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Protein

Cytochrome c oxidase subunit 2

Gene

mt-co2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper ACurated
Metal bindingi196 – 1961Copper ACurated
Metal bindingi200 – 2001Copper ACurated
Metal bindingi204 – 2041Copper ACurated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_333715. Respiratory electron transport.
REACT_357088. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:mt-co2
Synonyms:coii, cox2, coxii, mtco2
Encoded oniMitochondrion
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Mitochondrion

Organism-specific databases

ZFINiZDB-GENE-011205-15. mt-co2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei27 – 4822HelicalSequence AnalysisAdd
BLAST
Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei63 – 8220HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 230148Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Cytochrome c oxidase subunit 2PRO_0000183520Add
BLAST

Proteomic databases

PRIDEiQ9MIY7.

Expressioni

Gene expression databases

BgeeiQ9MIY7.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000087872.

Structurei

3D structure databases

ProteinModelPortaliQ9MIY7.
SMRiQ9MIY7. Positions 1-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
GeneTreeiENSGT00390000017410.
HOGENOMiHOG000264988.
HOVERGENiHBG012727.
InParanoidiQ9MIY7.
KOiK02261.
OMAiYMVPTQD.
OrthoDBiEOG7TJ3JX.
PhylomeDBiQ9MIY7.
TreeFamiTF344269.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MIY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHPAQLGFQ DAASPVMEEL LCFHDHALMI VFLISTLVLY IIIAMVSTKL
60 70 80 90 100
TNKFILDSQE IEIVWTVLPA IILILIALPS LRILYLMDEI NDPHVTIKAV
110 120 130 140 150
GHQWYWSYEY TDYENLEFDS YMVPTQDLTP GGFRLLETDH RMVVPKESPI
160 170 180 190 200
RILVSAEDVL HSWAVPSLGI KMDAVPGRLN QTAFIVSRPG VFYGQCSEIC
210 220 230
GANHSFMPIV VEAVPLEFFE NWSSAMLEDA
Length:230
Mass (Da):25,985
Last modified:October 1, 2000 - v1
Checksum:i91BC51E34D22DDC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024175 Genomic DNA. Translation: AAF74300.1.
RefSeqiNP_059334.1. NC_002333.2.

Genome annotation databases

EnsembliENSDART00000093609; ENSDARP00000087872; ENSDARG00000063908.
GeneIDi140540.
KEGGidre:140540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024175 Genomic DNA. Translation: AAF74300.1.
RefSeqiNP_059334.1. NC_002333.2.

3D structure databases

ProteinModelPortaliQ9MIY7.
SMRiQ9MIY7. Positions 1-227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000087872.

Proteomic databases

PRIDEiQ9MIY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000093609; ENSDARP00000087872; ENSDARG00000063908.
GeneIDi140540.
KEGGidre:140540.

Organism-specific databases

CTDi4513.
ZFINiZDB-GENE-011205-15. mt-co2.

Phylogenomic databases

eggNOGiCOG1622.
GeneTreeiENSGT00390000017410.
HOGENOMiHOG000264988.
HOVERGENiHBG012727.
InParanoidiQ9MIY7.
KOiK02261.
OMAiYMVPTQD.
OrthoDBiEOG7TJ3JX.
PhylomeDBiQ9MIY7.
TreeFamiTF344269.

Enzyme and pathway databases

ReactomeiREACT_333715. Respiratory electron transport.
REACT_357088. TP53 Regulates Metabolic Genes.

Miscellaneous databases

NextBioi20797021.
PROiQ9MIY7.

Gene expression databases

BgeeiQ9MIY7.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA."
    Broughton R.E., Milam J.E., Roe B.A.
    Genome Res. 11:1958-1967(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiCOX2_DANRE
AccessioniPrimary (citable) accession number: Q9MIY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.