Reviewed, UniProtKB/Swiss-Prot Q9MUL1 (NU1C_MESVI)

Names and origin

Protein names

Recommended name:
    NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic
    EC=1.6.5.-
Alternative name(s):
    NAD(P)H dehydrogenase subunit 1
      Short name=NDH subunit 1
    NADH-plastoquinone oxidoreductase subunit 1

Gene names

Name:

ndhA

Encoded on

Plastid; Chloroplast

Organism

Mesostigma viride

Taxonomic identifier

41882 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Mesostigmatophyceae › Mesostigmatales › Mesostigmataceae › Mesostigma

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus By similarity.
Subcellular location	Plastid › chloroplast thylakoid membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Chloroplast Membrane Plastid Thylakoid
Domain	Transmembrane
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: HAMAP
Cellular component	chloroplast thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic HAMAP MF_01350		PRO_0000117511
Regions
	Transmembrane	29 – 49	21	Potential
	Transmembrane	96 – 116	21	Potential
	Transmembrane	128 – 148	21	Potential
	Transmembrane	176 – 196	21	Potential
	Transmembrane	204 – 224	21	Potential
	Transmembrane	266 – 286	21	Potential
	Transmembrane	304 – 324	21	Potential
	Transmembrane	347 – 367	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9MUL1-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 158CF9E44A58EB98	FASTA	367	40,369
	10 20 30 40 50 60 MLLTINLKDS FLTFFSNLGF SNEFSKALWI PLPILLLIIL AVVGVLVVVW LERKISAAVQ 70 80 90 100 110 120 QRIGPEYAGP LGVLQPLADG LKLAFKEDII PSKGDVLLFT LGPAIVVIPI FLSYLIVPFG 130 140 150 160 170 180 ENLIVSNINL GIFFWITVSS VAPLGLLMSG YGSNNKYSFL GGLRATAQSL SYEIPLALCV 190 200 210 220 230 240 LSICLLSDSL STIDIVQKQS TYGILGWNIW RQPIGFIAFI IAALAECERL PFDLPEAEEE 250 260 270 280 290 300 LVAGYQTEYT GMKFGLFYIG SYVNLLVSAL FASVLYLGGW SLPIPIEFLL NKMSLNASDS 310 320 330 340 350 360 EVQVISAFLG IGMTLLKTYL FLFLSILTRW TMPRVRIDQL LDLGWKFLLP ISLGNLLLTA SLKIALL

References

[1]	"Ancestral chloroplast genome in Mesostigma viride reveals an early branch of green plant evolution." Lemieux C., Otis C., Turmel M. Nature 403:649-652(2000) [PubMed: 10688199] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NIES-296.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF166114 Genomic DNA. Translation: AAF43887.1.
RefSeq	NP_038449.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	800902.
Family and domain databases
HAMAP	MF_01350. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_MESVI

Accession

Primary (citable) accession number: Q9MUL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)