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Q9MD59 (Q9MD59_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 2 RuleBase RU003403

EC=1.6.5.3 RuleBase RU003403
Gene names
Name:mt-Nd2 MGI 102500 Ensembl ENSMUSP00000080992
Synonyms:ND2 EMBL BAA95796.1, Nd2 EMBL ADR03157.1
Encoded onMitochondrion EMBL BAA95796.1 Ensembl ENSMUSP00000080992
OrganismMus musculus (Mouse) [Reference proteome] EMBL BAA95796.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. SAAS SAAS010933

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). SAAS SAAS010933 RuleBase RU003403

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity SAAS SAAS010933 RuleBase RU003403.

Sequence similarities

Belongs to the complex I subunit 2 family. RuleBase RU003403

Sequences

Sequence LengthMass (Da)Tools
Q9MD59 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F6855CA2CA3F2E59

FASTA34538,752
        10         20         30         40         50         60 
MNPITLAIIY FTIFLGPVIT MSSTNLMLMW VGLEFSLLAI IPMLINKKNP RSTEAATKYF 

        70         80         90        100        110        120 
VTQATASMII LLAIVLNYKQ LGTWMFQQQT NGLILNMTLM ALSMKLGLAP FHFWLPEVTQ 

       130        140        150        160        170        180 
GIPLHMGLIL LTWQKIAPLS ILIQIYPLLN STIILMLAIT SIFMGAWGGL NQTQMRKIMA 

       190        200        210        220        230        240 
YSSIAHMGWM LAILPYNPSL TLLNLMIYII LTAPMFMALM LNNSMTINSI SLLWNKTPAM 

       250        260        270        280        290        300 
LTMISLMLLS LGGLPPLTGF LPKWIIITEL MKNNCLIMAT LMAMMALLNL FFYTRLIYST 

       310        320        330        340 
SLTMFPTNNN SKMMTHQTKT KPNLMFSTLA IMSTMTLPLA PQLIT 

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References

[1]"Unique transitional nucleotide mutations in the mitochondrial DNA of Senescence-accelerated Mouse (SAM) strains."
Mori M., Higuchi K., Tanaka M.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: SAMP1 EMBL BAA95641.1, SAMP8 EMBL BAA95796.1 and SAMR1 EMBL BAA95654.1.
Tissue: Liver EMBL BAA95796.1.
[2]"Unique mutations in mitochondrial DNA of Senescence-Accelerated Mouse (SAM) strains."
Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C3H/He EMBL BAB13802.1.
[3]"An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA."
Acin-Perez R., Bayona-Bafaluy M., Bueno M., Machicado C., Fernandez-Silva P., Perez-Martos A., Montoya J., Lopez-Perez M.J., Sancho J., Enriquez J.A.
Hum. Mol. Genet. 12:329-339(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Balb/cJ EMBL CAD54433.1 and C3H/An EMBL CAD33908.1.
Tissue: Connective EMBL CAD33908.1 and Platelets EMBL CAD54433.1.
[4]"Revisiting the mouse mitochondrial DNA sequence."
Bayona-Bafaluy M.P., Acin-Perez R., Mullikin J.C., Park J.S., Moreno-Loshuertos R., Hu P., Perez-Martos A., Fernandez-Silva P., Bai Y., Enriquez J.A.
Nucleic Acids Res. 31:5349-5355(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Balb/cJ EMBL CAD54433.1, C3H/An EMBL CAD33908.1 and C57BL/6J EMBL AAN85123.1 Ensembl ENSMUSP00000080992.
Tissue: Connective EMBL CAD33908.1 and Platelets EMBL CAD54433.1.
[5]Gusdon A.M., Spirina O., Bykhovskaya Y., Fischel-Ghodsia N., Libert T., Trucco M., Mathews C.E.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ALS/Lt EMBL AAS01440.1, NOD/LtJ EMBL AAS01453.1 and NON/Lt EMBL AAS01466.1.
[6]"The ALR/Lt Mouse: Contribution of the Mitochondrial Genome in Resistance Against both Chemically-Induced and Autoimmune Diabetes."
Mathews C.E., Leiter E.H., Spirina O., Bykhovskaya Y., Fischel-Ghodsian N.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ALS/Lt EMBL AAS01440.1, NOD/LtJ EMBL AAS01453.1 and NON/Lt EMBL AAS01466.1.
[7]"Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors."
Kiebish M.A., Seyfried T.N.
BMC Cancer 5:102-102(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL AAY96690.1 and VM EMBL AAY96703.1.
Tissue: Brain EMBL AAY96690.1.
[8]"Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants."
Moreno-Loshuertos R., Acin-Perez R., Fernandez-Silva P., Movilla N., Perez-Martos A., de Cordoba S.R., Gallardo M.E., Enriquez J.A.
Nat. Genet. 38:1261-1268(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CBA/J EMBL AAR21196.1.
[9]"mtDNA phylogeny and evolution of laboratory mouse strains."
Goios A., Pereira L., Bogue M., Macaulay V., Amorim A.
Genome Res. 17:293-298(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129S1/SvImJ EMBL ABK79094.1, A/J EMBL ABK79107.1, AKR/J EMBL ABK79120.1, BALB/cByJ EMBL ABK79133.1, BTBR T+ tf/J EMBL ABK79146.1, C3H/HeJ EMBL ABK79159.1, C57BL/6J EMBL ABK79172.1, DBA/2J EMBL ABK79185.1, FVB/NJ EMBL ABK79198.1, NOD/LtJ EMBL ABK79224.1 and NZW/LacJ EMBL ABK79237.1.
[10]"Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse."
Sachadyn P., Zhang X.M., Clark L.D., Naviaux R.K., Heber-Katz E.
Mitochondrion 8:358-366(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MRL/MpJ EMBL ACA01524.1.
Tissue: Heart EMBL ACA01524.1.
[11]"Strong purifying selection in transmission of mammalian mitochondrial DNA."
Stewart J.B., Freyer C., Elson J.L., Wredenberg A., Cansu Z., Trifunovic A., Larsson N.G.
PLoS Biol. 6:E10-E10(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6NCrl EMBL ADZ23168.1.
[12]"ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis."
Ishikawa K., Takenaga K., Akimoto M., Koshikawa N., Yamaguchi A., Imanishi H., Nakada K., Honma Y., Hayashi J.
Science 320:661-664(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C3H/An EMBL ABX79729.1 and C57BL/6 EMBL ABX79703.1.
[13]"Innate immunity in the host mice targets cells with polymorphic mutations in mtDNA."
Ishikawa K., Toyama-Sorimachi N., Nakada K., Morimoto M., Niikura M., Takenaga K., Yonekawa H., Hayashi J.-I.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C3H/An EMBL ACN91096.1.
[14]"Mitochondrion complete sequence of BN/aW mouse strain."
Gajewska M., Unrug-Bielawska K., Strzalkowska A.
Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN/aW EMBL ADR03157.1.
[15]"The Mitochondrial Genome Is a 'Genetic Sanctuary' during the Oncogenic Process."
Seoane M., Mosquera-Miguel A., Gonzalez T., Fraga M., Salas A., Costoya J.A.
PLoS ONE 6:E23327-E23327(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: FVB/NJ EMBL AEN03370.1.
[16]Fayzulin R., Alexeyev M.
Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[17]Stewart J.B.
Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6NCrl EMBL ADZ23168.1.
[18]"Mus musculus strain WOM/W mitochondrion, complete genom."
Strzalkowska A., Unrug-Bielawska K., Gajewska M.
Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: WOM/W EMBL AEV56598.1.
[19]"Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype."
Imanishi H., Takibuchi G., Hayashi J.
Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6 EMBL BAM93584.1.
[20]"Suppression of tumor formation of mouse carcinoma cells with specific mutations in mtDNA by innate immune system."
Imanishi H., Takibuchi G., Hayashi J.
Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[21]"Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene."
Shimizu A., Mito T., Hayashi C., Ogasawara E., Koba R., Negishi I., Takenaga K., Nakada K., Hayashi J.
Proc. Natl. Acad. Sci. U.S.A. 111:3104-3109(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAO42851.1.
[22]Ensembl
Submitted (MAR-2014) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000080992.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY172335 Genomic DNA. Translation: AAN85123.1.
AY466499 Genomic DNA. Translation: AAR21196.1.
AY533106 Genomic DNA. Translation: AAS01440.1.
AY533107 Genomic DNA. Translation: AAS01453.1.
AY533108 Genomic DNA. Translation: AAS01466.1.
AY999076 Genomic DNA. Translation: AAX83013.1.
DQ106412 Genomic DNA. Translation: AAY96690.1.
DQ106413 Genomic DNA. Translation: AAY96703.1.
EF108330 Genomic DNA. Translation: ABK79094.1.
EF108331 Genomic DNA. Translation: ABK79107.1.
EF108332 Genomic DNA. Translation: ABK79120.1.
EF108333 Genomic DNA. Translation: ABK79133.1.
EF108334 Genomic DNA. Translation: ABK79146.1.
EF108335 Genomic DNA. Translation: ABK79159.1.
EF108336 Genomic DNA. Translation: ABK79172.1.
EF108337 Genomic DNA. Translation: ABK79185.1.
EF108338 Genomic DNA. Translation: ABK79198.1.
EF108340 Genomic DNA. Translation: ABK79224.1.
EF108341 Genomic DNA. Translation: ABK79237.1.
EU312160 Genomic DNA. Translation: ABX79703.1.
EU312161 Genomic DNA. Translation: ABX79716.1.
EU315228 Genomic DNA. Translation: ABX79729.1.
EU315229 Genomic DNA. Translation: ABX79742.1.
EU450583 Genomic DNA. Translation: ACA01524.1.
FJ803909 Genomic DNA. Translation: ACN91096.1.
HQ586004 Genomic DNA. Translation: ADR03157.1.
HQ877407 Genomic DNA. Translation: ADW83066.1.
JF286601 Genomic DNA. Translation: ADZ23168.1.
HQ675026 Genomic DNA. Translation: AEN03370.1.
HQ675027 Genomic DNA. Translation: AEN03383.1.
HQ675028 Genomic DNA. Translation: AEN03396.1.
HQ675029 Genomic DNA. Translation: AEN03409.1.
HQ675030 Genomic DNA. Translation: AEN03422.1.
HQ675031 Genomic DNA. Translation: AEN03435.1.
JQ003190 Genomic DNA. Translation: AEV56598.1.
AB042524 Genomic DNA. Translation: BAA95641.1.
AB042523 Genomic DNA. Translation: BAA95654.1.
AB042809 Genomic DNA. Translation: BAA95796.1.
AB049357 Genomic DNA. Translation: BAB13802.1.
AP013030 Genomic DNA. Translation: BAM93584.1.
AP013054 Genomic DNA. Translation: BAN16593.1.
AP014540 Genomic DNA. Translation: BAO42851.1.
AP014541 Genomic DNA. Translation: BAO42864.1.
AJ489607 Genomic DNA. Translation: CAD33908.1.
AJ512208 Genomic DNA. Translation: CAD54433.1.
RefSeqNP_904329.1. NC_005089.1.
YP_220551.1. NC_006914.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082396; ENSMUSP00000080992; ENSMUSG00000064345.
GeneID17717.
3338894.
KEGGmmu:17717.

Organism-specific databases

CTD4536.
MGIMGI:102500. mt-Nd2.

Phylogenomic databases

GeneTreeENSGT00730000111348.
HOVERGENHBG016692.
InParanoidQ9MD59.
KOK03879.
OMAKLGMAPF.

Gene expression databases

GenevestigatorQ9MD59.

Family and domain databases

InterProIPR010933. NADH_DH_su2_C.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003917. NADH_UbQ_OxRdtase_chain2.
[Graphical view]
PfamPF06444. NADH_dehy_S2_C. 1 hit.
PF00361. Oxidored_q1. 1 hit.
[Graphical view]
PRINTSPR01436. NADHDHGNASE2.
ProtoNetSearch...

Other

NextBio292335.
SOURCESearch...

Entry information

Entry nameQ9MD59_MOUSE
AccessionPrimary (citable) accession number: Q9MD59
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)