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Q9MZ03

- CD38_RABIT

UniProt

Q9MZ03 - CD38_RABIT

Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene

CD38

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity.2 Publications

    Catalytic activityi

    NAD+ + H2O = ADP-D-ribose + nicotinamide.
    NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei117 – 1171By similarity
    Active sitei199 – 1991By similarity

    GO - Molecular functioni

    1. NAD(P)+ nucleosidase activity Source: UniProtKB-EC
    2. NAD+ nucleosidase activity Source: UniProtKB
    3. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular signal transduction Source: UniProtKB
    2. metabolic process Source: GOC

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Ligandi

    NAD, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC:3.2.2.6)
    Alternative name(s):
    2'-phospho-ADP-ribosyl cyclase
    2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)
    2'-phospho-cyclic-ADP-ribose transferase
    ADP-ribosyl cyclase 1
    Short name:
    ADPRC 1
    Cyclic ADP-ribose hydrolase 1
    Short name:
    cADPr hydrolase 1
    CD_antigen: CD38
    Gene namesi
    Name:CD38
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular membrane-bounded organelle Source: UniProtKB
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1PRO_0000144069Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi64 ↔ 80By similarity
    Disulfide bondi97 ↔ 178By similarity
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi158 ↔ 171By similarity
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi252 ↔ 273By similarity
    Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi285 ↔ 294By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Osteoclasts.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9MZ03.
    SMRiQ9MZ03. Positions 49-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini43 – 298256ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADP-ribosyl cyclase family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42596.
    HOGENOMiHOG000293141.
    HOVERGENiHBG005277.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR003193. ADP-ribosyl_cyclase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR10912. PTHR10912. 1 hit.
    PfamiPF02267. Rib_hydrolayse. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9MZ03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDYEFSPAS GDRPRSWISK QVLIVLGVCL PVILALAIWV GVLTWRQSSM    50
    GATDHVSAIV LGRCLTYTRN MHPELRNQDC KKILNTFTSA FVSKDPCNIT 100
    KEDYQPLIDL VTQTVPCNKT LFWSRSKELA HQYSGIQKEM FTLEDTLLGY 150
    IADNLVWCGD PRTSEVKEEF CPYRNENCSS TATSVFWTVV SQKFAESACG 200
    TVYVMLNGSR TTAFSKASTF GSVEVFNLHP DRVHTLHAWV MHDIGGVERD 250
    SCLGSSIKEL KSIVNQRNIS FFCQDDYRPA RFVQCVRHPE HPSCSVLM 298
    Length:298
    Mass (Da):33,637
    Last modified:October 1, 2000 - v1
    Checksum:i7A4942F5A4625B60
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF272974 mRNA. Translation: AAF87715.1.
    PIRiJC7323.
    RefSeqiNP_001076152.1. NM_001082683.1.
    UniGeneiOcu.1561.

    Genome annotation databases

    GeneIDi100009409.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF272974 mRNA. Translation: AAF87715.1 .
    PIRi JC7323.
    RefSeqi NP_001076152.1. NM_001082683.1.
    UniGenei Ocu.1561.

    3D structure databases

    ProteinModelPortali Q9MZ03.
    SMRi Q9MZ03. Positions 49-277.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100009409.

    Organism-specific databases

    CTDi 952.

    Phylogenomic databases

    eggNOGi NOG42596.
    HOGENOMi HOG000293141.
    HOVERGENi HBG005277.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR003193. ADP-ribosyl_cyclase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10912. PTHR10912. 1 hit.
    Pfami PF02267. Rib_hydrolayse. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.
      Tissue: Osteoclast.
    2. "Molecular cloning, expression, and functional characterization of a novel member of the CD38 family of ADP-ribosyl cyclases."
      Adebanjo O.A., Koval A., Moonga B.S., Wu X.B., Yao S., Bevis P.J.R., Kumegawa M., Zaidi M., Sun L.
      Biochem. Biophys. Res. Commun. 273:884-889(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
      Tissue: Osteoclast.

    Entry informationi

    Entry nameiCD38_RABIT
    AccessioniPrimary (citable) accession number: Q9MZ03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3