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Protein

NADH-ubiquinone oxidoreductase chain 2

Gene

mt-Nd2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).SAAS annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Electron transport, Respiratory chainSAAS annotation, Transport

Keywords - Ligandi

NADUniRule annotationSAAS annotation, UbiquinoneUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_278797. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 2UniRule annotationSAAS annotation (EC:1.6.5.3UniRule annotationSAAS annotation)
Gene namesi
Name:mt-Nd2Imported
Synonyms:ND2Imported, Nd2Imported
Encoded oniMitochondrionImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:102500. mt-Nd2.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotationSAAS annotation; Multi-pass membrane protein UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080992.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG016692.
KOiK03879.
OMAiKMKWQFE.

Family and domain databases

InterProiIPR010933. NADH_DH_su2_C.
IPR003917. NADH_UbQ_OxRdtase_chain2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF06444. NADH_dehy_S2_C. 1 hit.
PF00361. Oxidored_q1. 1 hit.
[Graphical view]
PRINTSiPR01436. NADHDHGNASE2.

Sequencei

Sequence statusi: Complete.

Q9MD59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPITLAIIY FTIFLGPVIT MSSTNLMLMW VGLEFSLLAI IPMLINKKNP
60 70 80 90 100
RSTEAATKYF VTQATASMII LLAIVLNYKQ LGTWMFQQQT NGLILNMTLM
110 120 130 140 150
ALSMKLGLAP FHFWLPEVTQ GIPLHMGLIL LTWQKIAPLS ILIQIYPLLN
160 170 180 190 200
STIILMLAIT SIFMGAWGGL NQTQMRKIMA YSSIAHMGWM LAILPYNPSL
210 220 230 240 250
TLLNLMIYII LTAPMFMALM LNNSMTINSI SLLWNKTPAM LTMISLMLLS
260 270 280 290 300
LGGLPPLTGF LPKWIIITEL MKNNCLIMAT LMAMMALLNL FFYTRLIYST
310 320 330 340
SLTMFPTNNN SKMMTHQTKT KPNLMFSTLA IMSTMTLPLA PQLIT
Length:345
Mass (Da):38,752
Last modified:October 1, 2000 - v1
Checksum:iF6855CA2CA3F2E59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY466499 Genomic DNA. Translation: AAR21196.1.
AY533106 Genomic DNA. Translation: AAS01440.1.
AY533107 Genomic DNA. Translation: AAS01453.1.
AY533108 Genomic DNA. Translation: AAS01466.1.
AY999076 Genomic DNA. Translation: AAX83013.1.
DQ106412 Genomic DNA. Translation: AAY96690.1.
DQ106413 Genomic DNA. Translation: AAY96703.1.
EF108330 Genomic DNA. Translation: ABK79094.1.
EF108331 Genomic DNA. Translation: ABK79107.1.
EF108332 Genomic DNA. Translation: ABK79120.1.
EF108333 Genomic DNA. Translation: ABK79133.1.
EF108334 Genomic DNA. Translation: ABK79146.1.
EF108335 Genomic DNA. Translation: ABK79159.1.
EF108336 Genomic DNA. Translation: ABK79172.1.
EF108337 Genomic DNA. Translation: ABK79185.1.
EF108338 Genomic DNA. Translation: ABK79198.1.
EF108340 Genomic DNA. Translation: ABK79224.1.
EF108341 Genomic DNA. Translation: ABK79237.1.
EU312160 Genomic DNA. Translation: ABX79703.1.
EU312161 Genomic DNA. Translation: ABX79716.1.
EU315228 Genomic DNA. Translation: ABX79729.1.
EU315229 Genomic DNA. Translation: ABX79742.1.
EU450583 Genomic DNA. Translation: ACA01524.1.
FJ803909 Genomic DNA. Translation: ACN91096.1.
HQ586004 Genomic DNA. Translation: ADR03157.1.
HQ877407 Genomic DNA. Translation: ADW83066.1.
JF286601 Genomic DNA. Translation: ADZ23168.1.
HQ675026 Genomic DNA. Translation: AEN03370.1.
HQ675027 Genomic DNA. Translation: AEN03383.1.
HQ675028 Genomic DNA. Translation: AEN03396.1.
HQ675029 Genomic DNA. Translation: AEN03409.1.
HQ675030 Genomic DNA. Translation: AEN03422.1.
HQ675031 Genomic DNA. Translation: AEN03435.1.
JQ003190 Genomic DNA. Translation: AEV56598.1.
KP090294 Genomic DNA. Translation: AJE26557.1.
KP260514 Genomic DNA. Translation: AJK91487.1.
KP260515 Genomic DNA. Translation: AJK91500.1.
KP260516 Genomic DNA. Translation: AJK91513.1.
KP260517 Genomic DNA. Translation: AJK91526.1.
AB042524 Genomic DNA. Translation: BAA95641.1.
AB042523 Genomic DNA. Translation: BAA95654.1.
AB042809 Genomic DNA. Translation: BAA95796.1.
AB049357 Genomic DNA. Translation: BAB13802.1.
AP013030 Genomic DNA. Translation: BAM93584.1.
AP013054 Genomic DNA. Translation: BAN16593.1.
AP014540 Genomic DNA. Translation: BAO42851.1.
AP014541 Genomic DNA. Translation: BAO42864.1.
AJ489607 Genomic DNA. Translation: CAD33908.1.
AJ512208 Genomic DNA. Translation: CAD54433.1.
RefSeqiNP_904329.1. NC_005089.1.
YP_220551.1. NC_006914.1.

Genome annotation databases

GeneIDi17717.
3338894.
KEGGimmu:17717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY466499 Genomic DNA. Translation: AAR21196.1.
AY533106 Genomic DNA. Translation: AAS01440.1.
AY533107 Genomic DNA. Translation: AAS01453.1.
AY533108 Genomic DNA. Translation: AAS01466.1.
AY999076 Genomic DNA. Translation: AAX83013.1.
DQ106412 Genomic DNA. Translation: AAY96690.1.
DQ106413 Genomic DNA. Translation: AAY96703.1.
EF108330 Genomic DNA. Translation: ABK79094.1.
EF108331 Genomic DNA. Translation: ABK79107.1.
EF108332 Genomic DNA. Translation: ABK79120.1.
EF108333 Genomic DNA. Translation: ABK79133.1.
EF108334 Genomic DNA. Translation: ABK79146.1.
EF108335 Genomic DNA. Translation: ABK79159.1.
EF108336 Genomic DNA. Translation: ABK79172.1.
EF108337 Genomic DNA. Translation: ABK79185.1.
EF108338 Genomic DNA. Translation: ABK79198.1.
EF108340 Genomic DNA. Translation: ABK79224.1.
EF108341 Genomic DNA. Translation: ABK79237.1.
EU312160 Genomic DNA. Translation: ABX79703.1.
EU312161 Genomic DNA. Translation: ABX79716.1.
EU315228 Genomic DNA. Translation: ABX79729.1.
EU315229 Genomic DNA. Translation: ABX79742.1.
EU450583 Genomic DNA. Translation: ACA01524.1.
FJ803909 Genomic DNA. Translation: ACN91096.1.
HQ586004 Genomic DNA. Translation: ADR03157.1.
HQ877407 Genomic DNA. Translation: ADW83066.1.
JF286601 Genomic DNA. Translation: ADZ23168.1.
HQ675026 Genomic DNA. Translation: AEN03370.1.
HQ675027 Genomic DNA. Translation: AEN03383.1.
HQ675028 Genomic DNA. Translation: AEN03396.1.
HQ675029 Genomic DNA. Translation: AEN03409.1.
HQ675030 Genomic DNA. Translation: AEN03422.1.
HQ675031 Genomic DNA. Translation: AEN03435.1.
JQ003190 Genomic DNA. Translation: AEV56598.1.
KP090294 Genomic DNA. Translation: AJE26557.1.
KP260514 Genomic DNA. Translation: AJK91487.1.
KP260515 Genomic DNA. Translation: AJK91500.1.
KP260516 Genomic DNA. Translation: AJK91513.1.
KP260517 Genomic DNA. Translation: AJK91526.1.
AB042524 Genomic DNA. Translation: BAA95641.1.
AB042523 Genomic DNA. Translation: BAA95654.1.
AB042809 Genomic DNA. Translation: BAA95796.1.
AB049357 Genomic DNA. Translation: BAB13802.1.
AP013030 Genomic DNA. Translation: BAM93584.1.
AP013054 Genomic DNA. Translation: BAN16593.1.
AP014540 Genomic DNA. Translation: BAO42851.1.
AP014541 Genomic DNA. Translation: BAO42864.1.
AJ489607 Genomic DNA. Translation: CAD33908.1.
AJ512208 Genomic DNA. Translation: CAD54433.1.
RefSeqiNP_904329.1. NC_005089.1.
YP_220551.1. NC_006914.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080992.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17717.
3338894.
KEGGimmu:17717.

Organism-specific databases

CTDi4536.
MGIiMGI:102500. mt-Nd2.

Phylogenomic databases

HOVERGENiHBG016692.
KOiK03879.
OMAiKMKWQFE.

Enzyme and pathway databases

ReactomeiREACT_278797. Respiratory electron transport.

Miscellaneous databases

NextBioi292335.
SOURCEiSearch...

Family and domain databases

InterProiIPR010933. NADH_DH_su2_C.
IPR003917. NADH_UbQ_OxRdtase_chain2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF06444. NADH_dehy_S2_C. 1 hit.
PF00361. Oxidored_q1. 1 hit.
[Graphical view]
PRINTSiPR01436. NADHDHGNASE2.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Unique transitional nucleotide mutations in the mitochondrial DNA of Senescence-accelerated Mouse (SAM) strains."
    Mori M., Higuchi K., Tanaka M.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SAMP1Imported, SAMP8Imported and SAMR1Imported.
    Tissue: LiverImported.
  2. "Unique mutations in mitochondrial DNA of Senescence-Accelerated Mouse (SAM) strains."
    Mizutani J., Chiba T., Tanaka M., Higuchi K., Mori M.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H/HeImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Balb/cJImported and C3H/AnImported.
    Tissue: ConnectiveImported and PlateletsImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Balb/cJImported and C3H/AnImported.
    Tissue: ConnectiveImported and PlateletsImported.
  5. Gusdon A.M., Spirina O., Bykhovskaya Y., Fischel-Ghodsia N., Libert T., Trucco M., Mathews C.E.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ALS/LtImported, NOD/LtJImported and NON/LtImported.
  6. "The ALR/Lt Mouse: Contribution of the Mitochondrial Genome in Resistance Against both Chemically-Induced and Autoimmune Diabetes."
    Mathews C.E., Leiter E.H., Spirina O., Bykhovskaya Y., Fischel-Ghodsian N.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ALS/LtImported, NOD/LtJImported and NON/LtImported.
  7. "Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors."
    Kiebish M.A., Seyfried T.N.
    BMC Cancer 5:102-102(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and VMImported.
    Tissue: BrainImported.
  8. "Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants."
    Moreno-Loshuertos R., Acin-Perez R., Fernandez-Silva P., Movilla N., Perez-Martos A., de Cordoba S.R., Gallardo M.E., Enriquez J.A.
    Nat. Genet. 38:1261-1268(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CBA/JImported.
  9. "mtDNA phylogeny and evolution of laboratory mouse strains."
    Goios A., Pereira L., Bogue M., Macaulay V., Amorim A.
    Genome Res. 17:293-298(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129S1/SvImJImported, A/JImported, AKR/JImported, BALB/cByJImported, BTBR T+ tf/JImported, C3H/HeJImported, C57BL/6JImported, DBA/2JImported, FVB/NJImported, NOD/LtJImported and NZW/LacJImported.
  10. "Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse."
    Sachadyn P., Zhang X.M., Clark L.D., Naviaux R.K., Heber-Katz E.
    Mitochondrion 8:358-366(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MRL/MpJImported.
    Tissue: HeartImported.
  11. "Strong purifying selection in transmission of mammalian mitochondrial DNA."
    Stewart J.B., Freyer C., Elson J.L., Wredenberg A., Cansu Z., Trifunovic A., Larsson N.G.
    PLoS Biol. 6:E10-E10(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6NCrlImported.
  12. "ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis."
    Ishikawa K., Takenaga K., Akimoto M., Koshikawa N., Yamaguchi A., Imanishi H., Nakada K., Honma Y., Hayashi J.
    Science 320:661-664(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H/AnImported and C57BL/6Imported.
  13. "Innate immunity in the host mice targets cells with polymorphic mutations in mtDNA."
    Ishikawa K., Toyama-Sorimachi N., Nakada K., Morimoto M., Niikura M., Takenaga K., Yonekawa H., Hayashi J.-I.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H/AnImported.
  14. "Mitochondrion complete sequence of BN/aW mouse strain."
    Gajewska M., Unrug-Bielawska K., Strzalkowska A.
    Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BN/aWImported.
  15. "The Mitochondrial Genome Is a 'Genetic Sanctuary' during the Oncogenic Process."
    Seoane M., Mosquera-Miguel A., Gonzalez T., Fraga M., Salas A., Costoya J.A.
    PLoS ONE 6:E23327-E23327(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FVB/NJImported.
  16. Fayzulin R., Alexeyev M.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  17. Stewart J.B.
    Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6NCrlImported.
  18. "Mus musculus strain WOM/W mitochondrion, complete genom."
    Strzalkowska A., Unrug-Bielawska K., Gajewska M.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WOM/WImported.
  19. "Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype."
    Imanishi H., Takibuchi G., Hayashi J.
    Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
  20. "Suppression of tumor formation of mouse carcinoma cells with specific mutations in mtDNA by innate immune system."
    Imanishi H., Takibuchi G., Hayashi J.
    Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  21. "Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene."
    Shimizu A., Mito T., Hayashi C., Ogasawara E., Koba R., Negishi I., Takenaga K., Nakada K., Hayashi J.
    Proc. Natl. Acad. Sci. U.S.A. 111:3104-3109(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  22. Liu Z.-G.
    Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/KaLwRijImported.
  23. Wang N.
    Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: M13Imported, M17Imported, M6Imported and MEImported.

Entry informationi

Entry nameiQ9MD59_MOUSE
AccessioniPrimary (citable) accession number: Q9MD59
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.