Q9MYP6 (DHB14_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
17-beta-hydroxysteroid dehydrogenase 14
Short name=17-beta-HSD 14
EC=1.1.1.-

Alternative name(s):
17-beta-hydroxysteroid dehydrogenase DHRS10
Dehydrogenase/reductase SDR family member 10
Retinal short-chain dehydrogenase/reductase retSDR3

Gene names

Name:	HSD17B14
Synonyms:	DHRS10, SDR3

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro) By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Detected in retina.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Lipid metabolism Steroid metabolism
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	steroid catabolic process Inferred from electronic annotation. Source: Compara
Cellular_component	centrosome Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara
Molecular_function	estradiol 17-beta-dehydrogenase activity Inferred from electronic annotation. Source: Compara testosterone 17-beta-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	17-beta-hydroxysteroid dehydrogenase 14		PRO_0000054653
Regions
	Nucleotide binding	13 – 40	28	NAD By similarity
Sites
	Active site	154	1	Proton acceptor By similarity
	Binding site	141	1	Substrate By similarity
	Binding site	158	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9MYP6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 0A7E6F84C289FF1C	FASTA	270	28,421
	10 20 30 40 50 60 MAMGTRYAGK VVIVTGGGRG IGAGIVRAFV ESGAQVVICD KDEARGRAVE RELPGTVFLL 70 80 90 100 110 120 CDVTREEDVR TLVSETIRRF GRLDCIVNNA GYHPPPQWPE ETSAQGFRQL LELNLLGTYT 130 140 150 160 170 180 LTKLALPHLR KSRGNVINIS SLVGAIGQSQ AVPYVATKGA VTAMTKALAL DESQYGVRVN 190 200 210 220 230 240 CISPGNIWTP LWEELAASTP DPTATIREGT LAQPLGRMGQ PAEVAAAAVF LASEATFCTG 250 260 270 TELLVTGGAE LGYGRKAGQA APAEAPTTPS

References

[1]	Haeseleer F., Palczewski K. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF202997 mRNA. Translation: AAF62401.1. AF238859 mRNA. Translation: AAF44666.1.
IPI	IPI00692054.
RefSeq	NP_777126.1. NM_174701.2.
UniGene	Bt.88264.
3D structure databases
ProteinModelPortal	Q9MYP6.
SMR	Q9MYP6. Positions 4-259.
ModBase	Search...
Proteomic databases
PaxDb	Q9MYP6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000012090; ENSBTAP00000012090; ENSBTAG00000009174.
GeneID	282652.
KEGG	bta:282652.
Organism-specific databases
CTD	51171.
Phylogenomic databases
eggNOG	COG1028.
GeneTree	ENSGT00690000101945.
HOVERGEN	HBG105555.
InParanoid	Q9MYP6.
OMA	FGHLDCV.
OrthoDB	EOG4Q84ZF.
Enzyme and pathway databases
BioCyc	CATTLE:282652-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806331.

Entry information

Entry name

DHB14_BOVIN

Accession

Primary (citable) accession number: Q9MYP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	October 1, 2000
Last modified:	May 29, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program