Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9MZ08

- BCAM_BOVIN

UniProt

Q9MZ08 - BCAM_BOVIN

Protein

Basal cell adhesion molecule

Gene

BCAM

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Laminin alpha-5 receptor. May mediate intracellular signaling By similarity.By similarity

    GO - Molecular functioni

    1. laminin receptor activity Source: Ensembl

    GO - Biological processi

    1. cell-matrix adhesion Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Basal cell adhesion molecule
    Alternative name(s):
    B-CAM cell surface glycoprotein
    Lutheran antigen
    CD_antigen: CD239
    Gene namesi
    Name:BCAM
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131By similarityAdd
    BLAST
    Chaini32 – 628597Basal cell adhesion moleculePRO_0000383337Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 125PROSITE-ProRule annotation
    Disulfide bondi172 ↔ 237PROSITE-ProRule annotation
    Disulfide bondi291 ↔ 337PROSITE-ProRule annotation
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi384 ↔ 424PROSITE-ProRule annotation
    Disulfide bondi473 ↔ 522PROSITE-ProRule annotation
    Modified residuei596 – 5961PhosphoserineBy similarity
    Modified residuei598 – 5981PhosphoserineBy similarity
    Modified residuei621 – 6211PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ9MZ08.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000012495.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9MZ08.
    SMRiQ9MZ08. Positions 32-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 547516ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini569 – 62860CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei548 – 56821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 142111Ig-like V-type 1Add
    BLAST
    Domaini150 – 253104Ig-like V-type 2Add
    BLAST
    Domaini254 – 355102Ig-like C2-type 1Add
    BLAST
    Domaini355 – 44187Ig-like C2-type 2Add
    BLAST
    Domaini448 – 53891Ig-like C2-type 3Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150030.
    GeneTreeiENSGT00530000063457.
    HOGENOMiHOG000113409.
    InParanoidiQ9MZ08.
    KOiK06578.
    OMAiHYPTEHV.
    OrthoDBiEOG7GBFWH.
    TreeFamiTF330534.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    SM00408. IGc2. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9MZ08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPPDARAGA RRAPRLLVLA LLLAAPPGSK AEVRLSVPPL VEVMRGESVT    50
    LDCSPLGTHD YFMLEWFLVD RSGARHRLAS AELRGSELRD KELNSRGRSP 100
    PYQLDSQGRL VLPEAQVGDE RDYVCVVKAG AAGTAEATAR LKVFAKPEAP 150
    EVSPNKGILS VMDDFAQEIA TCSSRNGNPA PQIMWYRNGQ PLAVPLEVNS 200
    EGYMTTRTVR EASGLLSLTS TLYLRLHKPD REASFHCSVH YYLPAGQHGR 250
    LDGPSFSLTL HYPTEHVLFW LGSQSTAEGW VREGDSVQLL CQGDGSPTPE 300
    YTFFWLQDKQ EDVLKTSLEG NLTLERVQRN QSGTYGCRVE DFDVPEDAEL 350
    SKTLELRVAY LDSLELSAGE ELSLPLHNST TVTCSARGLP TPTLYWTKDS 400
    APMGEDPTLS LHSVTFDSAG TYTCEAYMPR IPLLSRTRSF RLLVQGTPEL 450
    KAKETQPKAE GSWTEGDEVT LICYARGYPK PKLTWSQLGG SPTEPAPGGQ 500
    GWVSSSLTLK VTSALSQDGV SCEASNPLGN THHVFHFGTV APQTSQAGVA 550
    VMAVAISVAL LLLVVAVFYC MRRKGRPGCC QWGEKGSPPP GEPKLSHSGS 600
    QRPEQTGLLM GSASGGAKHG SGGFGDEC 628
    Length:628
    Mass (Da):68,003
    Last modified:December 1, 2001 - v2
    Checksum:i2128B1F1B73E6A93
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF270512 mRNA. Translation: AAF81749.2.
    BC123496 mRNA. Translation: AAI23497.1.
    RefSeqiNP_777166.1. NM_174741.2.
    UniGeneiBt.7873.

    Genome annotation databases

    EnsembliENSBTAT00000012495; ENSBTAP00000012495; ENSBTAG00000009495.
    GeneIDi282862.
    KEGGibta:282862.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF270512 mRNA. Translation: AAF81749.2 .
    BC123496 mRNA. Translation: AAI23497.1 .
    RefSeqi NP_777166.1. NM_174741.2.
    UniGenei Bt.7873.

    3D structure databases

    ProteinModelPortali Q9MZ08.
    SMRi Q9MZ08. Positions 32-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000012495.

    Proteomic databases

    PRIDEi Q9MZ08.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000012495 ; ENSBTAP00000012495 ; ENSBTAG00000009495 .
    GeneIDi 282862.
    KEGGi bta:282862.

    Organism-specific databases

    CTDi 4059.

    Phylogenomic databases

    eggNOGi NOG150030.
    GeneTreei ENSGT00530000063457.
    HOGENOMi HOG000113409.
    InParanoidi Q9MZ08.
    KOi K06578.
    OMAi HYPTEHV.
    OrthoDBi EOG7GBFWH.
    TreeFami TF330534.

    Miscellaneous databases

    NextBioi 20806391.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    SM00408. IGc2. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vascular proteomics and subtractive antibody expression cloning."
      Shusta E.V., Boado R.J., Pardridge W.M.
      Mol. Cell. Proteomics 1:75-82(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal skin.
    3. "Selective Lutheran glycoprotein gene expression at the blood-brain barrier in normal brain and in human brain tumors."
      Boado R.J., Li J.Y., Pardridge W.M.
      J. Cereb. Blood Flow Metab. 20:1096-1102(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiBCAM_BOVIN
    AccessioniPrimary (citable) accession number: Q9MZ08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3