SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9MYN5

- CDKN3_PIG

UniProt

Q9MYN5 - CDKN3_PIG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cyclin-dependent kinase inhibitor 3
Gene
CDKN3, KAP
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner By similarity.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401Phosphocysteine intermediate By similarityBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase inhibitor 3 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDK2-associated dual-specificity phosphatase
Kinase-associated phosphatase
Gene namesi
Name:CDKN3
Synonyms:KAP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Cytoplasmperinuclear region By similarity By similarity

GO - Cellular componenti

  1. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Cyclin-dependent kinase inhibitor 3
PRO_0000396638Add
BLAST

Interactioni

Subunit structurei

Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9MYN5.
SMRiQ9MYN5. Positions 21-203.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3434Interaction with CDK2 By similarityBy similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG075798.
KOiK14167.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR008425. CDK_inhib_3.
IPR022778. CDKN3.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR23339:SF24. PTHR23339:SF24. 1 hit.
PfamiPF05706. CDKN3. 1 hit.
[Graphical view]
PIRSFiPIRSF037322. CDKN3. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MYN5-1 [UniParc]FASTAAdd to Basket

« Hide

MKPPSSIQTS EFDSSDEEPI EDEQTPIQIS WLPLSRVNYS QFLGLCALPG    50
CKFKDVRRNI QKDTEELKSC GIQDVFVFCT RGELSKYRVP NLLDLYHQYG 100
IITHHHPIPD GGAPDIASCC EIMEELEICL QNNRKTLIHC YGGLGRSCLV 150
AACLLLYLSD TVSPQQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL 200
SSRESLSRSV SR 212
Length:212
Mass (Da):23,906
Last modified:October 1, 2000 - v1
Checksum:i3AD675A1EA40347E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61S → V.1 Publication
Natural varianti39 – 391Y → C.1 Publication
Natural varianti60 – 601I → F.1 Publication
Natural varianti76 – 761F → C.1 Publication
Natural varianti78 – 781F → S.1 Publication
Natural varianti79 – 791C → G.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ404882 mRNA. Translation: CAB97522.1.
AJ404883, AJ404884 Genomic DNA. Translation: CAB98135.1.
RefSeqiNP_999485.1. NM_214320.1.
UniGeneiSsc.7286.

Genome annotation databases

GeneIDi397589.
KEGGissc:397589.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ404882 mRNA. Translation: CAB97522.1 .
AJ404883 , AJ404884 Genomic DNA. Translation: CAB98135.1 .
RefSeqi NP_999485.1. NM_214320.1.
UniGenei Ssc.7286.

3D structure databases

ProteinModelPortali Q9MYN5.
SMRi Q9MYN5. Positions 21-203.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397589.
KEGGi ssc:397589.

Organism-specific databases

CTDi 1033.

Phylogenomic databases

HOVERGENi HBG075798.
KOi K14167.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR008425. CDK_inhib_3.
IPR022778. CDKN3.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR23339:SF24. PTHR23339:SF24. 1 hit.
Pfami PF05706. CDKN3. 1 hit.
[Graphical view ]
PIRSFi PIRSF037322. CDKN3. 1 hit.
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rapid communication: nucleotide sequence and physical mapping of the porcine cyclin-dependent kinase inhibitor 3 (CDKN3) gene."
    Maak S., Jaesert S., Neumann K., von Lengerken G.
    J. Anim. Sci. 80:1698-1699(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Thigh muscle.
  2. "Characterization of the porcine CDKN3 gene as a potential candidate for congenital splay leg in piglets."
    Maak S., Jaesert S., Neumann K., von Lengerken G.
    Genet. Sel. Evol. 35:S157-S165(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-6; CYS-39; PHE-60; CYS-76; SER-78 AND GLY-79.

Entry informationi

Entry nameiCDKN3_PIG
AccessioniPrimary (citable) accession number: Q9MYN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi