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Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene

CD38

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity.2 Publications

Catalytic activityi

NAD+ + H2O = ADP-D-ribose + nicotinamide.
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171By similarity
Active sitei199 – 1991By similarity

GO - Molecular functioni

  1. NAD(P)+ nucleosidase activity Source: UniProtKB-EC
  2. NAD+ nucleosidase activity Source: UniProtKB
  3. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: UniProtKB
  2. metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC:3.2.2.6)
Alternative name(s):
2'-phospho-ADP-ribosyl cyclase
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)
2'-phospho-cyclic-ADP-ribose transferase
ADP-ribosyl cyclase 1
Short name:
ADPRC 1
Cyclic ADP-ribose hydrolase 1
Short name:
cADPr hydrolase 1
CD_antigen: CD38
Gene namesi
Name:CD38
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei22 – 4221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini43 – 298256ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: UniProtKB
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1PRO_0000144069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 80By similarity
Disulfide bondi97 ↔ 178By similarity
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi158 ↔ 171By similarity
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi252 ↔ 273By similarity
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi285 ↔ 294By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Osteoclasts.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9MZ03.
SMRiQ9MZ03. Positions 49-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosyl cyclase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42596.
HOGENOMiHOG000293141.
HOVERGENiHBG005277.
InParanoidiQ9MZ03.
KOiK01242.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10912. PTHR10912. 1 hit.
PfamiPF02267. Rib_hydrolayse. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MZ03-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDYEFSPAS GDRPRSWISK QVLIVLGVCL PVILALAIWV GVLTWRQSSM
60 70 80 90 100
GATDHVSAIV LGRCLTYTRN MHPELRNQDC KKILNTFTSA FVSKDPCNIT
110 120 130 140 150
KEDYQPLIDL VTQTVPCNKT LFWSRSKELA HQYSGIQKEM FTLEDTLLGY
160 170 180 190 200
IADNLVWCGD PRTSEVKEEF CPYRNENCSS TATSVFWTVV SQKFAESACG
210 220 230 240 250
TVYVMLNGSR TTAFSKASTF GSVEVFNLHP DRVHTLHAWV MHDIGGVERD
260 270 280 290
SCLGSSIKEL KSIVNQRNIS FFCQDDYRPA RFVQCVRHPE HPSCSVLM
Length:298
Mass (Da):33,637
Last modified:October 1, 2000 - v1
Checksum:i7A4942F5A4625B60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272974 mRNA. Translation: AAF87715.1.
PIRiJC7323.
RefSeqiNP_001076152.1. NM_001082683.1.
UniGeneiOcu.1561.

Genome annotation databases

GeneIDi100009409.
KEGGiocu:100009409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272974 mRNA. Translation: AAF87715.1.
PIRiJC7323.
RefSeqiNP_001076152.1. NM_001082683.1.
UniGeneiOcu.1561.

3D structure databases

ProteinModelPortaliQ9MZ03.
SMRiQ9MZ03. Positions 49-277.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009409.
KEGGiocu:100009409.

Organism-specific databases

CTDi952.

Phylogenomic databases

eggNOGiNOG42596.
HOGENOMiHOG000293141.
HOVERGENiHBG005277.
InParanoidiQ9MZ03.
KOiK01242.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10912. PTHR10912. 1 hit.
PfamiPF02267. Rib_hydrolayse. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.
    Tissue: Osteoclast.
  2. "Molecular cloning, expression, and functional characterization of a novel member of the CD38 family of ADP-ribosyl cyclases."
    Adebanjo O.A., Koval A., Moonga B.S., Wu X.B., Yao S., Bevis P.J.R., Kumegawa M., Zaidi M., Sun L.
    Biochem. Biophys. Res. Commun. 273:884-889(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Osteoclast.

Entry informationi

Entry nameiCD38_RABIT
AccessioniPrimary (citable) accession number: Q9MZ03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.