Q9MIY7 (COX2_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	mt-co2
Synonyms:	coii, cox2, coxii, mtco2

Encoded on

Mitochondrion

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Cytochrome c oxidase subunit 2		PRO_0000183520
Regions
	Topological domain	1 – 26	26	Mitochondrial intermembrane Potential
	Transmembrane	27 – 48	22	Helical; Potential
	Topological domain	49 – 62	14	Mitochondrial matrix Potential
	Transmembrane	63 – 82	20	Helical; Potential
	Topological domain	83 – 230	148	Mitochondrial intermembrane Potential
Sites
	Metal binding	161	1	Copper A Probable
	Metal binding	196	1	Copper A Probable
	Metal binding	200	1	Copper A Probable
	Metal binding	204	1	Copper A Probable

Sequences

	Sequence		Length	Mass (Da)
	Q9MIY7 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 91BC51E34D22DDC5	FASTA	230	25,985
	10 20 30 40 50 60 MAHPAQLGFQ DAASPVMEEL LCFHDHALMI VFLISTLVLY IIIAMVSTKL TNKFILDSQE 70 80 90 100 110 120 IEIVWTVLPA IILILIALPS LRILYLMDEI NDPHVTIKAV GHQWYWSYEY TDYENLEFDS 130 140 150 160 170 180 YMVPTQDLTP GGFRLLETDH RMVVPKESPI RILVSAEDVL HSWAVPSLGI KMDAVPGRLN 190 200 210 220 230 QTAFIVSRPG VFYGQCSEIC GANHSFMPIV VEAVPLEFFE NWSSAMLEDA

References

[1]	"The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA." Broughton R.E., Milam J.E., Roe B.A. Genome Res. 11:1958-1967(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC024175 Genomic DNA. Translation: AAF74300.1.
IPI	IPI00492845.
RefSeq	NP_059334.1. NC_002333.2.
3D structure databases
ProteinModelPortal	Q9MIY7.
SMR	Q9MIY7. Positions 1-227.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000087872.
Proteomic databases
PRIDE	Q9MIY7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000093609; ENSDARP00000087872; ENSDARG00000063908.
GeneID	140540.
KEGG	dre:140540.
Organism-specific databases
CTD	4513.
ZFIN	ZDB-GENE-011205-15. mt-co2.
Phylogenomic databases
eggNOG	COG1622.
GeneTree	ENSGT00390000017410.
HOGENOM	HOG000264988.
HOVERGEN	HBG012727.
InParanoid	Q9MIY7.
KO	K02261.
OrthoDB	EOG4BZN3N.
ProtClustDB	MTH00129.
Gene expression databases
Bgee	Q9MIY7.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20797021.

Entry information

Entry name

COX2_DANRE

Accession

Primary (citable) accession number: Q9MIY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program