Q9MUV9 (FTSI_MESVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidoglycan synthase ftsI homolog
EC=2.4.1.129

Alternative name(s):
Peptidoglycan glycosyltransferase

Gene names

Name:

ftsI

Encoded on

Plastid; Chloroplast

Organism

Mesostigma viride

Taxonomic identifier

41882 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Mesostigmatophyceae › Mesostigmatales › Mesostigmataceae › Mesostigma

Protein attributes

Sequence length	598 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates Potential.
Catalytic activity	(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location	Plastid › chloroplast membrane; Single-pass membrane protein Potential.
Miscellaneous	The presence of this gene in the chloroplast genome suggests there may be an unsuspected vestigal peptidoglycan layer in this organism's chloroplasts.
Sequence similarities	Belongs to the transpeptidase family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Peptidoglycan synthesis
Cellular component	Chloroplast Membrane Plastid
Domain	Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chloroplast membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	penicillin binding Inferred from electronic annotation. Source: InterPro peptidoglycan glycosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 598	598	Peptidoglycan synthase ftsI homolog		PRO_0000195461
Regions
	Transmembrane	12 – 33	22	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9MUV9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: DB1B7948EB9DB4DA	FASTA	598	67,214
	10 20 30 40 50 60 MNKKKIFGFS RIVLVWILFF SGSSLLLGRL FYLQVMKGSW LTNKAKNQQT IILNTFQPRR 70 80 90 100 110 120 TICDRNGIPL AIDTLAYDIF AHPLHFKKST FDIANELYSI LNLDVEYLQN LFIKNTTGIC 130 140 150 160 170 180 IAHQAPEQIA NQIIAKNIEG IELVQHPKRY YPYKQLCADV IGYVNTLHEG QAGLELSCQE 190 200 210 220 230 240 SLQLQSPEVV SAIDGRGFLI NDGIPRELFK QDSLCLQLTI DLDLQKASYL AIYDGIKKCN 250 260 270 280 290 300 AKRGTVIILD PYTGAILALV TAPSYDPNVY YDFPIERFKN WPVIDLYEPG STFKPINMAI 310 320 330 340 350 360 ALEAKAIKKN DFFYDEGCIQ ISDTIITNNN YYNKQFACDK NSHLNITDVL SNSSNVGMVH 370 380 390 400 410 420 ILQRLAPEIY YQWIQKLGLG NNVFLETDFP LSSYSSLKNI LEFTSYNIES AVTSFGQGLA 430 440 450 460 470 480 MTPIKLAQLY ACLSNGGNII RPYIVDGLFD IQNEKLFTLN NNIFDQNISL KRKLLKTKVF 490 500 510 520 530 540 SPSTTEIVLD MLEEVIFNGT GSSCFLPGYR IGGKTGTSQK HAEQGGYSTK HILTSFAAIF 550 560 570 580 590 PINNPQYVIL SVIDEPSIPL SFGSNTAGPV VRSIIESLIR IKKIPPSIPT LTHHYYCK

References

[1]	"Ancestral chloroplast genome in Mesostigma viride reveals an early branch of green plant evolution." Lemieux C., Otis C., Turmel M. Nature 403:649-652(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NIES-296.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF166114 Genomic DNA. Translation: AAF43792.1.
RefSeq	NP_038351.1. NC_002186.1.
3D structure databases
ProteinModelPortal	Q9MUV9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	800933.
Phylogenomic databases
ProtClustDB	CLSC858421.
Enzyme and pathway databases
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.40.710.10. 1 hit.
InterPro	IPR012338. Beta-lactam/transpept-like. IPR005311. PBP_dimer. IPR001460. PCN-bd_Tpept. [Graphical view]
Pfam	PF03717. PBP_dimer. 1 hit. PF00905. Transpeptidase. 1 hit. [Graphical view]
SUPFAM	SSF56519. PBP_dimer. 1 hit. SSF56601. PBP_transp_fold. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FTSI_MESVI

Accession

Primary (citable) accession number: Q9MUV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program