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Protein

Basal cell adhesion molecule

Gene

BCAM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Basal cell adhesion molecule
Alternative name(s):
B-CAM cell surface glycoprotein
Lutheran antigen
CD_antigen: CD239
Gene namesi
Name:BCAM
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:49138 BCAM

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 547ExtracellularSequence analysisAdd BLAST516
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Topological domaini569 – 628CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000038333732 – 628Basal cell adhesion moleculeAdd BLAST597

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 125PROSITE-ProRule annotation
Disulfide bondi172 ↔ 237PROSITE-ProRule annotation
Disulfide bondi291 ↔ 337PROSITE-ProRule annotation
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi384 ↔ 424PROSITE-ProRule annotation
Disulfide bondi473 ↔ 522PROSITE-ProRule annotation
Modified residuei596PhosphoserineBy similarity1
Modified residuei598PhosphoserineBy similarity1
Modified residuei600PhosphoserineBy similarity1
Modified residuei621PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9MZ08
PeptideAtlasiQ9MZ08
PRIDEiQ9MZ08

Expressioni

Gene expression databases

BgeeiENSBTAG00000009495

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012495

Structurei

3D structure databases

ProteinModelPortaliQ9MZ08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 142Ig-like V-type 1Add BLAST111
Domaini150 – 253Ig-like V-type 2Add BLAST104
Domaini254 – 355Ig-like C2-type 1Add BLAST102
Domaini355 – 441Ig-like C2-type 2Add BLAST87
Domaini448 – 538Ig-like C2-type 3Add BLAST91

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJIS Eukaryota
ENOG4111XZT LUCA
GeneTreeiENSGT00530000063457
HOGENOMiHOG000113409
InParanoidiQ9MZ08
KOiK06578
OMAiRDASFHC
OrthoDBiEOG091G05IA
TreeFamiTF330534

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9MZ08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPDARAGA RRAPRLLVLA LLLAAPPGSK AEVRLSVPPL VEVMRGESVT
60 70 80 90 100
LDCSPLGTHD YFMLEWFLVD RSGARHRLAS AELRGSELRD KELNSRGRSP
110 120 130 140 150
PYQLDSQGRL VLPEAQVGDE RDYVCVVKAG AAGTAEATAR LKVFAKPEAP
160 170 180 190 200
EVSPNKGILS VMDDFAQEIA TCSSRNGNPA PQIMWYRNGQ PLAVPLEVNS
210 220 230 240 250
EGYMTTRTVR EASGLLSLTS TLYLRLHKPD REASFHCSVH YYLPAGQHGR
260 270 280 290 300
LDGPSFSLTL HYPTEHVLFW LGSQSTAEGW VREGDSVQLL CQGDGSPTPE
310 320 330 340 350
YTFFWLQDKQ EDVLKTSLEG NLTLERVQRN QSGTYGCRVE DFDVPEDAEL
360 370 380 390 400
SKTLELRVAY LDSLELSAGE ELSLPLHNST TVTCSARGLP TPTLYWTKDS
410 420 430 440 450
APMGEDPTLS LHSVTFDSAG TYTCEAYMPR IPLLSRTRSF RLLVQGTPEL
460 470 480 490 500
KAKETQPKAE GSWTEGDEVT LICYARGYPK PKLTWSQLGG SPTEPAPGGQ
510 520 530 540 550
GWVSSSLTLK VTSALSQDGV SCEASNPLGN THHVFHFGTV APQTSQAGVA
560 570 580 590 600
VMAVAISVAL LLLVVAVFYC MRRKGRPGCC QWGEKGSPPP GEPKLSHSGS
610 620
QRPEQTGLLM GSASGGAKHG SGGFGDEC
Length:628
Mass (Da):68,003
Last modified:December 1, 2001 - v2
Checksum:i2128B1F1B73E6A93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270512 mRNA Translation: AAF81749.2
BC123496 mRNA Translation: AAI23497.1
RefSeqiNP_777166.1, NM_174741.2
UniGeneiBt.7873

Genome annotation databases

EnsembliENSBTAT00000012495; ENSBTAP00000012495; ENSBTAG00000009495
GeneIDi282862
KEGGibta:282862

Similar proteinsi

Entry informationi

Entry nameiBCAM_BOVIN
AccessioniPrimary (citable) accession number: Q9MZ08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health