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Q9MIY4 (COX3_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:mt-co3
Synonyms:coiii, cox3, coxiii, mtco3
Encoded onMitochondrion
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183749

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane31 – 5121Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane239 – 25921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9MIY4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 01D24FFDD1266586

FASTA26129,501
        10         20         30         40         50         60 
MAHQAHAYHM VDPSPWPLTG AVAALLMSSG LAIWFHLHSM TLIVLGMILL ILTMIQWWRD 

        70         80         90        100        110        120 
IIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFLGFFWA FYHSSLAPTP ELGGCWPPTG 

       130        140        150        160        170        180 
LTTLDPFEVP LLNTAVLLAS GVTVTWAHHS LMEGERKQAI QSLALTILLG LYFTALQAME 

       190        200        210        220        230        240 
YYEAPFTIAD GVYGSTFFVA TGFHGLHVII GSTFLAVCLL RQVLFHFTSD HHFGFEAAAW 

       250        260 
YWHFVDVVWL FLYVSIYWWG S 

« Hide

References

[1]"The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA."
Broughton R.E., Milam J.E., Roe B.A.
Genome Res. 11:1958-1967(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC024175 Genomic DNA. Translation: AAF74303.1.
RefSeqNP_059337.1. NC_002333.2.

3D structure databases

ProteinModelPortalQ9MIY4.
SMRQ9MIY4. Positions 1-261.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000087875.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000093613; ENSDARP00000087875; ENSDARG00000063912.
GeneID140541.
KEGGdre:140541.

Organism-specific databases

CTD4514.
ZFINZDB-GENE-011205-16. mt-co3.

Phylogenomic databases

eggNOGCOG1845.
GeneTreeENSGT00390000013064.
HOGENOMHOG000264954.
HOVERGENHBG016686.
InParanoidQ9MIY4.
KOK02262.
OMAFFWAFYH.
OrthoDBEOG72VH70.
PhylomeDBQ9MIY4.
TreeFamTF343435.

Gene expression databases

BgeeQ9MIY4.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20797022.
PROQ9MIY4.

Entry information

Entry nameCOX3_DANRE
AccessionPrimary (citable) accession number: Q9MIY4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families