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Q9MIY7

- COX2_DANRE

UniProt

Q9MIY7 - COX2_DANRE

Protein

Cytochrome c oxidase subunit 2

Gene

mt-co2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi161 – 1611Copper ACurated
    Metal bindingi196 – 1961Copper ACurated
    Metal bindingi200 – 2001Copper ACurated
    Metal bindingi204 – 2041Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:mt-co2
    Synonyms:coii, cox2, coxii, mtco2
    Encoded oniMitochondrion
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Mitochondrion

    Organism-specific databases

    ZFINiZDB-GENE-011205-15. mt-co2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230Cytochrome c oxidase subunit 2PRO_0000183520Add
    BLAST

    Proteomic databases

    PRIDEiQ9MIY7.

    Expressioni

    Gene expression databases

    BgeeiQ9MIY7.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000087872.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9MIY7.
    SMRiQ9MIY7. Positions 1-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini83 – 230148Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4822HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8220HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    GeneTreeiENSGT00390000017410.
    HOGENOMiHOG000264988.
    HOVERGENiHBG012727.
    InParanoidiQ9MIY7.
    KOiK02261.
    OMAiDHALMIV.
    OrthoDBiEOG7TJ3JX.
    PhylomeDBiQ9MIY7.
    TreeFamiTF344269.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9MIY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHPAQLGFQ DAASPVMEEL LCFHDHALMI VFLISTLVLY IIIAMVSTKL    50
    TNKFILDSQE IEIVWTVLPA IILILIALPS LRILYLMDEI NDPHVTIKAV 100
    GHQWYWSYEY TDYENLEFDS YMVPTQDLTP GGFRLLETDH RMVVPKESPI 150
    RILVSAEDVL HSWAVPSLGI KMDAVPGRLN QTAFIVSRPG VFYGQCSEIC 200
    GANHSFMPIV VEAVPLEFFE NWSSAMLEDA 230
    Length:230
    Mass (Da):25,985
    Last modified:October 1, 2000 - v1
    Checksum:i91BC51E34D22DDC5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC024175 Genomic DNA. Translation: AAF74300.1.
    RefSeqiNP_059334.1. NC_002333.2.

    Genome annotation databases

    EnsembliENSDART00000093609; ENSDARP00000087872; ENSDARG00000063908.
    GeneIDi140540.
    KEGGidre:140540.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC024175 Genomic DNA. Translation: AAF74300.1 .
    RefSeqi NP_059334.1. NC_002333.2.

    3D structure databases

    ProteinModelPortali Q9MIY7.
    SMRi Q9MIY7. Positions 1-227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000087872.

    Proteomic databases

    PRIDEi Q9MIY7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000093609 ; ENSDARP00000087872 ; ENSDARG00000063908 .
    GeneIDi 140540.
    KEGGi dre:140540.

    Organism-specific databases

    CTDi 4513.
    ZFINi ZDB-GENE-011205-15. mt-co2.

    Phylogenomic databases

    eggNOGi COG1622.
    GeneTreei ENSGT00390000017410.
    HOGENOMi HOG000264988.
    HOVERGENi HBG012727.
    InParanoidi Q9MIY7.
    KOi K02261.
    OMAi DHALMIV.
    OrthoDBi EOG7TJ3JX.
    PhylomeDBi Q9MIY7.
    TreeFami TF344269.

    Miscellaneous databases

    NextBioi 20797021.
    PROi Q9MIY7.

    Gene expression databases

    Bgeei Q9MIY7.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA."
      Broughton R.E., Milam J.E., Roe B.A.
      Genome Res. 11:1958-1967(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AB.

    Entry informationi

    Entry nameiCOX2_DANRE
    AccessioniPrimary (citable) accession number: Q9MIY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3