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Q9MIY4

- COX3_DANRE

UniProt

Q9MIY4 - COX3_DANRE

Protein

Cytochrome c oxidase subunit 3

Gene

mt-co3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:mt-co3
    Synonyms:coiii, cox3, coxiii, mtco3
    Encoded oniMitochondrion
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Mitochondrion

    Organism-specific databases

    ZFINiZDB-GENE-011205-16. mt-co3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Cytochrome c oxidase subunit 3PRO_0000183749Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ9MIY4.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000087875.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9MIY4.
    SMRiQ9MIY4. Positions 1-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1845.
    GeneTreeiENSGT00390000013064.
    HOGENOMiHOG000264954.
    HOVERGENiHBG016686.
    InParanoidiQ9MIY4.
    KOiK02262.
    OMAiYFVPGPS.
    OrthoDBiEOG72VH70.
    PhylomeDBiQ9MIY4.
    TreeFamiTF343435.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9MIY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHQAHAYHM VDPSPWPLTG AVAALLMSSG LAIWFHLHSM TLIVLGMILL    50
    ILTMIQWWRD IIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFLGFFWA 100
    FYHSSLAPTP ELGGCWPPTG LTTLDPFEVP LLNTAVLLAS GVTVTWAHHS 150
    LMEGERKQAI QSLALTILLG LYFTALQAME YYEAPFTIAD GVYGSTFFVA 200
    TGFHGLHVII GSTFLAVCLL RQVLFHFTSD HHFGFEAAAW YWHFVDVVWL 250
    FLYVSIYWWG S 261
    Length:261
    Mass (Da):29,501
    Last modified:October 1, 2000 - v1
    Checksum:i01D24FFDD1266586
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC024175 Genomic DNA. Translation: AAF74303.1.
    RefSeqiNP_059337.1. NC_002333.2.

    Genome annotation databases

    EnsembliENSDART00000093613; ENSDARP00000087875; ENSDARG00000063912.
    GeneIDi140541.
    KEGGidre:140541.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC024175 Genomic DNA. Translation: AAF74303.1 .
    RefSeqi NP_059337.1. NC_002333.2.

    3D structure databases

    ProteinModelPortali Q9MIY4.
    SMRi Q9MIY4. Positions 1-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000087875.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000093613 ; ENSDARP00000087875 ; ENSDARG00000063912 .
    GeneIDi 140541.
    KEGGi dre:140541.

    Organism-specific databases

    CTDi 4514.
    ZFINi ZDB-GENE-011205-16. mt-co3.

    Phylogenomic databases

    eggNOGi COG1845.
    GeneTreei ENSGT00390000013064.
    HOGENOMi HOG000264954.
    HOVERGENi HBG016686.
    InParanoidi Q9MIY4.
    KOi K02262.
    OMAi YFVPGPS.
    OrthoDBi EOG72VH70.
    PhylomeDBi Q9MIY4.
    TreeFami TF343435.

    Miscellaneous databases

    NextBioi 20797022.
    PROi Q9MIY4.

    Gene expression databases

    Bgeei Q9MIY4.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA."
      Broughton R.E., Milam J.E., Roe B.A.
      Genome Res. 11:1958-1967(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AB.

    Entry informationi

    Entry nameiCOX3_DANRE
    AccessioniPrimary (citable) accession number: Q9MIY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3