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Protein

Melanin-concentrating hormone receptor 1

Gene

MCHR1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-416476. G alpha (q) signalling events.
R-SSC-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
Gene namesi
Name:MCHR1
Synonyms:GPR24
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 33›33CytoplasmicSequence analysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini55 – 7016ExtracellularSequence analysisAdd
BLAST
Transmembranei71 – 9121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini92 – ›121›30CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›121›121Melanin-concentrating hormone receptor 1PRO_0000069738Add
BLAST

Proteomic databases

PaxDbiQ9MZ01.

Expressioni

Gene expression databases

GenevisibleiQ9MZ01. SS.

Interactioni

Subunit structurei

Interacts with NCDN.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000079.

Structurei

3D structure databases

ProteinModelPortaliQ9MZ01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
InParanoidiQ9MZ01.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9MZ01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TAAYVRILQR MTSSVAPASQ RSIRLRTKRV TRTAIAICLV FFVCWAPYYV
60 70 80 90 100
LQLTQLSISR PTLTFVYLYN AAISLGYANS CLNPFVYIVL CETFRKRLVL
110 120
SVKPAAQGQL RAVSNAQTAE E
Length:121
Mass (Da):13,583
Last modified:October 1, 2000 - v1
Checksum:i884D8268B6F9F010
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei121 – 1211

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273611 mRNA. Translation: AAF81827.1.
UniGeneiSsc.15970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273611 mRNA. Translation: AAF81827.1.
UniGeneiSsc.15970.

3D structure databases

ProteinModelPortaliQ9MZ01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000079.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9MZ01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
InParanoidiQ9MZ01.

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-416476. G alpha (q) signalling events.
R-SSC-418594. G alpha (i) signalling events.

Gene expression databases

GenevisibleiQ9MZ01. SS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sus scrofa melanin-concentrating hormone (MCH) receptor."
    Matteri R.L.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.

Entry informationi

Entry nameiMCHR1_PIG
AccessioniPrimary (citable) accession number: Q9MZ01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: October 1, 2000
Last modified: February 17, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.