270512 mRNA. Translation: AAF81749.2.
BC123496 mRNA. Translation: AAI23497.1.
RefSeqNP_777166.1. NM_174741.2.
UniGeneBt.7873.

3D structure databases

ProteinModelPortalQ9MZ08.
SMRQ9MZ08. Positions 32-262.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000012495.

Proteomic databases

PRIDEQ9MZ08.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000012495; ENSBTAP00000012495; ENSBTAG00000009495.
GeneID282862.
KEGGbta:282862.

Organism-specific databases

CTD4059.

Phylogenomic databases

eggNOGNOG150030.
GeneTreeENSGT00530000063457.
HOGENOMHOG000113409.
InParanoidQ9MZ08.
KOK06578.
OMAHYPTEHV.
OrthoDBEOG7GBFWH.
TreeFamTF330534.

Family and domain databases

Gene3D2.60.40.10. 5 hits.
InterProIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806391.

Entry information

Entry nameBCAM_BOVIN
AccessionPrimary (citable) accession number: Q9MZ08
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families