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Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene

CD38

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity.2 Publications

Catalytic activityi

NAD+ + H2O = ADP-D-ribose + nicotinamide.
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei117By similarity1
Active sitei199By similarity1

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Transferase
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC:3.2.2.6)
Alternative name(s):
2'-phospho-ADP-ribosyl cyclase
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)
2'-phospho-cyclic-ADP-ribose transferase
ADP-ribosyl cyclase 1
Short name:
ADPRC 1
Cyclic ADP-ribose hydrolase 1
Short name:
cADPr hydrolase 1
CD_antigen: CD38
Gene namesi
Name:CD38
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini43 – 298ExtracellularSequence analysisAdd BLAST256

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440691 – 298ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 80By similarity
Disulfide bondi97 ↔ 178By similarity
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi158 ↔ 171By similarity
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi252 ↔ 273By similarity
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi285 ↔ 294By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Osteoclasts.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000015283.

Structurei

3D structure databases

ProteinModelPortaliQ9MZ03.
SMRiQ9MZ03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosyl cyclase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH8E. Eukaryota.
ENOG4111W33. LUCA.
HOGENOMiHOG000293141.
HOVERGENiHBG005277.
InParanoidiQ9MZ03.
KOiK01242.

Family and domain databases

CDDicd04759. Rib_hydrolase. 1 hit.
InterProiView protein in InterPro
IPR003193. ADP-ribosyl_cyclase.
IPR033567. CD38.
PANTHERiPTHR10912. PTHR10912. 1 hit.
PTHR10912:SF9. PTHR10912:SF9. 1 hit.
PfamiView protein in Pfam
PF02267. Rib_hydrolayse. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9MZ03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDYEFSPAS GDRPRSWISK QVLIVLGVCL PVILALAIWV GVLTWRQSSM
60 70 80 90 100
GATDHVSAIV LGRCLTYTRN MHPELRNQDC KKILNTFTSA FVSKDPCNIT
110 120 130 140 150
KEDYQPLIDL VTQTVPCNKT LFWSRSKELA HQYSGIQKEM FTLEDTLLGY
160 170 180 190 200
IADNLVWCGD PRTSEVKEEF CPYRNENCSS TATSVFWTVV SQKFAESACG
210 220 230 240 250
TVYVMLNGSR TTAFSKASTF GSVEVFNLHP DRVHTLHAWV MHDIGGVERD
260 270 280 290
SCLGSSIKEL KSIVNQRNIS FFCQDDYRPA RFVQCVRHPE HPSCSVLM
Length:298
Mass (Da):33,637
Last modified:October 1, 2000 - v1
Checksum:i7A4942F5A4625B60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272974 mRNA. Translation: AAF87715.1.
PIRiJC7323.
RefSeqiNP_001076152.1. NM_001082683.1.
UniGeneiOcu.1561.

Genome annotation databases

GeneIDi100009409.
KEGGiocu:100009409.

Similar proteinsi

Entry informationi

Entry nameiCD38_RABIT
AccessioniPrimary (citable) accession number: Q9MZ03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families