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Q9MYP6

- DHB14_BOVIN

UniProt

Q9MYP6 - DHB14_BOVIN

Protein

17-beta-hydroxysteroid dehydrogenase 14

Gene

HSD17B14

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro) By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei141 – 1411SubstrateBy similarity
    Active sitei154 – 1541Proton acceptorPROSITE-ProRule annotation
    Binding sitei158 – 1581NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 4028NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. estradiol 17-beta-dehydrogenase activity Source: Ensembl
    2. testosterone 17-beta-dehydrogenase (NADP+) activity Source: Ensembl

    GO - Biological processi

    1. steroid catabolic process Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid metabolism, Steroid metabolism

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    17-beta-hydroxysteroid dehydrogenase 14 (EC:1.1.1.-)
    Short name:
    17-beta-HSD 14
    Alternative name(s):
    17-beta-hydroxysteroid dehydrogenase DHRS10
    Dehydrogenase/reductase SDR family member 10
    Retinal short-chain dehydrogenase/reductase retSDR3
    Gene namesi
    Name:HSD17B14
    Synonyms:DHRS10, SDR3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytosol Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 27027017-beta-hydroxysteroid dehydrogenase 14PRO_0000054653Add
    BLAST

    Proteomic databases

    PaxDbiQ9MYP6.

    Expressioni

    Tissue specificityi

    Detected in retina.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9MYP6.
    SMRiQ9MYP6. Positions 4-259.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    GeneTreeiENSGT00710000106273.
    HOVERGENiHBG105555.
    InParanoidiQ9MYP6.
    OMAiHMIKRNG.
    OrthoDBiEOG7WT421.
    TreeFamiTF354307.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9MYP6-1 [UniParc]FASTAAdd to Basket

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    MAMGTRYAGK VVIVTGGGRG IGAGIVRAFV ESGAQVVICD KDEARGRAVE    50
    RELPGTVFLL CDVTREEDVR TLVSETIRRF GRLDCIVNNA GYHPPPQWPE 100
    ETSAQGFRQL LELNLLGTYT LTKLALPHLR KSRGNVINIS SLVGAIGQSQ 150
    AVPYVATKGA VTAMTKALAL DESQYGVRVN CISPGNIWTP LWEELAASTP 200
    DPTATIREGT LAQPLGRMGQ PAEVAAAAVF LASEATFCTG TELLVTGGAE 250
    LGYGRKAGQA APAEAPTTPS 270
    Length:270
    Mass (Da):28,421
    Last modified:October 1, 2000 - v1
    Checksum:i0A7E6F84C289FF1C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF202997 mRNA. Translation: AAF62401.1.
    AF238859 mRNA. Translation: AAF44666.1.
    RefSeqiNP_777126.1. NM_174701.2.
    UniGeneiBt.88264.

    Genome annotation databases

    EnsembliENSBTAT00000012090; ENSBTAP00000012090; ENSBTAG00000009174.
    GeneIDi282652.
    KEGGibta:282652.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF202997 mRNA. Translation: AAF62401.1 .
    AF238859 mRNA. Translation: AAF44666.1 .
    RefSeqi NP_777126.1. NM_174701.2.
    UniGenei Bt.88264.

    3D structure databases

    ProteinModelPortali Q9MYP6.
    SMRi Q9MYP6. Positions 4-259.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9MYP6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000012090 ; ENSBTAP00000012090 ; ENSBTAG00000009174 .
    GeneIDi 282652.
    KEGGi bta:282652.

    Organism-specific databases

    CTDi 51171.

    Phylogenomic databases

    eggNOGi COG1028.
    GeneTreei ENSGT00710000106273.
    HOVERGENi HBG105555.
    InParanoidi Q9MYP6.
    OMAi HMIKRNG.
    OrthoDBi EOG7WT421.
    TreeFami TF354307.

    Miscellaneous databases

    NextBioi 20806331.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Haeseleer F., Palczewski K.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.

    Entry informationi

    Entry nameiDHB14_BOVIN
    AccessioniPrimary (citable) accession number: Q9MYP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3