SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9MYP6

- DHB14_BOVIN

UniProt

Q9MYP6 - DHB14_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
17-beta-hydroxysteroid dehydrogenase 14
Gene
HSD17B14, DHRS10, SDR3
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro) By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei141 – 1411Substrate By similarity
Active sitei154 – 1541Proton acceptor By similarity
Binding sitei158 – 1581NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 4028NAD By similarity
Add
BLAST

GO - Molecular functioni

  1. estradiol 17-beta-dehydrogenase activity Source: Ensembl
  2. testosterone 17-beta-dehydrogenase (NADP+) activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. steroid catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase 14 (EC:1.1.1.-)
Short name:
17-beta-HSD 14
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase DHRS10
Dehydrogenase/reductase SDR family member 10
Retinal short-chain dehydrogenase/reductase retSDR3
Gene namesi
Name:HSD17B14
Synonyms:DHRS10, SDR3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytosol Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27027017-beta-hydroxysteroid dehydrogenase 14
PRO_0000054653Add
BLAST

Proteomic databases

PaxDbiQ9MYP6.

Expressioni

Tissue specificityi

Detected in retina.

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9MYP6.
SMRiQ9MYP6. Positions 4-259.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00710000106273.
HOVERGENiHBG105555.
InParanoidiQ9MYP6.
OMAiHMIKRNG.
OrthoDBiEOG7WT421.
TreeFamiTF354307.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MYP6-1 [UniParc]FASTAAdd to Basket

« Hide

MAMGTRYAGK VVIVTGGGRG IGAGIVRAFV ESGAQVVICD KDEARGRAVE    50
RELPGTVFLL CDVTREEDVR TLVSETIRRF GRLDCIVNNA GYHPPPQWPE 100
ETSAQGFRQL LELNLLGTYT LTKLALPHLR KSRGNVINIS SLVGAIGQSQ 150
AVPYVATKGA VTAMTKALAL DESQYGVRVN CISPGNIWTP LWEELAASTP 200
DPTATIREGT LAQPLGRMGQ PAEVAAAAVF LASEATFCTG TELLVTGGAE 250
LGYGRKAGQA APAEAPTTPS 270
Length:270
Mass (Da):28,421
Last modified:October 1, 2000 - v1
Checksum:i0A7E6F84C289FF1C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF202997 mRNA. Translation: AAF62401.1.
AF238859 mRNA. Translation: AAF44666.1.
RefSeqiNP_777126.1. NM_174701.2.
UniGeneiBt.88264.

Genome annotation databases

EnsembliENSBTAT00000012090; ENSBTAP00000012090; ENSBTAG00000009174.
GeneIDi282652.
KEGGibta:282652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF202997 mRNA. Translation: AAF62401.1 .
AF238859 mRNA. Translation: AAF44666.1 .
RefSeqi NP_777126.1. NM_174701.2.
UniGenei Bt.88264.

3D structure databases

ProteinModelPortali Q9MYP6.
SMRi Q9MYP6. Positions 4-259.
ModBasei Search...

Proteomic databases

PaxDbi Q9MYP6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000012090 ; ENSBTAP00000012090 ; ENSBTAG00000009174 .
GeneIDi 282652.
KEGGi bta:282652.

Organism-specific databases

CTDi 51171.

Phylogenomic databases

eggNOGi COG1028.
GeneTreei ENSGT00710000106273.
HOVERGENi HBG105555.
InParanoidi Q9MYP6.
OMAi HMIKRNG.
OrthoDBi EOG7WT421.
TreeFami TF354307.

Miscellaneous databases

NextBioi 20806331.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Haeseleer F., Palczewski K.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.

Entry informationi

Entry nameiDHB14_BOVIN
AccessioniPrimary (citable) accession number: Q9MYP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi