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Q9MYP6 (DHB14_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
17-beta-hydroxysteroid dehydrogenase 14

Short name=17-beta-HSD 14
EC=1.1.1.-
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase DHRS10
Dehydrogenase/reductase SDR family member 10
Retinal short-chain dehydrogenase/reductase retSDR3
Gene names
Name:HSD17B14
Synonyms:DHRS10, SDR3
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro) By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Detected in retina.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   Biological processLipid metabolism
Steroid metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsteroid catabolic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcentrosome

Inferred from electronic annotation. Source: Ensembl

cytosol

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionestradiol 17-beta-dehydrogenase activity

Inferred from electronic annotation. Source: Ensembl

testosterone 17-beta-dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 27027017-beta-hydroxysteroid dehydrogenase 14
PRO_0000054653

Regions

Nucleotide binding13 – 4028NAD By similarity

Sites

Active site1541Proton acceptor By similarity
Binding site1411Substrate By similarity
Binding site1581NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9MYP6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 0A7E6F84C289FF1C

FASTA27028,421
        10         20         30         40         50         60 
MAMGTRYAGK VVIVTGGGRG IGAGIVRAFV ESGAQVVICD KDEARGRAVE RELPGTVFLL 

        70         80         90        100        110        120 
CDVTREEDVR TLVSETIRRF GRLDCIVNNA GYHPPPQWPE ETSAQGFRQL LELNLLGTYT 

       130        140        150        160        170        180 
LTKLALPHLR KSRGNVINIS SLVGAIGQSQ AVPYVATKGA VTAMTKALAL DESQYGVRVN 

       190        200        210        220        230        240 
CISPGNIWTP LWEELAASTP DPTATIREGT LAQPLGRMGQ PAEVAAAAVF LASEATFCTG 

       250        260        270 
TELLVTGGAE LGYGRKAGQA APAEAPTTPS 

« Hide

References

[1]Haeseleer F., Palczewski K.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF202997 mRNA. Translation: AAF62401.1.
AF238859 mRNA. Translation: AAF44666.1.
RefSeqNP_777126.1. NM_174701.2.
UniGeneBt.88264.

3D structure databases

ProteinModelPortalQ9MYP6.
SMRQ9MYP6. Positions 4-259.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9MYP6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000012090; ENSBTAP00000012090; ENSBTAG00000009174.
GeneID282652.
KEGGbta:282652.

Organism-specific databases

CTD51171.

Phylogenomic databases

eggNOGCOG1028.
GeneTreeENSGT00710000106273.
HOVERGENHBG105555.
InParanoidQ9MYP6.
OMAHMIKRNG.
OrthoDBEOG7WT421.
TreeFamTF354307.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806331.

Entry information

Entry nameDHB14_BOVIN
AccessionPrimary (citable) accession number: Q9MYP6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families