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Q9MYN5 (CDKN3_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase inhibitor 3

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
CDK2-associated dual-specificity phosphatase
Kinase-associated phosphatase
Gene names
Name:CDKN3
Synonyms:KAP
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner By similarity. UniProtKB Q16667

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. UniProtKB Q16667

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity By similarity. UniProtKB Q16667

Subcellular location

Cytoplasmperinuclear region By similarity UniProtKB Q16667.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family.

Ontologies

Keywords
   Biological processCell cycle
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperinuclear region of cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Cyclin-dependent kinase inhibitor 3
PRO_0000396638

Regions

Region1 – 3434Interaction with CDK2 By similarity UniProtKB Q16667

Sites

Active site1401Phosphocysteine intermediate By similarity

Natural variations

Natural variant61S → V. Ref.2
Natural variant391Y → C. Ref.2
Natural variant601I → F. Ref.2
Natural variant761F → C. Ref.2
Natural variant781F → S. Ref.2
Natural variant791C → G. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9MYN5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 3AD675A1EA40347E

FASTA21223,906
        10         20         30         40         50         60 
MKPPSSIQTS EFDSSDEEPI EDEQTPIQIS WLPLSRVNYS QFLGLCALPG CKFKDVRRNI 

        70         80         90        100        110        120 
QKDTEELKSC GIQDVFVFCT RGELSKYRVP NLLDLYHQYG IITHHHPIPD GGAPDIASCC 

       130        140        150        160        170        180 
EIMEELEICL QNNRKTLIHC YGGLGRSCLV AACLLLYLSD TVSPQQAIDS LRDLRGSGAI 

       190        200        210 
QTIKQYNYLH EFRDKLAAHL SSRESLSRSV SR 

« Hide

References

[1]"Rapid communication: nucleotide sequence and physical mapping of the porcine cyclin-dependent kinase inhibitor 3 (CDKN3) gene."
Maak S., Jaesert S., Neumann K., von Lengerken G.
J. Anim. Sci. 80:1698-1699(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Thigh muscle.
[2]"Characterization of the porcine CDKN3 gene as a potential candidate for congenital splay leg in piglets."
Maak S., Jaesert S., Neumann K., von Lengerken G.
Genet. Sel. Evol. 35:S157-S165(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS VAL-6; CYS-39; PHE-60; CYS-76; SER-78 AND GLY-79.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ404882 mRNA. Translation: CAB97522.1.
AJ404883, AJ404884 Genomic DNA. Translation: CAB98135.1.
RefSeqNP_999485.1. NM_214320.1.
UniGeneSsc.7286.

3D structure databases

ProteinModelPortalQ9MYN5.
SMRQ9MYN5. Positions 21-203.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397589.
KEGGssc:397589.

Organism-specific databases

CTD1033.

Phylogenomic databases

HOVERGENHBG075798.
KOK14167.

Family and domain databases

InterProIPR008425. CDK_inhib_3.
IPR022778. CDKN3.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERPTHR23339:SF24. PTHR23339:SF24. 1 hit.
PfamPF05706. CDKN3. 1 hit.
[Graphical view]
PIRSFPIRSF037322. CDKN3. 1 hit.
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDKN3_PIG
AccessionPrimary (citable) accession number: Q9MYN5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families