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Protein

Melanin-concentrating hormone receptor 1

Gene

MCHR1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
Gene namesi
Name:MCHR1
Synonyms:GPR24
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 33›33CytoplasmicSequence analysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini55 – 7016ExtracellularSequence analysisAdd
BLAST
Transmembranei71 – 9121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini92 – ›121›30CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›121›121Melanin-concentrating hormone receptor 1PRO_0000069738Add
BLAST

Proteomic databases

PaxDbiQ9MZ01.

Expressioni

Gene expression databases

GenevisibleiQ9MZ01. SS.

Interactioni

Subunit structurei

Interacts with NCDN.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000079.

Structurei

3D structure databases

ProteinModelPortaliQ9MZ01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
InParanoidiQ9MZ01.
OrthoDBiEOG091G0HEN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9MZ01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TAAYVRILQR MTSSVAPASQ RSIRLRTKRV TRTAIAICLV FFVCWAPYYV
60 70 80 90 100
LQLTQLSISR PTLTFVYLYN AAISLGYANS CLNPFVYIVL CETFRKRLVL
110 120
SVKPAAQGQL RAVSNAQTAE E
Length:121
Mass (Da):13,583
Last modified:October 1, 2000 - v1
Checksum:i884D8268B6F9F010
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei121 – 1211

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273611 mRNA. Translation: AAF81827.1.
UniGeneiSsc.15970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273611 mRNA. Translation: AAF81827.1.
UniGeneiSsc.15970.

3D structure databases

ProteinModelPortaliQ9MZ01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000079.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9MZ01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
InParanoidiQ9MZ01.
OrthoDBiEOG091G0HEN.

Gene expression databases

GenevisibleiQ9MZ01. SS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCHR1_PIG
AccessioniPrimary (citable) accession number: Q9MZ01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.