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Q9MYW6

- XDH_FELCA

UniProt

Q9MYW6 - XDH_FELCA

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Protein
Xanthine dehydrogenase/oxidase
Gene
XDH
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species By similarity.

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.
Xanthine + H2O + O2 = urate + H2O2.

Cofactori

Binds 2 2Fe-2S clusters By similarity.
FAD By similarity.
Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.

Enzyme regulationi

Can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi43 – 431Iron-sulfur 1 By similarity
Metal bindingi48 – 481Iron-sulfur 1 By similarity
Metal bindingi51 – 511Iron-sulfur 1 By similarity
Metal bindingi73 – 731Iron-sulfur 1 By similarity
Metal bindingi113 – 1131Iron-sulfur 2 By similarity
Metal bindingi116 – 1161Iron-sulfur 2 By similarity
Metal bindingi148 – 1481Iron-sulfur 2 By similarity
Metal bindingi150 – 1501Iron-sulfur 2 By similarity
Binding sitei335 – 3351FAD By similarity
Binding sitei358 – 3581FAD By similarity
Binding sitei402 – 4021FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei420 – 4201FAD By similarity
Metal bindingi766 – 7661Molybdenum By similarity
Metal bindingi797 – 7971Molybdenum; via carbonyl oxygen By similarity
Binding sitei801 – 8011Substrate By similarity
Binding sitei879 – 8791Substrate By similarity
Metal bindingi911 – 9111Molybdenum; via amide nitrogen By similarity
Binding sitei913 – 9131Substrate By similarity
Binding sitei1009 – 10091Substrate; via amide nitrogen By similarity
Metal bindingi1078 – 10781Molybdenum; via amide nitrogen By similarity
Active sitei1260 – 12601Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi257 – 2648FAD By similarity
Nucleotide bindingi345 – 3495FAD By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
  2. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
  3. electron carrier activity Source: InterPro
  4. flavin adenine dinucleotide binding Source: UniProtKB
  5. iron ion binding Source: InterPro
  6. molybdopterin cofactor binding Source: UniProtKB
  7. xanthine dehydrogenase activity Source: UniProtKB
  8. xanthine oxidase activity Source: UniProtKB

GO - Biological processi

  1. xanthine catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine dehydrogenase/oxidase
Including the following 2 domains:
Xanthine dehydrogenase (EC:1.17.1.4)
Short name:
XD
Xanthine oxidase (EC:1.17.3.2)
Short name:
XO
Alternative name(s):
Xanthine oxidoreductase
Short name:
XOR
Gene namesi
Name:XDH
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

Cytoplasm By similarity. Peroxisome By similarity. Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Peroxisome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 13311330Xanthine dehydrogenase/oxidase
PRO_0000246176Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi534 ↔ 991In oxidase form By similarity
Glycosylationi1072 – 10721N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Subject to partial proteolysis By similarity; this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O) By similarity.
Contains sulfhydryl groups that are easily oxidized (in vitro); this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O) By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer. Interacts with BTN1A1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9MYW6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 91882Fe-2S ferredoxin-type
Add
BLAST
Domaini229 – 412184FAD-binding PCMH-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4630.
HOVERGENiHBG004182.
KOiK00106.

Family and domain databases

Gene3Di1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.365.10. 6 hits.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.1170.50. 1 hit.
InterProiIPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR016208. Ald_Oxase/xanthine_DH.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
IPR022407. OxRdtase_Mopterin_BS.
IPR014307. Xanthine_DH_ssu.
[Graphical view]
PfamiPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000127. Xanthine_DH. 1 hit.
SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
SM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF54665. SSF54665. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56003. SSF56003. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR02963. xanthine_xdhA. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9MYW6-1 [UniParc]FASTAAdd to Basket

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MTADELVFFV NGKKVVEKNA DPETTLLAYL RRKLGLSGTK LGCGEGGCGA     50
CTVMLSKYDR FQNKIVHFSA NACLAPICSL HHVAVTTVEG IGSTKSRLHP 100
VQERIAKSHG SQCGFCTPGI VMSMYTLLRN QPEPTIEEIE DAFQGNLCRC 150
TGYRPILQGF RTFARDGGCC GGSGNDLNCC MNQKTDHKIT LSPSLFNPEE 200
FTPLDPTQEP IFPPELLRLK DTPQKQLRFE GERVTWIQAS TLQELLDLKA 250
QDPEAKLVVG NTEIGIEMKF KNMLFPKMVC PAWIPEPVEH GPEGISFGAS 300
CPLSLVEKTL LDAVANLPAH QTEVFKGVLE QLRWFAGKQV KSVASIGGNI 350
ITASPISDLN PVFMASGAKL TIVSTGTRRT VRMDHTFFPA YRKTLLAPEE 400
ILLSIEIPYS REGEYFSAFK QASRREDDIA KVTSGMRVLF NPGTAQVKEL 450
ALCYGGMHDR TVSALQTTRK QISNFWNEEL LQNVCAGLAE ELSLAPDAPG 500
GMVEFRRTLT LSFFFKFYLT VLQKLGIQNS KDKCGKLDPT HASATLLFQK 550
DPPANVQLFQ EVPKGQCEED MVGRPLPHLA AAMQASGEAV YCDDIPRYEN 600
ELSLRLVTST RAHAKIKSID TSEAQKVPGF VCFISADDVP GSNITGIGND 650
EMVFAKDKVT CIGHIIGAVV TDTREHAQRA AQAVRITYED LPAIITIEDA 700
IAKDSFYEPE LKIEKGNLTK GFSEADNIVS GELYIGGQEH FYLETHCTIA 750
VPKGEAGEME LFVSTQNTTK TQSFVANMLG VPANRILVRV KRMGGGFGGK 800
ETRSTVVSTA VPLAAYKTGR PVRCMLDRDE DMLITGGRHP FLARYKVGFM 850
KTGRVVALKV EHYSNAGNTL DLSQSIMERA LFHMDNCYNI PNIRGTGRIC 900
KTNLPSNTAF RGFGGPQGML IAEHWMSEVA VTCGLPAEEV RRKNMYKEGD 950
LTHFNQKLEG FTLPRCWEEC LASSQYHARK READKFNEEN CWKKRGLSII 1000
PTKFGISFTV PFLNQAGALV HVYTDGSVLL THGGTEMGQG LHTKMVQVAS 1050
RALKIPTSKI YISETSTNTV PNTSPTAASV STDINGQAVY EACQTILKRL 1100
EPFKKKNPSG SWEDWVTAAY LDAVSLSATG FYKTPNIGYS FETNSGNPFH 1150
YFSYGVACSE VEIDCLTGDH KNLRTDIVMD VGSSLNPAID IGQVEGAFVQ 1200
GLGLFTLEEL HYSPEGSLHT RGPSTYKIPA FGSIPSEFRV SLLRDCPNKK 1250
AIYASKAVGE PPLFLAASIF FAIKDAICAA RAGNPDCKTK KLFQLNSPAT 1300
PEKIRNACVD QFTRLCVTGT AESCKPWSVR V 1331
Length:1,331
Mass (Da):146,122
Last modified:January 23, 2007 - v3
Checksum:i726C4F72C3B5FB09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF286379 mRNA. Translation: AAF97949.1.
RefSeqiNP_001009217.1. NM_001009217.1.

Genome annotation databases

GeneIDi493692.
KEGGifca:493692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF286379 mRNA. Translation: AAF97949.1 .
RefSeqi NP_001009217.1. NM_001009217.1.

3D structure databases

ProteinModelPortali Q9MYW6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493692.
KEGGi fca:493692.

Organism-specific databases

CTDi 7498.

Phylogenomic databases

eggNOGi COG4630.
HOVERGENi HBG004182.
KOi K00106.

Family and domain databases

Gene3Di 1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.365.10. 6 hits.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.1170.50. 1 hit.
InterProi IPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR016208. Ald_Oxase/xanthine_DH.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
IPR022407. OxRdtase_Mopterin_BS.
IPR014307. Xanthine_DH_ssu.
[Graphical view ]
Pfami PF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000127. Xanthine_DH. 1 hit.
SMARTi SM01008. Ald_Xan_dh_C. 1 hit.
SM01092. CO_deh_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF54665. SSF54665. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56003. SSF56003. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsi TIGR02963. xanthine_xdhA. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a cDNA coding for feline liver xanthine dehydrogenase."
    Tsuchida S., Yamada R., Ikemoto S., Tagawa M.
    J. Vet. Med. Sci. 63:353-355(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiXDH_FELCA
AccessioniPrimary (citable) accession number: Q9MYW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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