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Protein

17-beta-hydroxysteroid dehydrogenase 14

Gene

HSD17B14

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei141SubstrateBy similarity1
Active sitei154Proton acceptorPROSITE-ProRule annotation1
Binding sitei158NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 40NADBy similarityAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism, Steroid metabolism
LigandNAD

Enzyme and pathway databases

ReactomeiR-BTA-193144 Estrogen biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase 14 (EC:1.1.1.-)
Short name:
17-beta-HSD 14
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase DHRS10
Dehydrogenase/reductase SDR family member 10
Retinal short-chain dehydrogenase/reductase retSDR3
Gene namesi
Name:HSD17B14
Synonyms:DHRS10, SDR3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:29972 HSD17B14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546531 – 27017-beta-hydroxysteroid dehydrogenase 14Add BLAST270

Proteomic databases

PaxDbiQ9MYP6
PeptideAtlasiQ9MYP6
PRIDEiQ9MYP6

Expressioni

Tissue specificityi

Detected in retina.

Gene expression databases

BgeeiENSBTAG00000009174

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012090

Structurei

3D structure databases

ProteinModelPortaliQ9MYP6
SMRiQ9MYP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00910000144022
HOVERGENiHBG105555
InParanoidiQ9MYP6
OMAiICDKDES
OrthoDBiEOG091G0GO6
TreeFamiTF354307

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9MYP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMGTRYAGK VVIVTGGGRG IGAGIVRAFV ESGAQVVICD KDEARGRAVE
60 70 80 90 100
RELPGTVFLL CDVTREEDVR TLVSETIRRF GRLDCIVNNA GYHPPPQWPE
110 120 130 140 150
ETSAQGFRQL LELNLLGTYT LTKLALPHLR KSRGNVINIS SLVGAIGQSQ
160 170 180 190 200
AVPYVATKGA VTAMTKALAL DESQYGVRVN CISPGNIWTP LWEELAASTP
210 220 230 240 250
DPTATIREGT LAQPLGRMGQ PAEVAAAAVF LASEATFCTG TELLVTGGAE
260 270
LGYGRKAGQA APAEAPTTPS
Length:270
Mass (Da):28,421
Last modified:October 1, 2000 - v1
Checksum:i0A7E6F84C289FF1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202997 mRNA Translation: AAF62401.1
AF238859 mRNA Translation: AAF44666.1
RefSeqiNP_777126.1, NM_174701.2
UniGeneiBt.88264

Genome annotation databases

EnsembliENSBTAT00000012090; ENSBTAP00000012090; ENSBTAG00000009174
GeneIDi282652
KEGGibta:282652

Similar proteinsi

Entry informationi

Entry nameiDHB14_BOVIN
AccessioniPrimary (citable) accession number: Q9MYP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health