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Protein

NADH-ubiquinone oxidoreductase chain 2

Gene

mt-Nd2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.SAAS annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Electron transport, Respiratory chainSAAS annotation, Transport

Keywords - Ligandi

NADUniRule annotationSAAS annotation, UbiquinoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 2UniRule annotationSAAS annotation (EC:1.6.5.3UniRule annotationSAAS annotation)
Gene namesi
Name:mt-Nd2Imported
Synonyms:ND2Imported, Nd2Imported
Encoded oniMitochondrionImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:102500. mt-Nd2.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotationSAAS annotation; Multi-pass membrane protein UniRule annotationSAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 47HelicalSequence analysisAdd BLAST18
Transmembranei59 – 78HelicalSequence analysisAdd BLAST20
Transmembranei93 – 115HelicalSequence analysisAdd BLAST23
Transmembranei152 – 171HelicalSequence analysisAdd BLAST20
Transmembranei178 – 196HelicalSequence analysisAdd BLAST19
Transmembranei202 – 221HelicalSequence analysisAdd BLAST20
Transmembranei233 – 256HelicalSequence analysisAdd BLAST24
Transmembranei276 – 298HelicalSequence analysisAdd BLAST23
Transmembranei323 – 344HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000064345.
ExpressionAtlasiQ9MD59. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080992.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 283Proton_antipo_MInterPro annotationAdd BLAST261
Domaini290 – 344NADH_dehy_S2_CInterPro annotationAdd BLAST55

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPMV. Eukaryota.
COG1007. LUCA.
HOVERGENiHBG016692.
KOiK03879.
OMAiEASTKYF.
OrthoDBiEOG091G0J50.

Family and domain databases

InterProiIPR010933. NADH_DH_su2_C.
IPR003917. NADH_UbQ_OxRdtase_chain2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF06444. NADH_dehy_S2_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01436. NADHDHGNASE2.

Sequencei

Sequence statusi: Complete.

Q9MD59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPITLAIIY FTIFLGPVIT MSSTNLMLMW VGLEFSLLAI IPMLINKKNP
60 70 80 90 100
RSTEAATKYF VTQATASMII LLAIVLNYKQ LGTWMFQQQT NGLILNMTLM
110 120 130 140 150
ALSMKLGLAP FHFWLPEVTQ GIPLHMGLIL LTWQKIAPLS ILIQIYPLLN
160 170 180 190 200
STIILMLAIT SIFMGAWGGL NQTQMRKIMA YSSIAHMGWM LAILPYNPSL
210 220 230 240 250
TLLNLMIYII LTAPMFMALM LNNSMTINSI SLLWNKTPAM LTMISLMLLS
260 270 280 290 300
LGGLPPLTGF LPKWIIITEL MKNNCLIMAT LMAMMALLNL FFYTRLIYST
310 320 330 340
SLTMFPTNNN SKMMTHQTKT KPNLMFSTLA IMSTMTLPLA PQLIT
Length:345
Mass (Da):38,752
Last modified:October 1, 2000 - v1
Checksum:iF6855CA2CA3F2E59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY466499 Genomic DNA. Translation: AAR21196.1.
AY533106 Genomic DNA. Translation: AAS01440.1.
AY533107 Genomic DNA. Translation: AAS01453.1.
AY533108 Genomic DNA. Translation: AAS01466.1.
AY999076 Genomic DNA. Translation: AAX83013.1.
DQ106412 Genomic DNA. Translation: AAY96690.1.
DQ106413 Genomic DNA. Translation: AAY96703.1.
EF108330 Genomic DNA. Translation: ABK79094.1.
EF108331 Genomic DNA. Translation: ABK79107.1.
EF108332 Genomic DNA. Translation: ABK79120.1.
EF108333 Genomic DNA. Translation: ABK79133.1.
EF108334 Genomic DNA. Translation: ABK79146.1.
EF108335 Genomic DNA. Translation: ABK79159.1.
EF108336 Genomic DNA. Translation: ABK79172.1.
EF108337 Genomic DNA. Translation: ABK79185.1.
EF108338 Genomic DNA. Translation: ABK79198.1.
EF108340 Genomic DNA. Translation: ABK79224.1.
EF108341 Genomic DNA. Translation: ABK79237.1.
EU312160 Genomic DNA. Translation: ABX79703.1.
EU312161 Genomic DNA. Translation: ABX79716.1.
EU315228 Genomic DNA. Translation: ABX79729.1.
EU315229 Genomic DNA. Translation: ABX79742.1.
EU450583 Genomic DNA. Translation: ACA01524.1.
FJ803909 Genomic DNA. Translation: ACN91096.1.
HQ586004 Genomic DNA. Translation: ADR03157.1.
HQ877407 Genomic DNA. Translation: ADW83066.1.
JF286601 Genomic DNA. Translation: ADZ23168.1.
HQ675026 Genomic DNA. Translation: AEN03370.1.
HQ675027 Genomic DNA. Translation: AEN03383.1.
HQ675028 Genomic DNA. Translation: AEN03396.1.
HQ675029 Genomic DNA. Translation: AEN03409.1.
HQ675030 Genomic DNA. Translation: AEN03422.1.
HQ675031 Genomic DNA. Translation: AEN03435.1.
JQ003190 Genomic DNA. Translation: AEV56598.1.
KP090294 Genomic DNA. Translation: AJE26557.1.
KP260514 Genomic DNA. Translation: AJK91487.1.
KP260515 Genomic DNA. Translation: AJK91500.1.
KP260516 Genomic DNA. Translation: AJK91513.1.
KP260517 Genomic DNA. Translation: AJK91526.1.
KR020497 Genomic DNA. Translation: AKS10713.1.
AB042524 Genomic DNA. Translation: BAA95641.1.
AB042523 Genomic DNA. Translation: BAA95654.1.
AB042809 Genomic DNA. Translation: BAA95796.1.
AB049357 Genomic DNA. Translation: BAB13802.1.
AP013030 Genomic DNA. Translation: BAM93584.1.
AP013054 Genomic DNA. Translation: BAN16593.1.
AP014540 Genomic DNA. Translation: BAO42851.1.
AP014541 Genomic DNA. Translation: BAO42864.1.
AP014941 Genomic DNA. Translation: BAS29533.1.
AJ489607 Genomic DNA. Translation: CAD33908.1.
AJ512208 Genomic DNA. Translation: CAD54433.1.
RefSeqiNP_904329.1. NC_005089.1.
YP_220551.1. NC_006914.1.

Genome annotation databases

GeneIDi17717.
3338894.
KEGGimmu:17717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY466499 Genomic DNA. Translation: AAR21196.1.
AY533106 Genomic DNA. Translation: AAS01440.1.
AY533107 Genomic DNA. Translation: AAS01453.1.
AY533108 Genomic DNA. Translation: AAS01466.1.
AY999076 Genomic DNA. Translation: AAX83013.1.
DQ106412 Genomic DNA. Translation: AAY96690.1.
DQ106413 Genomic DNA. Translation: AAY96703.1.
EF108330 Genomic DNA. Translation: ABK79094.1.
EF108331 Genomic DNA. Translation: ABK79107.1.
EF108332 Genomic DNA. Translation: ABK79120.1.
EF108333 Genomic DNA. Translation: ABK79133.1.
EF108334 Genomic DNA. Translation: ABK79146.1.
EF108335 Genomic DNA. Translation: ABK79159.1.
EF108336 Genomic DNA. Translation: ABK79172.1.
EF108337 Genomic DNA. Translation: ABK79185.1.
EF108338 Genomic DNA. Translation: ABK79198.1.
EF108340 Genomic DNA. Translation: ABK79224.1.
EF108341 Genomic DNA. Translation: ABK79237.1.
EU312160 Genomic DNA. Translation: ABX79703.1.
EU312161 Genomic DNA. Translation: ABX79716.1.
EU315228 Genomic DNA. Translation: ABX79729.1.
EU315229 Genomic DNA. Translation: ABX79742.1.
EU450583 Genomic DNA. Translation: ACA01524.1.
FJ803909 Genomic DNA. Translation: ACN91096.1.
HQ586004 Genomic DNA. Translation: ADR03157.1.
HQ877407 Genomic DNA. Translation: ADW83066.1.
JF286601 Genomic DNA. Translation: ADZ23168.1.
HQ675026 Genomic DNA. Translation: AEN03370.1.
HQ675027 Genomic DNA. Translation: AEN03383.1.
HQ675028 Genomic DNA. Translation: AEN03396.1.
HQ675029 Genomic DNA. Translation: AEN03409.1.
HQ675030 Genomic DNA. Translation: AEN03422.1.
HQ675031 Genomic DNA. Translation: AEN03435.1.
JQ003190 Genomic DNA. Translation: AEV56598.1.
KP090294 Genomic DNA. Translation: AJE26557.1.
KP260514 Genomic DNA. Translation: AJK91487.1.
KP260515 Genomic DNA. Translation: AJK91500.1.
KP260516 Genomic DNA. Translation: AJK91513.1.
KP260517 Genomic DNA. Translation: AJK91526.1.
KR020497 Genomic DNA. Translation: AKS10713.1.
AB042524 Genomic DNA. Translation: BAA95641.1.
AB042523 Genomic DNA. Translation: BAA95654.1.
AB042809 Genomic DNA. Translation: BAA95796.1.
AB049357 Genomic DNA. Translation: BAB13802.1.
AP013030 Genomic DNA. Translation: BAM93584.1.
AP013054 Genomic DNA. Translation: BAN16593.1.
AP014540 Genomic DNA. Translation: BAO42851.1.
AP014541 Genomic DNA. Translation: BAO42864.1.
AP014941 Genomic DNA. Translation: BAS29533.1.
AJ489607 Genomic DNA. Translation: CAD33908.1.
AJ512208 Genomic DNA. Translation: CAD54433.1.
RefSeqiNP_904329.1. NC_005089.1.
YP_220551.1. NC_006914.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080992.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17717.
3338894.
KEGGimmu:17717.

Organism-specific databases

CTDi4536.
MGIiMGI:102500. mt-Nd2.

Phylogenomic databases

eggNOGiENOG410IPMV. Eukaryota.
COG1007. LUCA.
HOVERGENiHBG016692.
KOiK03879.
OMAiEASTKYF.
OrthoDBiEOG091G0J50.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064345.
ExpressionAtlasiQ9MD59. baseline and differential.

Family and domain databases

InterProiIPR010933. NADH_DH_su2_C.
IPR003917. NADH_UbQ_OxRdtase_chain2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF06444. NADH_dehy_S2_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01436. NADHDHGNASE2.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9MD59_MOUSE
AccessioniPrimary (citable) accession number: Q9MD59
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.