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Q9MYN5

- CDKN3_PIG

UniProt

Q9MYN5 - CDKN3_PIG

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Protein

Cyclin-dependent kinase inhibitor 3

Gene

CDKN3

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase inhibitor 3ImportedBy similarity1 Publication (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDK2-associated dual-specificity phosphataseBy similarity1 Publication
Kinase-associated phosphataseBy similarity
Gene namesi
Name:CDKN3Imported
Synonyms:KAPBy similarity
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Cytoplasmperinuclear region By similarity

GO - Cellular componenti

  1. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Cyclin-dependent kinase inhibitor 3PRO_0000396638Add
BLAST

Interactioni

Subunit structurei

Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9MYN5.
SMRiQ9MYN5. Positions 21-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3434Interaction with CDK2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family.Sequence Analysis

Phylogenomic databases

HOVERGENiHBG075798.
InParanoidiQ9MYN5.
KOiK14167.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR008425. CDK_inhib_3.
IPR022778. CDKN3.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR23339:SF24. PTHR23339:SF24. 1 hit.
PfamiPF05706. CDKN3. 1 hit.
[Graphical view]
PIRSFiPIRSF037322. CDKN3. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MYN5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPPSSIQTS EFDSSDEEPI EDEQTPIQIS WLPLSRVNYS QFLGLCALPG
60 70 80 90 100
CKFKDVRRNI QKDTEELKSC GIQDVFVFCT RGELSKYRVP NLLDLYHQYG
110 120 130 140 150
IITHHHPIPD GGAPDIASCC EIMEELEICL QNNRKTLIHC YGGLGRSCLV
160 170 180 190 200
AACLLLYLSD TVSPQQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL
210
SSRESLSRSV SR
Length:212
Mass (Da):23,906
Last modified:October 1, 2000 - v1
Checksum:i3AD675A1EA40347E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61S → V.1 Publication
Natural varianti39 – 391Y → C.1 Publication
Natural varianti60 – 601I → F.1 Publication
Natural varianti76 – 761F → C.1 Publication
Natural varianti78 – 781F → S.1 Publication
Natural varianti79 – 791C → G.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404882 mRNA. Translation: CAB97522.1.
AJ404883, AJ404884 Genomic DNA. Translation: CAB98135.1.
RefSeqiNP_999485.1. NM_214320.1.
UniGeneiSsc.7286.

Genome annotation databases

GeneIDi397589.
KEGGissc:397589.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404882 mRNA. Translation: CAB97522.1 .
AJ404883 , AJ404884 Genomic DNA. Translation: CAB98135.1 .
RefSeqi NP_999485.1. NM_214320.1.
UniGenei Ssc.7286.

3D structure databases

ProteinModelPortali Q9MYN5.
SMRi Q9MYN5. Positions 21-203.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397589.
KEGGi ssc:397589.

Organism-specific databases

CTDi 1033.

Phylogenomic databases

HOVERGENi HBG075798.
InParanoidi Q9MYN5.
KOi K14167.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR008425. CDK_inhib_3.
IPR022778. CDKN3.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR23339:SF24. PTHR23339:SF24. 1 hit.
Pfami PF05706. CDKN3. 1 hit.
[Graphical view ]
PIRSFi PIRSF037322. CDKN3. 1 hit.
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rapid communication: nucleotide sequence and physical mapping of the porcine cyclin-dependent kinase inhibitor 3 (CDKN3) gene."
    Maak S., Jaesert S., Neumann K., von Lengerken G.
    J. Anim. Sci. 80:1698-1699(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Thigh muscle1 Publication.
  2. "Characterization of the porcine CDKN3 gene as a potential candidate for congenital splay leg in piglets."
    Maak S., Jaesert S., Neumann K., von Lengerken G.
    Genet. Sel. Evol. 35:S157-S165(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-6; CYS-39; PHE-60; CYS-76; SER-78 AND GLY-79.

Entry informationi

Entry nameiCDKN3_PIG
AccessioniPrimary (citable) accession number: Q9MYN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3