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Protein

Cytochrome c oxidase subunit 3

Gene

mt-co3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

ReactomeiREACT_333715. Respiratory electron transport.
REACT_357088. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt-co3
Synonyms:coiii, cox3, coxiii, mtco3
Encoded oniMitochondrion
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Mitochondrion

Organism-specific databases

ZFINiZDB-GENE-011205-16. mt-co3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Cytochrome c oxidase subunit 3PRO_0000183749Add
BLAST

Expressioni

Gene expression databases

BgeeiQ9MIY4.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000087875.

Structurei

3D structure databases

ProteinModelPortaliQ9MIY4.
SMRiQ9MIY4. Positions 1-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
GeneTreeiENSGT00390000013064.
HOGENOMiHOG000264954.
HOVERGENiHBG016686.
InParanoidiQ9MIY4.
KOiK02262.
OMAiGFFWAFY.
OrthoDBiEOG72VH70.
PhylomeDBiQ9MIY4.
TreeFamiTF343435.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MIY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHQAHAYHM VDPSPWPLTG AVAALLMSSG LAIWFHLHSM TLIVLGMILL
60 70 80 90 100
ILTMIQWWRD IIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFLGFFWA
110 120 130 140 150
FYHSSLAPTP ELGGCWPPTG LTTLDPFEVP LLNTAVLLAS GVTVTWAHHS
160 170 180 190 200
LMEGERKQAI QSLALTILLG LYFTALQAME YYEAPFTIAD GVYGSTFFVA
210 220 230 240 250
TGFHGLHVII GSTFLAVCLL RQVLFHFTSD HHFGFEAAAW YWHFVDVVWL
260
FLYVSIYWWG S
Length:261
Mass (Da):29,501
Last modified:October 1, 2000 - v1
Checksum:i01D24FFDD1266586
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024175 Genomic DNA. Translation: AAF74303.1.
RefSeqiNP_059337.1. NC_002333.2.

Genome annotation databases

EnsembliENSDART00000093613; ENSDARP00000087875; ENSDARG00000063912.
GeneIDi140541.
KEGGidre:140541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024175 Genomic DNA. Translation: AAF74303.1.
RefSeqiNP_059337.1. NC_002333.2.

3D structure databases

ProteinModelPortaliQ9MIY4.
SMRiQ9MIY4. Positions 1-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000087875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000093613; ENSDARP00000087875; ENSDARG00000063912.
GeneIDi140541.
KEGGidre:140541.

Organism-specific databases

CTDi4514.
ZFINiZDB-GENE-011205-16. mt-co3.

Phylogenomic databases

eggNOGiCOG1845.
GeneTreeiENSGT00390000013064.
HOGENOMiHOG000264954.
HOVERGENiHBG016686.
InParanoidiQ9MIY4.
KOiK02262.
OMAiGFFWAFY.
OrthoDBiEOG72VH70.
PhylomeDBiQ9MIY4.
TreeFamiTF343435.

Enzyme and pathway databases

ReactomeiREACT_333715. Respiratory electron transport.
REACT_357088. TP53 Regulates Metabolic Genes.

Miscellaneous databases

NextBioi20797022.
PROiQ9MIY4.

Gene expression databases

BgeeiQ9MIY4.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA."
    Broughton R.E., Milam J.E., Roe B.A.
    Genome Res. 11:1958-1967(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiCOX3_DANRE
AccessioniPrimary (citable) accession number: Q9MIY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2000
Last modified: May 27, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.