NADH-ubiquinone oxidoreductase chain 2

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Q9MD59 (Q9MD59_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
NADH-ubiquinone oxidoreductase chain 2 RuleBase RU003403
EC=1.6.5.3 RuleBase RU003403

Gene names

Name:	mt-Nd2 MGI 102500
Synonyms:	ND2 EMBL BAA95796.1, Nd2 EMBL ADR03157.1

Encoded on

Mitochondrion EMBL BAA95796.1

Organism

Mus musculus (Mouse) [Reference proteome] EMBL BAA95796.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. SAAS SAAS003917
Catalytic activity	NADH + ubiquinone = NAD⁺ + ubiquinol. SAAS SAAS003917 RuleBase RU003403
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity SAAS SAAS003917 RuleBase RU003403.
Sequence similarities	Belongs to the complex I subunit 2 family. RuleBase RU003403

Ontologies

Keywords
Biological process	Electron transport Respiratory chain SAAS SAAS003917 Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane SAAS SAAS003917
Domain	Transmembrane Transmembrane helix SAAS SAAS003917
Ligand	NAD SAAS SAAS003917 RuleBase RU003403 Ubiquinone SAAS SAAS003917 RuleBase RU003403
Molecular function	Oxidoreductase SAAS SAAS003917 RuleBase RU003403 EMBL AAN85123.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial electron transport, NADH to ubiquinone Inferred from electronic annotation. Source: InterPro reactive oxygen species metabolic process Inferred from direct assay PubMed 17189252. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain complex I Inferred from electronic annotation. Source: Compara mitochondrion Inferred from direct assay PubMed 18614015. Source: MGI
Molecular_function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9MD59 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F6855CA2CA3F2E59
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FASTA

345

38,752

        10         20         30         40         50         60 
MNPITLAIIY FTIFLGPVIT MSSTNLMLMW VGLEFSLLAI IPMLINKKNP RSTEAATKYF 

        70         80         90        100        110        120 
VTQATASMII LLAIVLNYKQ LGTWMFQQQT NGLILNMTLM ALSMKLGLAP FHFWLPEVTQ 

       130        140        150        160        170        180 
GIPLHMGLIL LTWQKIAPLS ILIQIYPLLN STIILMLAIT SIFMGAWGGL NQTQMRKIMA 

       190        200        210        220        230        240 
YSSIAHMGWM LAILPYNPSL TLLNLMIYII LTAPMFMALM LNNSMTINSI SLLWNKTPAM 

       250        260        270        280        290        300 
LTMISLMLLS LGGLPPLTGF LPKWIIITEL MKNNCLIMAT LMAMMALLNL FFYTRLIYST 

       310        320        330        340 
SLTMFPTNNN SKMMTHQTKT KPNLMFSTLA IMSTMTLPLA PQLIT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Unique transitional nucleotide mutations in the mitochondrial DNA of Senescence-accelerated Mouse (SAM) strains." Mori M., Higuchi K., Tanaka M. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SAMP1 EMBL BAA95641.1, SAMP8 EMBL BAA95796.1 and SAMR1 EMBL BAA95654.1. Tissue: Liver EMBL BAA95796.1.
[2]	"Unique mutations in mitochondrial DNA of Senescence-Accelerated Mouse (SAM) strains." Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C3H/He EMBL BAB13802.1.
[3]	"An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA." Acin-Perez R., Bayona-Bafaluy M., Bueno M., Machicado C., Fernandez-Silva P., Perez-Martos A., Montoya J., Lopez-Perez M.J., Sancho J., Enriquez J.A. Hum. Mol. Genet. 12:329-339(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Balb/cJ EMBL CAD54433.1 and C3H/An EMBL CAD33908.1. Tissue: Connective EMBL CAD33908.1 and Platelets EMBL CAD54433.1.
[4]	"Revisiting the mouse mitochondrial DNA sequence." Bayona-Bafaluy M.P., Acin-Perez R., Mullikin J.C., Park J.S., Moreno-Loshuertos R., Hu P., Perez-Martos A., Fernandez-Silva P., Bai Y., Enriquez J.A. Nucleic Acids Res. 31:5349-5355(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Balb/cJ EMBL CAD54433.1, C3H/An EMBL CAD33908.1 and C57BL/6J EMBL AAN85123.1. Tissue: Connective EMBL CAD33908.1 and Platelets EMBL CAD54433.1.
[5]	Gusdon A.M., Spirina O., Bykhovskaya Y., Fischel-Ghodsia N., Libert T., Trucco M., Mathews C.E. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: ALS/Lt EMBL AAS01440.1, NOD/LtJ EMBL AAS01453.1 and NON/Lt EMBL AAS01466.1.
[6]	"The ALR/Lt Mouse: Contribution of the Mitochondrial Genome in Resistance Against both Chemically-Induced and Autoimmune Diabetes." Mathews C.E., Leiter E.H., Spirina O., Bykhovskaya Y., Fischel-Ghodsian N. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: ALS/Lt EMBL AAS01440.1, NOD/LtJ EMBL AAS01453.1 and NON/Lt EMBL AAS01466.1.
[7]	Kiebish M.A., Seyfried T.N. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL AAY96690.1 and VM EMBL AAY96703.1. Tissue: Brain EMBL AAY96690.1.
[8]	"Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants." Moreno-Loshuertos R., Acin-Perez R., Fernandez-Silva P., Movilla N., Perez-Martos A., de Cordoba S.R., Gallardo M.E., Enriquez J.A. Nat. Genet. 38:1261-1268(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: CBA/J EMBL AAR21196.1.
[9]	"mtDNA phylogeny and evolution of laboratory mouse strains." Goios A., Pereira L., Bogue M., Macaulay V., Amorim A. Genome Res. 17:293-298(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129S1/SvImJ EMBL ABK79094.1, A/J EMBL ABK79107.1, AKR/J EMBL ABK79120.1, BALB/cByJ EMBL ABK79133.1, BTBR T+ tf/J EMBL ABK79146.1, C3H/HeJ EMBL ABK79159.1, C57BL/6J EMBL ABK79172.1, DBA/2J EMBL ABK79185.1, FVB/NJ EMBL ABK79198.1, NOD/LtJ EMBL ABK79224.1 and NZW/LacJ EMBL ABK79237.1.
[10]	"Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse." Sachadyn P., Zhang X.M., Clark L.D., Naviaux R.K., Heber-Katz E. Mitochondrion 8:358-366(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: MRL/MpJ EMBL ACA01524.1. Tissue: Heart EMBL ACA01524.1.
[11]	"Strong purifying selection in transmission of mammalian mitochondrial DNA." Stewart J.B., Freyer C., Elson J.L., Wredenberg A., Cansu Z., Trifunovic A., Larsson N.G. PLoS Biol. 6:E10-E10(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6NCrl EMBL ADZ23168.1.
[12]	"ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis." Ishikawa K., Takenaga K., Akimoto M., Koshikawa N., Yamaguchi A., Imanishi H., Nakada K., Honma Y., Hayashi J. Science 320:661-664(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C3H/An EMBL ABX79729.1 and C57BL/6 EMBL ABX79703.1.
[13]	"Innate immunity in the host mice targets cells with polymorphic mutations in mtDNA." Ishikawa K., Toyama-Sorimachi N., Nakada K., Morimoto M., Niikura M., Takenaga K., Yonekawa H., Hayashi J.-I. Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C3H/An EMBL ACN91096.1.
[14]	"Mitochondrion complete sequence of BN/aW mouse strain." Gajewska M., Unrug-Bielawska K., Strzalkowska A. Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN/aW EMBL ADR03157.1.
[15]	"The Mitochondrial Genome Is a 'Genetic Sanctuary' during the Oncogenic Process." Seoane M., Mosquera-Miguel A., Gonzalez T., Fraga M., Salas A., Costoya J.A. PLoS ONE 6:E23327-E23327(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: FVB/NJ EMBL AEN03370.1.
[16]	Fayzulin R., Alexeyev M. Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[17]	Stewart J.B. Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6NCrl EMBL ADZ23168.1.
[18]	"Mus musculus strain WOM/W mitochondrion, complete genom." Strzalkowska A., Unrug-Bielawska K., Gajewska M. Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: WOM/W EMBL AEV56598.1.
[19]	"Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype." Imanishi H., Takibuchi G., Hayashi J. Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6 EMBL BAM93584.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY172335 Genomic DNA. Translation: AAN85123.1. AY466499 Genomic DNA. Translation: AAR21196.1. AY533106 Genomic DNA. Translation: AAS01440.1. AY533107 Genomic DNA. Translation: AAS01453.1. AY533108 Genomic DNA. Translation: AAS01466.1. AY999076 Genomic DNA. Translation: AAX83013.1. DQ106412 Genomic DNA. Translation: AAY96690.1. DQ106413 Genomic DNA. Translation: AAY96703.1. EF108330 Genomic DNA. Translation: ABK79094.1. EF108331 Genomic DNA. Translation: ABK79107.1. EF108332 Genomic DNA. Translation: ABK79120.1. EF108333 Genomic DNA. Translation: ABK79133.1. EF108334 Genomic DNA. Translation: ABK79146.1. EF108335 Genomic DNA. Translation: ABK79159.1. EF108336 Genomic DNA. Translation: ABK79172.1. EF108337 Genomic DNA. Translation: ABK79185.1. EF108338 Genomic DNA. Translation: ABK79198.1. EF108340 Genomic DNA. Translation: ABK79224.1. EF108341 Genomic DNA. Translation: ABK79237.1. EU312160 Genomic DNA. Translation: ABX79703.1. EU312161 Genomic DNA. Translation: ABX79716.1. EU315228 Genomic DNA. Translation: ABX79729.1. EU315229 Genomic DNA. Translation: ABX79742.1. EU450583 Genomic DNA. Translation: ACA01524.1. FJ803909 Genomic DNA. Translation: ACN91096.1. HQ586004 Genomic DNA. Translation: ADR03157.1. HQ877407 Genomic DNA. Translation: ADW83066.1. JF286601 Genomic DNA. Translation: ADZ23168.1. HQ675026 Genomic DNA. Translation: AEN03370.1. HQ675027 Genomic DNA. Translation: AEN03383.1. HQ675028 Genomic DNA. Translation: AEN03396.1. HQ675029 Genomic DNA. Translation: AEN03409.1. HQ675030 Genomic DNA. Translation: AEN03422.1. HQ675031 Genomic DNA. Translation: AEN03435.1. JQ003190 Genomic DNA. Translation: AEV56598.1. AB042524 Genomic DNA. Translation: BAA95641.1. AB042523 Genomic DNA. Translation: BAA95654.1. AB042809 Genomic DNA. Translation: BAA95796.1. AB049357 Genomic DNA. Translation: BAB13802.1. AP013030 Genomic DNA. Translation: BAM93584.1. AJ489607 Genomic DNA. Translation: CAD33908.1. AJ512208 Genomic DNA. Translation: CAD54433.1.
IPI	IPI00355228.
RefSeq	NP_904329.1. NC_005089.1.
3D structure databases
SMR	Q9MD59. Positions 15-302.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	17717.
KEGG	mmu:17717.
Organism-specific databases
CTD	4536.
MGI	MGI:102500. mt-Nd2.
Phylogenomic databases
GeneTree	ENSGT00530000063968.
HOVERGEN	HBG016692.
InParanoid	Q9MD59.
KO	K03879.
ProtClustDB	MTH00105.
Gene expression databases
Genevestigator	Q9MD59.
Family and domain databases
InterPro	IPR010933. NADH_DH_su2_C. IPR001750. NADH_UbQ/plastoQ_OxRdtase. IPR003917. NADH_UbQ_OxRdtase_chain2. [Graphical view]
Pfam	PF06444. NADH_dehy_S2_C. 1 hit. PF00361. Oxidored_q1. 1 hit. [Graphical view]
PRINTS	PR01436. NADHDHGNASE2.
ProtoNet	Search...
Other
NextBio	292335.
SOURCE	Search...

Entry information

Entry name

Q9MD59_MOUSE

Accession

Primary (citable) accession number: Q9MD59

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information