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Protein

Vascular endothelial growth factor A

Gene

VEGFA

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-CFA-114608. Platelet degranulation.
R-CFA-194313. VEGF ligand-receptor interactions.
R-CFA-195399. VEGF binds to VEGFR leading to receptor dimerization.
R-CFA-3928663. EPHA-mediated growth cone collapse.
R-CFA-4420097. VEGFA-VEGFR2 Pathway.
R-CFA-5218921. VEGFR2 mediated cell proliferation.

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor A
Short name:
VEGF-A
Alternative name(s):
Vascular permeability factor
Short name:
VPF
Gene namesi
Name:VEGFA
Synonyms:VEGF
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 12

Subcellular locationi

  • Secreted By similarity

  • Note: Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002338427 – 214Vascular endothelial growth factor AAdd BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 93By similarity
Disulfide bondi76InterchainBy similarity
Disulfide bondi82 ↔ 127By similarity
Disulfide bondi85InterchainBy similarity
Disulfide bondi86 ↔ 129By similarity
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9MYV3.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-29294N.
STRINGi9615.ENSCAFP00000041911.

Structurei

3D structure databases

ProteinModelPortaliQ9MYV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGCM. Eukaryota.
ENOG410ZWYU. LUCA.
GeneTreeiENSGT00730000110791.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiQ9MYV3.
KOiK05448.

Family and domain databases

CDDicd00135. PDGF. 1 hit.
Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform VEGF-188 (identifier: Q9MYV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA GGEHKPHEVV KFMDVYQRSY
60 70 80 90 100
CRPIETLVDI FQEYPDEIEY IFKPSCVPLM RCGGCCNDEG LECVPTEEFN
110 120 130 140 150
ITMQIMRIKP HQGQHIGEMS FLQHSKCECR PKKDRARQEK KSIRGKGKGQ
160 170 180 190 200
KRKRKKSRYK PWSVPCGPCS ERRKHLFVQD PQTCKCSCKN TDSRCKARQL
210
ELNERTCRCD KPRR
Length:214
Mass (Da):25,175
Last modified:October 1, 2000 - v1
Checksum:i0AC980A158C44B27
GO
Isoform VEGF-182 (identifier: Q9MYV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-164: Missing.

Show »
Length:208
Mass (Da):24,414
Checksum:iCF652EC90DDEBBBE
GO
Isoform VEGF-164 (identifier: Q9MYV3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: K → N
     141-164: Missing.

Show »
Length:190
Mass (Da):22,292
Checksum:i2053500BC9085CE0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143I → V in AAD29683 (Ref. 2) Curated1
Sequence conflicti143I → V in AAD29684 (Ref. 2) Curated1
Sequence conflicti161P → S in AAD29683 (Ref. 2) Curated1
Sequence conflicti161P → S in AAD29684 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004615140K → N in isoform VEGF-164. 1 Publication1
Alternative sequenceiVSP_004616141 – 164Missing in isoform VEGF-164. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_004617159 – 164Missing in isoform VEGF-182. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133758 mRNA. Translation: CAB82426.1.
AF133250 mRNA. Translation: AAD29684.1.
AF133249 mRNA. Translation: AAD29683.1.
AF133248 mRNA. Translation: AAD29682.1.
RefSeqiNP_001003175.2. NM_001003175.2. [Q9MYV3-1]
NP_001103971.1. NM_001110501.1. [Q9MYV3-2]
NP_001103972.1. NM_001110502.1. [Q9MYV3-3]
UniGeneiCfa.3581.

Genome annotation databases

EnsembliENSCAFT00000003063; ENSCAFP00000002844; ENSCAFG00000001938. [Q9MYV3-3]
GeneIDi403802.
KEGGicfa:403802.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133758 mRNA. Translation: CAB82426.1.
AF133250 mRNA. Translation: AAD29684.1.
AF133249 mRNA. Translation: AAD29683.1.
AF133248 mRNA. Translation: AAD29682.1.
RefSeqiNP_001003175.2. NM_001003175.2. [Q9MYV3-1]
NP_001103971.1. NM_001110501.1. [Q9MYV3-2]
NP_001103972.1. NM_001110502.1. [Q9MYV3-3]
UniGeneiCfa.3581.

3D structure databases

ProteinModelPortaliQ9MYV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29294N.
STRINGi9615.ENSCAFP00000041911.

Proteomic databases

PaxDbiQ9MYV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000003063; ENSCAFP00000002844; ENSCAFG00000001938. [Q9MYV3-3]
GeneIDi403802.
KEGGicfa:403802.

Organism-specific databases

CTDi7422.

Phylogenomic databases

eggNOGiENOG410IGCM. Eukaryota.
ENOG410ZWYU. LUCA.
GeneTreeiENSGT00730000110791.
HOGENOMiHOG000230896.
HOVERGENiHBG000105.
InParanoidiQ9MYV3.
KOiK05448.

Enzyme and pathway databases

ReactomeiR-CFA-114608. Platelet degranulation.
R-CFA-194313. VEGF ligand-receptor interactions.
R-CFA-195399. VEGF binds to VEGFR leading to receptor dimerization.
R-CFA-3928663. EPHA-mediated growth cone collapse.
R-CFA-4420097. VEGFA-VEGFR2 Pathway.
R-CFA-5218921. VEGFR2 mediated cell proliferation.

Family and domain databases

CDDicd00135. PDGF. 1 hit.
Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVEGFA_CANLF
AccessioniPrimary (citable) accession number: Q9MYV3
Secondary accession number(s): Q9XSF3, Q9XSF4, Q9XSF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.