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Q9MIY4

- COX3_DANRE

UniProt

Q9MIY4 - COX3_DANRE

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Protein
Cytochrome c oxidase subunit 3
Gene
mt-co3, coiii, cox3, coxiii, mtco3
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt-co3
Synonyms:coiii, cox3, coxiii, mtco3
Encoded oniMitochondrion
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Mitochondrion

Organism-specific databases

ZFINiZDB-GENE-011205-16. mt-co3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST
Transmembranei31 – 5121Helical; Reviewed prediction
Add
BLAST
Transmembranei81 – 10121Helical; Reviewed prediction
Add
BLAST
Transmembranei127 – 14721Helical; Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183749Add
BLAST

Expressioni

Gene expression databases

BgeeiQ9MIY4.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000087875.

Structurei

3D structure databases

ProteinModelPortaliQ9MIY4.
SMRiQ9MIY4. Positions 1-261.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
GeneTreeiENSGT00390000013064.
HOGENOMiHOG000264954.
HOVERGENiHBG016686.
InParanoidiQ9MIY4.
KOiK02262.
OMAiYFVPGPS.
OrthoDBiEOG72VH70.
PhylomeDBiQ9MIY4.
TreeFamiTF343435.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MIY4-1 [UniParc]FASTAAdd to Basket

« Hide

MAHQAHAYHM VDPSPWPLTG AVAALLMSSG LAIWFHLHSM TLIVLGMILL    50
ILTMIQWWRD IIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFLGFFWA 100
FYHSSLAPTP ELGGCWPPTG LTTLDPFEVP LLNTAVLLAS GVTVTWAHHS 150
LMEGERKQAI QSLALTILLG LYFTALQAME YYEAPFTIAD GVYGSTFFVA 200
TGFHGLHVII GSTFLAVCLL RQVLFHFTSD HHFGFEAAAW YWHFVDVVWL 250
FLYVSIYWWG S 261
Length:261
Mass (Da):29,501
Last modified:October 1, 2000 - v1
Checksum:i01D24FFDD1266586
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC024175 Genomic DNA. Translation: AAF74303.1.
RefSeqiNP_059337.1. NC_002333.2.

Genome annotation databases

EnsembliENSDART00000093613; ENSDARP00000087875; ENSDARG00000063912.
GeneIDi140541.
KEGGidre:140541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC024175 Genomic DNA. Translation: AAF74303.1 .
RefSeqi NP_059337.1. NC_002333.2.

3D structure databases

ProteinModelPortali Q9MIY4.
SMRi Q9MIY4. Positions 1-261.
ModBasei Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000087875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000093613 ; ENSDARP00000087875 ; ENSDARG00000063912 .
GeneIDi 140541.
KEGGi dre:140541.

Organism-specific databases

CTDi 4514.
ZFINi ZDB-GENE-011205-16. mt-co3.

Phylogenomic databases

eggNOGi COG1845.
GeneTreei ENSGT00390000013064.
HOGENOMi HOG000264954.
HOVERGENi HBG016686.
InParanoidi Q9MIY4.
KOi K02262.
OMAi YFVPGPS.
OrthoDBi EOG72VH70.
PhylomeDBi Q9MIY4.
TreeFami TF343435.

Miscellaneous databases

NextBioi 20797022.
PROi Q9MIY4.

Gene expression databases

Bgeei Q9MIY4.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA."
    Broughton R.E., Milam J.E., Roe B.A.
    Genome Res. 11:1958-1967(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AB.

Entry informationi

Entry nameiCOX3_DANRE
AccessioniPrimary (citable) accession number: Q9MIY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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