SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9MZ03

- CD38_RABIT

UniProt

Q9MZ03 - CD38_RABIT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Gene
CD38
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity.2 Publications

Catalytic activityi

NAD+ + H2O = ADP-D-ribose + nicotinamide.
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171 By similarity
Active sitei199 – 1991 By similarity

GO - Molecular functioni

  1. NAD(P)+ nucleosidase activity Source: UniProtKB-EC
  2. NAD+ nucleosidase activity Source: UniProtKB
  3. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: UniProtKB
  2. metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC:3.2.2.6)
Alternative name(s):
2'-phospho-ADP-ribosyl cyclase
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)
2'-phospho-cyclic-ADP-ribose transferase
ADP-ribosyl cyclase 1
Short name:
ADPRC 1
Cyclic ADP-ribose hydrolase 1
Short name:
cADPr hydrolase 1
CD_antigen: CD38
Gene namesi
Name:CD38
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Cell membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei22 – 4221Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini43 – 298256Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: UniProtKB
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
PRO_0000144069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 80 By similarity
Disulfide bondi97 ↔ 178 By similarity
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi158 ↔ 171 By similarity
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi252 ↔ 273 By similarity
Glycosylationi268 – 2681N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi285 ↔ 294 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Osteoclasts.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9MZ03.
SMRiQ9MZ03. Positions 49-277.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42596.
HOGENOMiHOG000293141.
HOVERGENiHBG005277.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10912. PTHR10912. 1 hit.
PfamiPF02267. Rib_hydrolayse. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MZ03-1 [UniParc]FASTAAdd to Basket

« Hide

MPDYEFSPAS GDRPRSWISK QVLIVLGVCL PVILALAIWV GVLTWRQSSM    50
GATDHVSAIV LGRCLTYTRN MHPELRNQDC KKILNTFTSA FVSKDPCNIT 100
KEDYQPLIDL VTQTVPCNKT LFWSRSKELA HQYSGIQKEM FTLEDTLLGY 150
IADNLVWCGD PRTSEVKEEF CPYRNENCSS TATSVFWTVV SQKFAESACG 200
TVYVMLNGSR TTAFSKASTF GSVEVFNLHP DRVHTLHAWV MHDIGGVERD 250
SCLGSSIKEL KSIVNQRNIS FFCQDDYRPA RFVQCVRHPE HPSCSVLM 298
Length:298
Mass (Da):33,637
Last modified:October 1, 2000 - v1
Checksum:i7A4942F5A4625B60
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF272974 mRNA. Translation: AAF87715.1.
PIRiJC7323.
RefSeqiNP_001076152.1. NM_001082683.1.
UniGeneiOcu.1561.

Genome annotation databases

GeneIDi100009409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF272974 mRNA. Translation: AAF87715.1 .
PIRi JC7323.
RefSeqi NP_001076152.1. NM_001082683.1.
UniGenei Ocu.1561.

3D structure databases

ProteinModelPortali Q9MZ03.
SMRi Q9MZ03. Positions 49-277.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100009409.

Organism-specific databases

CTDi 952.

Phylogenomic databases

eggNOGi NOG42596.
HOGENOMi HOG000293141.
HOVERGENi HBG005277.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR10912. PTHR10912. 1 hit.
Pfami PF02267. Rib_hydrolayse. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.
    Tissue: Osteoclast.
  2. "Molecular cloning, expression, and functional characterization of a novel member of the CD38 family of ADP-ribosyl cyclases."
    Adebanjo O.A., Koval A., Moonga B.S., Wu X.B., Yao S., Bevis P.J.R., Kumegawa M., Zaidi M., Sun L.
    Biochem. Biophys. Res. Commun. 273:884-889(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Osteoclast.

Entry informationi

Entry nameiCD38_RABIT
AccessioniPrimary (citable) accession number: Q9MZ03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi