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Protein

Basal cell adhesion molecule

Gene

BCAM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Basal cell adhesion molecule
Alternative name(s):
B-CAM cell surface glycoprotein
Lutheran antigen
CD_antigen: CD239
Gene namesi
Name:BCAM
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 547516ExtracellularSequence AnalysisAdd
BLAST
Transmembranei548 – 56821HelicalSequence AnalysisAdd
BLAST
Topological domaini569 – 62860CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131By similarityAdd
BLAST
Chaini32 – 628597Basal cell adhesion moleculePRO_0000383337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 125PROSITE-ProRule annotation
Disulfide bondi172 ↔ 237PROSITE-ProRule annotation
Disulfide bondi291 ↔ 337PROSITE-ProRule annotation
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi384 ↔ 424PROSITE-ProRule annotation
Disulfide bondi473 ↔ 522PROSITE-ProRule annotation
Modified residuei596 – 5961PhosphoserineBy similarity
Modified residuei598 – 5981PhosphoserineBy similarity
Modified residuei600 – 6001PhosphoserineBy similarity
Modified residuei621 – 6211PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9MZ08.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012495.

Structurei

3D structure databases

ProteinModelPortaliQ9MZ08.
SMRiQ9MZ08. Positions 32-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 142111Ig-like V-type 1Add
BLAST
Domaini150 – 253104Ig-like V-type 2Add
BLAST
Domaini254 – 355102Ig-like C2-type 1Add
BLAST
Domaini355 – 44187Ig-like C2-type 2Add
BLAST
Domaini448 – 53891Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150030.
GeneTreeiENSGT00530000063457.
HOGENOMiHOG000113409.
InParanoidiQ9MZ08.
KOiK06578.
OMAiHYPTEHV.
OrthoDBiEOG7GBFWH.
TreeFamiTF330534.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9MZ08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPDARAGA RRAPRLLVLA LLLAAPPGSK AEVRLSVPPL VEVMRGESVT
60 70 80 90 100
LDCSPLGTHD YFMLEWFLVD RSGARHRLAS AELRGSELRD KELNSRGRSP
110 120 130 140 150
PYQLDSQGRL VLPEAQVGDE RDYVCVVKAG AAGTAEATAR LKVFAKPEAP
160 170 180 190 200
EVSPNKGILS VMDDFAQEIA TCSSRNGNPA PQIMWYRNGQ PLAVPLEVNS
210 220 230 240 250
EGYMTTRTVR EASGLLSLTS TLYLRLHKPD REASFHCSVH YYLPAGQHGR
260 270 280 290 300
LDGPSFSLTL HYPTEHVLFW LGSQSTAEGW VREGDSVQLL CQGDGSPTPE
310 320 330 340 350
YTFFWLQDKQ EDVLKTSLEG NLTLERVQRN QSGTYGCRVE DFDVPEDAEL
360 370 380 390 400
SKTLELRVAY LDSLELSAGE ELSLPLHNST TVTCSARGLP TPTLYWTKDS
410 420 430 440 450
APMGEDPTLS LHSVTFDSAG TYTCEAYMPR IPLLSRTRSF RLLVQGTPEL
460 470 480 490 500
KAKETQPKAE GSWTEGDEVT LICYARGYPK PKLTWSQLGG SPTEPAPGGQ
510 520 530 540 550
GWVSSSLTLK VTSALSQDGV SCEASNPLGN THHVFHFGTV APQTSQAGVA
560 570 580 590 600
VMAVAISVAL LLLVVAVFYC MRRKGRPGCC QWGEKGSPPP GEPKLSHSGS
610 620
QRPEQTGLLM GSASGGAKHG SGGFGDEC
Length:628
Mass (Da):68,003
Last modified:December 1, 2001 - v2
Checksum:i2128B1F1B73E6A93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270512 mRNA. Translation: AAF81749.2.
BC123496 mRNA. Translation: AAI23497.1.
RefSeqiNP_777166.1. NM_174741.2.
UniGeneiBt.7873.

Genome annotation databases

EnsembliENSBTAT00000012495; ENSBTAP00000012495; ENSBTAG00000009495.
GeneIDi282862.
KEGGibta:282862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270512 mRNA. Translation: AAF81749.2.
BC123496 mRNA. Translation: AAI23497.1.
RefSeqiNP_777166.1. NM_174741.2.
UniGeneiBt.7873.

3D structure databases

ProteinModelPortaliQ9MZ08.
SMRiQ9MZ08. Positions 32-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012495.

Proteomic databases

PRIDEiQ9MZ08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012495; ENSBTAP00000012495; ENSBTAG00000009495.
GeneIDi282862.
KEGGibta:282862.

Organism-specific databases

CTDi4059.

Phylogenomic databases

eggNOGiNOG150030.
GeneTreeiENSGT00530000063457.
HOGENOMiHOG000113409.
InParanoidiQ9MZ08.
KOiK06578.
OMAiHYPTEHV.
OrthoDBiEOG7GBFWH.
TreeFamiTF330534.

Miscellaneous databases

NextBioi20806391.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Vascular proteomics and subtractive antibody expression cloning."
    Shusta E.V., Boado R.J., Pardridge W.M.
    Mol. Cell. Proteomics 1:75-82(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.
  3. "Selective Lutheran glycoprotein gene expression at the blood-brain barrier in normal brain and in human brain tumors."
    Boado R.J., Li J.Y., Pardridge W.M.
    J. Cereb. Blood Flow Metab. 20:1096-1102(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiBCAM_BOVIN
AccessioniPrimary (citable) accession number: Q9MZ08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: December 1, 2001
Last modified: May 27, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.