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Q9MD59

- Q9MD59_MOUSE

UniProt

Q9MD59 - Q9MD59_MOUSE

Protein

NADH-ubiquinone oxidoreductase chain 2

Gene

mt-Nd2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.SAAS annotation

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
    2. reactive oxygen species metabolic process Source: MGI

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Electron transport, Respiratory chainSAAS annotation, Transport

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation, UbiquinoneUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 2UniRule annotation (EC:1.6.5.3UniRule annotation)
    Gene namesi
    Name:mt-Nd2Imported
    Synonyms:ND2Imported, Nd2Imported
    Encoded oniMitochondrionImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Mitochondrion

    Organism-specific databases

    MGIiMGI:102500. mt-Nd2.

    Subcellular locationi

    Mitochondrion inner membrane UniRule annotationSAAS annotation; Multi-pass membrane protein UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex I Source: Ensembl
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membraneSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ9MD59.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000111348.
    HOVERGENiHBG016692.
    InParanoidiQ9MD59.
    KOiK03879.
    OMAiKLGMAPF.

    Family and domain databases

    InterProiIPR010933. NADH_DH_su2_C.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003917. NADH_UbQ_OxRdtase_chain2.
    [Graphical view]
    PfamiPF06444. NADH_dehy_S2_C. 1 hit.
    PF00361. Oxidored_q1. 1 hit.
    [Graphical view]
    PRINTSiPR01436. NADHDHGNASE2.

    Sequencei

    Sequence statusi: Complete.

    Q9MD59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPITLAIIY FTIFLGPVIT MSSTNLMLMW VGLEFSLLAI IPMLINKKNP    50
    RSTEAATKYF VTQATASMII LLAIVLNYKQ LGTWMFQQQT NGLILNMTLM 100
    ALSMKLGLAP FHFWLPEVTQ GIPLHMGLIL LTWQKIAPLS ILIQIYPLLN 150
    STIILMLAIT SIFMGAWGGL NQTQMRKIMA YSSIAHMGWM LAILPYNPSL 200
    TLLNLMIYII LTAPMFMALM LNNSMTINSI SLLWNKTPAM LTMISLMLLS 250
    LGGLPPLTGF LPKWIIITEL MKNNCLIMAT LMAMMALLNL FFYTRLIYST 300
    SLTMFPTNNN SKMMTHQTKT KPNLMFSTLA IMSTMTLPLA PQLIT 345
    Length:345
    Mass (Da):38,752
    Last modified:October 1, 2000 - v1
    Checksum:iF6855CA2CA3F2E59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY172335 Genomic DNA. Translation: AAN85123.1.
    AY466499 Genomic DNA. Translation: AAR21196.1.
    AY533106 Genomic DNA. Translation: AAS01440.1.
    AY533107 Genomic DNA. Translation: AAS01453.1.
    AY533108 Genomic DNA. Translation: AAS01466.1.
    AY999076 Genomic DNA. Translation: AAX83013.1.
    DQ106412 Genomic DNA. Translation: AAY96690.1.
    DQ106413 Genomic DNA. Translation: AAY96703.1.
    EF108330 Genomic DNA. Translation: ABK79094.1.
    EF108331 Genomic DNA. Translation: ABK79107.1.
    EF108332 Genomic DNA. Translation: ABK79120.1.
    EF108333 Genomic DNA. Translation: ABK79133.1.
    EF108334 Genomic DNA. Translation: ABK79146.1.
    EF108335 Genomic DNA. Translation: ABK79159.1.
    EF108336 Genomic DNA. Translation: ABK79172.1.
    EF108337 Genomic DNA. Translation: ABK79185.1.
    EF108338 Genomic DNA. Translation: ABK79198.1.
    EF108340 Genomic DNA. Translation: ABK79224.1.
    EF108341 Genomic DNA. Translation: ABK79237.1.
    EU312160 Genomic DNA. Translation: ABX79703.1.
    EU312161 Genomic DNA. Translation: ABX79716.1.
    EU315228 Genomic DNA. Translation: ABX79729.1.
    EU315229 Genomic DNA. Translation: ABX79742.1.
    EU450583 Genomic DNA. Translation: ACA01524.1.
    FJ803909 Genomic DNA. Translation: ACN91096.1.
    HQ586004 Genomic DNA. Translation: ADR03157.1.
    HQ877407 Genomic DNA. Translation: ADW83066.1.
    JF286601 Genomic DNA. Translation: ADZ23168.1.
    HQ675026 Genomic DNA. Translation: AEN03370.1.
    HQ675027 Genomic DNA. Translation: AEN03383.1.
    HQ675028 Genomic DNA. Translation: AEN03396.1.
    HQ675029 Genomic DNA. Translation: AEN03409.1.
    HQ675030 Genomic DNA. Translation: AEN03422.1.
    HQ675031 Genomic DNA. Translation: AEN03435.1.
    JQ003190 Genomic DNA. Translation: AEV56598.1.
    AB042524 Genomic DNA. Translation: BAA95641.1.
    AB042523 Genomic DNA. Translation: BAA95654.1.
    AB042809 Genomic DNA. Translation: BAA95796.1.
    AB049357 Genomic DNA. Translation: BAB13802.1.
    AP013030 Genomic DNA. Translation: BAM93584.1.
    AP013054 Genomic DNA. Translation: BAN16593.1.
    AP014540 Genomic DNA. Translation: BAO42851.1.
    AP014541 Genomic DNA. Translation: BAO42864.1.
    AJ489607 Genomic DNA. Translation: CAD33908.1.
    AJ512208 Genomic DNA. Translation: CAD54433.1.
    RefSeqiNP_904329.1. NC_005089.1.
    YP_220551.1. NC_006914.1.

    Genome annotation databases

    EnsembliENSMUST00000082396; ENSMUSP00000080992; ENSMUSG00000064345.
    GeneIDi17717.
    3338894.
    KEGGimmu:17717.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY172335 Genomic DNA. Translation: AAN85123.1 .
    AY466499 Genomic DNA. Translation: AAR21196.1 .
    AY533106 Genomic DNA. Translation: AAS01440.1 .
    AY533107 Genomic DNA. Translation: AAS01453.1 .
    AY533108 Genomic DNA. Translation: AAS01466.1 .
    AY999076 Genomic DNA. Translation: AAX83013.1 .
    DQ106412 Genomic DNA. Translation: AAY96690.1 .
    DQ106413 Genomic DNA. Translation: AAY96703.1 .
    EF108330 Genomic DNA. Translation: ABK79094.1 .
    EF108331 Genomic DNA. Translation: ABK79107.1 .
    EF108332 Genomic DNA. Translation: ABK79120.1 .
    EF108333 Genomic DNA. Translation: ABK79133.1 .
    EF108334 Genomic DNA. Translation: ABK79146.1 .
    EF108335 Genomic DNA. Translation: ABK79159.1 .
    EF108336 Genomic DNA. Translation: ABK79172.1 .
    EF108337 Genomic DNA. Translation: ABK79185.1 .
    EF108338 Genomic DNA. Translation: ABK79198.1 .
    EF108340 Genomic DNA. Translation: ABK79224.1 .
    EF108341 Genomic DNA. Translation: ABK79237.1 .
    EU312160 Genomic DNA. Translation: ABX79703.1 .
    EU312161 Genomic DNA. Translation: ABX79716.1 .
    EU315228 Genomic DNA. Translation: ABX79729.1 .
    EU315229 Genomic DNA. Translation: ABX79742.1 .
    EU450583 Genomic DNA. Translation: ACA01524.1 .
    FJ803909 Genomic DNA. Translation: ACN91096.1 .
    HQ586004 Genomic DNA. Translation: ADR03157.1 .
    HQ877407 Genomic DNA. Translation: ADW83066.1 .
    JF286601 Genomic DNA. Translation: ADZ23168.1 .
    HQ675026 Genomic DNA. Translation: AEN03370.1 .
    HQ675027 Genomic DNA. Translation: AEN03383.1 .
    HQ675028 Genomic DNA. Translation: AEN03396.1 .
    HQ675029 Genomic DNA. Translation: AEN03409.1 .
    HQ675030 Genomic DNA. Translation: AEN03422.1 .
    HQ675031 Genomic DNA. Translation: AEN03435.1 .
    JQ003190 Genomic DNA. Translation: AEV56598.1 .
    AB042524 Genomic DNA. Translation: BAA95641.1 .
    AB042523 Genomic DNA. Translation: BAA95654.1 .
    AB042809 Genomic DNA. Translation: BAA95796.1 .
    AB049357 Genomic DNA. Translation: BAB13802.1 .
    AP013030 Genomic DNA. Translation: BAM93584.1 .
    AP013054 Genomic DNA. Translation: BAN16593.1 .
    AP014540 Genomic DNA. Translation: BAO42851.1 .
    AP014541 Genomic DNA. Translation: BAO42864.1 .
    AJ489607 Genomic DNA. Translation: CAD33908.1 .
    AJ512208 Genomic DNA. Translation: CAD54433.1 .
    RefSeqi NP_904329.1. NC_005089.1.
    YP_220551.1. NC_006914.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082396 ; ENSMUSP00000080992 ; ENSMUSG00000064345 .
    GeneIDi 17717.
    3338894.
    KEGGi mmu:17717.

    Organism-specific databases

    CTDi 4536.
    MGIi MGI:102500. mt-Nd2.

    Phylogenomic databases

    GeneTreei ENSGT00730000111348.
    HOVERGENi HBG016692.
    InParanoidi Q9MD59.
    KOi K03879.
    OMAi KLGMAPF.

    Miscellaneous databases

    NextBioi 292335.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9MD59.

    Family and domain databases

    InterProi IPR010933. NADH_DH_su2_C.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003917. NADH_UbQ_OxRdtase_chain2.
    [Graphical view ]
    Pfami PF06444. NADH_dehy_S2_C. 1 hit.
    PF00361. Oxidored_q1. 1 hit.
    [Graphical view ]
    PRINTSi PR01436. NADHDHGNASE2.
    ProtoNeti Search...

    Publicationsi

    1. "Unique transitional nucleotide mutations in the mitochondrial DNA of Senescence-accelerated Mouse (SAM) strains."
      Mori M., Higuchi K., Tanaka M.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SAMP1Imported, SAMP8Imported and SAMR1Imported.
      Tissue: LiverImported.
    2. "Unique mutations in mitochondrial DNA of Senescence-Accelerated Mouse (SAM) strains."
      Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C3H/HeImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Balb/cJImported and C3H/AnImported.
      Tissue: ConnectiveImported and PlateletsImported.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Balb/cJImported, C3H/AnImported and C57BL/6JImported.
      Tissue: ConnectiveImported and PlateletsImported.
    5. Gusdon A.M., Spirina O., Bykhovskaya Y., Fischel-Ghodsia N., Libert T., Trucco M., Mathews C.E.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ALS/LtImported, NOD/LtJImported and NON/LtImported.
    6. "The ALR/Lt Mouse: Contribution of the Mitochondrial Genome in Resistance Against both Chemically-Induced and Autoimmune Diabetes."
      Mathews C.E., Leiter E.H., Spirina O., Bykhovskaya Y., Fischel-Ghodsian N.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ALS/LtImported, NOD/LtJImported and NON/LtImported.
    7. "Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors."
      Kiebish M.A., Seyfried T.N.
      BMC Cancer 5:102-102(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and VMImported.
      Tissue: BrainImported.
    8. "Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants."
      Moreno-Loshuertos R., Acin-Perez R., Fernandez-Silva P., Movilla N., Perez-Martos A., de Cordoba S.R., Gallardo M.E., Enriquez J.A.
      Nat. Genet. 38:1261-1268(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CBA/JImported.
    9. "mtDNA phylogeny and evolution of laboratory mouse strains."
      Goios A., Pereira L., Bogue M., Macaulay V., Amorim A.
      Genome Res. 17:293-298(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129S1/SvImJImported, A/JImported, AKR/JImported, BALB/cByJImported, BTBR T+ tf/JImported, C3H/HeJImported, C57BL/6JImported, DBA/2JImported, FVB/NJImported, NOD/LtJImported and NZW/LacJImported.
    10. "Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse."
      Sachadyn P., Zhang X.M., Clark L.D., Naviaux R.K., Heber-Katz E.
      Mitochondrion 8:358-366(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MRL/MpJImported.
      Tissue: HeartImported.
    11. "Strong purifying selection in transmission of mammalian mitochondrial DNA."
      Stewart J.B., Freyer C., Elson J.L., Wredenberg A., Cansu Z., Trifunovic A., Larsson N.G.
      PLoS Biol. 6:E10-E10(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6NCrlImported.
    12. "ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis."
      Ishikawa K., Takenaga K., Akimoto M., Koshikawa N., Yamaguchi A., Imanishi H., Nakada K., Honma Y., Hayashi J.
      Science 320:661-664(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C3H/AnImported and C57BL/6Imported.
    13. "Innate immunity in the host mice targets cells with polymorphic mutations in mtDNA."
      Ishikawa K., Toyama-Sorimachi N., Nakada K., Morimoto M., Niikura M., Takenaga K., Yonekawa H., Hayashi J.-I.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C3H/AnImported.
    14. "Mitochondrion complete sequence of BN/aW mouse strain."
      Gajewska M., Unrug-Bielawska K., Strzalkowska A.
      Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BN/aWImported.
    15. "The Mitochondrial Genome Is a 'Genetic Sanctuary' during the Oncogenic Process."
      Seoane M., Mosquera-Miguel A., Gonzalez T., Fraga M., Salas A., Costoya J.A.
      PLoS ONE 6:E23327-E23327(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: FVB/NJImported.
    16. Fayzulin R., Alexeyev M.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    17. Stewart J.B.
      Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6NCrlImported.
    18. "Mus musculus strain WOM/W mitochondrion, complete genom."
      Strzalkowska A., Unrug-Bielawska K., Gajewska M.
      Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WOM/WImported.
    19. "Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype."
      Imanishi H., Takibuchi G., Hayashi J.
      Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6Imported.
    20. "Suppression of tumor formation of mouse carcinoma cells with specific mutations in mtDNA by innate immune system."
      Imanishi H., Takibuchi G., Hayashi J.
      Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    21. "Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene."
      Shimizu A., Mito T., Hayashi C., Ogasawara E., Koba R., Negishi I., Takenaga K., Nakada K., Hayashi J.
      Proc. Natl. Acad. Sci. U.S.A. 111:3104-3109(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    22. Ensembl
      Submitted (MAR-2014) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ9MD59_MOUSE
    AccessioniPrimary (citable) accession number: Q9MD59
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3