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Protein

17-beta-hydroxysteroid dehydrogenase 14

Gene

HSD17B14

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro) (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei141 – 1411SubstrateBy similarity
Active sitei154 – 1541Proton acceptorPROSITE-ProRule annotation
Binding sitei158 – 1581NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 4028NADBy similarityAdd
BLAST

GO - Molecular functioni

  1. estradiol 17-beta-dehydrogenase activity Source: Ensembl
  2. testosterone 17-beta-dehydrogenase (NADP+) activity Source: Ensembl

GO - Biological processi

  1. steroid catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase 14 (EC:1.1.1.-)
Short name:
17-beta-HSD 14
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase DHRS10
Dehydrogenase/reductase SDR family member 10
Retinal short-chain dehydrogenase/reductase retSDR3
Gene namesi
Name:HSD17B14
Synonyms:DHRS10, SDR3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27027017-beta-hydroxysteroid dehydrogenase 14PRO_0000054653Add
BLAST

Proteomic databases

PaxDbiQ9MYP6.

Expressioni

Tissue specificityi

Detected in retina.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9MYP6.
SMRiQ9MYP6. Positions 4-259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105555.
InParanoidiQ9MYP6.
OMAiGITHPAR.
OrthoDBiEOG7WT421.
TreeFamiTF354307.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MYP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMGTRYAGK VVIVTGGGRG IGAGIVRAFV ESGAQVVICD KDEARGRAVE
60 70 80 90 100
RELPGTVFLL CDVTREEDVR TLVSETIRRF GRLDCIVNNA GYHPPPQWPE
110 120 130 140 150
ETSAQGFRQL LELNLLGTYT LTKLALPHLR KSRGNVINIS SLVGAIGQSQ
160 170 180 190 200
AVPYVATKGA VTAMTKALAL DESQYGVRVN CISPGNIWTP LWEELAASTP
210 220 230 240 250
DPTATIREGT LAQPLGRMGQ PAEVAAAAVF LASEATFCTG TELLVTGGAE
260 270
LGYGRKAGQA APAEAPTTPS
Length:270
Mass (Da):28,421
Last modified:October 1, 2000 - v1
Checksum:i0A7E6F84C289FF1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202997 mRNA. Translation: AAF62401.1.
AF238859 mRNA. Translation: AAF44666.1.
RefSeqiNP_777126.1. NM_174701.2.
UniGeneiBt.88264.

Genome annotation databases

EnsembliENSBTAT00000012090; ENSBTAP00000012090; ENSBTAG00000009174.
GeneIDi282652.
KEGGibta:282652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202997 mRNA. Translation: AAF62401.1.
AF238859 mRNA. Translation: AAF44666.1.
RefSeqiNP_777126.1. NM_174701.2.
UniGeneiBt.88264.

3D structure databases

ProteinModelPortaliQ9MYP6.
SMRiQ9MYP6. Positions 4-259.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9MYP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012090; ENSBTAP00000012090; ENSBTAG00000009174.
GeneIDi282652.
KEGGibta:282652.

Organism-specific databases

CTDi51171.

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105555.
InParanoidiQ9MYP6.
OMAiGITHPAR.
OrthoDBiEOG7WT421.
TreeFamiTF354307.

Miscellaneous databases

NextBioi20806331.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Haeseleer F., Palczewski K.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.

Entry informationi

Entry nameiDHB14_BOVIN
AccessioniPrimary (citable) accession number: Q9MYP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.