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Q9MIY7 (COX2_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:mt-co2
Synonyms:coii, cox2, coxii, mtco2
Encoded onMitochondrion
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 230230Cytochrome c oxidase subunit 2
PRO_0000183520

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4822Helical; Potential
Topological domain49 – 6214Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Potential
Topological domain83 – 230148Mitochondrial intermembrane Potential

Sites

Metal binding1611Copper A Probable
Metal binding1961Copper A Probable
Metal binding2001Copper A Probable
Metal binding2041Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
Q9MIY7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 91BC51E34D22DDC5

FASTA23025,985
        10         20         30         40         50         60 
MAHPAQLGFQ DAASPVMEEL LCFHDHALMI VFLISTLVLY IIIAMVSTKL TNKFILDSQE 

        70         80         90        100        110        120 
IEIVWTVLPA IILILIALPS LRILYLMDEI NDPHVTIKAV GHQWYWSYEY TDYENLEFDS 

       130        140        150        160        170        180 
YMVPTQDLTP GGFRLLETDH RMVVPKESPI RILVSAEDVL HSWAVPSLGI KMDAVPGRLN 

       190        200        210        220        230 
QTAFIVSRPG VFYGQCSEIC GANHSFMPIV VEAVPLEFFE NWSSAMLEDA 

« Hide

References

[1]"The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA."
Broughton R.E., Milam J.E., Roe B.A.
Genome Res. 11:1958-1967(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AB.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC024175 Genomic DNA. Translation: AAF74300.1.
RefSeqNP_059334.1. NC_002333.2.

3D structure databases

ProteinModelPortalQ9MIY7.
SMRQ9MIY7. Positions 1-227.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000087872.

Proteomic databases

PRIDEQ9MIY7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000093609; ENSDARP00000087872; ENSDARG00000063908.
GeneID140540.
KEGGdre:140540.

Organism-specific databases

CTD4513.
ZFINZDB-GENE-011205-15. mt-co2.

Phylogenomic databases

eggNOGCOG1622.
GeneTreeENSGT00390000017410.
HOGENOMHOG000264988.
HOVERGENHBG012727.
InParanoidQ9MIY7.
KOK02261.
OMAEDVLHSW.
OrthoDBEOG7TJ3JX.
PhylomeDBQ9MIY7.
ProtClustDBMTH00129.
TreeFamTF344269.

Gene expression databases

BgeeQ9MIY7.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20797021.
PROQ9MIY7.

Entry information

Entry nameCOX2_DANRE
AccessionPrimary (citable) accession number: Q9MIY7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families