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Q9MYU4

- ENTP1_PIG

UniProt

Q9MYU4 - ENTP1_PIG

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Protein
Ectonucleoside triphosphate diphosphohydrolase 1
Gene
ENTPD1, CD39
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactori

Ca2+ or Mg2+ By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei174 – 1741Proton acceptor By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydrolase activity Source: UniProtKB-KW
  3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 1 (EC:3.6.1.5)
Short name:
NTPDase 1
Alternative name(s):
Ecto-ATP diphosphohydrolase 1
Short name:
Ecto-ATPDase 1
Short name:
Ecto-ATPase 1
Ecto-apyrase
Lymphoid cell activation antigen
CD_antigen: CD39
Cleaved into the following 2 chains:
Gene namesi
Name:ENTPD1
Synonyms:CD39
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Topological domaini38 – 477440Extracellular Reviewed prediction
Add
BLAST
Transmembranei478 – 49821Helical; Reviewed prediction
Add
BLAST
Topological domaini499 – 51012Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Ectonucleoside triphosphate diphosphohydrolase 1
PRO_0000019905Add
BLAST
Chaini1 – 201201Ectonucleoside triphosphate diphosphohydrolase 1 27 kDa subunit
PRO_0000019906Add
BLAST
Chaini202 – 510309Ectonucleoside triphosphate diphosphohydrolase 1 54 kDa subunit
PRO_0000019907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi84 ↔ 108 By similarity
Glycosylationi245 – 2451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi255 ↔ 300 By similarity
Glycosylationi274 – 2741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi281 ↔ 324 By similarity
Glycosylationi291 – 2911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi333 – 3331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi337 ↔ 342 By similarity
Glycosylationi370 – 3701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi390 ↔ 413 By similarity
Glycosylationi457 – 4571N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Cleaved into two polypeptides that seem to stay together by noncovalent interactions.

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Highest expression found in vascular endothelium, smooth muscle, spleen and lung.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011184.

Structurei

3D structure databases

ProteinModelPortaliQ9MYU4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5371.
HOGENOMiHOG000059572.
HOVERGENiHBG018982.
KOiK01510.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
SUPFAMiSSF56327. SSF56327. 1 hit.
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9MYU4-1 [UniParc]FASTAAdd to Basket

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MEDRRESELK TFCSKNILVI LGFSSIIAVI ALLALGLTQN KPLPENVKFG    50
IVLDAGSSHT SLYIYKWPAE KENDTGVVSQ VEECKLKGPG ISEFAKKLGE 100
IDIYLEACME RARTVVPKSQ HAETPVYLGA TAGMRLLRMK NENLASKILS 150
TVAESITRYP FDFQGARIIT GQEEGAYGWI TINYLLDKFI QKSGWFNLKP 200
RKGDTQETYG ALDLGGASTQ ITFVPQNQVL ESPENTLHFR LYGKNYSVYT 250
HSFLCYGKDQ ALLQKLTKDL KNTNGTIHEP CFHSGYQRRM NVSHLYEAPC 300
TRRFLTSLPF PELEIQGTGD FQKCQQSIRP LFNTSYCPYS RCSFDGVFLP 350
LPQGDFAAFS AFYYVMGFLN LTSEEGSFQS KVTSTLEAFC SRPWAELQMY 400
FGDVKEKYLS EYCFSGTYIL TLLLSGYHFT AETWKNIHFM GKVQSTSVGW 450
TLGYMLNLTN MIPSEEPSST RLSHSTYVFL MVLFSLILVI VVIIGLFVCH 500
RPSYFWKDMV 510
Length:510
Mass (Da):57,757
Last modified:October 1, 2000 - v1
Checksum:i82F86869040D7735
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031G → S AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133746 mRNA. Translation: CAB95871.1.
RefSeqiNP_999318.1. NM_214153.1.
UniGeneiSsc.52334.

Genome annotation databases

GeneIDi397298.
KEGGissc:397298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133746 mRNA. Translation: CAB95871.1 .
RefSeqi NP_999318.1. NM_214153.1.
UniGenei Ssc.52334.

3D structure databases

ProteinModelPortali Q9MYU4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000011184.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397298.
KEGGi ssc:397298.

Organism-specific databases

CTDi 953.

Phylogenomic databases

eggNOGi COG5371.
HOGENOMi HOG000059572.
HOVERGENi HBG018982.
KOi K01510.

Family and domain databases

InterProi IPR000407. GDA1_CD39_NTPase.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
[Graphical view ]
PANTHERi PTHR11782. PTHR11782. 1 hit.
Pfami PF01150. GDA1_CD39. 1 hit.
[Graphical view ]
SUPFAMi SSF56327. SSF56327. 1 hit.
PROSITEi PS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Distribution, cloning, and characterization of porcine nucleoside triphosphate diphosphohydrolase-1."
    Lemmens R., Vanduffel L., Kittel A., Beaudoin A.R., Benrezzak O., Sevigny J.
    Eur. J. Biochem. 267:4106-4114(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aortic endothelium.
  2. "Identification and characterization of CD39/vascular ATP diphosphohydrolase."
    Kaczmarek E., Koziak K., Sevigny J., Siegel J.B., Anrather J., Beaudoin A.R., Bach F.H., Robson S.C.
    J. Biol. Chem. 271:33116-33122(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 202-220.
    Tissue: Pancreas.

Entry informationi

Entry nameiENTP1_PIG
AccessioniPrimary (citable) accession number: Q9MYU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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