ID Q9MD59_MOUSE Unreviewed; 345 AA. AC Q9MD59; DT 01-OCT-2000, integrated into UniProtKB/TrEMBL. DT 01-OCT-2000, sequence version 1. DT 27-MAR-2024, entry version 183. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2 {ECO:0000256|ARBA:ARBA00021008, ECO:0000256|RuleBase:RU003403}; DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU003403}; GN Name=mt-Nd2 {ECO:0000313|MGI:MGI:102500}; GN Synonyms=mt-ND2 {ECO:0000313|EMBL:QPG85856.1}, ND2 GN {ECO:0000313|EMBL:BAA95796.1}, Nd2 {ECO:0000313|EMBL:ADR03157.1}; OS Mus musculus (Mouse). OG Mitochondrion {ECO:0000313|EMBL:BAA95796.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAA95796.1}; RN [1] {ECO:0000313|EMBL:BAA95796.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SAMP1 {ECO:0000313|EMBL:BAA95641.1}, SAMP8 RC {ECO:0000313|EMBL:BAA95796.1}, and SAMR1 RC {ECO:0000313|EMBL:BAA95654.1}; RC TISSUE=Liver {ECO:0000313|EMBL:BAA95796.1}; RA Mori M., Higuchi K., Tanaka M.; RT "Unique transitional nucleotide mutations in the mitochondrial DNA of RT Senescence-accelerated Mouse (SAM) strains."; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:BAB13802.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C3H/He {ECO:0000313|EMBL:BAB13802.1}; RA Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.; RT "Unique mutations in mitochondrial DNA of Senescence-Accelerated Mouse RT (SAM) strains."; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:CAD33908.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Balb/cJ {ECO:0000313|EMBL:CAD54433.1}, and C3H/An RC {ECO:0000313|EMBL:CAD33908.1}; RC TISSUE=Connective {ECO:0000313|EMBL:CAD33908.1}, and Platelets RC {ECO:0000313|EMBL:CAD54433.1}; RX PubMed=12554686; DOI=10.1093/hmg/ddg021; RA Acin-Perez R., Bayona-Bafaluy M., Bueno M., Machicado C., RA Fernandez-Silva P., Perez-Martos A., Montoya J., Lopez-Perez M.J., RA Sancho J., Enriquez J.A.; RT "An intragenic suppressor in the cytochrome c oxidase I gene of mouse RT mitochondrial DNA."; RL Hum. Mol. Genet. 12:329-339(2003). RN [4] {ECO:0000313|EMBL:CAD33908.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Balb/cJ {ECO:0000313|EMBL:CAD54433.1}, and C3H/An RC {ECO:0000313|EMBL:CAD33908.1}; RC TISSUE=Connective {ECO:0000313|EMBL:CAD33908.1}, and Platelets RC {ECO:0000313|EMBL:CAD54433.1}; RX PubMed=12954771; DOI=10.1093/nar/gkg739; RA Bayona-Bafaluy M.P., Acin-Perez R., Mullikin J.C., Park J.S., RA Moreno-Loshuertos R., Hu P., Perez-Martos A., Fernandez-Silva P., Bai Y., RA Enriquez J.A.; RT "Revisiting the mouse mitochondrial DNA sequence."; RL Nucleic Acids Res. 31:5349-5355(2003). RN [5] {ECO:0000313|EMBL:AAS01440.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ALS/Lt {ECO:0000313|EMBL:AAS01440.1}, NOD/LtJ RC {ECO:0000313|EMBL:AAS01453.1}, and NON/Lt RC {ECO:0000313|EMBL:AAS01466.1}; RA Gusdon A.M., Spirina O., Bykhovskaya Y., Fischel-Ghodsia N., Libert T., RA Trucco M., Mathews C.E.; RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AAS01440.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ALS/Lt {ECO:0000313|EMBL:AAS01440.1}, NOD/LtJ RC {ECO:0000313|EMBL:AAS01453.1}, and NON/Lt RC {ECO:0000313|EMBL:AAS01466.1}; RA Mathews C.E., Leiter E.H., Spirina O., Bykhovskaya Y., Fischel-Ghodsian N.; RT "The ALR/Lt Mouse: Contribution of the Mitochondrial Genome in Resistance RT Against both Chemically-Induced and Autoimmune Diabetes."; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:AAY96690.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AAY96690.1}, and VM RC {ECO:0000313|EMBL:AAY96703.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAY96690.1}; RX PubMed=16105171; DOI=10.1186/1471-2407-5-102; RA Kiebish M.A., Seyfried T.N.; RT "Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors."; RL BMC Cancer 5:102-102(2005). RN [8] {ECO:0000313|EMBL:AAR21196.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CBA/J {ECO:0000313|EMBL:AAR21196.1}; RX PubMed=17013393; DOI=10.1038/ng1897; RA Moreno-Loshuertos R., Acin-Perez R., Fernandez-Silva P., Movilla N., RA Perez-Martos A., de Cordoba S.R., Gallardo M.E., Enriquez J.A.; RT "Differences in reactive oxygen species production explain the phenotypes RT associated with common mouse mitochondrial DNA variants."; RL Nat. Genet. 38:1261-1268(2006). RN [9] {ECO:0000313|EMBL:ABK79094.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=129S1/SvImJ {ECO:0000313|EMBL:ABK79094.1}, A/J RC {ECO:0000313|EMBL:ABK79107.1}, AKR/J {ECO:0000313|EMBL:ABK79120.1}, RC BALB/cByJ {ECO:0000313|EMBL:ABK79133.1}, BTBR T+ tf/J RC {ECO:0000313|EMBL:ABK79146.1}, C3H/HeJ {ECO:0000313|EMBL:ABK79159.1}, RC C57BL/6J {ECO:0000313|EMBL:ABK79172.1}, DBA/2J RC {ECO:0000313|EMBL:ABK79185.1}, FVB/NJ {ECO:0000313|EMBL:ABK79198.1}, RC NOD/LtJ {ECO:0000313|EMBL:ABK79224.1}, and NZW/LacJ RC {ECO:0000313|EMBL:ABK79237.1}; RX PubMed=17284675; DOI=10.1101/gr.5941007; RA Goios A., Pereira L., Bogue M., Macaulay V., Amorim A.; RT "mtDNA phylogeny and evolution of laboratory mouse strains."; RL Genome Res. 17:293-298(2007). RN [10] {ECO:0000313|EMBL:ACA01524.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MRL/MpJ {ECO:0000313|EMBL:ACA01524.1}; RC TISSUE=Heart {ECO:0000313|EMBL:ACA01524.1}; RX PubMed=18761428; DOI=10.1016/j.mito.2008.07.007; RA Sachadyn P., Zhang X.M., Clark L.D., Naviaux R.K., Heber-Katz E.; RT "Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse."; RL Mitochondrion 8:358-366(2008). RN [11] {ECO:0000313|EMBL:ADZ23168.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6NCrl {ECO:0000313|EMBL:ADZ23168.1}; RX PubMed=18232733; DOI=10.1371/journal.pbio.0060010; RA Stewart J.B., Freyer C., Elson J.L., Wredenberg A., Cansu Z., RA Trifunovic A., Larsson N.G.; RT "Strong purifying selection in transmission of mammalian mitochondrial RT DNA."; RL PLoS Biol. 6:E10-E10(2008). RN [12] {ECO:0000313|EMBL:ABX79703.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C3H/An {ECO:0000313|EMBL:ABX79729.1}, and C57BL/6 RC {ECO:0000313|EMBL:ABX79703.1}; RX PubMed=18388260; DOI=10.1126/science.1156906; RA Ishikawa K., Takenaga K., Akimoto M., Koshikawa N., Yamaguchi A., RA Imanishi H., Nakada K., Honma Y., Hayashi J.; RT "ROS-generating mitochondrial DNA mutations can regulate tumor cell RT metastasis."; RL Science 320:661-664(2008). RN [13] {ECO:0000313|EMBL:ACN91096.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C3H/An {ECO:0000313|EMBL:ACN91096.1}; RA Ishikawa K., Toyama-Sorimachi N., Nakada K., Morimoto M., Niikura M., RA Takenaga K., Yonekawa H., Hayashi J.-I.; RT "Innate immunity in the host mice targets cells with polymorphic mutations RT in mtDNA."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [15] {ECO:0000313|EMBL:ADR03157.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN/aW {ECO:0000313|EMBL:ADR03157.1}; RA Gajewska M., Unrug-Bielawska K., Strzalkowska A.; RT "Mitochondrion complete sequence of BN/aW mouse strain."; RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:AEN03370.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FVB/NJ {ECO:0000313|EMBL:AEN03370.1}; RX PubMed=21858071; DOI=10.1371/journal.pone.0023327; RA Seoane M., Mosquera-Miguel A., Gonzalez T., Fraga M., Salas A., RA Costoya J.A.; RT "The Mitochondrial Genome Is a 'Genetic Sanctuary' during the Oncogenic RT Process."; RL PLoS ONE 6:E23327-E23327(2011). RN [17] {ECO:0000313|EMBL:ADW83066.1} RP NUCLEOTIDE SEQUENCE. RA Fayzulin R., Alexeyev M.; RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:ADZ23168.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6NCrl {ECO:0000313|EMBL:ADZ23168.1}; RA Stewart J.B.; RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:AEV56598.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=WOM/W {ECO:0000313|EMBL:AEV56598.1}; RA Strzalkowska A., Unrug-Bielawska K., Gajewska M.; RT "Mus musculus strain WOM/W mitochondrion, complete genom."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:BAM93584.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:BAM93584.1}; RA Imanishi H., Takibuchi G., Hayashi J.; RT "Polymorphic mutations in mouse mitochondrial DNA regulate a tumor RT phenotype."; RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:BAN16593.1} RP NUCLEOTIDE SEQUENCE. RA Imanishi H., Takibuchi G., Hayashi J.; RT "Suppression of tumor formation of mouse carcinoma cells with specific RT mutations in mtDNA by innate immune system."; RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|EMBL:BAO42851.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAO42851.1}; RX PubMed=24510903; DOI=10.1073/pnas.1318109111; RA Shimizu A., Mito T., Hayashi C., Ogasawara E., Koba R., Negishi I., RA Takenaga K., Nakada K., Hayashi J.; RT "Transmitochondrial mice as models for primary prevention of diseases RT caused by mutation in the tRNALys gene."; RL Proc. Natl. Acad. Sci. U.S.A. 111:3104-3109(2014). RN [23] {ECO:0000313|EMBL:AJE26557.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/KaLwRij {ECO:0000313|EMBL:AJE26557.1}; RA Liu Z.-G.; RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:AJK91487.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=M13 {ECO:0000313|EMBL:AJK91513.1}, M17 RC {ECO:0000313|EMBL:AJK91487.1}, M6 {ECO:0000313|EMBL:AJK91526.1}, and RC ME {ECO:0000313|EMBL:AJK91500.1}; RA Wang N.; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|EMBL:AKS10713.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6N {ECO:0000313|EMBL:AKS10713.1}; RA Hayashi K., Okamura K., Hata K., Nakabayashi K.; RT "Development of an extension-based assembler and demonstration of RT determining complete mitochondrial genome sequences of several mouse RT strains."; RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:BAS29533.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C3H/An {ECO:0000313|EMBL:BAS29533.1}; RA Rikkerink E.H.A., Fineran P.C.; RT "Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the Causal RT Agent of Kiwifruit Canker Disease."; RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases. RN [27] {ECO:0000313|EMBL:QPG85856.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27626666; RA Kauppila JHK, Baines HL, Bratic A, Simard ML, Freyer C, Mourier A, Stamp C, RA Filograna R, Larsson NG, Greaves LC Stewart.JB.; RT "A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA RT Mutations Causing Mitochondrial Disease."; RL Cell Rep. 16:2980-2990(2016). RN [28] {ECO:0000313|EMBL:ART65694.1} RP NUCLEOTIDE SEQUENCE. RA StJohn J.; RT "Mitochondrial DNA haplotypes induce differential patterns of DNA RT methylation that result in differential chromosomal gene expression RT patterns."; RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases. RN [29] {ECO:0000313|EMBL:QPG85856.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30250142; RA Gammage PA, Viscomi C, Simard ML, Costa ASH, Gaude E, Powell CA, RA Van Haute L, McCann BJ, Rebelo-Guiomar P, Cerutti R, Zhang L, Rebar EJ, RA Zeviani M, Frezza C, Stewart JB Minczuk.M.; RT "Genome editing in mitochondria corrects a pathogenic mtDNA mutation in RT vivo."; RL Nat. Med. 24:1691-1695(2018). RN [30] {ECO:0000313|EMBL:QPG85856.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30250143; RA Bacman SR, Kauppila JHK, Pereira CV, Nissanka N, Miranda M, Pinto M, RA Williams SL, Larsson NG, Stewart JB Moraes.CT.; RT "MitoTALEN reduces mutant mtDNA load and restores tRNA(Ala) levels in a RT mouse model of heteroplasmic mtDNA mutation."; RL Nat. Med. 24:1696-1700(2018). RN [31] {ECO:0000313|EMBL:QPG85856.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=33099782; DOI=10.1002/jimd.12324; RA Stewart J.B.; RT "Current progress with mammalian models of mitochondrial DNA disease."; RL J. Inherit. Metab. Dis. 0:0-0(2020). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity and assembly of complex CC I. {ECO:0000256|RuleBase:RU003403}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU003403}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC inner membrane {ECO:0000256|ARBA:ARBA00004448, CC ECO:0000256|RuleBase:RU003403}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU003403}. CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. CC {ECO:0000256|ARBA:ARBA00007012, ECO:0000256|RuleBase:RU003403}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY466499; AAR21196.1; -; Genomic_DNA. DR EMBL; AY533106; AAS01440.1; -; Genomic_DNA. DR EMBL; AY533107; AAS01453.1; -; Genomic_DNA. DR EMBL; AY533108; AAS01466.1; -; Genomic_DNA. DR EMBL; AY999076; AAX83013.1; -; Genomic_DNA. DR EMBL; DQ106412; AAY96690.1; -; Genomic_DNA. DR EMBL; DQ106413; AAY96703.1; -; Genomic_DNA. DR EMBL; EF108330; ABK79094.1; -; Genomic_DNA. DR EMBL; EF108331; ABK79107.1; -; Genomic_DNA. DR EMBL; EF108332; ABK79120.1; -; Genomic_DNA. DR EMBL; EF108333; ABK79133.1; -; Genomic_DNA. DR EMBL; EF108334; ABK79146.1; -; Genomic_DNA. DR EMBL; EF108335; ABK79159.1; -; Genomic_DNA. DR EMBL; EF108336; ABK79172.1; -; Genomic_DNA. DR EMBL; EF108337; ABK79185.1; -; Genomic_DNA. DR EMBL; EF108338; ABK79198.1; -; Genomic_DNA. DR EMBL; EF108340; ABK79224.1; -; Genomic_DNA. DR EMBL; EF108341; ABK79237.1; -; Genomic_DNA. DR EMBL; EU312160; ABX79703.1; -; Genomic_DNA. DR EMBL; EU312161; ABX79716.1; -; Genomic_DNA. DR EMBL; EU315228; ABX79729.1; -; Genomic_DNA. DR EMBL; EU315229; ABX79742.1; -; Genomic_DNA. DR EMBL; EU450583; ACA01524.1; -; Genomic_DNA. DR EMBL; FJ803909; ACN91096.1; -; Genomic_DNA. DR EMBL; HQ586004; ADR03157.1; -; Genomic_DNA. DR EMBL; HQ877407; ADW83066.1; -; Genomic_DNA. DR EMBL; JF286601; ADZ23168.1; -; Genomic_DNA. DR EMBL; HQ675026; AEN03370.1; -; Genomic_DNA. DR EMBL; HQ675027; AEN03383.1; -; Genomic_DNA. DR EMBL; HQ675028; AEN03396.1; -; Genomic_DNA. DR EMBL; HQ675029; AEN03409.1; -; Genomic_DNA. DR EMBL; HQ675030; AEN03422.1; -; Genomic_DNA. DR EMBL; HQ675031; AEN03435.1; -; Genomic_DNA. DR EMBL; JQ003190; AEV56598.1; -; Genomic_DNA. DR EMBL; KP090294; AJE26557.1; -; Genomic_DNA. DR EMBL; KP260514; AJK91487.1; -; Genomic_DNA. DR EMBL; KP260515; AJK91500.1; -; Genomic_DNA. DR EMBL; KP260516; AJK91513.1; -; Genomic_DNA. DR EMBL; KP260517; AJK91526.1; -; Genomic_DNA. DR EMBL; KR020497; AKS10713.1; -; Genomic_DNA. DR EMBL; KY018919; ART65694.1; -; Genomic_DNA. DR EMBL; AB042524; BAA95641.1; -; Genomic_DNA. DR EMBL; AB042523; BAA95654.1; -; Genomic_DNA. DR EMBL; AB042809; BAA95796.1; -; Genomic_DNA. DR EMBL; AB049357; BAB13802.1; -; Genomic_DNA. DR EMBL; AP013030; BAM93584.1; -; Genomic_DNA. DR EMBL; AP013054; BAN16593.1; -; Genomic_DNA. DR EMBL; AP014540; BAO42851.1; -; Genomic_DNA. DR EMBL; AP014541; BAO42864.1; -; Genomic_DNA. DR EMBL; AP014941; BAS29533.1; -; Genomic_DNA. DR EMBL; AJ489607; CAD33908.1; -; Genomic_DNA. DR EMBL; AJ512208; CAD54433.1; -; Genomic_DNA. DR EMBL; MT937073; QPG85856.1; -; Genomic_DNA. DR RefSeq; NP_904329.1; NC_005089.1. DR RefSeq; YP_220551.1; NC_006914.1. DR AlphaFoldDB; Q9MD59; -. DR SMR; Q9MD59; -. DR MaxQB; Q9MD59; -. DR Antibodypedia; 47876; 80 antibodies from 19 providers. DR GeneID; 17717; -. DR GeneID; 3338894; -. DR KEGG; mmu:17717; -. DR AGR; MGI:102500; -. DR CTD; 4536; -. DR MGI; MGI:102500; mt-Nd2. DR VEuPathDB; HostDB:ENSMUSG00000064345; -. DR HOGENOM; CLU_007100_1_3_1; -. DR OMA; HFWVPEV; -. DR OrthoDB; 5390400at2759; -. DR ChiTaRS; mt-Nd2; mouse. DR ExpressionAtlas; Q9MD59; baseline and differential. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl. DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:Ensembl. DR InterPro; IPR010933; NADH_DH_su2_C. DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2. DR InterPro; IPR001750; ND/Mrp_mem. DR PANTHER; PTHR46552; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2; 1. DR PANTHER; PTHR46552:SF1; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2; 1. DR Pfam; PF06444; NADH_dehy_S2_C; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01436; NADHDHGNASE2. PE 1: Evidence at protein level; KW Electron transport {ECO:0000256|ARBA:ARBA00022982, KW ECO:0000256|RuleBase:RU003403}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003403}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128, KW ECO:0000256|RuleBase:RU003403}; KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792, KW ECO:0000256|RuleBase:RU003403}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003403}; KW Oxidoreductase {ECO:0000313|EMBL:AAR21196.1}; KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660, KW ECO:0000256|RuleBase:RU003403}; KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003403}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003403}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU003403}; Transport {ECO:0000256|ARBA:ARBA00022448}; KW Ubiquinone {ECO:0000256|ARBA:ARBA00023075, ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 30..47 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT TRANSMEM 59..78 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT TRANSMEM 93..115 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT TRANSMEM 152..171 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT TRANSMEM 178..196 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT TRANSMEM 202..221 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT TRANSMEM 233..256 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT TRANSMEM 276..298 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT TRANSMEM 323..344 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003403" FT DOMAIN 23..285 FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane FT subunit" FT /evidence="ECO:0000259|Pfam:PF00361" FT DOMAIN 290..343 FT /note="NADH dehydrogenase subunit 2 C-terminal" FT /evidence="ECO:0000259|Pfam:PF06444" SQ SEQUENCE 345 AA; 38752 MW; F6855CA2CA3F2E59 CRC64; MNPITLAIIY FTIFLGPVIT MSSTNLMLMW VGLEFSLLAI IPMLINKKNP RSTEAATKYF VTQATASMII LLAIVLNYKQ LGTWMFQQQT NGLILNMTLM ALSMKLGLAP FHFWLPEVTQ GIPLHMGLIL LTWQKIAPLS ILIQIYPLLN STIILMLAIT SIFMGAWGGL NQTQMRKIMA YSSIAHMGWM LAILPYNPSL TLLNLMIYII LTAPMFMALM LNNSMTINSI SLLWNKTPAM LTMISLMLLS LGGLPPLTGF LPKWIIITEL MKNNCLIMAT LMAMMALLNL FFYTRLIYST SLTMFPTNNN SKMMTHQTKT KPNLMFSTLA IMSTMTLPLA PQLIT //